Clinical trials: Open Fractures
Femoral Fractures, Hemorrhage, Surgical
Effectiveness of Tranexamic Acid in Reducing Blood Loss During Femoral Nail Surgery
This clinical study aims to evaluate the safety and effectiveness of administering a single intravenous dose of tranexamic acid (TXA) before surgery to reduce blood loss in patients undergoing open intramedullary nailing for…
- Conditions
- Femoral Fractures, Hemorrhage, Surgical, Tranexamic Acid Use
- Trial name
- TXA-FemNail (NCT07261930)
- Testing
- Tranexamic Acid
- Where
- Uganda
- Volunteers
- 43 people
- Sponsor
- Masaka Regional Referral Hospital
Distal Radius Fracture
Paper- vs Digital Application-based Exercises to Support Rehabilitation After Osteosynthesis of Distal Radius Fracture
The aim of this study is to evaluate the difference between the use of paper- versus application-based (smartphone application) exercises in the rehabilitation of intra-articular fractures of the distal radius at the Cantonal…
- Trial name
- NCT06005857
- Testing
- Standard hand therapy + home digital application-based exercises, standard hand therapy + home paper-based exercises
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- Hôpital Fribourgeois
Distal Humerus Fracture, Comminuted Fracture
Elbow Hemiarthroplasty Versus ORIF for Distal Humeral Fractures
This is a randomized control trial comparing the outcome of ORIF (open reduction and internal fixation) with EHA (elbow hemiarthroplasty) for distal humeral fractures in patients aged 50 years or above.
- Conditions
- Distal Humerus Fracture, Comminuted Fracture, Intra-Articular Fractures
- Trial name
- NCT04163172
- Testing
- Surgical treatment of distal humeral fracture with elbow hemiarthroplasty, Surgical treatment of distal humeral fracture with double plating.
- Where
- Denmark
- Volunteers
- 44 people
- Sponsor
- Herlev and Gentofte Hospital
Pathologic Fracture, Bone Metastases
Metastatic Pathologic Fractures, Short Term Results
This is a single center prospective study to compare the short term results of prosthesis, nail and plate-screw surgeries for metastatic pathologic fractures.
- Conditions
- Pathologic Fracture, Bone Metastases, Metastatic Cancer
- Trial name
- NCT05825456
- Testing
- endoprosthetic reconstruction, Intramedullary nailing, Open reduction internal fixation with plate and screws
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Ankara University
Open Tibia Fracture
Low-cost Negative Pressure Wound Therapy vs Standard Dressings for Gustilo IIIb Tibial Fractures (Bukavu Pilot RCT)
Negative-pressure wound therapy (NPWT) is widely used in the management of acute and chronic wounds, but commercial systems are costly and may be inaccessible in low-resource settings.
- Trial name
- BukavuNPWTRC (NCT07790991)
- Testing
- intervention2: standard wound dressing, Intervention1: Low-cost NPWT
- Where
- 2 sites in Democratic Republic of the Congo
- Volunteers
- 66 people
- Sponsor
- Université Catholique de Bukavu
Postmenopausal Women With Osteoporosis
To Evaluate the Efficacy and Safety of SAL056 for Postmenopausal Women With Osteoporosis at High Fracture Risk
To Evaluate the Efficacy and Safety of SAL056 for Postmenopausal Women with Osteoporosis at High Fracture Risk
- Trial name
- NCT07028320
- Testing
- SAL056 (56.5μg), Alendronate
- Where
- China
- Volunteers
- 493 people
- Sponsor
- Shenzhen Salubris Pharmaceuticals Co., Ltd.
Open tíbia Fracture With Sub-segmental Bone Loss
Calcium Sulfate Spacer in Open Tibia Fractures
Investigators will compare antibiotic impregnated Calcium sulfate versus PMMA versus nothing in these sub-segmental bone defects.
- Trial name
- NCT03042546
- Testing
- Calcium Sulfate, PMMA, No treatment
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Washington
Open Tibia Fracture
Pilot RCT Local Gentamicin for Open Tibial Fractures in Tanzania
Local application of antibiotics directly to the traumatic wound is a promising strategy for the prevention of infection after open tibia fractures, which are a significant source of disease burden globally, particularly in…
- Trial name
- pGO-Tibia (NCT03559400)
- Testing
- local gentamicin injection
- Where
- Tanzania
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Ankle Fractures
Open Reduction Syndesmosis Tightrope Versus Screw Fixation
Tibia-fibular syndesmosis injury occurs in a significant proportion of ankle injuries and is assumed to disrupt the syndesmotic ligaments.
- Trial name
- NCT02199249
- Testing
- Open reduction Tightrope fixation, open reduction screw fixation
- Where
- Canada
- Volunteers
- 103 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Postmenopausal Women With Osteoporosis
A Phase II Clinical Trial of the Safety and Efficacy of SAL056 at Different Doses and Dosing Regimens
This is a multicenter, randomized, open-label, parallel-controlled Phase II study designed to evaluate the differences in safety among four different dosing regimens of SAL056.
- Trial name
- NCT07579936
- Testing
- SAL056 56.5μg, Intervention Group 1, Intervention Group 2
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Shenzhen Salubris Pharmaceuticals Co., Ltd.
