Clinical trials: Open Fractures
Venous Thromboembolism
Prevention of Venous Thromboembolism in Subjects Undergoing Hip Fracture Surgery or Surgery in the Lower Extremities
The study objective is to evaluate the efficacy and safety of oral YM150 for prevention of venous thromboembolism in subjects undergoing hip fracture surgery or surgery in the lower extremities.
- Trial name
- NCT00937911
- Testing
- YM150
- Where
- 8 sites in Japan
- Volunteers
- 101 people
- Sponsor
- Astellas Pharma Inc
Trauma Injury
ICG Fluorescence Imaging in Open Fracture Trauma Patients
This is a prospective observational study that will evaluate the association between bone and tissue perfusion, as measured by indocyanine green (ICG) fluorescence imaging, and complications, in an effort to develop ICG…
- Trial name
- NCT04416412
- Testing
- Immunofluorescence Imaging
- Where
- 4 sites in United States
- Volunteers
- 124 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Aseptic Loosening, Osteolysis
Post-Market Study of the Modular Revision Hip System
The purpose of this study is to examine the short term efficacy of the MRH system as well as determine if operating room time is decreased using this simple, two-tray system.
- Conditions
- Aseptic Loosening, Osteolysis, Traumatic Fracture, Failed Total Hip Implant
- Trial name
- MRHS (NCT01464645)
- Testing
- Modular Revision Hip System
- Where
- 6 sites in United States
- Volunteers
- 16 people
- Sponsor
- Encore Medical, L.P.
Orthopaedic Fractures
Improving Pain Management and Long Term Outcomes Following High Energy Orthopedic Trauma (Pain Study)
The purpose of this study is to definitively resolve questions regarding the use of multimodal pharmacologic pain management for orthopedic trauma patients in the context of a multicenter, randomized clinical trial.
- Trial name
- PAIN (NCT01789216)
- Testing
- NSAID, Gabapentinoids
- Where
- 17 sites in United States
- Volunteers
- 450 people
- Sponsor
- Major Extremity Trauma Research Consortium
Calcaneus Fracture
Primary Subtalar Arthrodesis Versus Late Subtalar Arthrodesis in Sanders Type IV Calcaneal Fractures
Fracture calcaneus accounts for up to 2% of all fractures. 75% of calcaneal fractures are displaced intra-articular fractures and historically have been associated with poor functional outcomes.
- Trial name
- NCT05504304
- Testing
- open reduction and internal fixation plus primary subtalar arthrodesis, conservative management then calcaneoplasty and subtalar arthrodesis.
- Where
- Egypt
- Volunteers
- 34 people
- Sponsor
- Ain Shams University
Tibial Fractures
rhBMP-2 Versus Autograft in Critical Size Tibial Defects
The purpose of our study is to evaluate the use of recombinant human bone morphogenetic protein 2 (RhBMP-2) as compared to standard ICBG in the treatment of severe open tibia fractures with a critical size bone defect (at least…
- Trial name
- NCT00853489
- Testing
- recombinant bone morphogenetic protein 2, Autogenous iliac crest bone graft
- Where
- 13 sites in United States
- Volunteers
- 33 people
- Sponsor
- St. Louis University
Fractures
A New Treatment Protocol for Paediatric Mandibular Condylar Fractures
This study aim to evaluate the clinical and radiographic outcomes of mandibular condylar fractures in pediatrics treated simply with a mandibular manipulation technique accompanied by mouth opening training.
- Trial name
- NCT02237040
- Testing
- Mandibular manipulation technique
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Sun Yat-sen University
Patella Fracture
Effects Of Intra-Operative Intra-Articular Cocktail Injection In Patella Open Reduction And Internal Fixation
The objective of this study is to demonstrate the safety and efficacy of an intra-articular analgesics cocktail injection for post-operative patella fracture fixation patients, by comparing post-operative pain relief and…
- Trial name
- NCT07006168
- Testing
- Ketorolac 15mg, Triamcinolone Acetonide 40mg, Ropivacaine HCL 1% 15ml
- Where
- Hong Kong
- Volunteers
- 56 people
- Sponsor
- The University of Hong Kong
Femur Fracture
Vastus Intermedius Dry Needling for Knee Stiffness Resulted From Surgically Managed Femoral Fractures With Open Reduction & Internal Fixation.
Orthopedic traumatic injuries are considered a major health epidemic, challenged by high morbidity, mortality, and socioeconomic burden.
- Trial name
- NCT06307587
- Testing
- dry needling
- Volunteers
- 44 people
- Sponsor
- Al-Razi Hospital
Sacroiliac Joint, Pain
Sacroiliac (SI) Screws: The Effect of SI Screw Removal on Patient-Reported Pain and Functional Outcomes
Chronic pain following surgical stabilization of a pelvic fracture is very prominent and can have a major affect on a patient's quality of life.
- Conditions
- Sacroiliac Joint, Pain, Pelvis
- Trial name
- SIS (NCT02652611)
- Testing
- SI Screw Removal Surgery, Non-screw removal treatment (non-operative management)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Maryland, Baltimore
Osteoporosis in Post-menopausal Women, Osteoporosis
Intravenous Infusion of Human Mesenchymal Stem Cells (HMM910 ) in Postmenopausal Women With Osteoporosis at High Risk of Fracture
The primary objective of this study is to evaluate the safety and tolerability of human umbilical cord-derived mesenchymal stem cells for injection (HMM910 ) in postmenopausal women with osteoporosis who are at high risk of…
- Trial name
- NCT06949137
- Testing
- Human Umbilical Cord-derived Mesenchymal stem cell
- Where
- China
- Volunteers
- 9 people
- Sponsor
- HELP Therapeutics Co., Ltd.
Mandible Fracture, Post-operative Antibiotics
The MANTRA Trial (MANdibular TRauma and Antibiotic Use)
1. FULL TITLE OF THE PROJECT Should we use post-operative antibiotics following surgery for patients with mandible fractures? The MANTRA trial (MANdibular TRauma and Antibiotic use) 2.
- Trial name
- MANTRA (NCT05964140)
- Testing
- Different post-operative antibiotic regimens following surgical treatment of mandible fractures
- Where
- 2 sites in United Kingdom
- Volunteers
- 2,841 people
- Sponsor
- East Lancashire Hospitals NHS Trust
Open Fracture
Implementation of Vancomycin Powder Application in the Emergency Department for Open Fractures
To evaluate the feasibility, safety, and potential efficacy of applying vancomycin powder locally to open fractures in the emergency department prior to definitive surgical intervention.
- Trial name
- NCT07659886
- Testing
- Vancomycin (VAN) treatment, Standard Open Fracture Care
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Atlantic Health System
Disc Degenerative Disease, Spondylolisthesis
A Clinical Study of a Spine Fusion System in Vertebral Body Fusion Surgery
The primary objective of this study is to demonstrate that the efficacy and safety of Spine fusion system manufactured in China is no inferior than imported product.
- Conditions
- Disc Degenerative Disease, Spondylolisthesis, Spinal Fracture, Spinal Deformity
- Trial name
- NCT02252185
- Testing
- Johnson&Johnson Medical Suzhou made Spine Fusion System, Imported EXPEDIUM screws and OPAL cage
- Where
- 8 sites in China
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Medical (Suzhou) Ltd.
Tibial Fractures
Safety Study of Treatment of Leg Fractures
This study evaluates the safety of the EVOS SMALL Plating system in patients who have a fracture of the tibia requiring surgery.
- Trial name
- EVOS SMALL (NCT03881241)
- Where
- 2 sites in United States
- Volunteers
- 2 people
- Sponsor
- Smith & Nephew, Inc.
Infections
Vancomycin and Tobramycin Powder Use in Acute Open Fractures
The investigators overall aim of this study is to determine the difference in 6-month infection rates in patients treated with the combined vancomycin and tobramycin (VT) powder compared to the standard of care (SC).
- Trial name
- NCT05849090
- Testing
- Cephalosporin or clindamycin/vancomycin antibiotics.., Vancomycin and Tobramycin antibiotics.
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Utah
Failed Lumbar Fusion
Study on Allogeneic Osteoblastic Cells Implantation in Rescue Interbody Fusion
Failed fusion and failure to relieve back pain following spinal fusion are still frequent, irrespective of the type of procedures or grafts used by the surgeon.
- Trial name
- NCT02328287
- Testing
- ALLOB®
- Where
- 3 sites in Belgium
- Volunteers
- 6 people
- Sponsor
- Bone Therapeutics S.A
Anxiety Disorder
Cipralex® for Anxiety Disorders in Adolescents
The primary objective is to examine whether Cipralex® is effective and safe in the treatment of anxiety disorders in youth. The secondary objective is to identify changes in arousal and stress response from pre- to post-treatment…
- Trial name
- CAP-E (NCT01293838)
- Testing
- Cipralex®
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of Ottawa
Rib; Fracture, Multiple, With Flail Chest
Prospective Follow up of Minimally Invasive Chest Wall Surgery After Trauma
The purpose of this study is to assess the outcome of a muscle sparing, minimally invasive open surgical technique for unstable ribcage injuries after trauma.
- Trial name
- NCT04710602
- Testing
- Minimally invasive surgical fixation of unstable rib cage, Large incision surgical fixation of unstable rib cage.
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Sahlgrenska University Hospital
Pediatric Ankle Fracture
Point-of-Care Ultrasonography for Pediatric Ankle Fracture Detection
This prospective observational study evaluated the diagnostic accuracy of point-of-care ultrasonography (POCUS) for detecting ankle fractures in children presenting to the emergency department with acute isolated ankle trauma.
- Trial name
- NCT07872124
- Testing
- Point-of-Care Ultrasonography (POCUS)
- Where
- Turkey (Türkiye)
- Volunteers
- 74 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital