Clinical trials: Open Thoracotomy
Lung Cancer, Lung Tumor
NeoMend ProGEL™ Pleural Air Leak Sealant Post-Approval Study
The purpose of this post approval study is to further characterize the safety profile of the ProGEL™ Pleural Air Leak Sealant in commercial use, with specific reference to long-term safety over 90 days of follow-up.
- Trial name
- NCT01394978
- Testing
- Control, ProGEL Pleural Air Leak Sealant with standard surgical closure, ProGEL Pleural Air Leak Sealant without standard surgical closure
- Where
- 18 sites in United States
- Volunteers
- 444 people
- Sponsor
- C. R. Bard
Non-small Cell Lung Cancer
Is Video-assisted Thoracoscopic Lobectomy a Clinical Alternative for Surgically Resectable Pathologic N2 NSCLC Patients
The study was designed to compare the safety and effectiveness of vedio-assisted thoracoscopic lobectomy with open lobectomy for patients with surgically resectable pathologic N2 non-small cell lung cancer
- Trial name
- NCT03613467
- Testing
- VATS lobectomy, Thoracotomy lobectomy
- Where
- 10 sites in China
- Volunteers
- 2,145 people
- Sponsor
- Tang-Du Hospital
Lung Cancer, Robotic Thoracic Surgery
Impact of Robotic Approach Compared to VATS and Open Approach on Quality of Life in Patients With Lung Cancer
The aim of the study is to compare quality of life and early and late post-operative pain after anatomical lung resection (lobectomy or segmentectomy) performed by a robotic approach compared to the videothoracoscopic approach…
- Conditions
- Lung Cancer, Robotic Thoracic Surgery, Video-assisted Thoracis Surgery (VATS), Open Thoracotomy Surgery
- Trial name
- QoL (NCT04353349)
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Istituto Clinico Humanitas
Postoperative Pain
Dose Finding Posterolateral Thoracotomy Study
To review safety and effectiveness of two doses compared to current standard of care.
- Trial name
- NCT00807209
- Testing
- Low Dose SKY0402, High Dose SKY0402, Fentanyl via PCA
- Where
- 5 sites in United States
- Volunteers
- 3 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Lung Cancer
VATS Versus Open Pulmonary Lobectomy in the Limelight of OEP
The standard operative approach to pulmonary lesions has been via postero-lateral thoracotomy and direct vision. This technique has some advantages but its morbidity is significant.
- Trial name
- VOLO (NCT02910453)
- Testing
- Pulmonary lobectomy
- Where
- Italy
- Volunteers
- 78 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Open Thoracotomy
PleuraSeal Pivotal Study (US)
To evaluate the safety and effectiveness of Confluent Surgical's PleuraSeal Sealant System in the treatment and control of intra and postoperative air leaks following pulmonary resection via an open thoracotomy.
- Trial name
- NCT00748124
- Testing
- PleuraSeal Sealant System, Standard Tissue Closure Techniques
- Where
- United States
- Volunteers
- 230 people
- Sponsor
- Integra LifeSciences Corporation
Lung Disease, Pulmonary Lobectomy
PleuraSeal Post Market Study (Europe)
To further characterize the PleuraSeal Sealant System as compared to standard of care (sutures and staples only) in subjects undergoing an elective pulmonary lobectomy and segmentectomy via open thoractomy.
- Trial name
- NCT00704171
- Testing
- Standard Tissue Closure Techniques, PleuraSeal Lung Sealant System
- Where
- 9 sites in United States, Austria and 4 more
- Volunteers
- 121 people
- Sponsor
- Integra LifeSciences Corporation
Opioid Consumption, Postoperative
Postoperative Opioid Consumption of Serratus Posterior Superior Intercostal Plane Block Versus Thoracic Paravertebral Block
Previous studies found that paravertebral and thoracic epidural continuous infusions of opioid-free local anaesthetic were found to be comparable, but paravertebral analgesia (PVA) was associated with less respiratory…
- Trial name
- NCT07613697
- Testing
- Serratus Posterior Superior Intercostal Plane Block (single injection), Thoracic Paravertebral block (single injection)
- Where
- Egypt
- Volunteers
- 48 people
- Sponsor
- Zagazig University
Laparotomy, Thoracotomy
Peritoneal Cavity Conditioning During Open Surgery.
Given the observations in animal models and the available data in the human our hypothesis is that peritoneal cavity conditioning (carbon dioxide with 4% of oxygen and 10% of N2O, 100% humidification at 32°C,) during open…
- Trial name
- NCT01098175
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- KU Leuven
Pleural Effusion, Pneumothorax
Suturing With U-Technique Versus Un-Reapproximated Wound Edges During Removal of Closed Thoracostomy Tube Drain
The study will be carried out by the principal investigator and his team at the Division of Cardiovascular and Thoracic Surgery of the Department of Surgery, College of Medicine, University of Ibadan and the University College…
- Conditions
- Pleural Effusion, Pneumothorax, Chest Trauma, Video-assisted Thoracoscopic Surgery
- Trial name
- SUTURE (NCT04193241)
- Testing
- Closure of chest tube wound
- Where
- Nigeria
- Volunteers
- 142 people
- Sponsor
- University of Ibadan
Thoracotomy, Pain, Postoperative
Gabapentin Dosages for Postoperative Analgesia Following Open Thoracotomy
Gabapentin is a nerve medication that treats pain. The specific aim of the study is to compare the difference in the postoperative use of no gabapentin, 300 mg gabapentin 3x daily, or 300 mg gabapentin once at night.
- Trial name
- NCT05172570
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Indiana University
Lung Cancer, Thoracotomy
The Effect of Post-thoracotomy Pulmonary Rehabilitation on Quality of Life
The purpose of this study is to evaluate the effects of an integrated multidisciplinary rehabilitation program on health related quality of life in the 12 months postoperative period in patients with an elective thoracotomy and…
- Conditions
- Lung Cancer, Thoracotomy, Pulmonary Rehabilitation
- Trial name
- NCT00460668
- Testing
- pulmonary rehabilitation
- Where
- Netherlands
- Volunteers
- 57 people
- Sponsor
- Isala
Lung Cancer
Study to See if Microcoil Insertion Reduces the Rate of Open Thoracotomy for Removal of Lung Nodules
LAY ABSTRACT 1. Statement of the health problem or issue: Of the estimated 24,000 Canadians who will be diagnosed with lung cancer in 2008, 21,000 will die of their disease.
- Trial name
- NCT01028417
- Testing
- Platinum microcoil
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of British Columbia
Thoracotomy
Ultrasound-guided Approach Combined With Pressure Measurement Technique to Thoracic Paravertebral Block
Posterolateral thoracotomies are among the most painful procedures of surgery and may cause severe postoperative chest pain and impaired respiratory performance.
- Trial name
- NCT03868917
- Testing
- thoracic paravertebral block using pressure measurement technique
- Where
- South Korea
- Volunteers
- 72 people
- Sponsor
- Yeungnam University College of Medicine
Heart Valve Diseases or Prosthesis, Aortic Valve Stenosis
Comparison of Early Postoperative Outcomes Between Minimally Invasive Valve Surgery Via Right Thoracotomy and Conventional Valve Surgery Via Sternotomy.
This randomized controlled trial aims to compare early postoperative outcomes between Minimally Invasive Valve Surgery (MIVS) via right thoracotomy and Conventional Valve Surgery via median sternotomy in patients undergoing…
- Conditions
- Heart Valve Diseases or Prosthesis, Aortic Valve Stenosis, Aortic Valve Insufficiency, Valvular Heart Disease Stenosis and Regurgitation (Diagnosis)
- Trial name
- NCT07251660
- Testing
- Minimally Invasive Valve Surgery, Conventional Valve Surgery
- Volunteers
- 32 people
- Sponsor
- Chaudhry Pervaiz Elahi Institute of Cardiology
Inflammation
Inflammation After One Lung Ventilation
The aim of the study was to prospectively investigate the influence of one-lung ventilation (OLV) on the inflammatory response and to identify possible antiinflammatory effects of the volatile anaesthetic sevoflurane.
- Trial name
- NCT02188407
- Testing
- Sevoflurane, Propofol
- Where
- Slovenia
- Volunteers
- 40 people
- Sponsor
- University Medical Centre Ljubljana
Postoperative Pain Management
Study in Adult Subjects Undergoing Posterolateral Thoracotomy
Primary Objective: To characterize the pharmacokinetic (PK) profile of EXPAREL when administered as a posterior intercostal nerve block. Secondary Objective: To assess the safety and tolerability of EXPAREL in this surgical model.
- Trial name
- NCT03428984
- Testing
- EXPAREL
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Open Thoracotomy
Pharmacokinetic of Thoracic Paravertebral Ropivacaine
The study aims to investigate the pharmacokinetic of ropivacaine in patients undergoing ultrasound guided thoracic paravertebral block (TPVB) both after a single-bolus injection via the thoracic paravertebral catheter given…
- Trial name
- NCT03721406
- Testing
- Ropivacaine
- Where
- 2 sites in Greece
- Volunteers
- 20 people
- Sponsor
- Attikon Hospital
Elective Open Thoracotomy
Remifentanil Without Muscle Relaxant for Thoracotomy
Although the administration of muscle relaxation is essential standard of care for thoracic procedures, it could cause long-reversal times and postoperative residual curarization (PORC) increasing length of post-anesthesia care…
- Trial name
- NCT02030808
- Testing
- Muscle Relaxants (MR) group, Non- Muscle Relaxants (NMR) group
- Where
- Saudi Arabia
- Volunteers
- 66 people
- Sponsor
- Imam Abdulrahman Bin Faisal University
Ipsilateral Shoulder Pain
Sphenopalatine Ganglion Block to Treat Shoulder Pain After Thoracotomy
The purpose of this pilot study is to evaluate the utility of sphenopalatine ganglion (SPG) block to manage ipsilateral shoulder pain (ISP) after thoracotomy.
- Trial name
- NCT02733393
- Testing
- Sphenopalatine Ganglion (SPG) Block, lidocaine
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- NYU Langone Health