Clinical trials: Oocyte Fertilization
Oocyte Retrieval, Adverse Events
The Use of Virtual Reality Technology During Oocyte Retrieval for in Vitro Fertilization
Ultrasound-guided oocyte retrieval (OR) is a short, but oftentimes painful procedure, during which the follicles are punctured trans-vaginally to obtain oocytes for in vitro fertilization (IVF).
- Conditions
- Oocyte Retrieval, Adverse Events, Procedural Anxiety, Pain Intensity
- Trial name
- NCT06733701
- Testing
- VR-based intervention (VRReliever Software V0.3.4 fromXRHealth), VR headset without any scenery
- Volunteers
- 50 people
- Sponsor
- Mount Sinai Hospital, Canada
Infertility Primary
AOA in Recurrent Fertilization Failure
Background: Despite the high success rate of ICSI, total fertilization failure still occurs in 1-3% of all ICSI cycles and can recur in subsequent cycles, even when a sufficient number of oocytes and motile spermatozoa are…
- Trial name
- AOA (NCT04744753)
- Testing
- Calcium Ionophore A23187
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- MOHAMED BEHERY
Infertility
Day of Embryo Transfer for Patients Undergoing In Vitro Fertilization
We are examining whether pregnancy rates differ based on day of embryo transfer in patients who replace all available embryos after an In vitro Fertilization (IVF) cycle.
- Trial name
- NCT00615771
- Testing
- Day 3 embryo transfer, Day 2 embryo transfer
- Where
- United States
- Volunteers
- 242 people
- Sponsor
- Stanford University
Infertility, Oocytes
Efficacy of a Simulator Based (PickUpSimTM) Residents' Training Program for Oocyte Retrievals
Simulation is an educational approach that has recently found an application in healthcare.acquire. Angers university hospital has decided to acquire, in December 2016, the high-fidelity Oocyte Pick up (OPU) simulator…
- Conditions
- Infertility, Oocytes, Fertilization in Vitro
- Trial name
- NCT03700255
- Testing
- PickUpSimTM simulation training program
- Where
- France
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
IVF, Infertility
Improvement of Fertilization Rate and Embryo Quality by Treating Calcium Ionophore in IVF Patients: a Sibling Oocyte Control Study
GM508 CultActive is a bicarbonate buffered reagent and ready-to-use designed to investigate oocytes of patients with failed fertilization after previous Intracytoplasmatic Sperm Injection cycles.
- Conditions
- IVF, Infertility, Artificial Oocyte Activation
- Trial name
- GM508 in IVF (NCT05722067)
- Testing
- calcium ionophore
- Where
- Taiwan
- Volunteers
- 68 people
- Sponsor
- Chang Gung Memorial Hospital
Polycystic Ovary Syndrome
Myo-Inositol for Ovarian Stimulation and ICSI Outcomes in Women With PCOS
Polycystic ovary syndrome (PCOS) is a common endocrine disorder that may affect ovarian function, insulin sensitivity, and fertility.
- Trial name
- NCT07779850
- Testing
- Myo-Inositol, Folic Acid
- Where
- Egypt
- Volunteers
- 88 people
- Sponsor
- Kafrelsheikh University
Infertility
Effect of Follicle Flushing on Oocyte Fertilization Rate
The purpose of this study is to investigate the impact of follicular flushing on fertilization rate in women undergoing IVF treatment
- Trial name
- NCT03353285
- Testing
- intracytoplasmic sperm injection (ICSI)
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- Eugonia
PCOS, IVF
IVM Versus IVF in High Antral Follicle Count Patients
In vitro maturation (IVM) is postulated to be an alternative to conventional in vitro fertilization (IVF) to avoid ovarian hyperstimulation syndrome.
- Conditions
- PCOS, IVF, IVM
- Trial name
- NCT03405701
- Testing
- IVM, IVF
- Where
- Vietnam
- Volunteers
- 546 people
- Sponsor
- Mỹ Đức Hospital
Midazolam Overdose
Measurement of Midazolam Levels in Follicular Fluid
To determine the impact of Midazolam levels in follicular fluid on morpho-kinetics and morpho-genetics. The reason to measure Midazolam levels in larger size follicles in this study is to maximize the chances to get a mature…
- Trial name
- NCT03049293
- Testing
- Midazolam
- Where
- United Arab Emirates
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
In Vitro Fertilisation (IVF) Treatment
Effect of Oxytocin and Vasopressin Antagonists on Uterine Contractions
The main purpose of this clinical research trial was to evaluate the effects of barusiban and atosiban compared to placebo on luteal phase uterine contractions in oocyte donors supplemented with progesterone.
- Trial name
- OVANCON (NCT00587327)
- Testing
- Barusiban, Atosiban
- Where
- 5 sites in Belgium, Czechia and 1 more
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Ferring Pharmaceuticals
Polycystic Ovary Syndrome (PCOS), In Vitro Maturation of Oocytes
IVM - Fresh ET (THE SAIGON PROTOCOL) Versus IVF - FET in PCOS Women
Assisted Reproductive Technologies (ART) aim to increase success rates while minimizing patient risks. For women with high AFC or PCOS, conventional IVF carries a high risk of OHSS (Ho et al., 2019).
- Conditions
- Polycystic Ovary Syndrome (PCOS), In Vitro Maturation of Oocytes, Fresh Embryo Transfer
- Trial name
- SAIGON-PTC (NCT07171970)
- Testing
- IVM-Fresh (No gonadotropin + Fresh embryo transfer), IVF-FET (GnRH-Antagonist - Agonist Trigger - Frozen embryo transfer)
- Where
- Vietnam
- Volunteers
- 600 people
- Sponsor
- Mỹ Đức Hospital
In Vitro Fertilization, Infertility
Sibling Oocyte Study of Medium for In Vitro Fertilization/Intracytoplasmic Sperm Injection (IVF/ICSI) With no Human Serum Albumine
The purpose of this study is to determine if a new medium with no human serum albumine added is as good as the media conventionally used for IVF/ICSI.
- Trial name
- NCT00541892
- Testing
- Medium with no human serum albumine added, Conventional medium
- Where
- Norway
- Sponsor
- Sykehuset Telemark
Fertilization
Clinical Application of Artificial Oocyte Activation Technique (AOA) in ART
Oocyte activation is an imperative stage in the initiation of embryo development during the fertilization. Indeed, the entrance of sperm into the oocyte causes sequences of calcium oscillations in its cytoplasm, regulating a…
- Trial name
- NCT04519918
- Testing
- AOA
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Tang-Du Hospital
Fertilization
Evaluation of the Impact of Vitrification on Oocytes
The purpose of this study is to determine the rate of cryosurvival of mature oocytes following vitrification, and to then compare the reproductive potential of vitrified oocytes relative to those which have not been cryopreserved.
- Trial name
- NCT01223118
- Testing
- Vitrification and PGD
- Where
- 2 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Reproductive Medicine Associates of New Jersey
Postoperative Pain, IVF
Oral Versus Intravenous Acetaminophen for Postoperative Pain Control
The investigators are going to study the difference in postoperative pain control after administration of oral versus intravenous formulation of acetaminophen
- Trial name
- NCT04662567
- Testing
- acetaminophen
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Northwell Health
Infertility
The Influence of Different Concentrations of Glucose in Culture Media on In Vitro Fertilization (IVF) Outcome of Sibling Oocytes
The importance of glucose in culture media on fertilization and embryo development is still controversial. Although it has been reported that glucose is essential for fertilization process and biosynthesis of membrane lipid and…
- Trial name
- NCT02066584
- Testing
- Sibling oocyte incubation
- Where
- Israel
- Volunteers
- 600 people
- Sponsor
- Hillel Yaffe Medical Center
Aging, Infertility
Effects of Resveratrol Supplementation on Oocyte Quality
The goal of this randomized, double-blind, placebo-controlled clinical trial is to verify if 3-month oral supplementation with resveratrol can enhance the oocyte quality in advanced maternal age women undergoing in vitro…
- Trial name
- NCT06235294
- Testing
- Resveratrol, Folic acid
- Volunteers
- 88 people
- Sponsor
- Unidade Local de Saúde de Coimbra, EPE
Automatic Vitrification, Manual Vitrification
Interest of Automated Oocyte Freezing
In the space of a few decades, oocyte cryopreservation has become established in the world of reproductive biology with the authorization of oocyte vitrification.
- Trial name
- Instruvit (NCT03570073)
- Testing
- Manual vitrification, Vitrification with GaviTM system
- Where
- France
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
In Vitro Fertilization
Retrospective Analysis of the Incidence of Complications From Transvaginal Oocyte Retrieval (TVOR).
The investigators retrospectively analysed the complication rate of ultrasound guided transvaginal oocyte retrieval (TVOR) from all the procedures performed between 1996 and October 2016 in a tertiary level university based…
- Trial name
- TVOR (NCT03282279)
- Testing
- TVOR
- Volunteers
- 23,827 people
- Sponsor
- Istituto Clinico Humanitas
Infertility
Gamete Treatment to Correct Fertilization Failure
In this proposed research study, the investigators plan to assess the efficacy of gametes' (egg and sperm) treatment on fertilization as well as pre- and post-implantation embryo development.
- Trial name
- NCT01944332
- Testing
- gamete treatment
- Where
- United States
- Volunteers
- 1,200 people
- Sponsor
- Weill Medical College of Cornell University