Clinical trials: Oocyte
Oocyte Donation
Immunogenicity of Repeated Follicle Stimulating Hormone (FSH) Stimulation Cycles
The purpose of the study is to evaluate immunogenic potential of FSH-IBSA in healthy volunteers undergoing controlled ovarian hyperstimulation (COH) in an oocyte donation program.
- Trial name
- NCT01785095
- Testing
- FSH (Follicle Stimulating Hormone)
- Where
- Spain
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- IBSA Institut Biochimique SA
GERM CELLS
Motivations and Psychological Aspects of Gamete Donation
The objective of this project is to describe the motivations, the representation of donation and sterility, to evaluate the psychological aspects of the new male and female candidates to gamete donation and then to compare the…
- Trial name
- DONDON2 (NCT06014151)
- Testing
- questionnaires
- Where
- France
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Sterility, Infertility
Myo-Inositol- Based Co-treatment in Women With PCOS Undergoing Assisted Reproductive Technology
This is a prospective comparative randomized controlled study investigating the effect of Myo-Inositol-based co-treatment on oocyte quality measures in women with PCOS.
- Trial name
- NCT03177122
- Testing
- Myo-inositol
- Where
- Lebanon
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- American University of Beirut Medical Center
Oocytes Vitrified at Prophase-I Stage, Oocytes Matured in Vitro
Comparison of Vitrification Effect Before or After In Vitro Maturation
Human oocyte cryopreservation is routinely used for fertility preservation of women who will be exposed to gonadotoxic effect of cancer treatment. After ovarian stimulation, matured oocytes are vitrified.
- Trial name
- NCT03416400
- Testing
- Oocyte vitrification
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Infertility (IVF Patients), Infertility Treatment
Ketorolac Use and Fresh Embryo Transfer Outcomes
Ketorolac is a medication often used to relieve pain after surgery. In the past, infertility doctors have been cautious about using ketorolac after egg retrieval for patients planning a fresh embryo transfer (usually done 5 days…
- Conditions
- Infertility (IVF Patients), Infertility Treatment, Post-op Pain, Fresh Embryo Transfer
- Trial name
- NCT07185724
- Testing
- Ketorolac 30 mg IV
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Jessica D. Kresowik
Infertility
Oocyte Cryopreservation: The Impact of Cryopreservation on the Meiotic Spindle and Mitochondria of Human Oocytes.
Our aims is to document the possible effect of cryo- preservation at the meiotic spindle and mitochondrial levels.
- Trial name
- WCFC (NCT00716118)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- West Coast Fertility Centers
In Vitro Fertilisation (IVF) Treatment
Effect of Oxytocin Antagonist on Reduction of Uterine Contractions
The main purpose of this clinical research trial was to evaluate the effects of barusiban compared to placebo on uterine contractions on luteal phase uterine contractions in oocyte donors supplemented with progesterone.
- Trial name
- EFFORT (NCT01043120)
- Testing
- Barusiban
- Where
- 5 sites in Belgium, Czechia and 1 more
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Ferring Pharmaceuticals
Polycystic Ovary Syndrome
Repeated Doses of GnRH Agonist as Oocyte Triggering in Antagonist Protocol for Patients With Polycystic Ovary Syndrome
This is a prospective, randomized, proof-of-concept study, designed to compare the IVF results in patients diagnosed with polycystic ovarian syndrome (PCOS) defined as per the ESHRE/ASRM Rotterdam criteria (2003) undergoing…
- Trial name
- NCT04600986
- Testing
- Repeated dose of GnRH agonist
- Where
- Iran
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Royan Institute
Effect of Two Protocols of Ovarian Stimulation on Oocyte Quality
GnRH Agonist and Antagonists in an Oocyte Donation Program
The primary purpose of this study is to evaluate the effect of the two different protocols (long protocol vs antagonist protocol) on oocyte / embryo quality.
- Trial name
- NCT00505817
- Testing
- Cetrorelix and Leuprolide
- Where
- Spain
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Fertilization
Evaluation of the Impact of Vitrification on Oocytes
The purpose of this study is to determine the rate of cryosurvival of mature oocytes following vitrification, and to then compare the reproductive potential of vitrified oocytes relative to those which have not been cryopreserved.
- Trial name
- NCT01223118
- Testing
- Vitrification and PGD
- Where
- 2 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Reproductive Medicine Associates of New Jersey
Infertility, Female, Ovulation Induction
Oral GnRH Antagonist (Linzagolix) Versus Injectable GnRH Antagonist in Controlled Ovarian Stimulation for In Vitro Fertilization: A Randomized Controlled Non-Inferiority Trial With a Concurrent Comparator Cohort Undergoing Progestin-Primed Ovarian Stimulation (PPOS)
Women undergoing IVF/ICSI who are candidates for a GnRH-antagonist protocol are randomly assigned 1:1 to oral linzagolix or the standard injectable GnRH antagonist (ganirelix or cetrorelix).
- Trial name
- NCT07732348
- Testing
- Ganirelix ; Cetrorelix, Medroxyprogesterone Acetate ; Micronized Progesterone, Linzagolix
- Volunteers
- 120 people
- Sponsor
- Centro A.M.B.R.A. (Associazione Medici e Biologi per la Riproduzione Assistita)
Fertility
Fertility Preservation in Female Cancer Patients
The purpose of this study is to preserve the fertility potential in females diagnosed with cancer by vitrifying (rapidly freezing) their oocytes (eggs) before undergoing treatment for their cancer.
- Trial name
- NCT01268592
- Testing
- oocyte vitrification
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Northwell Health
Oocyte Retrieval
Interest of Hypnosis in Virtual Reality on Nociception During Oocyte Retrieval in a Medically Assisted Reproduction Procedure
Study on the effect of the virtual hypnosis mask in addition to local anaesthesia on anxiety and perioperative pain during oocyte puncture
- Trial name
- HypnoPO (NCT05567315)
- Testing
- local anaesthetic injection, hypnosis with Virtual reality mask
- Where
- France
- Volunteers
- 182 people
- Sponsor
- Clinique Mutualiste la Sagesse
Ovarian Hyperstimulation Syndrome
The Role of Cetrotide Acetate in Prevention of Ovarian Hyperstimulation Syndrome (OHSS) in Oocyte Donors
This pilot study aims to address whether the prophylactic use of Cetrorelix Acetate after a long gonadotropin-releasing hormone (GnRH) agonist protocol post-hCG (human chorionic gonadotropin) administration can significantly…
- Trial name
- NCT00867659
- Testing
- Cetrotide acetate
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Virginia Center for Reproductive Medicine
Infertility
Comparison Between Natural and Artificial Cycle in Recipient Oocyte Patients
The purpose of this study is to compare the natural cycle (without any medication) with the well-established artificial cycle in an egg donation program.
- Trial name
- NCT01353846
- Testing
- observation natural cycle, Agonist GnRH; estradiol Valerate; progesterone
- Where
- Spain
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Oocyte Retrieval for IVF, Pain
Analgesic Effect of TENS-WAA Combined With Tramadol Hydrochloride During Oocyte Retrieval Surgery
This study is a single-centre randomised controlled trial. It aimed to evaluate the efficacy and safety of transcutaneous electrical nerve stimulation based on wrist-ankle acupuncture theory(TENS-WAA) combined with tramadol…
- Trial name
- NCT07212127
- Testing
- Transcutaneous Electrical Nerve Stimulation based on Wrist-Ankle Acupuncture theory（TENS-WAA)
- Where
- China
- Volunteers
- 60 people
- Sponsor
- First Affiliated Hospital of the Chinese People's Liberation Army Naval Medical University
In Vitro Fertilization, Infertility
Effect of GnRH Agonist vs GnRH Antagonist on Oocyte Morphology in Polycystic Ovary Syndrome Patients During IVF/ICSI
Selection of developmentally competent oocytes enhances IVF efficiency. Usually, oocyte quality is determined based on its nuclear maturation and the presence of specific cytoplasmic and extracytoplasmic morphologic features.
- Conditions
- In Vitro Fertilization, Infertility, Intracytoplasmic Sperm Injection, Polycystic Ovary Syndrome
- Trial name
- NCT04727684
- Testing
- Triptorelin acetate, Cetrorelix, recombinant-FSH or recombinant-FSH + human Menopausal Gonadotropin
- Where
- Syria
- Volunteers
- 50 people
- Sponsor
- Damascus University
Infertility, Female, Fertility Disorders
DYG Versus Cetrorelix in Oocyte Donation
Prospective controlled study to assess the reproductive outcomes of OD recipients in which the donors were subjected to the DYG protocol (20mg/day) compared with those subjected to the short protocol with cetrorelix (0.25 mg/day)…
- Trial name
- NCT05577806
- Testing
- Dydrogesterone
- Volunteers
- 202 people
- Sponsor
- Clinica de la Mujer Medicina Reproductiva, Chile
Infertility
Oocyte Cryopreservation: Evaluation of an Oocyte Freezing and Thawing Technique
Over the past several decades, considerable effort has been expended toward the successful cryopreservation of various human cells.
- Trial name
- Slow-freeze (NCT00713869)
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- West Coast Fertility Centers
Primary Ovarian Insufficiency, Female Infertility Due to Diminished Ovarian Reserve
Effect of Testosterone Treatment on Embryo Quality
The purpose of this study is to determine the effect of treatment with trans-dermal testosterone cream compared to placebo on measures of ovarian reserve, oocyte and embryo quality, and pregnancy rates among women with evidence…
- Trial name
- NCT01662466
- Testing
- Testosterone cream (0.5mg per gram), DHEA
- Where
- 2 sites in United States
- Volunteers
- 180 people
- Sponsor
- Center for Human Reproduction