Open Fracture Wounds
Fluid Lavage of Open Wounds
Open fracture wounds are a constant challenge to orthopaedic surgeons, with infections a common complication. There is currently little evidence as to which is the most effective way to wash out these wounds.
- Trial name
- FLOW (NCT00788398)
- Testing
- Saline Solution, Soap solution, Gravity Flow Irrigation
- Where
- 31 sites in United States, Australia and 3 more
- Volunteers
- 2,540 people
- Sponsor
- Prisma Health-Upstate
Lateral Patellar Compression Syndrome, Patellar Dislocation
Tactile Guided Lateral Patellar Release
The lateral edge of the patella is identified by the surgeon's finger and the lateral ligament incision is performed with a blade through the skin.
- Conditions
- Lateral Patellar Compression Syndrome, Patellar Dislocation, Patellar (or Kneecap) Instability and Mal-alignment, Patella Alta
- Trial name
- TGLPR (NCT07637344)
- Testing
- Percutaneous lateral retinacular release of the patella
- Volunteers
- 23 people
- Sponsor
- Issa, Abdulhamid Sayed, M.D.
Scoliosis, Scoliosis; Adolescence
Study Comparing the PathKeeper System for Pedicle Screw Positioning in Spine Surgery With Traditional Care
The goal of this is to evaluate performance of the Pathkeeper Surgical System. The main question[s]it aims to answer are: 1) evaluate pedicle screw position Participants will in compare Experimental arm: PathKeeper System (PKS)…
- Conditions
- Scoliosis, Scoliosis; Adolescence, Scoliosis Kyphosis, Scoliosis Lumbar Region
- Trial name
- PKSforPSP (NCT06554093)
- Testing
- Medical Device - PKS
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Deep Health Ltd.
Ankle Fractures, Pilon Fracture
FRAME Study (Frailty-Related Ankle Fracture Management and Evaluation)
This will be a multi-centre randomized controlled trial, with London Health Sciences Centre (LHSC) as the lead site. Elderly patients with complex ankle fractures who meet the inclusion criteria and provide consent will be…
- Trial name
- FRAME (NCT05131321)
- Testing
- Primary ankle arthrodesis (fusion), ORIF (open reduction and internal fixation), Intramedullary Fibular Nailing (IMFN)
- Where
- Canada
- Volunteers
- 172 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Wound; Head, Multiple, Wound; Head, Scalp
Short Term Status of Free Dermal Fat Autografts for Complex Craniofacial Wounds
This study will evaluate the use of free autologous dermal fat grafting (also called free dermal fat autografting) to treat complex craniofacial wounds that have failed standard treatment and to understand how well these grafts…
- Conditions
- Wound; Head, Multiple, Wound; Head, Scalp, Wound; Head, Wound Infection
- Trial name
- FTFDT3 (NCT03872544)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Dufresne, Craig, MD, PC
Ankle Fractures
Diabetic Fibular Nail Study
Our null hypothesis is that fibular intramedullary fixation (IMFN) does not impact complication rates when compared to standard of care treatment with open reduction and internal fixation (ORIF).
- Trial name
- NCT05204485
- Testing
- Fibular intramedullary nail, Open reduction and internal fixation
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Chicago
Fracture;Elbow
Extended vs Flexed Elbow Casting
The study design is a prospective, randomized controlled trial comparing extended elbow and flexed elbow casting. This study design will provide the highest quality evidence to investigate our primary hypothesis that extended…
- Trial name
- NCT03935516
- Testing
- Cast
- Where
- United States
- Sponsor
- University of Wisconsin, Madison
Fractures, Comminuted, Fracture Fixation, Internal
Comparative Study of Fixation or Fusion of Calcaneal Fractures
A multicentre randomized controlled trial that will be conducted at Level 1 trauma centres across Canada. It will compare patients who receive open reduction, internal fixation for Sanders IV calcaneal fractures to patients who…
- Trial name
- Sanders IV (NCT00679393)
- Testing
- Open reduction internal fixation, Fusion
- Where
- 4 sites in Canada
- Volunteers
- 26 people
- Sponsor
- University of Calgary
Humeral Shaft Fractures
Open Reduction and Internal Fixation of Humeral Midshaft Fracture: Anterior Versus Posterior Plate Fixation
About 13 out of 10,000 patients get a humeral shaft fracture each year, accounting for 1.0-3.0% of all fractures. The central part of the humerus is where 60% of all humeral fractures occur.
- Trial name
- NCT07775690
- Testing
- Open Reduction Internal Fixation (ORIF) using Anterior approach for plate fixation, Open Reduction Internal Fixation (ORIF) using Posterior approach for plate fixation
- Where
- Pakistan
- Volunteers
- 150 people
- Sponsor
- Dr Jahanzaib Ramay
Sacral Fracture
Comparison of Minimally Invasive Versus Open Spinopelvic Fixation for Unstable Sacral Fractures
The aim of this retrospective study is to evaluate patients with vertically unstable high-energy sacral fracture operated on at our institution with spinopelvic fixation, to compare the traditionally open method of fixation with…
- Trial name
- NCT06755580
- Testing
- spinopelvic fixation
- Where
- Slovakia
- Volunteers
- 51 people
- Sponsor
- F.D. Roosevelt Teaching Hospital with Policlinic Banska Bystrica