Clinical trials: Oophorectomy
Reproductive Age, Oophorectomy for Benign Indications
Lifestyle Factors Study
The goals of this research proposal are to further our understanding of the reproductive aging process in women and to improve our ability to clinically assess and model reproductive aging.
- Trial name
- NCT00989183
- Testing
- Women undergoing a bilateral or unilateral oophorectomy at OU Medical Center, Oklahoma City, Oklahoma
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Pelvic Organ Prolapse (POP)
Are There Benefits of Using Energy-based Devices for Opportunistic Salpingo-oophorectomy During Vaginal Hysterectomy Compared to a Standard Cold Approach?
This study compares two methods for removing the fallopian tubes and ovaries during vaginal hysterectomy for pelvic organ prolapse.
- Trial name
- NCT07379411
- Testing
- LigaSure MaryLand, Standard salpingo-oophorectomy technique
- Where
- Israel
- Volunteers
- 70 people
- Sponsor
- Wolfson Medical Center
Salpingectomy
vNOTES Salpingo-oophorectomy or Bilateral Salpingectomy Compared With Laparoscopic.
Objective: To compare the vNOTES approach versus conventional laparoscopic approach used in elective Salpingo-oophorectomy surgery for benign disease or bilateral salpingectomy for sterilization.
- Trial name
- NCT05228938
- Testing
- VNOTES, laparoscopic
- Where
- Israel
- Volunteers
- 1 people
- Sponsor
- HaEmek Medical Center, Israel
Post Operative Pain
Effect of Pregabalin on Post Operative Pain in Abdominal Hysterectomy Under Spinal Anesthesia With Intrathecal Morphine
This study aims to compare the effect of pre-operative oral pregabalin on post operative morphine consumption after abdominal hysterectomy with/without salpingo-oophorectomy.
- Trial name
- NCT02285010
- Testing
- Pregabalin
- Where
- Thailand
- Volunteers
- 125 people
- Sponsor
- Mahidol University
Hereditary Breast and Ovarian Cancer
Study of Quality of Life Post Salpingo-oophorectomy in BRCA1/2 & PALB2 Mutation Carriers (BRCA-HRT)
1. Premenopausal BRCA1 / 2 or PALB2 gene mutation carriers who receive hormone replacement therapy (HRT) after preventive salpingo-oophorectomy (PBSO) have a better quality of sexual, psychological, cardiovascular and bone health…
- Trial name
- BRCA-HRT (NCT05409222)
- Where
- Spain
- Volunteers
- 45 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Hypoactive Sexual Desire Disorder
Study of Transdermal Testosterone Patches in Surgically Menopausal Women With Low Libido
This study is designed to evaluate efficacy and safety of a testosterone patch as treatment for low libido in surgically menopausal women who are taking estrogen therapy.
- Trial name
- NCT00331123
- Testing
- Testosterone Transdermal System
- Where
- 3 sites in United States, Australia and 1 more
- Volunteers
- 562 people
- Sponsor
- Warner Chilcott
Educational Problems, Surgery
Standardized Educational Videos of Laparoscopic Gynecological Surgeries
Owing to coronavirus disease-related social distancing requirements, online education has gained prominence. Surgical trainers consider online videos as a useful teaching aid that maximizes trainees' learning and skill…
- Conditions
- Educational Problems, Surgery, LAP, GYN Disorders
- Trial name
- AA-GYNLAP (NCT05227430)
- Testing
- Educational video tutorials
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Tubo-ovarian Carcinoma, High-grade Serous Carcinoma
Risk-reducing Strategies, Including Fimbriectomy, in Women With a Germline Mutation Predisposing to Ovarian or Pelvic Cancer
FIMBRIMENOP-2402 study aims to evaluate the long-term management of cancer risks in premenopausal women who have a genetic predisposition to tubo-ovarian or primary peritoneal carcinoma, such as mutations in BRCA1, BRCA2, RAD51C…
- Conditions
- Tubo-ovarian Carcinoma, High-grade Serous Carcinoma, Primary Peritoneal Carcinoma Stage III, Primary Peritoneal Carcinoma Stage IV
- Trial name
- FIMBRIMENOP (NCT06726330)
- Testing
- Fimbriectomy Followed by Delayed Oophorectomy (F-DO), Bilateral Salpingo-Oophorectomy
- Where
- 23 sites in France
- Volunteers
- 1,100 people
- Sponsor
- Centre Oscar Lambret
Uterine Neoplasms
Malignant Mixed Mesodermal Tumor (MMMT) - Early Stage With Postoperative XRT/Chemotherapy
Primary Objectives: 1. To test whether the addition of chemotherapy to radiotherapy improves the progression-free survival for patients with stage I, II and IIIa malignant mixed mesodermal tumor (MMMT) of the uterus. 2.
