Clinical trials: Open Fractures
Osteoporosis
Randomized, Open, Parallel, Active Controlled Study on Fracture Prevention in Antiosteoporosis Treatment (OF Study)
To investigate a new incidence and preventive effect of menatetrenone on vertebral fracture in patients with osteoporosis who were randomly assigned to either treatment arm receiving daily dose of calcium supplement as a…
- Trial name
- NCT00165607
- Testing
- MENATETRANONE
- Where
- Japan
- Sponsor
- Eisai Limited
Tibial Fractures
Results of Cross-leg Free Vascularized Fibular Graft
This study aims to evaluate the new technique of cross-leg vascularized fibular graft for reconstruction of post-traumatic long tibial bone defects in terms of restoring normal anatomy and function of the traumatized limb in a…
- Trial name
- NCT06491316
- Where
- Egypt
- Volunteers
- 22 people
- Sponsor
- Assiut University
Vitamin C Deficiency, Smoking
The Effect of Vitamin C on Wound Healing In Mandibular Fracture Patients
The goal of this study is to perform a randomized clinical trial to assess the effects of vitamin C versus placebo on wound healing in mandibular fracture patients.
- Conditions
- Vitamin C Deficiency, Smoking, Surgery, Surgery--Complications
- Trial name
- NCT03938584
- Testing
- Vitamin C
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Hennepin Healthcare Research Institute
Tibial Fractures
Prosthesis Versus Osteosynthesis in Proximal Tibia Fractures
The aim of this study is to compare knee function and pain one year after treatment of intra-articular proximal tibia fracture using either osteosynthesis with a locking plate (ORIF) or primary total knee replacement (TKR) in…
- Trial name
- POSITIF (NCT03172715)
- Testing
- Locking plate, TKR
- Where
- 8 sites in Finland
- Volunteers
- 98 people
- Sponsor
- Central Finland Hospital District
Acetabular Fracture
RCT Determining Best Treatment for Geriatric Acetabular Fractures
There is debate over the best management for acetabular (hip) fractures that occur within the geriatric population. Geriatric patients, 60 years or older, are at greater risk for operative complications because they tend to have…
- Trial name
- GeriTab (NCT03419182)
- Testing
- Open Reduction internal Fixation, Open Reduction Internal Fixation with Total Hip Arthroscopy
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- University of Maryland, Baltimore
Mandibular Fractures
Evaluation of Customized V Plate Versus Conventional Miniplates of Mandibular Angle Fracture
The aim of the study to evaluate the effect of customized V pattern plate fixation versus a conventional superior-inferior mini plates fixation of mandibular angle fracture on mouth opening and radio graphical parameters.
- Trial name
- NCT03761524
- Testing
- Customized V plate fixation, Conventional miniplates fixation
- Where
- Egypt
- Volunteers
- 24 people
- Sponsor
- Cairo University
Clavicle Fracture
Percutaneous Versus Open Plate Fixation of Diaphyseal Clavicle Fractures
This is a prospective, level II evidence comparison between two cohorts. This study is designed to compare the percutaneous versus open approach for plate fixation of diaphyseal clavicle fractures.
- Trial name
- NCT01405703
- Testing
- xrays
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Utah
Schatzker Type 2 or 3 Tibial Plateau Fracture
Comparative Evaluation of Minimally Invasive "tibial Tuberoplasty" Surgical Technique Versus Conventional Open Surgery for Tibial Plateau Fractures
PMSI (French Medico-Administrative Database) data shows more than 10000 proximal tibial fractures diagnosed in 2014 and 4055 lateral tibial plateau fractures operated in 2013 in France.
- Trial name
- TUBERIMPACT (NCT03444779)
- Testing
- Tibial Tuberoplasty, Open technique
- Where
- 12 sites in France, Martinique
- Volunteers
- 137 people
- Sponsor
- Poitiers University Hospital
Humeral Fracture, Proximal
Psychological Health Influences the Choice of Device in Proximal Humeral Fractures
It was conducted a prospective study with a series of 63 patients treated with O.R.I.F. (Open Reduction and Internal Fixation) (group A) and with RSA (Reverse Shoulder Arthroplasty) (group B) for three and four-part proximal…
- Trial name
- NCT04821180
- Testing
- Three and four-part proximal humeral fractures' treatment
- Volunteers
- 63 people
- Sponsor
- Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari
Osteopenia, Osteoporosis
Extension Study to Evaluate the Long Term Safety and Efficacy of Denosumab in the Treatment of Osteoporosis
The primary objective was to describe the safety and tolerability of up to 10 years or 7 years denosumab administration as measured by adverse event monitoring, immunogenicity and safety laboratory parameters in participants who…
- Trial name
- NCT00523341
- Testing
- Denosumab
- Volunteers
- 4,550 people
- Sponsor
- Amgen
Open Fracture
Evaluation of STIMULAN Device and AI Model in Preventing Fracture Infections
This is a prospective, single-center, double-blind randomized clinical trial aimed at evaluating the efficacy and safety of the extended-release antibiotic device, STIMULAN, in preventing infections in patients with open…
- Trial name
- NCT06033534
- Testing
- STIMULAN
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Università Vita-Salute San Raffaele
Surgery Complications, Surgery
SurgWeek-2: Identifying the Global Burden of Post Operative Complications: an International Prospective Cohort Study Protocol
This study aims to assess and improve the global outcomes following surgery. Every year approximately 313 million operations are performed, with 50 million people experiencing a complication and unfortunately 3.5 million people…
- Conditions
- Surgery Complications, Surgery, Global Surgery, Robotic
- Trial name
- SurgWeek-2 (NCT07785076)
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Proximal Humeral Fracture, Fracture Dislocation
Exactech Proximal Humerus Fracture Plate System Post Market Clinical Follow-up
The objective of this study is to collect and evaluate long-term clinical outcomes data in order to better understand the safety and performance of the Equinoxe Proximal Humerus Fracture Plates over time.
- Conditions
- Proximal Humeral Fracture, Fracture Dislocation, Non-Union Fracture
- Trial name
- NCT05703958
- Where
- United States
- Volunteers
- 151 people
- Sponsor
- Exactech
Fracture of Calcaneus, Pilon or Tibial Plateau
Vacuum Assisted Closure as a Treatment for Soft Tissue Injuries
This project is designed as a prospective, randomized, comparative study evaluating the use of a negative pressure vacuum device in treating soft tissue injuries and the surgical incision following open reduction and internal…
- Trial name
- VAC-ST (NCT00582998)
- Testing
- Standard Wound Dressing, Vacuum Assisted Closure Device
- Where
- United States
- Volunteers
- 249 people
- Sponsor
- University of Alabama at Birmingham
Talus Fracture
Treatment of Talus Fractures: a Retrospective Study
The main purpose of this retrospective case series study was to evaluate long-term radiographic and clinical outcomes of a consecutive series of patients with diagnosis of isolated, displaced, closed talar neck or body fractures…
- Trial name
- TTF2017 (NCT03639272)
- Testing
- open reduction and internal fixation (ORIF).
- Volunteers
- 40 people
- Sponsor
- University of Padova
Duchenne Muscular Dystrophy
A Study to Assess the Efficacy and Safety of Satralizumab in Duchenne Muscular Dystrophy (DMD)
The purpose of this study is to assess the efficacy, safety, pharmacokinetics (PK) and pharmacodynamics (PD) of satralizumab, a humanized anti-interleukin-6 receptor (aIL-6R) monoclonal antibody, in ambulatory and non-ambulatory…
- Trial name
- SHIELD DMD (NCT06450639)
- Testing
- Satralizumab
- Where
- 18 sites in United States, Denmark and 4 more
- Volunteers
- 30 people
- Sponsor
- Hoffmann-La Roche
Thoracolumbar Spine Trauma
Treatment of Thoracolumbar Spine Fractures: Percutaneously Placed Pedicle Screws Versus Open Treatment
In patients presenting with Type A and Type B1, B2 thoracolumbar fractures, there is a lack of evidence demonstrating similar outcomes between patients treated with percutaneous pedicle screws and those treated openly.
- Trial name
- NCT02146729
- Testing
- Percutaneous Pedicle Screw Fixation, Open Treatment
- Where
- United States
- Sponsor
- Daniel Altman
WALANT, Radius Fracture Distal
Prospective Observational Study Comparing GA and WALANT in Distal Radius Fracture Plating Surgery
The wide-awake local anesthesia no tourniquet (WALANT) has been widely used in the field of hand surgery in recent years. This surgical method has progressed to open reduction and internal fixation of distal radial fracture and…
- Trial name
- NCT04549441
- Testing
- Distal radius fracture plating surgery
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Kaohsiung Medical University
Spinal Cord Injury, Bone Loss
Effect of Alendronate on Bone in People With Chronic Spinal Cord Injury (SCI) Previously Treated With Teriparatide
The purpose of this study is to determine if a year of alendronate treatment will maintain or increase bone mass density (BMD) compared to baseline BMD values in people with chronic spinal cord injury (SCI).
- Conditions
- Spinal Cord Injury, Bone Loss, Osteoporosis
- Trial name
- NCT02195895
- Testing
- Alendronate, Calcium, Vitamin D
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Northwestern University
Opioid Free Anesthesia, Stress Response
The Impact Opioid Free Anesthesia on Postoperative Pain Intensity and Stress Response After Open Gynecology Surgery
This studi compared impact of multimodal balancing anesthesia vs opioid free anesthesia on postoperative pain intensity and stress response after open gynecology surgery.
- Conditions
- Opioid Free Anesthesia, Stress Response, Postoperative Pain
- Trial name
- NCT07138053
- Testing
- OFA group
- Where
- Bosnia and Herzegovina
- Volunteers
- 80 people
- Sponsor
- Cantonal Hospital Zenica