Clinical trials: Opacity
Cataract, Lens Opacities
PMCF Retrospective Study Outcomes of a Monofocal Toric Intraocular Lens
This is a monocentric retrospective, open-label clinical study in patients after unilateral or bilateral implantation of hydrophobic acrylic monofocal toric intraocular lens PODEYE TORIC and executed only with standard of care…
- Conditions
- Cataract, Lens Opacities, Astigmatism
- Trial name
- NCT05055076
- Testing
- PODEYE TORIC
- Where
- France
- Volunteers
- 105 people
- Sponsor
- Beaver-Visitec International, Inc.
Corneal Scarring Fibrosis
Losartan for Corneal Fibrosis
This is a prospective, randomized, double-blinded, controlled clinical trial designed to evaluate the efficacy and safety of topical losartan in improving visual acuity, contrast sensitivity and reducing corneal densitometry…
- Trial name
- NCT07449000
- Testing
- Topical losartan
- Where
- Mexico
- Volunteers
- 46 people
- Sponsor
- Universidad Autonoma de Nuevo Leon
Cancer
STING MARK Universal Fiducial Marker System
Currently available fiducial marker and fiducial insertion strategies are rudimentary, imprecise, not compatible with multiple insertion catheters/needles and are overall unreliable.
- Trial name
- StingMark (NCT05465161)
- Testing
- Sting Mark Fiducial Marker
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Children, Adult, Molar Incisor Hypomineralization
Effectiveness of Infiltration With Resin in Treatment of MIH Incisors in Children Showing Opacities
Enamel development defects are the result of a set of environmental, systemic and genetic causal agents that reveal a multifactorial etiology model, which in anterior teeth produces a serious aesthetic problem, converted into a…
- Conditions
- Children, Adult, Molar Incisor Hypomineralization, Dental Diseases, Opacity
- Trial name
- NCT05597956
- Testing
- white defects, yellow defects, brown defects
- Where
- Spain
- Volunteers
- 110 people
- Sponsor
- University of Valencia
Cataract, Lens Opacities
Clinical Investigation of the Multifocal IOL POD F GF in Cataracteous Eyes
To evaluate effectiveness and safety of the POD F GF Intraocular Lens (IOL) when implanted to replace the natural lens following cataract removal
- Conditions
- Cataract, Lens Opacities, Presbyopia
- Trial name
- NCT04699266
- Testing
- Assigned Intervention (POD F GF)
- Where
- Japan
- Volunteers
- 23 people
- Sponsor
- Beaver-Visitec International, Inc.
Pulmonary Nodule, Solitary
Is Bronchoscopy Necessary in the Preoperative Workup of GGO Lung Cancer?(ECTOP-1005)
This study is one of Eastern Cooperative Thoracic Oncology Projects (ECTOP-1005). It aims to evaluate the role of flexible bronchoscopy in the pre-operative workup of ground glass opacity featured lung cancer.
- Trial name
- NCT03591445
- Testing
- Flexible Bronchoscopy
- Where
- China
- Volunteers
- 615 people
- Sponsor
- Fudan University
Keratoconus, Cornea
Evaluation Of Deep Anterior Lamellar Keratoplasty By Anterior Segment Ocular Coherence Tomography
Investigators' research is concerned observing the post-operative anterior segment OCT changes throughout the post- operative follow up of the patient and relating to improve the visual outcome of the surgery which is the goal of…
- Conditions
- Keratoconus, Cornea, Corneal Opacity
- Trial name
- NCT05345652
- Testing
- deep anterior lamellar keratoplasty
- Volunteers
- 20 people
- Sponsor
- Assiut University
Hepatic Cancer, Liver Neoplasms
LC Bead LUMI Radio-Opaque Embolic Beads to Detect and Characterize the Vascularity of Hepatic Tumors
Background: Liver cancer begins in the cells of the liver. It can be treated with chemotherapy, radiation, or even a liver transplant. A less invasive treatment may be able to help some people with liver cancer.
- Conditions
- Hepatic Cancer, Liver Neoplasms, Hepatocellular Cancer, Liver Cancer
- Trial name
- NCT02649868
- Testing
- Transarterial embolization (TAE), LC Bead LUMI
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Thoracic Surgery, Video-Assisted
Preoperative Stereoscopic Localization Versus Methylene Blue Localization in GGO Wedge Resection
This study evaluates the feasibility，accuracy and safety of Preoperative Stereoscopic Localization Versus Methylene Blue Localization in GGO Wedge Resection.
- Trial name
- PSLVML (NCT03252210)
- Testing
- Preoperative Stereoscopic Localization
- Volunteers
- 20 people
- Sponsor
- Guangdong Provincial People's Hospital
Cataract, Lens Opacities
Comparison of Clinical Outcomes POD L GF vs POD F GF in Asian Eyes
Prospective, randomised, controlled, single-surgeon, single-center clinical study to compare the clinical outcomes of two trifocal IOLs differing in the dominance of additional power.
- Conditions
- Cataract, Lens Opacities, Presbyopia
- Trial name
- PHY1802 (NCT03688425)
- Testing
- IOL implantation experimental, IOL implantation active comparator
- Where
- Philippines
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Beaver-Visitec International, Inc.
