Clinical trials: Ophthalmic Imaging
Dry Eye Syndrome, Healthy
Non-invasive Ocular Surface Measurements Before and After Interventions
Objectively evaluate the ocular surface (pre-corneal tear film) of individuals prior to and after an intervention (such as a dry eye treatment, environmental change, artificial tear use, or contact lens wear) in a…
- Trial name
- NCT01228929
- Testing
- Environmental Chamber Condition Change Intervention
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Visual Field Defect, Stroke
Home-based Vision Rehabilitation Guided by Brain Imaging
The BRIGHT (Behavioral Rehabilitation Through Image-Guided Home-based Training) study aims to evaluate the effectiveness of image-guided, home-based perceptual training at improving visual performance in individuals with visual…
- Conditions
- Visual Field Defect, Stroke, Hemianopia Homonymous, Quadrantanopia
- Trial name
- BRIGHT (NCT07635329)
- Testing
- High-level perceptual learning-based training, Low-level perceptual learning-based training
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Georgetown University
AMD, Cancer
Age-Related Eye Disease Study 2 (AREDS2) 10-year Follow-On
Background: Age-related macular degeneration (AMD) and cataracts are two eye diseases. They were studied in the Age-Related Eye Disease Study (AREDS2) and the AREDS2 Follow-On study.
- Conditions
- AMD, Cancer, Cataract
- Trial name
- NCT03367767
- Where
- United States
- Volunteers
- 709 people
- Sponsor
- National Eye Institute (NEI)
Retinal Blood Vessels, Age-Related Macular Degeneration
Multimodal Imaging of Retinal Vessels
Retinal blood flow measurement is of scientific and clinical value. For this purpose retinal vessel morphology (such as diameter, vessel wall thickness, etc) determination is crucial.
- Trial name
- MIR (NCT02717026)
- Testing
- Optical coherence tomography, Fluorescein angiography, Fundus photography
- Where
- Austria
- Volunteers
- 50 people
- Sponsor
- Medical University of Graz
Retinal Disease
Structural Imaging Assisted Retinal Fluorescence Lifetime Imager (STARFLI)
To investigate the feasibility of a combined OCT/FLIM device
- Trial name
- STARFLI (NCT05819307)
- Testing
- OCT/FLIM
- Where
- Switzerland
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Mental Disorder
AI-Assisted Rapid Warning for Mental Disorders Based on High-Resolution Fundus Imaging and High-Speed Eye-Tracking
This project aims to collect eye-tracking trajectories and fundus imaging data from individuals seeking mental health services. By utilizing artificial intelligence, combining dynamic (eye-tracking) and static (fundus) data, and…
- Trial name
- NCT06511713
- Testing
- routine clinical treatment
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Shanghai Mental Health Center
Lacrimal Duct Obstruction, Lacrimal Stenosis
A Feasibility Study to Develop a Protocol for Functional Lacrimal Magnetic Resonance Imaging
Watering eyes (epiphora) is a very common ophthalmic condition. It is frequently caused by dysfunction of the lacrimal (tear) drainage system which is the 'pipework' that takes tears from the eye to the nasal cavity.
- Trial name
- NCT03411889
- Testing
- MRI scanning
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Brighton and Sussex University Hospitals NHS Trust
Parkinson Disease, REM Sleep Behavior Disorder
Artificial Intelligence in Molecular Imaging: Predicting Parkinson's Risk in REM Sleep Behavior Disorder
The study aims to systematically document the course of REM sleep behavior disorder (RBD) and investigate possible clinical and imaging biomarkers for disease progression and conversion risk to Parkinson's disease (PD), dementia…
- Conditions
- Parkinson Disease, REM Sleep Behavior Disorder, Dementia, Lewy Body
- Trial name
- NUK-RBD (NCT06629207)
- Testing
- PET/CT with 18-FDG, SPECT : 123 I-FP-CIT (DATSCAN), MRI
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Central Serous Chorioretinopathy
Multimodal Imaging in Central Serous Chorioretinopathy
This study aims to assess the contribution of the multimodal imaging, combining a routine examination using Optical Coherence Tomography (OCT) with an imaging procedure using adaptive optics retinal camera.
- Trial name
- IMO (NCT02889185)
- Testing
- RTX1 IMAGIN EYE retinal camera
- Where
- France
- Volunteers
- 3 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Geographic Atrophy, Age-Related Macular Degeneration
Retinal Fundus Flavoprotein Fluorescence in Age Related Macular Degeneration
The goal of this clinical trial is to learn if the areas of stressed cells in the retina correlate to areas of disease identified in standard imaging and whether the images are helpful to identify potential areas of concern…
- Trial name
- FPF in AMD (NCT06381596)
- Testing
- OcuMet Beacon
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Wisconsin, Madison
Cataract, Macula Edema
Intraoperative Berger Space Imaging (IBSI)
The investigational device is an approved femtosecond laser (FSL) device with an integrated imaging system to perform certain steps of the cataract procedure.
- Trial name
- IBSI (NCT04775849)
- Testing
- Femtosecond Laser
- Where
- Austria
- Volunteers
- 80 people
- Sponsor
- Medical University of Vienna
Glaucoma
Advanced Imaging for Glaucoma Study
The specific aims of the clinical studies are to: 1. Predict the development of glaucomatous visual field (VF) abnormality in glaucoma suspects and pre-perimetric glaucoma patients based on anatomic abnormalities detected by…
- Trial name
- AIGS (NCT01314326)
- Where
- 5 sites in United States
- Volunteers
- 832 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Retinitis Pigmentosa, Usher Syndrome Type 2
Retinal Imaging in CNTF -Releasing Encapsulated Cell Implant Treated Patients for Early-stage Retinitis Pigmentosa
This clinical trial is a single-site, 30 patient study for participants who have early stage retinitis pigmentosa, or Usher syndrome (type 2 or 3). Funding Source - FDA OOPD and Foundation Fighting Blindness.
- Conditions
- Retinitis Pigmentosa, Usher Syndrome Type 2, Usher Syndrome Type 3
- Trial name
- NCT01530659
- Testing
- NT-501
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Neurotech Pharmaceuticals
Retinoblastoma
SPT Screening in Irradiated Hereditary Retinoblastoma Survivors
Rationale: Hereditary retinoblastoma survivors have an increased risk to develop second primary tumors (SPT) at a later age (with the highest risk in their teens), especially when they have been irradiated for retinoblastoma.
- Trial name
- NCT02329002
- Testing
- Magnetic resonance imaging
- Where
- Netherlands
- Volunteers
- 400 people
- Sponsor
- Amsterdam UMC, location VUmc
Chronic Kidney Diseases
Eye-Brain-Kidney in CKD
The goal of this observational study is to learn about the interaction between the eyes, brain, and kidneys in adult patients with Chronic Kidney Disease (CKD).
- Trial name
- NCT07358572
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Beijing Friendship Hospital
Cortico Basal Degeneration, Corticobasal Syndrome
Imaging Studies in Corticobasal Syndrome
The primary goal of this study is to investigate inflammation and white matter damage in corticobasal syndrome and determine whether these processes are related to each other.
- Conditions
- Cortico Basal Degeneration, Corticobasal Syndrome, Corticobasal Syndrome(CBS), Corticobasal Degeneration
- Trial name
- I-CAN (NCT07000851)
- Testing
- C-11 ER176 Radiotracer, C-11 PiB, AV1451 Tau
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Jennifer Whitwell
Chronic Progressive External Ophthalmoplegia
MRI Study - Chronic Progressive External Ophthalmoplegia
The purpose of this study is to investigate the fraction of fat on a MRI scan of lower bag muscles, thighs and calves in patients with the mitochondrial disease chronic progressive external ophthalmoplegia (CPEO).
- Trial name
- CPEO (NCT02161848)
- Testing
- Magnetic Resonance Imaging
- Where
- Denmark
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Inflammation, Sjogren's Syndrome
Superb Microvascular Imaging Ultrasonography of Lacrimal Gland in Patients With Sjögren Syndrome
A prospective study will be conducted to evaluate inflammatory activity in lacrimal glands due to Sjögren's syndrome on Superb Microvascular Imaging (SMI), gray scale ultrasound (US), color Doppler US and Power Doppler US.
- Conditions
- Inflammation, Sjogren's Syndrome, Gland; Inflammation
- Trial name
- SMI (NCT05689749)
- Testing
- Superb Microvascular Imaging (SMI) (Toshiba)
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Nigde Omer Halisdemir University
Eye Abnormalities, Normal Eyes
The Heidelberg Engineering ANTERION Imaging Agreement Study
This is a prospective clinical study that will be conducted at one clinical site located in the United States to assess image quality of acquired biometry images of the eye
- Trial name
- NCT04068818
- Testing
- ANTERION
- Where
- United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Heidelberg Engineering GmbH
Corneal Edema Secondary to Corneal Endothelial Dystrophy
Early Experience With Descemet's Stripping Automated Endothelial Keratoplasty
The purpose of this study is to report the early clinical outcomes in patients undergoing Descemet's Stripping Automated Endothelial Keratoplasty (DSAEK) for corneal edema secondary to corneal endothelial cell dysfunction, and to…
- Trial name
- DSAEK (NCT00744796)
- Testing
- DSAEK, Anterior Segment Optical Coherence Topography (OCT), Best Spectacle Corrected Visual Acuity (BSCVA)
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center