- Trial name
- NCT00505492
- Testing
- Carboplatin, Cisplatin, Paclitaxel
- Where
- 2 sites in United States
- Volunteers
- 4 people
- Sponsor
- M.D. Anderson Cancer Center
Oophorectomy
Transvaginal Ultrasound and Photoacoustic Imaging of the Ovary
The investigators have developed co-registered photoacoustic and ultrasound (US) imaging technique that allows the investigators to visualize tumor structure and functional changes simultaneously, which may potentially reveal…
- Trial name
- NCT03262818
- Testing
- Transvaginal ultrasound, Ultrasound/Photoacoustic imaging
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Washington University School of Medicine
Ovarian Diseases
4K Versus 3D Total Laparoscopic Bilateral Oophorectomy: Tools in Comparison
Evaluate whether the 4K laparoscopic vision system can provide an advantage in performing bilateral oophorectomy procedures for benign conditions carried out by trainee surgeons compared to 3D laparoscopy
- Trial name
- TOLSTOY (NCT06750003)
- Testing
- 3D versus 4K laparoscopic bilateral salpingo-oophorectomy
- Volunteers
- 22 people
- Sponsor
- Azienda Sanitaria-Universitaria Integrata di Udine
Surgery
vNOTES for Salpingo-oophorectomy
The aim of this study is to compare the common approach of laparoscopy for bilateral salpingo - oophorectomy to a new approach via transvaginal natural orifice transluminal endoscopic surgery (vNOTES).
- Trial name
- NCT04012710
- Testing
- Laparoscopy, vNOTES
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Gynecologic Cancer
PSMA PET and MRI in Gynecological Cancers
The goal of this research is to determine the accuracy of PSMA positron emission tomography (PET) and multi-parametric magnetic resonance (MR) imaging to detect the presence of gynecological cancer cells in the body.
- Trial name
- NCT03302156
- Testing
- PSMA-based 18F-DCFPyL PET tracer
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Ovarian Carcinoma
Prophylactic Salpingectomy With Delayed Oophorectomy
The goal of this clinical research study is to compare ovarian cancer screening, risk-reducing salpingo-oophorectomy (RRSO), and prophylactic salpingectomy with delayed oophorectomy (PSDO).
- Trial name
- NCT01907789
- Testing
- Ovarian Cancer Screening, Prophylactic Salpingectomy with Delayed Oophorectomy, Risk-Reducing Salpingo-Oophorectomy
- Where
- 2 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Planned RRSO
E2 and LDX for the Treatment of Cognitive Complaints After Oophorectomy
This project seeks to address cognitive disturbance, which is a frequent adverse sequelae of riskreducing bilateral salpingo-oophorectomy (RRSO) with or without post-procedure chemotherapy and adjunctive treatments.
- Trial name
- E2LDX (NCT01986764)
- Testing
- Lisdexamfetamine, Estradiol
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Cardiovascular Risk Reduction
Oophorectomy, Estrogen Therapy and Cardiovascular Disease Risk in Young Women
Researchers are trying to assess the appropriate dose of estrogen for decreasing the risk of cardiovascular disease in women who have removal of their ovaries at a young age, before the age of 46 years.
- Trial name
- NCT03815929
- Testing
- Estradiol 100 Micrograms Patch, Estradiol Patch
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Ovarian Carcinoma
Pilot Study of Denosumab in BRCA1/2 Mutation Carriers Scheduled for Risk-Reducing Salpingo-Oophorectomy
This randomized pilot early phase I trial studies how well denosumab works in BRCA1/2 mutations carriers scheduled for risk-reducing salpingo-oophorectomy.
- Trial name
- NCT03382574
- Testing
- Denosumab, Salpingo-Oophorectomy
- Where
- 6 sites in United States, Israel
- Volunteers
- 2 people
- Sponsor
- National Cancer Institute (NCI)
Hypoactive Sexual Desire Disorder
Study of Transdermal Testosterone Patches in Surgically Menopausal Women With Low Libido
This study is designed to evaluate efficacy and safety of a testosterone patch as treatment for low libido in surgically menopausal women who are taking estrogen therapy.
- Trial name
- NCT00331214
- Testing
- Testosterone Transdermal System
- Where
- 3 sites in United States, Australia and 1 more
- Volunteers
- 533 people
- Sponsor
- Warner Chilcott
Abdomen Cancer, Pancreas Adenocarcinoma (MSI-H)
Implementation of a Pain Management Plan in Major Open Abdominal Surgeries.
Introduction: Major abdominal surgery encompasses a broad range of surgical procedures in heterogeneous patient populations.Management of postoperative pain has received keen attention in recent years with considerable concurrent…
- Conditions
- Abdomen Cancer, Pancreas Adenocarcinoma (MSI-H), Colectomy Left/Right/Total Under Laparotomy, Hepatectomy
- Trial name
- NCT07901582
- Testing
- Epidural administered opioid
- Where
- Greece
- Volunteers
- 58 people
- Sponsor
- National and Kapodistrian University of Athens
Menopause Surgical
Hormonal Regulation of Cardiometabolic Health Study
The goal of this observational study is to understand how the loss of ovarian function after oophorectomy affects the health and well being of women aged 35-50. The study focuses on four areas: 1.
- Trial name
- HoCa (NCT07406412)
- Testing
- Surgical removal of ovaries, Hormone Replacement Therapy (HRT)
- Where
- 7 sites in Finland
- Volunteers
- 120 people
- Sponsor
- University of Jyvaskyla