Clinical trials: Ophthalmic Imaging
Alzheimer Disease, Progressive Supranuclear Palsy
Tau Protein and SV2a Imaging in Patients With Tau Protein-related Diseases
Tau protein has been identified as one of the key pathological features of Tau proteinopathies, such as Alzheimer's disease (AD), progressive supranuclear palsy (PSP), frontotemporal dementia (FTD).
- Conditions
- Alzheimer Disease, Progressive Supranuclear Palsy, Frontotemporal Dementia
- Trial name
- NCT05260151
- Where
- China
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
Endophthalmitis
Vascular Changes Associated With Endophthalmitis.
This study aims to describe and investigate vascular changes associated with exogenous endophthalmitis, as well as to create a photo library where they are evidenced
- Trial name
- NCT07175311
- Testing
- Multimodal imaging findings
- Where
- Mexico
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Asociación para Evitar la Ceguera en México
Macular Degeneration, Choroidal Neovascularization
Enhancing the Lucentis (Ranibizumab) Management of Choroidal Neovascular Membranes With Hyperspectral Imaging
Clinical trial investigating the role of hyperspectral imaging in the management of patients undergoing standard clinical treatment for naive neovascular choroidal membranes in age-related macular degeneration.
- Trial name
- NCT03105609
- Testing
- Hyperspectral imaging
- Where
- Australia
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Center for Eye Research Australia
Age-Related Macular Degeneration, NAMD
Targeted Fluorescence Imaging in AMD
Rationale: To track performance of intravitreal distribution of anti-VEGF-A (Bevazicumab-800CW) and provide information about neovascularization and inflammation in Age-Related Macular Degeneration (AMD), thereby predicting…
- Trial name
- LEAF (NCT05262244)
- Testing
- Bevacizumab-IRDye800CW
- Where
- Netherlands
- Volunteers
- 12 people
- Sponsor
- University Medical Center Groningen
Diabetic Retinopathy
Intravitreal Aflibercept as Indicated by Real-Time Objective Imaging to Achieve Diabetic Retinopathy Improvement
The PRIME trial will assess the safety of 2 mg intravitreal aflibercept injections (IAI) to achieve and maintain DRSS improvements (2 or more steps) in patients with a baseline DRSS level of 47A to 71A inclusive through 104 weeks…
- Trial name
- NCT03531294
- Testing
- Aflibercept Injection
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Greater Houston Retina Research
Hyperopia and Myopia
Eye Imaging for the Study of Childhood Myopia
Myopia (nearsightedness) is increasing worldwide and is becoming a serious public health problem. Studies estimate that by 2050, if no action is taken, almost half of the world's population will be myopic.
- Trial name
- SELENA (NCT07335146)
- Testing
- Ophtalmic measurements to estimate geometrical distances, MRI, Ophtalmic measurements to measure wavefront aberrations
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Essilor International
Ophthalmic Imaging, Deep Learning
Diagnostic Performance of an AI-based Model for TCM Constitution Classification Using Ophthalmic Imaging
To evaluate the diagnostic performance of a multimodal deep learning model for identifying biased Traditional Chinese Medicine (TCM) constitutions using ophthalmic imaging
- Conditions
- Ophthalmic Imaging, Deep Learning, Artificial Intelligence (AI), Traditional Chinese Medicine Constitution
- Trial name
- NCT07127939
- Testing
- AI-based Ocular Diagnosis Model for TCM Constitutions
- Where
- China
- Volunteers
- 1,024 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Nanchang University
Multiple System Atrophy, Progressive Supranuclear Palsy (PSP)
Synaptic Loss in Multiple System Atrophy
In this study the investigators would like to investigate the degree of damage of the synapses, an important part of the neurons vital for the communications between neurons, in Multiple System Atrophy (MSA), and pathology…
- Trial name
- NCT05121012
- Testing
- Study procedures for MSA patients, Study procedures for PSP patients
- Where
- United Kingdom
- Volunteers
- 36 people
- Sponsor
- University of Exeter
Central Serous Chorioretinopathy
Central Serous Chorioretinopathy: Etiology, Course and Prognosis
Pathogenesis of central serous chorioretinopathy is not entirely understood yet, therefore further investigations are needed. During this study patients with an acute episode of central serous chorioretinopathy are observed with…
- Trial name
- NCT01378130
- Where
- Austria
- Volunteers
- 50 people
- Sponsor
- Medical University of Vienna
Neuro-Ophthalmology
Diagnostic Accuracy of Optimized Diffusion-Weighted Imaging for Detecting Anterior Ischemic Optic Neuropathy
The patient presents to the ophthalmological emergencies and / or to the internal medicine department. NOIA clinical discovery Patient referred in radiology for brain and visual MRI.
