Clinical trials: Open Angle Glaucoma
Primary Open Angle Glaucoma (POAG)
iStent Inject in OAG Subjects on 2 Pre-op Topical Ocular Hypotensive Medications
The purpose of this study is to evaluate the intraocular pressure (IOP) lowering effect of iStent inject in eyes of subjects with primary open-angle glaucoma previously on two anti-glaucoma medications.
- Trial name
- NCT03478293
- Testing
- iStent inject surgery
- Where
- Brazil
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Glaukos Corporation
Glaucoma, Primary Open Angle
LSFG in Patients With Normal Tension Glaucoma Tension Glaucoma
Glaucoma is the second leading cause of blindness worldwide. Literature shows increasing evidence that dysfunction of ocular microcirculation in the optic nerve influences the progression of glaucoma.
- Trial name
- NCT03318510
- Testing
- Laser Speckle Flowgraphy
- Where
- Austria
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Augenabteilung Allgemeines Krankenhaus Linz
Subject With Primary Open-angle Glaucoma (POAG)
A Prospective Evaluation of Open-Angle Glaucoma Subjects on Two Topical Hypotensive Medications Treated With One Suprachoroidal Stent
The purpose of this study is to assess the efficacy and safety of one iStent supra stent in the reduction of intraocular pressure associated with primary open-angle glaucoma.
- Trial name
- NCT01252914
- Testing
- iStent Supra Stent
- Where
- Armenia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Glaukos Corporation
Open-angle Glaucoma, Low Tension Glaucoma
Waveform Analysis of the Doppler Curve of Ophthalmic Arteries in Glaucoma Patients
Color Doppler Imaging (CDI) has been providing information about ocular blood flow over the past decades. This non-invasive procedure based on ultrasound technique has identified increased resistance and decreased systolic blood…
- Trial name
- NCT01487655
- Where
- Belgium
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Primary Open Angle Glaucoma (POAG)
One, Two, or Three iStents for the Reduction of Intraocular Pressure in Open-angle Glaucoma Subjects
The purpose of this study is to evaluate the safety and efficacy of the intraocular pressure (IOP) lowering effect of one, two, or three iStent devices in eyes of subjects previously on two anti-glaucoma medications.
- Trial name
- NCT01517477
- Testing
- iStent
- Where
- Armenia
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- Glaukos Corporation
Primary Open Angle Glaucoma (POAG)
Association Between Matrix Metalloproteinase-9 Gene Polymorphism and Susceptibility to Primary Open Angle Glaucoma Patients in Sohag University Hospital
The goal of this observational study is to investigate the potential association between MMP-9 gene polymorphism and susceptibility to Primary Open Angle Glaucoma development in Egyptian patients The main question it aims to
- Trial name
- NCT07119905
- Testing
- genotyping assay by polymerase chain reaction
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sohag University
Ocular Dryness, Ocular Irritation
Dry Eye and Irritation Comparison of Latanoprost With the Preservative Versus Travoprost Without Preservative
Although Benzalkonium chloride (BAC) has been used as a preservative for many years, many studies have demonstrated that prolonged use of topical ocular medications preserved with BAC may exacerbate sequelae associated with…
- Conditions
- Ocular Dryness, Ocular Irritation, Open-Angle Glaucoma, Ocular Hypertension
- Trial name
- NCT00803387
- Testing
- Travaprost without BAC (Travatan Z)
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- United States Air Force
Vitamin D Deficiency, Primary Open-angle Glaucoma
Comparison of Vitamin D Status and Vitamin D Receptor Polymorphisms in Patients With High Myopia and Primary Open-angle Glaucoma
Vitamin D deficiency is known to be significantly associated with high myopia. This study investigated the vitamin D status in patients with high myopia and primary open-angle glaucoma, in order to understand the relationship…
- Conditions
- Vitamin D Deficiency, Primary Open-angle Glaucoma, High Myopia, Vitamin D Receptor Polymorphisms
- Trial name
- NCT03021629
- Testing
- Serum levels of 1a, 25-Dihydroxyvitamin D3 were measured by an enzyme-linked immuno-absorbent assay
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Lv Yingjuan
Glaucoma, Open-Angle
The Effect of Pseudoexfoliation on Choroidal Thickness in Open Angle Glaucoma
Purpose: To investigate the effect of pseudoexfoliation (PEX) on choroidal thickness in primary open-angle glaucoma (POAG). Methods: This prospective, randomized study included 30 POAG patients and 30 PEX glaucoma patients with…
- Trial name
- NCT03373942
- Testing
- Choroidal thickness measurements with SD-OCT device
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Emine Deniz Egrilmez
Glaucoma
Polymorphisms in the Human Matrix Metalloproteinase Genes MMP1, MMP3, and MMP9: Genetic Risk Factors of Primary Open Angle Glaucoma?
