Clinical trials: Open Fracture Tibia
Open Tibia Fracture, Open Dislocation of Ankle
Accelerated Flap Coverage Versus Standard Timing in the Treatment of Severe Lower Extremity Musculoskeletal Injuries
The goal of this randomized controlled trial is to determine if accelerated flap coverage compared to standard flap coverage timing leads to improved infection-related complications in patients with open fractures and/or…
- Conditions
- Open Tibia Fracture, Open Dislocation of Ankle, Extremity Fracture Lower, Extremity Injuries Lower
- Trial name
- FLAP ATTACK (NCT07828613)
- Testing
- Accelerated Flap Coverage Surgery, Standard of Care Flap Timing
- Where
- 31 sites in United States
- Volunteers
- 356 people
- Sponsor
- Johns Hopkins University
Tibial Fracture, Soft Tissue Injury
Hyperbaric Oxygen in Lower Leg Trauma
Study hypothesis :Hyperbaric Oxygen may prevent complications and improve outcomes in severe lower limb trauma. We propose to investigate this hypothesis by conducting an International multi centre randomised control trial of…
- Trial name
- NCT00264511
- Testing
- Hyperbaric Oxygen Treatment
- Where
- 10 sites in United States, Australia and 7 more
- Volunteers
- 120 people
- Sponsor
- Bayside Health
Open Fracture Tibia
Evaluate Clinical and Radiological Outcomes After Limb Reconstruction Using Monorail Fixator Over Intramedullary Nailing in Tibial Open Fractures With Bone Loss
Road traffic accidents (RTA) is the most common cause of open fractures of long bones, increase in RTA leading to increase of complex non-unions incidence.
- Trial name
- NCT05296785
- Testing
- intramedullary nail with Limb Reconstruction System
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Assiut University
Open Type III (A&B)Pediatric and Adolescent Tibial Shaft Fractures, Ilizarov Fixation
Illizarov Fixation in Open Type III (A&B) Pediatric and Adolescent Tibial Shaft Fractures
The Ilizarov method is our usual treatment of choice for open, complex, physeal or unstable fractures and for patients in whom non-operative or other treatments have failed .
- Trial name
- NCT05448053
- Testing
- Ilizarov
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Assiut University
Tibial Fractures
rhBMP-2 Versus Autograft in Critical Size Tibial Defects
The purpose of our study is to evaluate the use of recombinant human bone morphogenetic protein 2 (RhBMP-2) as compared to standard ICBG in the treatment of severe open tibia fractures with a critical size bone defect (at least…
- Trial name
- NCT00853489
- Testing
- recombinant bone morphogenetic protein 2, Autogenous iliac crest bone graft
- Where
- 13 sites in United States
- Volunteers
- 33 people
- Sponsor
- St. Louis University
Tibial Fractures, Open Fracture of Tibia
Intramedullary Nailing Versus External Fixation in Open Tibia Fractures in Tanzania
The investigators propose to undertake a randomized, controlled trial which will generate Level 1 evidence concerning optimal fixation methods for the treatment of severe open tibia fractures in Dar es Salaam, Tanzania.
- Conditions
- Tibial Fractures, Open Fracture of Tibia, Trauma
- Trial name
- NCT03861624
- Testing
- Intramedullary nailing with standard SIGN nail, External Fixation with uniplanar Dispofix external fixator
- Volunteers
- 240 people
- Sponsor
- University of California, San Francisco
Open Tibia Fracture
Low-cost Negative Pressure Wound Therapy vs Standard Dressings for Gustilo IIIb Tibial Fractures (Bukavu Pilot RCT)
Negative-pressure wound therapy (NPWT) is widely used in the management of acute and chronic wounds, but commercial systems are costly and may be inaccessible in low-resource settings.
- Trial name
- BukavuNPWTRC (NCT07790991)
- Testing
- intervention2: standard wound dressing, Intervention1: Low-cost NPWT
- Where
- 2 sites in Democratic Republic of the Congo
- Volunteers
- 66 people
- Sponsor
- Université Catholique de Bukavu
Schatzker Type 2 or 3 Tibial Plateau Fracture
Comparative Evaluation of Minimally Invasive "tibial Tuberoplasty" Surgical Technique Versus Conventional Open Surgery for Tibial Plateau Fractures
PMSI (French Medico-Administrative Database) data shows more than 10000 proximal tibial fractures diagnosed in 2014 and 4055 lateral tibial plateau fractures operated in 2013 in France.
- Trial name
- TUBERIMPACT (NCT03444779)
- Testing
- Tibial Tuberoplasty, Open technique
- Where
- 12 sites in France, Martinique
- Volunteers
- 137 people
- Sponsor
- Poitiers University Hospital
Tibial Fracture
Study Evaluating CERAMENT™|G in Open Diaphyseal Tibial Fractures
The purpose of this study is to demonstrate the safety and effectiveness of CERAMENT™|G used in conjunction with standard-of-care treatment compared to standard-of-care treatment alone in the care of subjects with open fractures…
- Trial name
- NCT02820363
- Testing
- CERAMENT|G, SOC treatment
- Where
- 31 sites in United States, Germany and 2 more
- Volunteers
- 201 people
- Sponsor
- BONESUPPORT AB
Tibial Fractures
Bone Healing Accelerant Versus Standard of Care for Open Tibia Fractures
This clinical study is being conducted to demonstrate the safety and effectiveness of the Bone Healing Accelerant (BHA) product when applied to tibia (leg bone) fractures with an external wound or skin break (also called open…
- Trial name
- NCT03826784
- Testing
- BHA
- Where
- United States
- Sponsor
- Carmell Therapeutics Corporation
Tibial Fractures
A Multicenter Randomized Trial Comparing IM Nails and Plate Fixation in Proximal Tibial Fractures
This study looks at two types of surgical treatments and hopes to answer the question: which is the best way to surgically treat a proximal tibia fracture? Both procedures being studied are standard of care (used routinely) and…
- Trial name
- NCT00429585
- Testing
- reamed, interlocking intramedullary nail, locking periarticular plate
- Where
- 29 sites in United States, Canada
- Volunteers
- 108 people
- Sponsor
- Boston Medical Center
Tibial Plateau Fracture
Clinical Efficacy of Open Reduction and Suture Bridge Fixation for PCL Tibial Avulsion Fractures
Abstract Background: Posterior cruciate ligament (PCL) tibial avulsion fractures significantly impair knee function; however, optimal surgical fixation approaches are not agreed upon.
- Trial name
- fracture (NCT06918171)
- Testing
- Clinical Efficacy of Open Reduction and Anchor Suture Bridge Fixation
- Where
- China
- Volunteers
- 17 people
- Sponsor
- Second Affiliated Hospital of Soochow University
Gustilo-Anderson Type III Open Tibia Fracture
Randomized Trial Comparing Irrisept to Saline Irrigation for Infection Prevention
Early debridement and definitive fixation, at the initial operative setting, historically led to no difference in the infection rates for Gustilo-Anderson type III open tibia fractures. However, Lenarz et al.
- Trial name
- NCT05402995
- Testing
- Irrisept (Irrigation Solution), Saline
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Brett D. Crist
Tibial Plateau Fractures
Genicular Nerve Block After Open Reduction Internal Fixation of Tibial Plateau
The investigators are conducting this research study to find better ways of treating pain following knee surgery. There is a standard (accepted) approach, which involves injection of numbing medication into the area around the…
- Trial name
- NCT06639503
- Testing
- Bupivacain
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- University of Chicago
Trauma
Adjunctive Therapy to Treat Tibial Shaft Fractures
A phase 2, prospective, randomized, controlled, open-label (dose-blinded), parallel group, international multi-center study. The study will consist of four treatment groups - one control group (SoC) and three I-040202 groups…
- Trial name
- TSF (NCT00533793)
- Testing
- open fracture reduction
- Where
- 49 sites in Bulgaria, Czechia and 10 more
- Volunteers
- 201 people
- Sponsor
- Kuros Biosurgery AG
Tibial Fractures, Nonunion of Fracture
Intramedullary Bone Grafting for Open Tibial Shaft Fractures
This study will examine if there is a difference between the time to full union between the control group and the study group. Each group will be composed of patients who have an open fracture in the mid tibia.
- Conditions
- Tibial Fractures, Nonunion of Fracture, Delayed Union of Fracture
- Trial name
- NCT03891888
- Testing
- Intramedullary Bone Graft
- Where
- 2 sites in United States
- Volunteers
- 130 people
- Sponsor
- University of Louisville
Open tíbia Fracture
Open Tibia Fractures a Comparative Study Between Biplane External Fixator and Locked Intramedullary Nail
The objective of this research is to prospectively evaluate a group of patients with shaft compound fracture of the tibia, treated with a biplanar external fixator or locked intramedullary reamed nail.
- Trial name
- NCT02064595
- Testing
- External fixator, Intramedullary nail
- Volunteers
- 68 people
- Sponsor
- Fabio lucas rodrigues
Open Tibia Fracture, Open Dislocation of Ankle
Accelerated Flap Coverage in Severe Lower Extremity Trauma
The goal of this randomized controlled trial is to determine if accelerated flap coverage compared to standard flap coverage timing leads to improved infection-related complications in patients with open fractures and/or…
- Conditions
- Open Tibia Fracture, Open Dislocation of Ankle, Extremity Fracture Lower, Extremity Injuries Lower
- Trial name
- FLAP ATTACK (NCT06293469)
- Testing
- Accelerated Flap Coverage Surgery, Standard of Care Flap Timing
- Where
- 11 sites in United States, Australia and 2 more
- Volunteers
- 356 people
- Sponsor
- Johns Hopkins University
Tibia Fracture
OIF/β-TCP in Patients With Open Tibial Fractures in Need of Bone Grafting
A prospective, randomized, evaluator-blinded, controlled study for subjects with open tibial fractures classified as Gustilo type II, IIIA or IIIB (see Appendix 1) who will receive bone graft implantation for the potential of…
- Trial name
- NCT04960722
- Testing
- OIF/β-TCP
- Where
- Taiwan
- Volunteers
- 35 people
- Sponsor
- BioGend Therapeutics Co.Ltd
Surgical Wound Infection
Clinical Assessment of Next Science Solution on Gustilo and Anderson Type II and IIIA or IIIB Tibial Fractures
This is a prospective, randomized, controlled, double-blinded clinical feasibility study of subjects that are being treated for Gustilo and Anderson Type II or IIIA or IIIB Tibial Fractures
- Trial name
- NCT04906642
- Testing
- Next Science, Standard of Care
- Where
- 2 sites in United States
- Volunteers
- 17 people
- Sponsor
- Next Science TM