Clinical trials: Ophthalmic Disorders
Age-Related Macular Degeneration
AMD and Validation Rod-Meditated Dark Adaptation With Everyday Task Performance
The goal is to conduct a cross-sectional, single timepoint study on older adults with early and intermediate AMD, and with subretinal drusenoid deposits (SDD), and those in normal health, establishing an association between dark…
- Trial name
- NCT06619405
- Testing
- Streetlab VR
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Duke University
Microbiota
Intestinal Microbiota and Treatment of GD
Graves' disease is an organ-specific autoimmune disease in which both genetic predisposition and environmental factors serve as disease triggers.
- Trial name
- NCT03433352
- Testing
- Methimazole Pill, Propylthiouracil Pill
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Harbin Medical University
Hearing Impairment
Do Bluetooth Noise Cancelling Headphones Improve the Quality of Care in Hearing Impaired Patients?
Participants will be recruited by performing chart reviews of patients to be seen at University of Texas Medical Branch at Galveston Ophthalmology and Optometry Clinic. A sample size of at least 30 patients is needed (60 eyes).
- Trial name
- NCT05420038
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Presbyopia, Refractive Error
Visual Performance of Prototype Contact Lens Designs
The aim of this study is to assess the visual performance of prototype soft contact lens designs compared to a commercially available contact lens
- Trial name
- NCT02193555
- Testing
- Etafilcon A, Senofilcon A
- Where
- Australia
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Brien Holden Vision
Graves' Disease
Application of Digital Infrared Thermal Imaging (DITI) in Graves' Disease
Graves' disease is characterized by thyrotoxicosis, goiter, ophthalmopathy and dermopathy. Pathogenesis involves autoimmune process. The investigators think temperatures of the area involved in the inflammation may change.
- Trial name
- NCT01182584
- Where
- Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Neurosyphilis
Value of an Intrathecal Synthesis Index of Specific Antitreponema IgG for Neurosyphilis Diagnosis
A retro-prospective case-control Swiss study was conducted to evaluate the diagnostic performance of measuring an antibody index (AI) for intrathecal synthesis of specific anti-Treponema pallidum (T.
- Trial name
- NCT06152393
- Testing
- Measure of an antibody index for intrathecal synthesis of specific anti-Treponema pallidum IgG by ELISA.
- Where
- Switzerland
- Volunteers
- 181 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Diabetic Retinopathy
Vascular Remodeling and the Effects of Angiogenic Inhibition in Diabetic Retinopathy
The retinal vasculature changes dramatically in patients with diabetic retinopathy especially between non-proliferative and proliferative disease. The retinal vasculature can be imaged and quantified using special dyes.
- Trial name
- NCT00411333
- Testing
- triamcinolone acetonide (Kenalog)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Eye Institute (NEI)
Dry Eye Syndromes, Corneal Disease
Prospective Study to Validate the Imaging Biomarker for NCP (R33)
The aim of this study is establish the reliability and clinical utility of microneuromas as identified via in vivo confocal microscopy as the diagnostic biomarker for NCP.
- Trial name
- NCT05653921
- Testing
- In vivo confocal microscopy (IVCM)
- Where
- 2 sites in United States
- Volunteers
- 438 people, healthy volunteers welcome
- Sponsor
- Tufts Medical Center
Myopia
Contact Lenses and Myopia
The objective of this study is to determine if multifocal contact lenses affect accommodation and/or binocular vision when worn by pediatric patients.
- Trial name
- CLAM (NCT02180347)
- Testing
- Contact lenses
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- State University of New York College of Optometry
Progressive Supranuclear Palsy, Corticobasal Degeneration
Repetitive Transcranial Magnetic Stimulation (TMS) for Progressive Supranuclear Palsy and Corticobasal Degeneration
Drug therapy of atypical parkinsonism is generally considered either ineffective or minimal 1. Therefore, there is an urgent need to find alternative therapies to treat atypical parkinsonian disorders.
- Conditions
- Progressive Supranuclear Palsy, Corticobasal Degeneration, Parkinsonism
- Trial name
- NCT01174771
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Myopia
CHILDREN MYOPIA CONTROL
The purpose of this trial is evaluating the clinical effect of a myopia control spectacle lens compared to a single vision spectacle lens in slowing down the progression of myopia in children living in Israel.
