Clinical trials: Open Wound
Spinal Cord Injury (SCI)
Safety Study of Human Spinal Cord-derived Neural Stem Cell Transplantation for the Treatment of Chronic SCI
This is a safety study of human spinal cord-derived neural stem cell (HSSC) transplantation for the treatment of chronic spinal cord injury.
- Trial name
- SCI (NCT01772810)
- Testing
- Human spinal cord stem cells.
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Neuralstem Inc.
Wound Infection, Surgical
Clinical Outcome in View of Surgical Site Infection (SSI) With Antibacterial Skin Sutures
Background: Poor wound healing and the development of surgical site infection (SSI) continue to occur and remain a significant cause of disability among operated patients.
- Trial name
- NCT01540279
- Where
- Switzerland
- Volunteers
- 52 people
- Sponsor
- University Hospital, Basel, Switzerland
Post-stroke Spasticity, Spasticity Post-Traumatic Brain Injury
Dysport® Adult Lower Limb Spasticity Follow-on Study
The purpose of this research study is to assess the long term safety of Dysport® in hemiparetic subjects with lower limb spasticity due to stroke or traumatic brain injury over repeated treatment cycles.
- Trial name
- NCT01251367
- Testing
- Botulinum toxin type A
- Where
- 50 sites in United States, Australia and 9 more
- Volunteers
- 352 people
- Sponsor
- Ipsen
Spinal Cord Injuries
Safety and Pharmacokinetics Study of Oral Lithium in Patients With Chronic Spinal Cord Injury
The current study is a phase I open-label clinical trial to examine plasma levels after oral lithium treatments in 20 subjects with chronic spinal cord injury.
- Trial name
- NCT00431171
- Testing
- Lithium carbonate
- Where
- China
- Volunteers
- 20 people
- Sponsor
- The University of Hong Kong
Hypothermia
Local CO2 Increases Core and Wound Temperature
Eighty adult patients undergoing open colon surgery will be randomized to either:standard warming measures or to additional insufflation of humidified carbon dioxide in the open wound cavity during major abdominal surgery.
- Trial name
- NCT01213628
- Testing
- humidified warmed CO2
- Where
- Sweden
- Volunteers
- 80 people
- Sponsor
- Karolinska University Hospital
Chronic Lower Leg Ulcer, Diabetic Lower Extremity Ulcers
Use of Hydroprep Wound Therapy With Motion Negative Pressure Therapy for Treatment of Chronic Lower Extremity Wounds
Use of a motorized waterjet to debride wounds to improve healing outcomes.
- Conditions
- Chronic Lower Leg Ulcer, Diabetic Lower Extremity Ulcers, Pressure Injuries, Traumatic Wounds and Injuries
- Trial name
- NCT07653165
- Testing
- Motion NPWT
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- West Boca Center for Wound Healing
Carpal Tunnel Syndrome
Patient Outcomes With Endoscopic Versus Open Carpal Tunnel Release
Although some surgeons prefer one technique rather than the other, both endoscopic and open carpal tunnel release procedures are accepted as standard of care surgeries to relieve carpal tunnel syndrome.
- Trial name
- NCT00880295
- Testing
- endoscopic carpal tunnel release, open carpal tunnel release
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Penn State University
Ischemia-Reperfusion Injury
Effect of Dexmedetomidine Preconditioning on Myocardial Ischemia-reperfusion Injury in Patients Undergoing Open Heart Surgery With Cardiopulmonary Bypass
About 200000 cardiac operations are performed in China every year. Cardiopulmonary bypass is the basic strategy of open-heart surgery, which may lead to myocardial ischemia-reperfusion injury and low cardiac output syndrome.
- Trial name
- NCT05598177
- Testing
- dexmedetomidine
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Affiliated Hospital of Nantong University
Pilonidal Disease
Pilonidal Disease Wound Healing Study
The purpose of the study is to learn about the best way to treat pilonidal cyst wounds and learn which type of bandage (or dressing) can help the wound heal faster after having surgery.
- Trial name
- NCT01857128
- Testing
- Drawtex dressing, Negative Pressure Wound Therapy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Walter Reed National Military Medical Center
Pain, Postoperative, Pain, Acute
Cognitive Behavioural Therapy to Optimize Post-Operative Recovery Trial
Psychological factors such as stress, distress, anxiety, depression, and poor coping strategies may be associated with ongoing pain following injuries such as fractures.