Corneal Opacity
OCT-guided LALAK in Children
The primary goal of the trial is to determine if laser-assisted lamellar anterior keratoplasty (LALAK) will reduce the risks of post-operative complications such as adhesions, glaucoma and cataract that are associated with…
- Trial name
- LALAK (NCT01579643)
- Testing
- OCT guided laser-assisted lamellar anterior keratoplasty (LALAK), Penetrating Keratoplasty (KP)
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Oregon Health and Science University
Corneal Opacity
The Use of MMC During PRK and Its Effect on Postoperative Topical Steroid Requirements
1. Purpose To evaluate the use of mitomycin-C (MMC) as an intraoperative adjunct during photorefractive keratectomy (PRK), its effect on postoperative healing and its ability to reduce the postoperative topical steroid course…
- Trial name
- NCT02030990
- Testing
- Mitomycin-C, Fluorometholone 1% topical ocular steroid
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- United States Naval Medical Center, San Diego
Macula Lutea Opacity
Food or Supplemental Lutein Absorption
The aim of this study is to investigate in healthy adults, 18-40 years of age, how the absorption of 5 mg of L differs between consumption as a supplement, blended foods, and whole food equivalent of blended foods.
- Trial name
- FSLA20 (NCT04786392)
- Testing
- Lutein supplement, Food, blended, Food, unprocessed
- Where
- Australia
- Volunteers
- healthy volunteers welcome
- Sponsor
- The University of Queensland
Corneal Disease, Corneal Opacity
First in Human (FIH) Study to Assess Safety and Efficacy of the CorNeat KPro for the Treatment of Corneal Blindness
Prospective, open label, single arm, First in Human (FIH) clinical study to assess safety and efficacy of the CorNeat Keratoprosthesis, a synthetic cornea, for the treatment of corneal blindness
- Conditions
- Corneal Disease, Corneal Opacity, Corneal Injuries
- Trial name
- NCT04485858
- Testing
- CorNeat KPro
- Where
- 8 sites in United States, Canada and 3 more
- Volunteers
- 10 people
- Sponsor
- CorNeat Vision Ltd.
Lipoprotein Lipase Deficiency, Inborn Error of Lipid Metabolism
Biomarker for Homozygous Familial Hypercholesterolemia (BioHoFH)
Development of a new MS-based biomarker for the early and sensitive diagnosis of Homozygous familial Hypercholesterolemia from blood
- Conditions
- Lipoprotein Lipase Deficiency, Inborn Error of Lipid Metabolism, Corneal Arcus
- Trial name
- BioHoFH (NCT03198897)
- Where
- 4 sites in Germany, India and 1 more
- Sponsor
- CENTOGENE GmbH Rostock
Keratoconus, Corneal Dystrophies
Laser Assisted Procedures in Penetrating Keratoplasty
Laser- assisted procedures in penetrating keratoplasty (PK) are proposed to improve the surgical outcomes: minimally invasive procedures, improved biomechanical stability of the transplanted flap, reduction of rejection risks…
- Conditions
- Keratoconus, Corneal Dystrophies, Corneal Opacity
- Trial name
- NCT02173847
- Testing
- Penetrating keratoplasty, Femtosecond laser, Diode laser
- Where
- Italy
- Volunteers
- 22 people
- Sponsor
- Ospedale Santo Stefano
Corneal Opacities
Corneal Opacities in Children
A prospective observational study on corneal opacities in infants and children (1 month to 18 years old) will be conducted at CHLA. Most of these cases will be due to congenital corneal opacity (e.g.
- Trial name
- OCT (NCT02117323)
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Oregon Health and Science University
Central Compartment Atopic Disease (CCAD)
Development of A Multi-section Olfactory Cleft Opacity Staging System in Patients With CCAD
This study aims to develop a modified CT scoring system to evaluate the association between olfactory cleft obstruction patterns and olfactory dysfunction in patients with central region atopic disease (CCAD).
- Trial name
- NCT07380945
- Testing
- Computer Tomography
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Fluorosis, Dental, Non-Fluoride Enamel Opacities
Treatment of Hypersensitivity Using Diode Laser and Desensitising Agent on Fluorosed and Non-fluorosed Teeth
The present study was designed as a randomised controlled clinical trial which was unicenter, double-blinded, parallel designed study, according to the Consolidated Standards of Reporting Trials (CONSORT) criteria, 2010.
- Conditions
- Fluorosis, Dental, Non-Fluoride Enamel Opacities, Dentin Sensitivity
- Trial name
- NCT03237793
- Testing
- Fluorosed Group, Non Flourosed Group
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Krishnadevaraya College of Dental Sciences & Hospital
Cataract, Lens Opacities
Comparison of ISOPURE and EYHANCE (Switzerland)
This is a prospective randomised open-label study with the aim to compare the visual performance of the premium monofocal Isopure IOL versus the extended depth of focus Eyhance® IOL after phaco-emulsification cataract surgery.
- Trial name
- PHY2301 (NCT05875922)
- Testing
- IOL implantation experimental (ISOPURE 1.2.3.), IOL implantation active comparator (TECNIS Eyhance)
- Where
- Switzerland
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Beaver-Visitec International, Inc.