Clinical trials: Open Bite
Macular Edema, Diabetic Macular Edema
A Study to Evaluate the Safety, Tolerability and Pharmacokinetics of IVT MHU650 in Macular Edema Patients
This was an open-label, multi-center, FIH study with a single ascending dose (SAD) design that assessed the safety, tolerability and pharmacokinetics (PK) of a single IVT dose of MHU650 in up to 24 participants with macular edema.
- Conditions
- Macular Edema, Diabetic Macular Edema, Neovascular Age-related Macular Degeneration, Retinal Vein Occlusion
- Trial name
- NCT04635800
- Testing
- MHU650
- Where
- 6 sites in United States, Puerto Rico
- Volunteers
- 21 people
- Sponsor
- Novartis Pharmaceuticals
Branch Retinal Vein Occlusion
Evaluation of Macugen Treatment of Macular Edema Due to Branch Retinal Vein Occlusion
The purpose of this study is to evaluate the effect of intravitreal injections of Macugen every 6 weeks for the treatment of macular edema secondary to branch retinal vein occlusion (BRVO).
- Trial name
- NCT00406107
- Testing
- pegaptanib sodium (Macugen)
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- Palmetto Retina Center, LLC
Anterior Open Bite
Prevalence of Anterior Open Bite in a Group of Egyptian Children Aged Eight Years and Above
This study aims to determine the prevalence of anterior open bite and its etiological factors in a group of Egyptian children aged 8 years and above.
- Trial name
- NCT03494439
- Where
- Egypt
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Cairo University
Coronary Artery Bypass Graft Surgery, Atherosclerosis
Effect of Evolocumab on Saphenous Vein Graft Patency Following Coronary Artery Bypass Surgery
The purpose of this study is to determine if evolocumab added to regular statin therapy improves vein graft patency after coronary artery bypass graft (CABG) surgery.
- Conditions
- Coronary Artery Bypass Graft Surgery, Atherosclerosis, Vein Occlusion
- Trial name
- NEWTON-CABG (NCT03900026)
- Testing
- Evolocumab
- Where
- 22 sites in United States, Australia and 2 more
- Volunteers
- 782 people
- Sponsor
- Unity Health Toronto
Neovascular Age-related Macular Degeneration, Macular Oedema Secondary to RVO
A Trial to Evaluate the Safety and Usability of the SB15 PFS in Trial Participants With AMD, Macular Oedema Secondary to RVO, or Diabetic Macular Oedema
This is an open label, multicenter, Phase II trial to evaluate the safety and usability of the pre-filled syringe (PFS) of SB15 (Aflibercept biosimilar).
- Conditions
- Neovascular Age-related Macular Degeneration, Macular Oedema Secondary to RVO, Diabetic Macular Oedema
- Trial name
- NCT07844343
- Testing
- SB15 PFS
- Where
- 3 sites in South Korea
- Volunteers
- 33 people
- Sponsor
- Samsung Bioepis Co., Ltd.
Tongue Habits, Open Bite
Effects of Tongue Tamers as an Early Treatment of Anterior Open Bite
Anterior open bite (AOB) is a malocclusion that causes aesthetic, speech, feeding, and psychological concerns, emphasizing the significance of beginning treatment as soon as possible to correct the disorder.
- Trial name
- NCT05792553
- Testing
- bonded tongue tamers, customized bonded spurs, conventional fixed palatal spurs
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Tanta University
Snake Bites
Safety and Effectiveness of PANAF-Premium TM Snake Venom Antiserum As Standard Treatment for Snakebites
Snakebite envenomation (SBE) is a major public health problem in many developing countries. Standard snake antivenom (SA) remains the primary treatment and has been shown to reduce mortality in observational studies conducted in…
- Trial name
- PMS (NCT06615960)
- Where
- Cameroon
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Premium Serums & Vaccines Pvt.Ltd.
Dental Malocclusion
Maxillary Versus Bi-Maxillary Posterior Segments Intrusion Adult Subjects With Skeletal Open Bite
Compare between bi-maxillary (maxillary and mandibular) posterior dento-alveolar intrusion and maxillary posterior dento-alveolar intrusion as regards open bite closure.
- Trial name
- NCT04713280
- Testing
- Maxillary posterior dento-alveolar intrusion
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Cairo University
Orofacial Myofunctional Disorders, Anterior Open Bite Malocclusion
Oral Myofunctional Pattern in Children With Anterior Open Bite
Oral myofunctional disorders (OMD) are a key, internationally acknowledged environmental factor causing dental and skeletal malocclusion.
- Trial name
- OMBIT (NCT07045779)
- Testing
- Orofacial myofunctional therapy - traditional, Orofacial myofunctional therapy - reduced, Vocal warm up
- Where
- Belgium
- Volunteers
- 33 people
- Sponsor
- University Ghent