Clinical trials: Oocyte
Infertility, Female
The Difference Seen in Granulosa Cells and Immature Oocytes in IVF Treated Patients Sorted by Body Mass Index (BMI)
This study aims to discover the connection between BMI and oocyte and granulosa consistencies.
- Trial name
- NCT03020173
- Testing
- Laboratory study
- Volunteers
- 100 people
- Sponsor
- Hillel Yaffe Medical Center
Infertility
Clinical Pregnancies After Cryopreservation of Donor Oocytes With an Open or Closed Device
This randomized pilot study will assess if there is a difference in clinical pregnancies using donor oocytes cryopreserved in either a closed or a semi-closed vitrification device.
- Trial name
- NCT02940106
- Testing
- Cryotop device, CBSvit device
- Where
- Belgium
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Aneuploidy Rate
Aneuploidy Rate and Stimulation Protocol: Recombinant Follicle Stimulating Hormone (FSH) Versus Human FSH
Several stimulation protocols have been used in in vitro fertilization (IVF) in a cycle of egg donation; recombinant FSH and human FSH are included. The effect of each kind of hormone on aneuploidy rate it is unknown.
- Trial name
- NCT01164943
- Testing
- Stimulation with human FSH, Stimulation with recombinant FSH
- Where
- Spain
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- IVI Madrid
IVF
Propofol Sedation vs. Anaesthetist Guided Anaesthesia in Oocyte Pickup
Patients undergoing their first course of in vitro fertilisation receive either gynaecologist guided propofol only sedation or anaesthetist guided full anaesthesia.
- Trial name
- NCT05741814
- Testing
- Propofol
- Where
- Austria
- Volunteers
- 100 people
- Sponsor
- Wunschbaby Institut Feichtinger
Infertility
Use of Antagonist Versus Agonist GnRH in Oocyte Recipient Endometrium Preparation
Oocyte donation is a well established procedure in assisted reproduction treatments (ART). It is demonstrated that the use of hormonal substitution therapy, for the synchronization of the cycles between the recipients and the…
- Trial name
- NCT00633347
- Testing
- Antagonist GnRH Cetrotide, Agonist GnRH Acetate Triptoreline
- Where
- Spain
- Volunteers
- 570 people, healthy volunteers welcome
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Infertility
Ultrasound Guided Aspiration of Hydrosalpingeal Fluid and IVF-ET Outcomes
The aim of this study is to determine whether the ultrasound guided aspiration of hydrosalpingeal fluid at the time of oocyte retrieval can improve the outcomes of IVF-ET .
- Trial name
- NCT01040351
- Testing
- ultrasound guided aspiration of hydrosalpingeal fluid
- Where
- Egypt
- Volunteers
- 110 people
- Sponsor
- Cairo University
Infertility, Male
Selection of Non Apoptotic Human Sperm for in Vitro Fertilization by Using Magnetic Activated Cell Sorting (MACS)
This clinical study has been organised to help improve the embryo quality in couples having high rate of sperm showing apoptotic signs.
- Trial name
- MACS-HS (NCT03988361)
- Testing
- Magnetic Activated Cell Sorting
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Anxiety, in Vitro Fertilization
Impact of Virtual Reality Before Oocytes Retrieval on Anxiety and Pregnancy Rate
The primary objective of this study is to evaluate the impact of a session of virtual reality (VR) with the objective of lowering the anxiety level on the clinical pregnancy rate following an In-vitro fertilisation (IVF)…
- Conditions
- Anxiety, in Vitro Fertilization, Virtual Reality
- Trial name
- NCT03064061
- Testing
- Virtual reality
- Where
- Belgium
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Female Urogenital Diseases
Evaluation of Time Interval Between Ovulation Trigger With Triptorelin Acetate and Oocyte Retrieval
The aim of this study is to determine what is the best time interval between GnRH agonist (triptorelin acetate) ovulation induction allowing for the higher number of mature oocytes (MII) collected in IVF cycles.
- Trial name
- TIMING (NCT02244151)
- Testing
- Decapeptyl® diario, Decapeptyl® daily
- Where
- Spain
- Volunteers
- 130 people
- Sponsor
- Instituto de Investigacion Sanitaria La Fe
Female Infertility
Study for Obtaining Mature Oocytes by in Vitro Maturation in Oocyte-donor Women
In vitro maturation (IVM) is a technique for obtaining potentially fertilizable oocytes from immature oocytes. An oocyte must be mature both nuclearly and cytoplasmically in order to be competent in the reproductive process.
- Trial name
- IVM (NCT03998553)
- Testing
- IN VITRO MATURATION AND OOCYTE ACTIVATION
- Where
- Spain
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
INFERTILITY
Dual Triggering in Patients With a High Immature Oocyte Rate
In in vitro fertilization (IVF) cycles, even after adequate triggering, some patients present a high rate of immature oocytes retrieved after controlled ovarian stimulation.
- Trial name
- NCT02813239
- Testing
- hCG, hCG + GnRH agonist
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- IVI Madrid
Idiopathic Infertility, Infertility Unexplained
Biological Aging Hallmarks-Guided Integrative TCM and Conventional Medicine in Post-Treatment Unexplained Female Infertility
The goal of this clinical trial is to determine whether telomere profiling and other biological aging hallmarks can help identify underlying mechanisms of persistent infertility in women with post-treatment unexplained…
- Conditions
- Idiopathic Infertility, Infertility Unexplained, Infertility (IVF Patients), Infertility Assisted Reproductive Technology
- Trial name
- TECMI (NCT07404969)
- Testing
- 1. Aging Hallmarks Biomarker Profiling (Telomere-Based), 2. Integrative Botanical and Nutraceutical Intervention, 3. Natural Conception or Assisted Reproductive Technologies
- Where
- Switzerland
- Volunteers
- 15 people
- Sponsor
- BEYOND GENOMiX SA, AG, Ltd
Assisted Reproductive Technology
Oocyte Activation: Revised or Initial AGT Technique, Which is Better?! A Sibling-oocytes-split Design
This study will be conducted to compare two different Assisted Gamete treatment (AGT) with oocyte-sibling-split design control group : AGT- initial protocol for activating oocytes by culturing oocytes in calcium ionophore after…
- Trial name
- NCT05113238
- Testing
- Assisted gamete activation
- Where
- Egypt
- Volunteers
- 222 people
- Sponsor
- Royal Fertility Center, Egypt
Healthy
Effect of Body Composition and Metabolism on Oocyte Gene Expression
The investigators will test the hypothesis that obese women have a unique oocyte gene expression profile that differs significantly from that of normal weight women.
- Trial name
- NCT01480024
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Arkansas Children's Hospital Research Institute
In Vitro Fertilization
Retrospective Analysis of the Incidence of Complications From Transvaginal Oocyte Retrieval (TVOR).
The investigators retrospectively analysed the complication rate of ultrasound guided transvaginal oocyte retrieval (TVOR) from all the procedures performed between 1996 and October 2016 in a tertiary level university based…
- Trial name
- TVOR (NCT03282279)
- Testing
- TVOR
- Volunteers
- 23,827 people
- Sponsor
- Istituto Clinico Humanitas
ICSI, Testicular Sperm Extraction in Azoospermic Patients
Comparison of Two Types of Calcium (Ca²⁺) Ionophore Treatments for Oocyte Activation in Cases of Suboptimal Fertilization Potential
This study aims to investigate the effectiveness and safety of assisted oocyte activation (AOA) using Ca²⁺ ionophores in cases of total fertilization failure (TFF) due to oocyte activation deficiency (OAD).
- Conditions
- ICSI, Testicular Sperm Extraction in Azoospermic Patients, Male Infertility, PGT-A
- Trial name
- (Ca²⁺) (NCT07570342)
- Testing
- Group 1: Oocyte Activation (OA) CultActive, Group 2: Oocyte Activation (OA) Ionomycin, Group 3: Control
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Infertility, Infertility, Female
Effect of Vitrification and Warming Media on Pregnancy Rates in the Context of Oocyte Donation
Vitrification has become the gold standard for oocyte and embryo cryopreservation. Several commercial kits are available on the market, some are designed for specific developmental stages (e.g.
- Trial name
- NCT07288866
- Testing
- Vitrification and warming media for oocyte vitrification
- Where
- France
- Volunteers
- 111 people
- Sponsor
- University Hospital, Clermont-Ferrand
Oocyte Donors, Oocyte Donation
Luteal Phase Ovarian Stimulation With Follitropin Delta and Dydrogesterone
The last decade has shown a progressive scientific interest for new strategies to improve the outcomes of controlled ovarian stimulation (COS).
- Trial name
- LadyDe (NCT05521828)
- Testing
- Follitropin delta (Rekovelle), Duphaston, GnRH agonist (Gonapeptyl)
- Where
- Belgium
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- CRG UZ Brussel
Diminished Ovarian Reserve, Infertility
Delayed Start to Ovarian Stimulation
In couples with infertility secondary to Diminished Ovarian Reserve, the investigators hypothesize that a delayed start (7 day) to ovarian stimulation with an GnRH antagonist (Ganirelix) will improve oocyte maturation and…
- Conditions
- Diminished Ovarian Reserve, Infertility, In Vitro Fertilization
- Trial name
- DOS/DOR (NCT01614067)
- Testing
- Ganirelix acetate
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, San Francisco
Ovarian Hyperstimulation Syndrome
Luteal Phase Supplementation With Recombinant LH After GnRh Agonist Oocytes Triggering in Women at Risk of OHSS
The purpose of this study is to prove that luteal phase supplementation with recombinant LH can solve the luteal phase deficiency after Gnrh agonist oocytes triggering in women at risk of OHSS
- Trial name
- NCT02200952
- Testing
- recombinant LH
- Where
- Italy
- Volunteers
- 16 people
- Sponsor
- San Carlo Public Hospital, Potenza, Italy