Clinical trials: Open Angle Glaucoma -Ocular Hypertension
Glaucoma, Glaucoma, Open-Angle
Evaluation of Nanodropper-mediated Microdrops vs. Standard Drops of 0.5% Timolol Maleate in Glaucoma Patients
The purpose of this study is to evaluate the effect of microdrops vs. standard eyedrops of 0.5% timolol maleate in adults with primary open-angle glaucoma or ocular hypertension in terms of intraocular pressure-lowering efficacy…
- Conditions
- Glaucoma, Glaucoma, Open-Angle, Glaucoma, Primary Open Angle, Glaucoma and Ocular Hypertension
- Trial name
- NCT05181046
- Testing
- Nanodropper adaptor, Original eyedrop bottle/No Nanodropper
- Where
- 2 sites in India
- Volunteers
- 420 people
- Sponsor
- Nanodropper, Inc.
Primary Open-Angle Glaucoma (POAG), Ocular Hypertension
Dorzolamide/Brimonidine/Timolol Impact on Ocular Surface, Glaucoma Progression & Chatbot Follow-up: GLAUCO-TECH
The primary objective of this study is to evaluate the ocular surface safety of an ophthalmic solution indicated for the management of glaucoma, containing the active ingredients dorzolamide, timolol, and brimonidine, in patients…
- Trial name
- GLAUCO-TECH (NCT07690397)
- Testing
- Preservative-free dorzolamide-timolol-brimonidine combination, Preservative dorzolamide-timolol-brimonidine combination
- Where
- Colombia
- Volunteers
- 140 people
- Sponsor
- Tecnoquimicas
Primary Open Angle Glaucoma, Ocular Hypertension
Study to Compare the Safety and Efficacy of ALZ-1101 to Latanoprost in Patients With Intraocular Pressure Inadequately Controlled by Latanoprost
This is a pilot, proof of concept study to evaluate the safety and efficacy of ALZ-1101 dosed once daily for 28 days compared to latanoprost 0.005% ophthalmic solution in patients with elevated intraocular pressure not adequately…
- Conditions
- Primary Open Angle Glaucoma, Ocular Hypertension, Elevated Intraocular Pressure
- Trial name
- NCT01896180
- Testing
- ALZ-1101, Latanoprost
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Alleanza Pharmaceuticals, Inc.
Glaucoma, Open Angle Glaucoma
Performance and Safety of the ARGOS-SC Suprachoroidal Pressure Sensor in Patients With Glaucoma Undergoing Non-penetrating Glaucoma Surgery
The purpose of this study is to evaluate both the safety and feasibility of the surgical implantation of the ARGOS-SC implant during non-penetrating glaucoma surgery and the safety and usability of the ARGOS-SC implant and system…
- Trial name
- ARGOS-SC01 (NCT03756662)
- Testing
- ARGOS-SC suprachoroidal pressure sensor
- Where
- 5 sites in Germany, Switzerland
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Implandata Ophthalmic Products GmbH
Primary Open Angle Glaucoma (POAG)
Study to Compare Standard Perimetry With the New Scotoma-Oriented Perimetry (SCOPE) Using a New Fast German Adaptive Threshold Estimation (GATE) in Glaucoma Patients
The purpose of this study is to compare the two psychophysical perimetric techniques regarding progression of the visual field.
- Trial name
- TRASCO (NCT00902109)
- Testing
- Perimetry, Confocal Scanning Laser Tomography, Optical Coherence Tomography (OCT)
- Where
- Germany
- Volunteers
- 12 people
- Sponsor
- University Hospital Tuebingen
Ocular Hypertension, Open-Angle Glaucoma
Ocular Signs and Symptoms in Glaucoma Patients Switched From Latanoprost to Preservative Free Tafluprost Eye Drops
The purpose of this study is to investigate if changes in ocular signs and symptoms occur in patients with ocular hypertension or glaucoma when they switch from latanoprost 0.005% (Xalatan) to preservative free Tafluprost eye…
- Trial name
- NCT01087671
- Testing
- tafluprost
- Volunteers
- 185 people
- Sponsor
- Santen Oy
Open-angle Glaucoma
Safety and Tolerability of a Prostaglandin Ocular Implant for Treatment of Open Angle Glaucoma
A single centre, open label, study to assess the safety, tolerability and biodegradation of PA5108 ocular implant in adults who have Open Angle Glaucoma (Primary or Secondary).
- Trial name
- NCT03604328
- Testing
- PA5108
- Where
- 2 sites in Australia
- Volunteers
- 8 people
- Sponsor
- PolyActiva Pty Ltd
Primary Open Angle Glaucoma or Ocular Hypertension
Effect of Rhopressa on Intraocular Pressure (IOP) in Patients With Primary Open-Angle Glaucoma or Ocular Hypertension Post-SLT
The purpose of this study is to collect data about how Rhopressa affects IOP in patients who have had an SLT procedure in both eyes.
- Trial name
- NCT06865144
- Testing
- Netarsudil ophthalmic solution 0.02%, Artificial tears
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- East Coast Institute for Research
Primary Open Angle Glaucoma, Ocular Hypertension
Clinical Study of A Fixed Combination of Timolol-Brimonidine-Dorzolamide
To compare intraocular pressure lowering effectiveness of a new fixed combination drug.
- Trial name
- NCT01062971
- Testing
- dorzolamide-timolol-brimonidine
- Where
- Mexico
- Volunteers
- 124 people
- Sponsor
- Laboratorios Sophia S.A de C.V.