- Conditions
- Pain, Postoperative, Pain, Acute, Pain, Chronic, Fractures, Closed
- Trial name
- COPE (NCT04274530)
- Testing
- Cognitive Behavioural Therapy
- Where
- 10 sites in United States, Canada
- Volunteers
- 1,024 people
- Sponsor
- McMaster University
Lung Transplantation
Safety and Efficacy Study of Nitric Oxide in Patients Going Through Lung Transplantation
The purpose of this study is to assess the safety and efficacy of inhaled nitric oxide in prevention of lung graft dysfunction due to ischemia-reperfusion
- Trial name
- NCT00570245
- Testing
- Nitric oxide
- Where
- Spain
- Volunteers
- 49 people
- Sponsor
- Mallinckrodt
Rotator Cuff Tear
Outcomes in Rotator Cuff Repair Using Graft Reinforcement
The purpose of this study is to evaluate patient shoulder functional outcomes following rotator cuff repairs reinforced with a surgical mesh.
- Trial name
- NCT01025037
- Testing
- Conexa Reconstructive Tissue Matrix
- Where
- 6 sites in United States
- Volunteers
- 61 people
- Sponsor
- Stryker Trauma and Extremities
Autism Spectrum Disorder, Challenging Behaviour
Propranolol for Aggression, Self-Injury, and Severe Disruptive Behavior in Adolescents and Adults With Autism
The goal of this clinical trial is to learn if propranolol can help reduce challenging behaviors associated with Autism Spectrum Disorder, including aggression, self-injury, and severe disruptive behaviors.
- Conditions
- Autism Spectrum Disorder, Challenging Behaviour, Aggression, Severe Disruptive Behaviour Disorders
- Trial name
- NCT07091279
- Testing
- Propranolol
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Jeremy Veenstra-vanderweele
Head Trauma, Crushing Skull Injury
Detecting Traumatic Intracranial Hemorrhage With the InfraScanner 2500™ in Uganda
The goal of this study is to determine the sensitivity, specificity, and positive and negative predictive values of the portable near-infrared-based device (portable NIR-based device), the InfraScanner 2500™, to detect…
- Conditions
- Head Trauma, Crushing Skull Injury, Head Injury, Head Injuries, Multiple
- Trial name
- NCT06491173
- Testing
- InfraScanner 2500™
- Where
- 2 sites in Uganda
- Volunteers
- 180 people
- Sponsor
- Duke University
Nasopharyngeal Carcinoma, Quality of Life
Prophylactic Radiotherapy Optimization for Enhanced Thyroid Function Protection in NPC
This study is a multicenter, non-inferiority, open-label, randomized controlled Phase III clinical trial. It aims to compare the efficacy of modified delineation radiotherapy (experimental group) versus standard delineation…
- Conditions
- Nasopharyngeal Carcinoma, Quality of Life, Thyroid Diseases, Radiotherapy Side Effect
- Trial name
- PROTECT-NPC (NCT06752239)
- Testing
- Modified delineation, Standard delineation
- Where
- China
- Volunteers
- 474 people
- Sponsor
- Jiangxi Provincial Cancer Hospital
Joint Instability, Shoulder Dislocation
Arthroscopic Versus Open Stabilization for Traumatic Shoulder Instability
The purpose of this study is to compare arthroscopic and open shoulder stabilization procedures by measuring the disease-specific quality of life outcome in patients with traumatic unidirectional anterior instability of the…
- Trial name
- NCT00251264
- Testing
- Open stabilization, Arthroscopic stabilization
- Where
- Canada
- Volunteers
- 194 people
- Sponsor
- University of Calgary
Drug Induced Liver Injury, Chronic Liver Disease
Efficacy of Plasmapheresis in Patients of Drug-Induced Liver Injury (DILI) With Underlying Chronic Liver Disease
DILI is an underdiagnosed and under appreciated causal or contributing factor to liver injury. DILI can mimics features of the entire spectrum of acute and chronic liver disease.
- Trial name
- NCT06797011
- Testing
- High volume Plasma Exchange, Standard Medical Treatment
- Where
- India
- Volunteers
- 96 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Radiation Injuries
Effect and Safety of Apatinib on Radiation-Induced Brain Injury
Purpose: This early phase 2 clinical trial aims to evaluate the therapeutic effects and safety of apatinib in radiation-induced brain injury.
- Trial name
- NCT04152681
- Testing
- Apatinib
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Soft Tissue Injuries, Trauma
Acellular Adipose Tissue (AAT) for Soft Tissue Reconstruction
Although other methods (e.g., autologous fat transfer, dermal-/collagen-based fillers) for soft tissue reconstruction exist, each has distinct disadvantages leaving room for improvement in this treatment area.
- Trial name
- NCT03544632
- Testing
- Acellular Adipose Tissue (AAT)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Johns Hopkins University
Acute Respiratory Distress Syndrome
Lung Open Ventilation to Decrease Mortality in the Acute Respiratory Distress Syndrome
A multinational, randomized trial comparing two lung protecting strategies of respiratory life support among critically ill patients with severe lung injury.
- Trial name
- LOVS (NCT00182195)
- Testing
- Control Ventilation Strategy
- Where
- Canada
- Volunteers
- 980 people
- Sponsor
- Hamilton Health Sciences Corporation