Matrix metalloproteinases (MMPs) fulfill diverse important molecular functions and play pivotal roles in development, tissue morphogenesis, repair, aging, and inflammatory processes.
- Trial name
- NCT00312403
- Testing
- Blood Sample
- Where
- Austria
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Primary Open Angle Glaucoma, Healthy Subjects
Efficacy of 24-hour Intraocular Pressure Fluctuation Recording With the SENSIMED Triggerfish Contact Lens Sensor
The objectives of this study are to assess the safety and effectiveness of the SENSIMED Triggerfish® (TF) device in continuous recording of relative fluctuation in intraocular pressure (IOP).
- Trial name
- NCT01390779
- Testing
- SENSIMED Triggerfish
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Sensimed AG
Glaucoma, Open-Angle
Optic Nerve Head Strain as Biomarker for Glaucoma
The investigators will test the hypothesis that images of the optic nerve head taken a 2 different eye pressures will yield strain estimates that are predictive of the course of glaucoma.
- Trial name
- NCT06240312
- Testing
- Images of eye at 2 eye pressures
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Primary Open Angle Glaucoma
African Descent and Glaucoma Evaluation Study
According to the National Eye Institute, Glaucoma affects about three million Americans. Among Blacks in the United States, open- angle glaucoma is the leading cause of irreversible visual loss.
- Trial name
- ADAGES (NCT00221923)
- Where
- 3 sites in United States
- Volunteers
- 1,540 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Glaucoma, Open-Angle
Comparation of CLASS Combined With Phacoemulsification and CLASS Alone in the Treatment of Primary Open Angle Glaucoma
To compare the effect of intraocular pressure control and the incidence of peripheral anterior synechia between CLASS combined with phacoemulsification and CLASS alone in the treatment of primary open-angle glaucoma
- Trial name
- NCT04920227
- Testing
- phacoemulsification;
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Cataract, Primary Open-angle Glaucoma
Optical Coherence Tomography of Nerve Fiber Layer and Ganglion Cell Complex After Cataract Extraction
Optical coherence tomography (OCT) for retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) is done before and after cataract extraction in patients with or without primary open angle glaucoma (POAG)
- Trial name
- NCT03889652
- Testing
- Oct scans
- Where
- Egypt
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Kasr El Aini Hospital
Glaucoma, Myopia
Morphological Changes of Ciliary Body and Trabecular Meshwork
Glaucoma is the leading cause of irreversible blindness worldwide. Although the pathogenesis remains unclear, pathologic increase in intraocular pressure (IOP) due to blocked aqueous outflow through the trabecular-Schlemm canal…
- Trial name
- NCT05352854
- Testing
- 0.5% pilocarpine eye drops
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Yune Zhao
Glaucoma, Open-Angle
Visual Field Defect Estimation Using Sequentially Optimized Reconstruction Strategy on Healthy and Glaucoma Subjects
Perimetry is a well-established method that is used to measure the visual field functions of humans. Commercially available products, such as the OCTOPUS 900 (Haag-Streit AG, Koeniz, Switzerland), are commonly used for assessing…
- Trial name
- NCT03325751
- Testing
- Visual field testing
- Where
- Switzerland
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Glaucoma, Open-Angle
Trabeculectomy Versus 2-iStent and Prostaglandin Study
Investigators hypothesize that the synergistic action of iStent in increasing aqueous outflow through the trabecular meshwork and use of prostaglandin analog such as travoprost or latanoprost to increase uveoscleral outflow will…
- Trial name
- TIPS (NCT03274323)
- Testing
- iStent and travoprost or latanoprost, Trabeculectomy
- Volunteers
- healthy volunteers welcome
- Sponsor
- Johns Hopkins University
POAG, Primary Open Angle Glaucoma
A Comparison of Xalatan (Latanoprost) to Apo-latanoprost and Co-latanoprost in the Treatment of Glaucoma
The purpose of the study is to provide evidence that the efficacy of Xalatan will be superior to Apo-latanoprost and Co-latanoprost in the reduction of intraocular pressure in patients with primary open angle glaucoma.
- Conditions
- POAG, Primary Open Angle Glaucoma, Ocular Hypertension
- Trial name
- NCT02792803
- Testing
- Xalatan, Apo-Latanoprost, Co-Latanoprost
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Dr. David Yan
Glaucoma
Investigating the Genetic Basis of Pseudoexfoliation Syndrome, Angle-closure Glaucoma and Primary Open-angle Glaucoma
There is increasing evidence that there are genetic risk factors for several forms of glaucoma, such as glaucoma caused by pseudoexfoliation syndrome (PXF) ,primary angle closure glaucoma (PACG) and primary open-angle glaucoma…
- Trial name
- NCT03423758
- Testing
- Blood sample
- Where
- Austria
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna