Clinical trials: Open Angle Glaucoma -Ocular Hypertension
Glaucoma, Open-angle, Ocular Hypertension
A Study of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7058584 Following 7 Days of Instillation of Eye Drops in Patients With Primary Open Angle Glaucoma or Ocular Hypertension
This is a Phase I, multi-center, randomized, adaptive, investigator/patient-masked, placebo-controlled, parallel multiple-ascending dose study (Part A) with an extension including up to two selected doses from Part A and…
- Trial name
- NCT03293992
- Testing
- 0.01% RO7058584, 0.1% RO7058584, 1% RO7058584
- Where
- 8 sites in United States
- Volunteers
- 27 people
- Sponsor
- Hoffmann-La Roche
Open-angle Glaucoma, Ocular Hypertension
Safety and Intraocular Pressure (IOP) Lowering Efficacy of Low Dose Travoprost
The purpose of this study is to compare the safety and IOP-lowering efficacy of various low dose travoprost formulations in patients with open-angle glaucoma or ocular hypertension.
- Trial name
- NCT00637130
- Testing
- Travoprost ophthalmic solution, 0.0008%, Travoprost ophthalmic solution, 0.001%, Travoprost ophthalmic solution, 0.0012%
- Where
- United States
- Volunteers
- 138 people
- Sponsor
- Alcon Research
Ocular Hypertension
Efficacy Comparison of Xalatan and Azopt on POAG and OH
Prostaglandin analogs (PGAs) represent a new class of active ocular hypotensive agents and possess a unique mechanism of action.
- Trial name
- NCT01084902
- Testing
- Latanoprost, Brinzolamide
- Volunteers
- 130 people
- Sponsor
- Peking University First Hospital
Open Angle Glaucoma, Angle Closure Glaucoma
Oculusgen (Ologen) Glaucoma MMC Control in Estonia
To compare the safety and effectiveness between ologen collagen matrix and mitomycin-C (MMC) in glaucoma surgery. The ologen collagen matrix implantation procedure is same as traditional trabeculectomy except implant the ologen…
- Conditions
- Open Angle Glaucoma, Angle Closure Glaucoma, Uveitis Glaucoma, Young Age Glaucoma
- Trial name
- NCT00524758
- Testing
- ologen (oculusgen) collagen matrix, MMC in Trabeculectomy
- Where
- Estonia
- Volunteers
- 20 people
- Sponsor
- Pro Top & Mediking Company Limited
Glaucoma
Investigating the Genetic Basis of Pseudoexfoliation Syndrome, Angle-closure Glaucoma and Primary Open-angle Glaucoma
There is increasing evidence that there are genetic risk factors for several forms of glaucoma, such as glaucoma caused by pseudoexfoliation syndrome (PXF) ,primary angle closure glaucoma (PACG) and primary open-angle glaucoma…
- Trial name
- NCT03423758
- Testing
- Blood sample
- Where
- Austria
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Open-Angle Glaucoma
Diurnal Intraocular Pressure and Peripapillary Retinal Blood Flow in Medically Controlled Open-Angle Glaucoma
Diurnal fluctuations of intraocular pressure (IOP) and peripapillary retinal blood flow may have distinctive patterns in medically well-controlled open-angle glaucoma patients.
- Trial name
- IOPMG (NCT00481208)
- Where
- South Korea
- Volunteers
- 70 people
- Sponsor
- Yonsei University
Glaucoma Congenital
Viscotrabeculotomy in Pediatric Glaucoma Following Cataract Surgery
Long term Surgical Outcomes of Viscotrabeculotomy in Pediatric Glaucoma Following Cataract Surgery. Purpose: This study aims to compare outcomes of single-site rigid probe viscotrabeculotomy (VT) to two-site VT in pediatric…
- Trial name
- NCT05011747
- Testing
- single-site rigid probe viscotrabeculotomy (VT), two-site rigid probe viscotrabeculotomy (VT)
- Volunteers
- 20 people
- Sponsor
- Mansoura University
Glaucoma, Glaucoma, Open Angle
SOLX Titanium Sapphire Laser for Trabeculoplasty
Use of the Titanium Sapphire laser for laser trabeculoplasty to reduce intraocular pressure in patients with poorly controlled intraocular pressure on maximally tolerated medical therapy or prior failed laser trabeculoplasty.
- Trial name
- NCT00145535
- Testing
- SOLX Titanium Sapphire Laser (TiSaLT), Argon Laser Trabeculoplasty (ALT)
- Where
- 10 sites in United States, Canada and 2 more
- Volunteers
- 120 people
- Sponsor
- SOLX, Inc.
Open-angle Glaucoma, Papilledema
aICP in Glaucoma and Papilledema
Glaucoma remains a disease with an unclear and complex underlying pathophysiology. Recently, researchers have emphasized not only intraocular pressure (IOP) or vascular dysregulation, but also translaminar pressure's (TPG) role…
- Trial name
- aICP Ophtha (NCT02410148)
- Testing
- Non-invasive ICP measurement (Vittamed 305)
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- Kantonsspital Aarau
Open-angle Glaucoma, Ocular Hypertension
Multi-center Phase II Study Assessing the Safety and Efficacy of DE-117 Ophthalmic Solution in Subjects With Primary Open-angle Glaucoma or Ocular Hypertension
The purpose of this study is to investigate the safety and efficacy of five concentrations of DE-117 ophthalmic solution.
- Trial name
- SEE-1 (NCT02179008)
- Testing
- DE-117 Low Dose ophthalmic solution, DE-117 Low/Middle Dose ophthalmic solution, DE-117 Middle Dose ophthalmic solution
- Where
- 14 sites in United States
- Volunteers
- 184 people
- Sponsor
- Santen Inc.
Open Angle Glaucoma, Ocular Hypertension
Travoprost Intraocular Implant in Conjunction With Cataract Surgery
Subjects with cataract requiring extraction and who have open-angle glaucoma or ocular hypertension will undergo screening and washout from IOP-lowering medication, if applicable.
- Trial name
- NCT06061718
- Testing
- iDose TR
- Where
- Armenia
- Volunteers
- 60 people
- Sponsor
- Glaukos Corporation
Glaucoma, Open-Angle, Ocular Hypertension
Phase 1-2 Evaluation of OT-730 Eye Drops in Reducing the Intraocular Pressure in Patients With Ocular Hypertension or Open-Angle Glaucoma
The purpose of this study is to evaluate the safety and potential efficacy of a new drug, OT-730 ophthalmic solution (eye drops), in reducing intraocular pressure in the eyes of patients with open angle glaucoma or ocular…
- Trial name
- NCT00753168
- Testing
- OT-730 ophthalmic solution, timolol maleate ophthalmic solution
- Where
- 5 sites in United States
- Volunteers
- 48 people
- Sponsor
- Othera Pharmaceuticals
Glaucoma, Ocular Hypertension (OH)
A Dose Evaluation Study for the Latanoprost Punctal Plug Delivery System (L-PPDS) in Subjects With Ocular Hypertension or Open-Angle Glaucoma
The purpose of this study is to evaluate the efficacy, safety and duration of the L-PPDS (latanoprost punctal plug delivery system) at different dose levels.
- Trial name
- NCT01481051
- Testing
- Latanoprost-PPDS
- Where
- 6 sites in United States
- Volunteers
- 57 people
- Sponsor
- Mati Therapeutics Inc.
Open-Angle Glaucoma, Ocular Hypertension
The Effects of Cosopt® Vs Xalacom® on Ocular Hemodynamics and Intraocular Pressure (IOP) in Primary Open-angle Glaucoma (POAG)
Both Cosopt® and Xalatan® plus Timoptic® will significantly lower IOP, however only Cosopt® will demonstrate positive hemodynamic effects.
- Trial name
- Xal-Cos (NCT00815373)
- Testing
- Dorzolamide+Timolol Maleate0.5%, Latanoprost+Timolol Maleate0.5%+Lytears
- Where
- Israel
- Sponsor
- Meir Medical Center
Angiography, Glaucoma, Open-Angle
The Relationship Between Macular OCTA and GCIPL and Their Combinational Index Using AI
Macular GCIPLT and vessel density will be measured with Spectralis optical coherence tomography and Topcon swept-source OCT respectively.
- Trial name
- NCT03369886
- Testing
- Optical Coherence Tomography Angiography (OCTA)
- Where
- South Korea
- Volunteers
- 206 people, healthy volunteers welcome
- Sponsor
- Pusan National University Hospital
Glaucoma, Open-angle, Hypertension, Ocular
The Diurnal and Nocturnal Effect of Pilocarpine on Intraocular Pressure and Ocular Perfusion Pressure
The aim of this study will be to determine the effects of pilocarpine as an adjunct medication to latanoprost monotherapy at multiple intervals throughout a 24-hour period and compare these effects to latanoprost alone.
- Trial name
- NCT02754570
- Testing
- Pilocarpine
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of Colorado, Denver
Open Angle Glaucoma, Ocular Hypertension
Evaluation of Hyperemia With the Use of Ocular Prostaglandin Analogues
This study will evaluate hyperemia and ocular surface tolerability in patients on prostaglandin analogues
- Trial name
- NCT00539526
- Testing
- Bimatoprost 0.03%, travoprost 0.004%, latanoprost 0.005% eye drops
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- Allergan
Primary Open Angle Glaucoma, Intraocular Pressure
Microinvasive Glaucoma Surgery -The Lowering Effect of Intraocular Pressure on Glaucoma Patients With High Frequency Deep Sclerotomy
Highlights the high-frequency deep sclerotomy (HFDS) as a promising ab-interno surgery in primary open-angle glaucoma (POAG) patients and evaluates the efficacy and safety of the procedure.
- Conditions
- Primary Open Angle Glaucoma, Intraocular Pressure, Glaucoma Surgery
- Trial name
- HFDS (NCT05466526)
- Testing
- High frequency deep sclerotomy (HFDS)
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- National Taiwan University Hospital Hsin-Chu Branch
Glaucoma, Open-Angle
Ginkgo Biloba and Ocular Blood Flow in Primary Open-angle Glaucoma
Glaucoma is one of the leading causes of blindness. Ginkgo biloba may be part of an effective treatment strategy for glaucoma because it has been shown to improve blood flow, it has antioxidant properties, it can relax smooth…
- Trial name
- NCT02376114
- Testing
- Ginkgo biloba
- Where
- Canada
- Volunteers
- 19 people
- Sponsor
- Maisonneuve-Rosemont Hospital
Glaucoma, Open-Angle
An Observational Multicenter Clinical Study To Assess The Safety And Effectiveness Of The OMNI® Surgical System In Pseudophakic Eyes With Primary Open Angle Glaucoma (ORION 2.0)
The purpose of this study is to evaluate the safety and effectiveness of the OMNI® Surgical System in subjects who have undergone canaloplasty and trabeculotomy using OMNI® Surgical System without any concomitant surgery in…
- Trial name
- NCT04872348
- Testing
- OMNI® Surgical System
- Where
- 10 sites in United States
- Volunteers
- 28 people
- Sponsor
- Sight Sciences, Inc.
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