Clinical trials: Oocyte
Infertility
Autologous Mitochondrial Transfer in ICSI to Improve Oocyte and Embryo Quality in IVF Patients. Pilot Study
The principle objective is to improve embryo quality through autologous micro-injection of mitochondria isolated from Ovarian stem cells into the oocytes themselves, as a complementary ICSI technique in patients with low embryo…
- Trial name
- NCT02586298
- Testing
- Autologous mitochondria with ICSI, STANDARD ICSI PROCEDURE
- Where
- Spain
- Volunteers
- 59 people
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Increased Oocyte Death, in Vitro Maturation
GREM1, HAS2 and PTGS2 Gene Expression Following the in Vitro Maturation (IVM)
Poor ovarian reserve (POR) is an adverse prognostic factor for In-Vitro Fertilization (IVF) success. Numerous established data showed low live birth rates per IVF cycle; 6 to 10%, including the usage of In-Vitro Maturation (IVM).
- Conditions
- Increased Oocyte Death, in Vitro Maturation, GREM1 Gene Mutation, Cumulus Cell
- Trial name
- NCT06315777
- Testing
- cumulus cell oocytes complex (COC) among women with poor ovarian reserve
- Where
- Malaysia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National University of Malaysia
Infertility, Pregnancy, Multiple
Correlation Between Oocyte and Embryo Mechanical Properties on Embryo Development and Clinical Pregnancy After In Vitro Fertilization
The purpose of this study is to determine whether oocyte and embryo mechanical properties measured during in vitro fertilization can predict embryo development outcomes and clinical pregnancy.
- Trial name
- EMECH (NCT02530892)
- Testing
- EmbryoHug
- Where
- 3 sites in United States, China and 1 more
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- Stanford University
Endometriosis, Dermoid Cyst
Oocyte Freezing for Fertility Preservation in Benign Ovarian Tumors
Benign ovarian cysts are frequent during women's life. They are diagnosed with pelvic pain or fortuitously during an ultra-sonographic exam.
- Conditions
- Endometriosis, Dermoid Cyst, Mucinous Cyst
- Trial name
- OFBOT (NCT03823833)
- Where
- France
- Volunteers
- 82 people
- Sponsor
- University Hospital, Lille
Infertility
Co Administration of GnRH Agonist and hCG for Final Oocyte Maturation
All the studies, demonstrating improved oocyte maturity and high pregnancy rate with the dual trigger are all retrospective. The investigators therefore aim to perform a prospective randomized controlled study in normal…
- Trial name
- NCT02703584
- Testing
- Buseralin, pregnyl
- Where
- Canada
- Volunteers
- 276 people, healthy volunteers welcome
- Sponsor
- Mount Sinai Hospital, Canada
Decision Making, Infertility, Female
Oocyte Recipient's Decision in the Number of Embryos to be Transferred
Multiple pregnancies are considered an ART complication. The only effective way to reduce its incidence is to transfer a single embryo. Nonetheless, there is some reluctance among the patients to accept this strategy.
- Conditions
- Decision Making, Infertility, Female, Counseling
- Trial name
- NCT03185715
- Testing
- Oral and written counselling
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Fundacion Dexeus
Procedure-Related Pain, Acute Pain
Virtual Reality Intervention to Reduce Pain in Women Undergoing Elective Oocyte Cryopreservation
This randomized controlled study evaluates whether exposure to relaxing virtual reality (VR) scenery prior to oocyte retrieval can reduce pain in women undergoing elective oocyte cryopreservation.
- Trial name
- OPU-VR (NCT07484815)
- Testing
- Virtual reality relaxation intervention, Standard Care Control
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Hadassah Medical Organization
Ovarian Stimulation, Human Chorionic Gonadotropin
The Effect of Dual Trigger (GnRH Agonist + hCG) for Final Maturation in Oocyte Donors With History of a Previous Cycle With Suboptimal Response to GnRH Agonist Only Trigger
The goal of this clinical trial is to compare GnRH-agonist trigger with dual GnRH-agonist and HCG trigger in oocyte donors. The main questions it aims to answer are: Maturation rate (Metaphase II/ Total number of COCs collected)…
- Conditions
- Ovarian Stimulation, Human Chorionic Gonadotropin, Oocyte Donors
- Trial name
- NCT06142708
- Testing
- Dual trigger (human chorionic gonadotropin plus GnRH-agonist), GnRH-agonist only trigger
- Where
- Greece
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Embryolab Fertility Clinic
IVF, Oocyte Maturation Defect 1
IVF Outcome Following Progestogen Ovarian Stimulation
The new strategy is by using the progestogen to block the luteinizing hormone(LH) surge either endogenous during luteal phase stimulation, or exogenous in the follicular phase i.e progestin primed ovarian stimulation (PPOS).
- Conditions
- IVF, Oocyte Maturation Defect 1, Clinical Pregnancy Rate, Ovarian Hyperstimulation
- Trial name
- NCT04175990
- Testing
- Dydrogesterone Pill
- Where
- Malaysia
- Volunteers
- 155 people
- Sponsor
- National University of Malaysia
Breast Cancer Female
Combining Interventions of Fertility Preservation to Mitigate Fertility Loss After Breast Cancer
This clinical prospective randomised controlled trial will evaluate the impact of an ovarian biopsy on the oocyte yield after controlled ovarian stimulation before chemotherapy in view of breast cancer.
- Trial name
- Coimbra (NCT04586686)
- Testing
- Ovarian biopsy via laparoscopy, Transvaginal oocyte retrieval
- Where
- 2 sites in Belgium
- Volunteers
- 41 people
- Sponsor
- Universitair Ziekenhuis Brussel
Virtual Reality Therapy, Fertilization in Vitro
Effectiveness of Hypnosis Via Virtual Reality During Oocyte Retrieval
This study compares hypnosis via virtual reality to sedation with commonly used intravenous anesthetic agents (propofol and remifentanil) during oocyte retrieval.
- Conditions
- Virtual Reality Therapy, Fertilization in Vitro, Propofol, Remifentanil
- Trial name
- NCT05244538
- Testing
- Virtual reality distraction, Propofol-remifentanil sedation
- Where
- Belgium
- Volunteers
- 48 people
- Sponsor
- Erasme University Hospital
Oocyte Retrieval, Postoperative Pain
Predictors of Postoperative Pain Following Oocyte Retrieval for Assisted Reproduction
The central objective of this study will be to evaluate the relationship between estrogen levels and the pain following oocyte retrieval in women undergoing in vitro fertilization.
- Trial name
- NCT03105518
- Testing
- Fentanyl, Acetaminophen, Oxycodone
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
In Vitro Fertilization
The Influence of Dopamine Agonist Cabergoline on Oocyte Maturation
The dopamine agonist cabergoline inhibits phosphorylation of the vascular endothelial growth factor receptor-2(VEGFR-2), which prevent vascular endothelial growth factor (VEGF) overexpression and reduce the severity of Ovarian…
- Trial name
- NCT01065376
- Testing
- the timing cabergoline administration
- Where
- Taiwan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Shin Kong Wu Ho-Su Memorial Hospital
Infertility
LH Hormone Pulsation in the Luteal Phase in GnRH Antagonist IVF Cycles Triggered by GnRH Agonist for Final Oocyte Maturation
Monitoring the LH pulsatility during the Luteal phase in GnRH antagonist IVF cycles triggered by GnRH agonist for final oocyte maturation.
- Trial name
- NCT02449642
- Where
- Israel
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Infertility, Female
Time Lag for Oocyte Denudation: A Better Choice for ICSI Outcome?!
This study aiming to investigate if difference in the timing of cumulus removal post retrieval would have any critical impact on fertilization and embryonic development.
- Trial name
- NCT04185623
- Testing
- denudation time lag
- Where
- Egypt
- Volunteers
- 300 people
- Sponsor
- Ahmed Saad
Oocyte Retrieval, Local Anaesthesia
Assessment of the Influence of the Virtual Reality Headset on Pain and Anxiety During Oocyte Retrieval Under Local Anesthesia
Medically Assisted Reproduction provides help to infertile couples, single women and couples of women with a pregnancy project, and to women who wish to preserve their gametes.
- Conditions
- Oocyte Retrieval, Local Anaesthesia, Virtual Reality
- Trial name
- OVOREV (NCT05528497)
- Testing
- VR+
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Rennes University Hospital
Ovarian Hyperstimulation Syndrome
Ovarian Hyperstimulation Syndrome (OHSS) Prevention With Agonist
The aim of the study is to explore the concept of GnRH-agonist triggering in combination with elective cryopreservation of all 2PN oocytes at larger scale in a pragmatic clinical setting.
- Trial name
- NCT00835523
- Where
- 10 sites in Germany
- Volunteers
- 51 people
- Sponsor
- University Hospital Schleswig-Holstein
Contraception
Cilostazol and Its Effects on Resumption of Meiosis in the Human Ovary
Combined oral contraceptive pills (COCs) are the most commonly used hormonal form of birth control in the United States with at least 87% of women of reproductive age reporting oral contraceptive use at some point in their lives…
- Trial name
- NCT01915069
- Testing
- Cilostazol
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Infertility, Female, Infertility
Use of Clomiphene Citrate as an Inhibitor of Ovulation in an Oocyte Cryopreservation Cycle
In vitro fertilization (IVF) has helped countless couples conceive where they otherwise were unable, but does come at a significant cost.
- Trial name
- CCOI (NCT05866068)
- Testing
- Clomiphene
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Neil Chappell
In Vitro Fertilization, Intracytoplasmic Sperm Injection
Effect of GnRH Agonist vs GnRH Antagonist on Oocyte Morphology During IVF/ICSI
Selection of developmentally competent oocytes enhances IVF efficiency. Usually, oocyte quality is determined based on its nuclear maturation and the presence of specific cytoplasmic and extracytoplasmic morphologic features.
- Conditions
- In Vitro Fertilization, Intracytoplasmic Sperm Injection, Infertility
- Trial name
- NCT04724486
- Testing
- Triptorelin acetate, Cetrorelix, recombinant-FSH or recombinant-FSH + human Menopausal Gonadotropin
- Where
- Syria
- Volunteers
- 50 people
- Sponsor
- Damascus University