- Trial name
- NCT05477329
- Testing
- Lenses
- Where
- Israel
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Shamir Optical Industry Ltd
Conjunctivitis, Allergic
Treg Effector Function and Th2/Treg Ratio in Allergic Conjunctivitis: Effect of Desensitization Therapy
This study aims to evaluate the effector function and expression of TIGIT and PD-1 on Tregs, as well as the Th2/Treg ratio, in patients with allergic conjunctivitis with and without desensitization therapy, compared to healthy…
- Trial name
- INMUNOREG (NCT07171307)
- Where
- Mexico
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Instituto de Oftalmología Fundación Conde de Valenciana
Graft Versus Host Disease in Eye, Ocular Complications
Ocular Complications From Cancer Therapy - Patient Registry and Biobank
The purpose of this study is to collect data on patients seen at University of Maryland after undergoing cancer therapy. Previous medications, ocular history, medical history, clinical evaluations, surgical procedures and…
- Conditions
- Graft Versus Host Disease in Eye, Ocular Complications, Inflammatory Dry Eye Disease
- Trial name
- NCT06874283
- Testing
- Eye exam
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Dry Eye, Meibomian Gland Dysfunction (Disorder)
Effect of Low-Level Light Therapy on Ocular Surface Parameters in Patients Undergoing Cataract Surgery
This randomized, controlled clinical trial investigates the perioperative use of low-level light therapy (LLLT) to prevent or reduce signs and symptoms of dry eye disease (DED) in patients undergoing cataract surgery.
- Conditions
- Dry Eye, Meibomian Gland Dysfunction (Disorder), Ocular Surface Disease
- Trial name
- LLLT-Cataract (NCT07067294)
- Testing
- Low-Level Light Therapy
- Where
- Romania
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Grigore T. Popa University of Medicine and Pharmacy
Soft Contact Lenses, Myopia
DAILIES TOTAL1 Versus ACUVUE TruEye - Effects on the Biology of the Ocular Surface and Lid Margin
This is a prospective, single center, randomized, bilateral crossover, dispensing clinical trial to evaluate the effects of the water gradient lens, DAILIES TOTAL1, on the biology of corneal epithelium over two months of daily…
- Trial name
- TruEyeTotal1 (NCT02347631)
- Testing
- Soft Contact Lens - Daily Disposable Alcon Dailies Total 1 and ACUVUE TruEye, Soft Contact Lens - Acuvue TruEye and Alcon DAILIES TOTAL 1.
- Where
- United States
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Myopia
Comparison of Verofilcon A Daily Disposable Lenses to Somofilcon A Daily Disposable Lenses
The objective of the study is to evaluate and compare the performance of verofilcon A to somofilcon A when worn on a daily disposable modality over a period of approximately one week each.
- Trial name
- NCT04305912
- Testing
- somofilcon A, verofilcon A
- Where
- Canada
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- CooperVision, Inc.
No Eye Disease
Optical Coherence Tomography (OCT) Data Collection Study
Collect OCT data to evaluate the range and age trend of eye measurements.
- Trial name
- NCT01459731
- Where
- 5 sites in United States, United Kingdom
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Optovue
Myopia, Astigmatism
Toric Orthokeratology - Slowing Eye Elongation
The aims of this study are to investigate the effects of ortho-k for astigmatic and myopic reduction and myopic control in children, and the long term effects on corneal curvatures and biomechanics.
- Trial name
- TO-SEE (NCT00978692)
- Testing
- Toric Orthokeratology lenses, Single-vision spectacles
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Preeclampsia, Intracranial Pressure Increase
Assessment of Optic Nerve Sheath Diameter in Preeclamptic Pregnant Women Using Ultrasonography and Anesthetic Management
Preeclampsia is a serious condition associated with complications such as pulmonary edema, placental abruption, hemolysis, thrombocytopenia, and cardiac, renal, and neurological complications, occurring at a rate of 2.7-8% in…
- Conditions
- Preeclampsia, Intracranial Pressure Increase, Pregnancy; Anesthesia, Adverse Effect, Central Nervous System
- Trial name
- NCT06522295
- Testing
- ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Kocaeli University
Myopia
Effect of Vision Therapy in Myopic Children With Poor Accommodative Response
This study aims to determine the treatment effect of vision therapy on myopic children by assessment of accommodative function before and after therapy.
- Trial name
- NCT03006601
- Testing
- Office-based accommodative/vergence therapy
- Where
- China
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
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