Glaucoma; Drugs, Normal Tension Glaucoma
Peripapillary Blood Flow After Use of Anti-glaucoma Medications: An OCT Angiography Study
This study evaluates the possible acute changes in peripapillary blood flow after instillation of antiglaucoma medications in patients with primary open angle glaucoma (POAG), normal tension glaucoma (NTG), or ocular hypertension…
- Conditions
- Glaucoma; Drugs, Normal Tension Glaucoma, Primary Open-angle Glaucoma
- Trial name
- NCT03323164
- Testing
- Timolol Maleate, Brimonidine Tartrate
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Wills Eye
Glaucoma, Open-Angle, Cataract
Results of Patients With Glaucoma Undergoing Minimally Invasive Glaucoma Surgery in Conjunction With Cataract Surgery
This study is designed to determine how well patients with glaucoma can see following cataract surgery with a special type of lens called an extended-depth-of-focus (EDOF) lens.
- Trial name
- NCT05624398
- Testing
- Vivity IOL
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Vold Vision P.L.L.C
Glaucoma, Open Angle or Ocular Hypertension
Therapeutic Equivalence Study of Generic Brinzolamide vs Azopt
The main purpose of this prospective study is to demonstrate the therapeutic equivalence of topical brinzolamide compared with AzoptTM
- Trial name
- NCT03896633
- Testing
- brinzolamide 1% ophthalmic suspension, Azopt 1%
- Where
- United States
- Volunteers
- 637 people
- Sponsor
- Bausch & Lomb Incorporated
Glaucoma
24-hour Intraocular Pressure Control With Travoprost/Timolol Fixed Combination Versus Travoprost
This 8-week, crossover study will compare the quality of 24-hour IOP control with TTFC versus travoprost when both medications are dosed in the evening.
- Trial name
- NCT00444184
- Testing
- Travoprost/timolol fixed combination, travoprost
- Where
- Greece
- Volunteers
- 32 people
- Sponsor
- Aristotle University Of Thessaloniki
Primary Open Angle Glaucoma, Ocular Hypertension
A Therapeutic Equivalence Study in Subjects With Primary Open Angle Glaucoma or Ocular Hypertension
This is a randomized, Investigator-masked, multi-center, parallel group, therapeutic equivalence study with clinical endpoint.
- Trial name
- NCT05022004
- Testing
- Brinzolamide ophthalmic suspension, Azopt®
- Where
- 40 sites in India, Russia
- Volunteers
- 599 people
- Sponsor
- Sun Pharmaceutical Industries Limited
Glaucoma Open-Angle
Combined Non-Invasive Brain and Visual Stimulation for Vision Improvement
Glaucoma is a complex disease that can result in progressive vision loss. It is the second leading cause of blindness, accounting for 23% of permanent blindness in Hong Kong.
- Trial name
- NCT07486323
- Testing
- NIBS, VTS, NIBS+VTS
- Where
- Hong Kong
- Volunteers
- 56 people
- Sponsor
- The Hong Kong Polytechnic University
Visual Field Defect, Peripheral, Glaucoma, Open-Angle
Nutritional Supplements and Performance During Visual Field Testing (B3 Vitamin)
This study seeks to test whether these over-the-counter nutritional supplements have an impact on patients' performance during visual field testing.
- Trial name
- NCT03797469
- Testing
- Vitamin B3, Pyruvate
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Columbia University
Open-Angle Glaucoma, Ocular Hypertension
Adjunctive Study of AL-37807 Ophthalmic Suspension
The purpose of the study is to compare the safety and intraocular pressure-lowering efficacy of AL-37807 ophthalmic suspension vs. Timolol gel forming solution vs.
- Trial name
- NCT00620256
- Testing
- AL-37807 ophthalmic suspension, 0.1%, Timolol gel forming solution, 0.5%, AL-37807 ophthalmic solution vehicle
- Where
- United States
- Volunteers
- 129 people
- Sponsor
- Alcon Research
Cataract, IOL
Visual Outcomes With a Trifocal IOL in Subjects With Open-angle Glaucoma
This study will examine the visual outcomes of subjects undergoing cataract surgery and minimally invasive glaucoma surgery with the implantation of a trifocal intraocular lens.
- Conditions
- Cataract, IOL, Glaucoma, Open-Angle
- Trial name
- NCT04619654
- Testing
- Cataract surgery with implantation of trifocal IOL combined with trabecular scaffold
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Vold Vision P.L.L.C
Glaucoma, Open-Angle
Saccadic Eye Movements Are Impaired In Glaucoma
The purpose of this study is to determine whether rapid eye movements called saccades are impaired in glaucoma, a neurodegenerative disease of visual pathways.
- Trial name
- NCT01254058
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Unity Health Toronto
Primary Open Angle Glaucoma
Clinical Study Evaluating the Safety and Performance of the MIST Device for Intraocular Pressure Reduction in Patients With Primary Open-Angle Glaucoma
It is an interventional study for the treatment of Primary Open-Angle Glaucoma (POAG) using the Hexiris Microinvasive Scleral Trephine (MIST) system. This medical device includes a sclerectomy punch and injector assembly.
- Trial name
- NCT07358650
- Testing
- Hexiris Microinvasive Scleral Trephine (MIST)
- Where
- 5 sites in Canada
- Volunteers
- 25 people
- Sponsor
- Hexiris Inc
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