Clinical trials: Operable Breast Neoplasms
Breast Neoplasm Female
Fulvestrant Versus Fulvestrant Plus Palbociclib in Operable Breast Cancer Responding to Fulvestrant
This is a multicenter, international, double-blind randomized Phase III study to evaluate the pathological complete response (pCR) according to Chevalier classification between Fulvestrant® and the combination of Fulvestrant®…
- Trial name
- SAFIA (NCT03447132)
- Testing
- Fulvestrant 500mg, Palbociclib 125mg, Goserelin 3.6 MG
- Where
- 14 sites in Algeria, Egypt and 6 more
- Volunteers
- 354 people
- Sponsor
- International Cancer Research Group, United Arab Emirates
Breast Cancer
GF-GS 01: Comparing Conventional Axillary Dissection Versus Sentinel Node Resection in Clinically Node-negative Operable Breast Cancer
Sentinel node resection appears as a promising advancement in the surgical treatment of breast cancer. The GF-GS 01 study, sponsored by a National Hospital Research Program, compares this new surgical method with a classical…
- Trial name
- NCT00144898
- Testing
- Sentinel Node Resection, Conventional Axillary Dissection
- Where
- France
- Volunteers
- 1,627 people
- Sponsor
- Hospices Civils de Lyon
Breast Cancer
A Prospective, Randomized Multicenter, Open-label Comparison of Preoperative Combination of Trastuzumab and Pertuzumab With or Without Concurrent Taxane Chemotherapy Given for Twelve Weeks in Patients With Operable HER2+/HR- Breast Cancer Within the ADAPT Protocol
Trial to evaluate efficacy of dual blockade with two anti-HER2 agents with or without chemotherapy backbone within the ADAPT trial.
- Trial name
- ADAPT (NCT01817452)
- Testing
- Trastuzumab, Pertuzumab, Paclitaxel
- Where
- Germany
- Volunteers
- 220 people
- Sponsor
- Women's Cancer Study Group GmbH
Breast Cancer
Chemotherapy Plus Surgery in Treating Women With Breast Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining surgery with chemotherapy may kill more tumor cells.
- Trial name
- NCT00003013
- Testing
- CMF regimen, cyclophosphamide, doxorubicin hydrochloride
- Where
- 28 sites in Austria, Czechia and 9 more
- Volunteers
- 450 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Breast Cancer
Sentinel Lymph Node Detection After Neoadjuvant Chemotherapy for Large Operable Breast Cancer
Neoadjuvant chemotherapy (NAC) is frequently proposed to patients with large tumours that can be operated in order to increase the chances of breast conservation.
- Trial name
- GANEA2 (NCT01221688)
- Testing
- Axillar Sentinel lymph node biopsy, SLNB and complete level I-II axillary lymphadenectomy
- Where
- 18 sites in France
- Volunteers
- 958 people
- Sponsor
- Institut Cancerologie de l'Ouest
Breast Cancer
Pegylated Liposomal Doxorubicin and Docetaxel in Treating Women With Locally Advanced Breast Cancer That Can Be Removed By Surgery
RATIONALE: Drugs used in chemotherapy, such as liposomal doxorubicin and docetaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00524459
- Testing
- docetaxel, pegylated liposomal doxorubicin hydrochloride, conventional surgery
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Roswell Park Cancer Institute
Female Breast Cancer
Adjuvant Endocrine Therapy for Estrogen Receptor-beta Positive Triple Negative Breast Cancer
The study is a prospective multi-center randomized control clinical trial which is sponsored by the researchers. The purpose of this study is to determine the effectiveness of adjuvant endocrine therapy for operable ER-beta…
- Trial name
- AETNBC (NCT02089854)
- Testing
- Toremifene; Anastrozole
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Peking Union Medical College Hospital
Breast Cancer, Cancer of Breast
Endocrine Treatment Alone for Elderly Patients With Estrogen Receptor Positive Operable Breast Cancer and Low Recurrence Score
Multiple neoadjuvant endocrine trials demonstrate that women with good prognosis tumors can be identified. These trials have also demonstrated that there are not adverse effects on overall outcome if women are treated with…
- Conditions
- Breast Cancer, Cancer of Breast, Breast Neoplasms, Cancer of the Breast
- Trial name
- NCT02476786
- Testing
- FACT-B, Goserelin, Anastrozole
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Washington University School of Medicine
Breast Cancer
PiA: Prognosis Used Every Day for Patients With Operable Breast Cancer - Comparison of Invasion Factors uPA/PAI-1 With Other Prognostic Factors
The improvement of the healing rates for breast cancer is based to an important part on the consistent use of so-called adjuvant ("supporting ") medicamentous therapies, including chemotherapy.
- Trial name
- PiA (NCT01592825)
- Volunteers
- 1,000 people
- Sponsor
- Martin-Luther-Universität Halle-Wittenberg
Operable Breast Cancer
Randomized Controlled Trial to Assess Blockade of Voltage Gated Sodium Channels During Surgery in Operable Breast Cancer
Voltage Gated Sodium Channels Over the years, there is more evidence that ionic channels are involved in the oncogenic process. Among these, voltage gated sodium channels (VGSC) expressed in non-nervous or non-muscular organs are…
- Trial name
- NCT01916317
- Testing
- 0.5% lignocaine 60mM
- Where
- 11 sites in India
- Volunteers
- 1,600 people
- Sponsor
- Tata Memorial Hospital
Invasive Breast Carcinoma
Impact of Neoadjuvant Chemotherapy on the Peripheral Blood Immune Phenotype in Operable Breast Cancer
This early phase I trial evaluates the impact of chemotherapy before surgery (neoadjuvant) on the peripheral blood immune phenotype in patients with operable breast cancer.
- Trial name
- ENHANCE (NCT04897009)
- Testing
- Biospecimen Collection
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Mayo Clinic
Breast Cancer
DIG-HIF-1 Pharmacodynamic Trial in Newly Diagnosed Operable Breast Cancer
The purpose of this study is to learn what effects digoxin (DIG) may have on human breast cancer tissue.
- Trial name
- NCT01763931
- Testing
- Digoxin
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Breast Cancer, Operable Breast Cancer
EXpander-based Versus Direct to Implant PRE-pectoral Breast Reconstruction: a Comparative Analysis of Surgical Outcomes
Recent advances in breast surgery, together with the increasing adoption of conservative surgical approaches, have renewed interest in pre-pectoral implant-based breast reconstruction.
- Trial name
- EXPRESSO (NCT07593651)
- Volunteers
- 276 people
- Sponsor
- IRCCS San Raffaele
Breast Cancer
Phase II Trial of Preoperative Therapy With Gefitinib and Chemotherapy in Patients With ERneg Breast Cancer
The aim of the study is to estimate the effect of preoperative gefitinib on the complete pathological response rate in primary estrogen receptor negative breast cancer at the time of surgery.
- Trial name
- NCT00239343
- Testing
- gefitinib
- Where
- 8 sites in Denmark, Norway and 1 more
- Volunteers
- 160 people
- Sponsor
- AstraZeneca
Breast Neoplasms, Carcinoma
Perioperative Chemotherapy After Primary Chemotherapy for Locally Advanced Breast Cancer
The role of early timing of adjuvant chemotherapy was postulated to be particularly important for patients with endocrine non-responsive disease.
- Trial name
- NCT00301548
- Testing
- perioperative chemotherapy
- Volunteers
- 172 people
- Sponsor
- European Institute of Oncology
Breast Cancer
Efficacy and Safety of Adjuvant Metformin for Operable Breast Cancer Patients
The investigators hypothesize that adjuvant metformin use in breast cancer patients with overweight or pre-diabetes mellitus (DM) may improve their body condition including weight loss.
- Trial name
- NCT00909506
- Testing
- Metformin
- Where
- South Korea
- Volunteers
- 105 people
- Sponsor
- Seoul National University Hospital
Breast Cancer
Phase I/II Study of Neoadjuvant Lapatinib in Breast Cancer
RATIONALE: Drugs used in chemotherapy, such as docetaxel, fluorouracil, epirubicin, and cyclophosphamide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00450892
- Testing
- docetaxel+lapatinib, docetaxel + trastuzumab, docetaxel + trastuzumab + lapatinib
- Where
- 15 sites in Belgium, France and 3 more
- Volunteers
- 129 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Breast Cancer
Supervised Aerobic Training During or After Chemotherapy for Operable Breast Cancer
The purpose of this study is to compare the effects of aerobic exercise training during and after chemotherapy for women who have recently been diagnosed with early-stage breast cancer.
- Trial name
- NCT01943695
- Testing
- Aerobic Training, Educational Information, Supervised Home Based Training
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Breast Cancer
Pre-operative Contrast Enhanced CT to Improve Delineation of the Tumorbed in Radiotherapy for Breast Cancer.
Rationale: Whole breast irradiation with 50 Gy after lumpectomy has been shown to reduce the local recurrence rate with a factor 3 to 4.
- Trial name
- NCT00721058
- Testing
- CT-scan
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- Maastricht Radiation Oncology
Breast Cancer
Preoperative Chemotherapy With Paclitaxel, Gemcitabine, and Lapatinib (Tykerb®) (PGT)
Primary objectives : 1. To evaluate the recommended dose of the combination of paclitaxel, gemcitabine, and lapatinib (Tykerb®) (PGT) as preoperative chemotherapy in patients with HER2 positive operable breast cancer Secondary…
- Trial name
- PGT (NCT01133912)
- Testing
- paclitaxel, gemcitabine, lapatinib
- Where
- South Korea
- Volunteers
- 13 people
- Sponsor
- Jungsil Ro