Clinical trials: Oocyte Donation
INFERTILITY, Fertility Preservation
Evolutive Potential of Embryos Obtained From Oocytes After Luteal Phase Ovarian Stimulation
The purpose of this study is to evaluate the clinical pregnancy rate per embryo transfer in oocytes recipients obtained after ovarian stimulation during the luteal phase of oocytes donors .
- Conditions
- INFERTILITY, Fertility Preservation, Ovulation Induction, Vitrification
- Trial name
- NCT01645241
- Testing
- gonadotropins plus GnRH antagonists, ganirelix
- Where
- Spain
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Fundacion Dexeus
Oocyte Donors, Oocyte Donation
Luteal Phase Ovarian Stimulation With Follitropin Delta and Dydrogesterone
The last decade has shown a progressive scientific interest for new strategies to improve the outcomes of controlled ovarian stimulation (COS).
- Trial name
- LadyDe (NCT05521828)
- Testing
- Follitropin delta (Rekovelle), Duphaston, GnRH agonist (Gonapeptyl)
- Where
- Belgium
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- CRG UZ Brussel
Preeclampsia, Oocyte-donation Pregnancies
Immunological and Cardiovascular Phenotyping of Oocyte-donation Pregnancies
The investigators conduct a study to evaluate the underlying causes of preeclampsia in oocyte-donation pregnancies.
- Trial name
- NCT04731012
- Where
- Germany
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Oocyte Donation
Corifollitropin Alfa on D5 Versus D7 After Contraceptive Pill
To evaluate if the administration of corifollitropin alfa on day 7 instead of on day 5 after pre-treatment with oral contraceptive pill results in a reduced total rFSH (recombinant follicle stimulating hormone ) consumption in a…
- Trial name
- NCT02490150
- Testing
- Corifollitropin alfa
- Where
- Spain
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Fundacion Dexeus
Aneuploidy Rate
Aneuploidy Rate and Stimulation Protocol: Recombinant Follicle Stimulating Hormone (FSH) Versus Human FSH
Several stimulation protocols have been used in in vitro fertilization (IVF) in a cycle of egg donation; recombinant FSH and human FSH are included. The effect of each kind of hormone on aneuploidy rate it is unknown.
- Trial name
- NCT01164943
- Testing
- Stimulation with human FSH, Stimulation with recombinant FSH
- Where
- Spain
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- IVI Madrid
Infertility
Comparison of DR-2011 to a Progesterone Vaginal Gel for Luteal Phase Replacement
This is a single-center, open-label, randomized, active-controlled study to compare DR-2011 to progesterone vaginal gel for luteal phase replacement.
- Trial name
- NCT00117468
- Testing
- DR-2011, Progesterone 8% Vaginal Gel
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Duramed Research
Female Reproductive Problem, Infertility
Use of Corifolitropin Alfa in Oocyte Donors
The purpose of this study is to determine if corifollitropin alfa (long-term gonadotropin administration) is effective in a controlled ovarian stimulation protocol in oocyte donors compared to daily gonadotropin administration…
- Trial name
- NCT02213627
- Testing
- Corifollitropin alfa, Recombinant FSH, HP-hMG
- Where
- Spain
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- IVI Madrid
Infertility, Infertility, Female
Effect of Vitrification and Warming Media on Pregnancy Rates in the Context of Oocyte Donation
Vitrification has become the gold standard for oocyte and embryo cryopreservation. Several commercial kits are available on the market, some are designed for specific developmental stages (e.g.
- Trial name
- NCT07288866
- Testing
- Vitrification and warming media for oocyte vitrification
- Where
- France
- Volunteers
- 111 people
- Sponsor
- University Hospital, Clermont-Ferrand
Subfertility
Endometrial Scratching in In Vitro Fertilization Cycles With Oocyte Donation
This study is designed to evaluate the potential benefit in pregnancy rates produced by an endometrial scratching made in an IVF cycle prior to embryo transfer in patients with donated oocytes.
- Trial name
- NCT01842178
- Testing
- scratching
- Where
- Spain
- Sponsor
- Centro de Infertilidad y Reproducción Humana
Ovarian Stimulation
Impact of Three Different Gonadotrophin Regimes on Egg Donation Program
Exploratory study assessing the effect of three gonadotrophin protocols on Controlled Ovarian Stimulation (COS) parameters and IVF outcome in oocyte donors undergoing GnRH analogue (long protocol).
- Trial name
- NCT00829075
- Testing
- r-FSH, HP-hMG, r-FSH plus HP-hMG
- Where
- Spain
- Volunteers
- healthy volunteers welcome
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Infertility, Female, Reproductive Sterility
Usefulness of Corifollitropin α as Alternative to Conventional Daily rFSH Protocols in Oocyte Donors Undergoing Pituitary Suppression With Medroxiprogesterona Acetate (MPA)
IVF patients frequently experience physical, emotional or physicological burden; this is particularly relevant in the case of oocyte donors, since young women undergo a procedure that is of no health benefit to them.
- Trial name
- TROPIX (NCT06193135)
- Testing
- Corifolitropin Alfa, Folitropin Beta
- Where
- 2 sites in Spain
- Volunteers
- 318 people
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Adenomyosis of Uterus, Implantation Failure
Linzagolix in Adenomyosis and Recurrent Implantation Failure
Adenomyosis is associated with impaired endometrial receptivity and reduced implantation rates in assisted reproduction, even when using high-quality embryos.
- Conditions
- Adenomyosis of Uterus, Implantation Failure, Infertility Female, Embryo Transfer
- Trial name
- LINZA-RIF (NCT07698561)
- Testing
- Linzagolix 200 mg (Yselty)
- Where
- 3 sites in Spain
- Volunteers
- 30 people
- Sponsor
- Vida Fertility Institute
Infertility, Female, Fertility Disorders
DYG Versus Cetrorelix in Oocyte Donation
Prospective controlled study to assess the reproductive outcomes of OD recipients in which the donors were subjected to the DYG protocol (20mg/day) compared with those subjected to the short protocol with cetrorelix (0.25 mg/day)…
- Trial name
- NCT05577806
- Testing
- Dydrogesterone
- Volunteers
- 202 people
- Sponsor
- Clinica de la Mujer Medicina Reproductiva, Chile
Preeclampsia (PE) Risk, Oocyte Donation
Preeclampsia and Defective Placentation in Oocyte Donation: Importance of HLA-C and KIR
The IMMUN-OR study aims to study HLA-C/KIR combinations when looking at the risk of development of preeclampsia (PE) in pregnancies after oocyte donation.
- Trial name
- IMMUN-OR (NCT07178652)
- Volunteers
- 2,325 people
- Sponsor
- Universitair Ziekenhuis Brussel
Ectopic Pregnancies
Activin A and Inhibin A in Predicting Outcome of Pregnancies of Unknown Location After Assisted Reproductive Technology
The purpose of this study is to determine the predictive value of a single serum determination of activin A and inhibin A for the prognosis of ectopic pregnancy after in Vitro Fertilization (IVF) cycles, in both native and…
- Trial name
- NCT01589016
- Where
- Spain
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Infertility
Use of Antagonist Versus Agonist GnRH in Oocyte Recipient Endometrium Preparation
Oocyte donation is a well established procedure in assisted reproduction treatments (ART). It is demonstrated that the use of hormonal substitution therapy, for the synchronization of the cycles between the recipients and the…
- Trial name
- NCT00633347
- Testing
- Antagonist GnRH Cetrotide, Agonist GnRH Acetate Triptoreline
- Where
- Spain
- Volunteers
- 570 people, healthy volunteers welcome
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Infertility
Subcutaneous Progesterone Versus Vaginal Progesterone for Endometrial Preparation in Fresh Donated Oocytes Recipients
Randomised, prospective, investigator-blinded, controlled, single-centre study to assess the impact on the ongoing pregnancy rate with the use of two progesterones with different administration routes, in recipients of fresh…
- Trial name
- NCT02363127
- Testing
- subcutaneous progesterone, vaginal progesterone
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Instituto Bernabeu
Disorder of Phosphate, Calcium and Vitamin D Metabolism, Female Infertility Due to Diminished Ovarian Reserve
Vitamin D Influence on Oocyte Donation
Objective: To investigate the correlation between total and bioavailable serum 25-OH vitamin D, ovarian reserve and ovarian response to controlled stimulation in egg donors.
- Conditions
- Disorder of Phosphate, Calcium and Vitamin D Metabolism, Female Infertility Due to Diminished Ovarian Reserve, Hormonal Requirement, Reproductive Disorder
- Trial name
- NCT02341365
- Testing
- vitamin D,AMH, AFC, reproductive outcome egg recipients
- Volunteers
- 269 people
- Sponsor
- IVI Madrid
Premature Luteinisation, Progesterone Elevation
Ovarian Stimulation With FSH Alone Versus FSH Plus GnRH Antagonist in an Oocyte Donor/Recipient Programme
The aim of this study is to compare the efficacy of a protocol using FSH alone with that of a protocol using FSH plus a GnRH antagonist for controlled ovarian hyperstimulation in cycles of elective freezing in the context of a…
- Trial name
- NCT05759871
- Testing
- GnRH antagonist
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Effect of Two Protocols of Ovarian Stimulation on Oocyte Quality
GnRH Agonist and Antagonists in an Oocyte Donation Program
The primary purpose of this study is to evaluate the effect of the two different protocols (long protocol vs antagonist protocol) on oocyte / embryo quality.
- Trial name
- NCT00505817
- Testing
- Cetrorelix and Leuprolide
- Where
- Spain
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA