Clinical trials: Oocyte Donation
Infertility
Comparison of Embryo Transfer in Egg Donation Recipients With Transvaginal and Transabdominal Ultrasound
Transabdominal ultrasound guidance is the golden standard for embryo transfers. Transvaginal ultrasound guidance was proposed recently to provide better visualization and reduce patient discomfort as embryo transfer can be…
- Trial name
- NCT01805505
- Testing
- Transvaginal ultrasound-guided embryo transfer, Transabdominal ultrasound-guided embryo transfer
- Where
- Spain
- Volunteers
- 346 people
- Sponsor
- IVI Madrid
Infertility
Closed Vitrification of Oocytes
This study is aimed to evaluate the use of a closed device for storage of vitrified oocytes.
- Trial name
- NCT01745536
- Testing
- Oocytes are vitrified/stored using a closed device, Oocytes are vitrified/stored using an open device
- Where
- 2 sites in Spain
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Premature Luteinization
Effect of Premature Luteinization on the Oocyte Quality in Oocyte Donation Program.
Analyze the possible effect of the progesterone levels of the hCG administration on the oocyte embryo quality. The primary endpoint of this study is the pregnancy rate.
- Trial name
- NCT00455949
- Where
- Spain
- Volunteers
- healthy volunteers welcome
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Female Infertility
Effect of Growth Hormone on Uterine Receptivity in Women With RIF in an Oocyte Donation Program
105 infertile women are enrolled in the randomized controlled trial: 70 women with a history of RIF with donated oocytes and 35 infertile women undergoing the first oocyte donation attempt.
- Trial name
- NCT03237117
- Testing
- Growth Hormone (GH)
- Where
- Spain
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Competence Centre on Health Technologies
Reproductive Techniques, Assisted
Effect of a Multivitamin Supplement With Probiotic (Seidivid Ferty4®) on Oocyte Retrieval and Quality
This study evaluates the effect of pretreatment with a multivitamin supplement with probiotics (Seidivid Ferty4®) on oocyte retrieval in normo-responder patients undergoing controlled ovarian hyperstimulation (COH) for oocyte…
- Trial name
- OvoVid (NCT05473039)
- Testing
- Seidivid Ferty4
- Where
- Spain
- Volunteers
- 196 people
- Sponsor
- SEID S.A.
Infertility
Biosimilar Versus Urinary Gonadotropins
Biosimilar drug marketing of recombinant FSH for the treatment of infertility is another step in simplifying fertility treatments, making them easier to manage and more accessible to patients.
- Trial name
- BEMDON (NCT02503605)
- Testing
- Biosimilar recombinant FSH, Urinary FSH
- Where
- Spain
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- IVI Madrid
Oocyte Donation, Infertility, Female
Transfer Strategy in an Oocyte Donation Programme
It has been previously shown that although the activation of the embryonic genome can begin as early as two days of initiation of the embryonic development (D2), it is expressed on day 3 (D3).
- Conditions
- Oocyte Donation, Infertility, Female, Embryo Transfer
- Trial name
- NCT03088735
- Testing
- Blastocyst-stage embryo transfer strategy, Cleavage-stage embryo transfer strategy
- Where
- Spain
- Volunteers
- 134 people
- Sponsor
- Fundacion Dexeus
GERM CELLS
Motivations and Psychological Aspects of Gamete Donation
The objective of this project is to describe the motivations, the representation of donation and sterility, to evaluate the psychological aspects of the new male and female candidates to gamete donation and then to compare the…
- Trial name
- DONDON2 (NCT06014151)
- Testing
- questionnaires
- Where
- France
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Infertility
Use of a Synthetic Macromolecule (Hydroxypropyl Cellulose ) and Trehalose as Additives for Oocyte Vitrification
This study is aimed to evaluate the use of Hydroxypropyl Cellulose (HPC) as substitute for the traditional protein supplement (Synthetic Serum Substitute; SSS) and Trehalose as substitute for the most widely used sugar (Sucrose)…
- Trial name
- NCT01745523
- Testing
- Synthetic macromolecule HPC and trehalose, SSS containing HSA and sucrose
- Where
- Spain
- Volunteers
- 440 people
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Ovulation, Ovarian Function
Exogenous Progesterone as Ovulation Trigger
The goal of this clinical trial is to learn whether the sudden administration of vaginal micronized progesterone during the late follicular phase can trigger an LH surge and reactivation of oocyte meiosis in healthy oocyte donors…
- Conditions
- Ovulation, Ovarian Function, Assisted Reproductive Treatments, Oocyte Maturation
- Trial name
- PRO-TRIGGER (NCT07466199)
- Testing
- Vaginal micronized progesterone
- Where
- Portugal
- Volunteers
- 10 people
- Sponsor
- Instituto Valenciano de Infertilidade de Lisboa
Infertility
Aurora Test for ART Donor Patients (AURORA-Donor)
This is a randomized observational study. The main aim is to determine potential oocyte competence predictive mRNA expression profiles in the cumulus cells isolated form individual oocytes.
- Trial name
- NCT06280677
- Testing
- AURORA-Donor
- Where
- Spain
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Fertiga, Belgium
Infertility, Oocyte Recipient
Single Embryo Transfer vs. Double Embryo Transfer in an Oocyte Donation Programme
Experimental study to assess the efficacy of single embryo transfer (SET) with respect to double embryo transfer (DET) in an oocyte donation programme, 160 recipients will be randomized in two groups
- Conditions
- Infertility, Oocyte Recipient, Single Embryo Transfer/Double Embryo Transfer, Cumulative Pregnancy Rate
- Trial name
- NCT01228474
- Testing
- Select the Number of embryos to transfer
- Where
- Spain
- Volunteers
- 65 people
- Sponsor
- Fundacion Dexeus
Pregnancy, Embryo Implantation
Administration of GnRH Antagonist to Oocyte Donation Recipients
This prospective and randomized study was performed to evaluate whether the replacement of GnRH agonist by a GnRH antagonist in oocyte donation recipients during endometrial preparation has any impact on pregnancy and…
- Trial name
- GnRH-Ovodon (NCT00635258)
- Testing
- triptorelin (Decapeptyl®, Ipsen Pharma, Barcelona, Spain), GnRH antagonist (Orgalutran®)
- Where
- Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Centro Ginecologia y Obstetricia.
Decision Making, Infertility, Female
Oocyte Recipient's Decision in the Number of Embryos to be Transferred
Multiple pregnancies are considered an ART complication. The only effective way to reduce its incidence is to transfer a single embryo. Nonetheless, there is some reluctance among the patients to accept this strategy.
- Conditions
- Decision Making, Infertility, Female, Counseling
- Trial name
- NCT03185715
- Testing
- Oral and written counselling
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Fundacion Dexeus
Infertility, Premature Ovarian Failure
Modified Natural Cycle Offers a Chance of Pregnancy in Patients With Poor Response and High Basal FSH
The purpose of this study is to evaluate the effectiveness of a modified natural cycle in patients with previous poor response to infertility drugs and high basal FSH, prior to proceeding to oocyte donation or abandoning…
- Trial name
- NCT00417157
- Testing
- recombinant FSH (Puregon, Organon, The Netherlands), GnRH antag: Ganirelix (Orgalutran, Organon, The Netherlands), hCG (Pregnyl, Organon, The Netherlands)
- Where
- Greece
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Eugonia
Pre-eclampsia, Oocyte Donation
PRIOR Study (Pre-eclampsia Risk In Oocyte Recipients)
The aim of this prospective observational cohort study is to investigate the pathophysiological mechanisms behind and risk of pre-eclampsia in women pregnant after fertility treatment with oocyte donation.
- Conditions
- Pre-eclampsia, Oocyte Donation, Pre-Eclampsia; Complicating Pregnancy, Pre-Eclampsia; Mild
- Trial name
- PRIOR (NCT07263490)
- Where
- 6 sites in Denmark
- Volunteers
- 462 people
- Sponsor
- Copenhagen University Hospital, Hvidovre
Vitrification, Egg Donor
Validation of Donor Oocytes Semi-automated Vitrification
Oocyte vitrification is an effective method of freezing which has been authorized in France since 2011. The arrival of this technique has led to real improvements in the survival rate of oocytes after warming compared to that…
- Conditions
- Vitrification, Egg Donor, Fertility, Assisted Reproductive Technology
- Trial name
- GAVIDO (NCT06238570)
- Testing
- Gavi, Merck® (automated vitrification instrument), Vitrolife system
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Clermont-Ferrand
Poor Response to Ovulation Induction
Ovarian Response in Oocyte Donors Triggered With GnRH Agonists
The use of agonist of GnRH (aGnRH) trigger to avoid ovarian hyperstimulation syndrome is nowadays widely used. The action of the aGnRH in the hypophysis triggers an LH and FSH surge, which mimicks the natural surge that occurs in…
- Trial name
- NCT05109403
- Where
- Spain
- Volunteers
- 224 people
- Sponsor
- Clínica EUGIN
Infertility
Ultrasound Study by Texturization as a Predictor of Pregnancy in Oocyte Donation Programs
This study is focused on analysing the application of ultrasound scanning techniques as new biomarkers in reproductive medicine.
- Trial name
- TEXTUGEST (NCT03507322)
- Testing
- Ultrasound texturization
- Where
- Spain
- Sponsor
- Vida Recoletas Sevilla
Pre-Eclampsia
Prevention of Preeclampsia With Aspirin in Recipients of Donated Oocytes.
The main objective of this trial is to study the occurrence of preeclampsia in recipients of donated oocytes receiving aspirin at an early stage during pregnancy and to compare the results with those obtained in patients…
- Trial name
- PROVAS (NCT02174328)
- Testing
- Acetylsalicylic acid
- Where
- Spain
- Volunteers
- 81 people
- Sponsor
- Instituto de Investigacion Sanitaria La Fe