- Trial name
- DACODAC (NCT04451265)
- Testing
- MRI
- Where
- 3 sites in France
- Volunteers
- 250 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Retinopathy, Diabetic
Evaluation of the Retina in Patients With Non-proliferative Diabetic Retinopathy After Aflibercept Injection in the Eye
The purpose of this study is to specifically assess the effect of intravitreal aflibercept injections on the health of cells and the flow of blood through the retinal blood vessels by using advanced technology called adaptive…
- Trial name
- PRAVA (NCT04702048)
- Testing
- Aflibercept Injection
- Where
- United States
- Sponsor
- University of Rochester
Retinal Disease, Retinal Degeneration
Performance of Long-wavelength Autofluorescence Imaging
Fundus autofluorescence imaging has become an important diagnostic tool in ophthalmology, guiding diagnosis and assessment of progression of retinal diseases.
- Conditions
- Retinal Disease, Retinal Degeneration, Retinal Dystrophies
- Trial name
- NCT03592017
- Testing
- Long-wavelength autofluorescence imaging
- Where
- United Kingdom
- Volunteers
- 262 people, healthy volunteers welcome
- Sponsor
- Oxford University Hospitals NHS Trust
Vitreous Diseases, Retinal Diseases
Advanced OCT and Adaptive Optics Imaging in Retinal Disease (The ACAD Study)
The objectives of this study include using the new technology of SS-OCT (swept source optical coherence tomography) to evaluate morphological abnormalities of the vitreous, retina and choroid and to assess the repeatability of…
- Conditions
- Vitreous Diseases, Retinal Diseases, Choroidal Diseases
- Trial name
- ACAD (NCT02828215)
- Testing
- Swept-source optical coherence tomography (SS-OCT)
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- Moorfields Eye Hospital NHS Foundation Trust
Healthy Volunteers, Alzheimer Disease
Phase 1 Test-retest Evaluation of [18F]MNI-958 PET
The overall goal of this protocol is to evaluate [18F]MNI-958 also known as APN-0000455 or PM-PBB3, a tau targeted radiopharmaceutical.
- Conditions
- Healthy Volunteers, Alzheimer Disease, Progressive Supranuclear Palsy
- Trial name
- NCT03545789
- Testing
- [18F]MNI-958
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Invicro
Ocular Tumor
A Study Comparing Two Optical Coherence Tomography Devices in People With Ocular Tumors
The purpose of this study is to compare two devices used for optical coherence tomography (OCT). OCT is a noninvasive imaging (scanning) method that uses reflected light to create pictures of the back of the eye, and doctors can…
- Trial name
- NCT07449195
- Testing
- Intalight Dream OCT, Heidelberg Spectralis OCT
- Where
- 7 sites in United States
- Volunteers
- 60 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Neovascular Age-related Macular Degeneration
Neovascular Age-related Macular Degeneration
Age-related macular degeneration (AMD) is the leading cause of blindness in non-Hispanic white Americans. Neovascular AMD is an advanced form of macular degeneration that historically has accounted for the majority of vision loss…
- Trial name
- NVAMD (NCT01712035)
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Oregon Health and Science University
Cataract, Myopia
Effect of TrueTear Corneal Surface Imaging
This study will evaluate the utility of TrueTear™ to improve anterior corneal surface imaging quality before cataract surgery, refractive lens exchange, or laser refractive surgery.
- Trial name
- NCT03637348
- Testing
- TrueTear
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Price Vision Group
Sjogren's Syndrome
Ultra-High Frequency Ultrasonography in Sjögren's Syndrome
Patients diagnosed with a diagnosis of Sjogren's syndrome performed according to the ACR/EULAR criteria will be included in the study.
- Trial name
- UltraSjögren (NCT06338735)
- Testing
- Ultra-High Frequency Ultrasound scan of minor salivary glands
- Where
- Italy
- Volunteers
- 800 people
- Sponsor
- University of Pisa
Meibomian Gland Dysfunction, Cataract
Ultrahigh-resolution Optical Coherence Tomography Imaging of the Anterior Eye Segment Structures
The development of optical coherence tomography (OCT) and its application for in vivo imaging has opened entirely new opportunities in ophthalmology.
- Conditions
- Meibomian Gland Dysfunction, Cataract, Glaucoma, Corneal Transplantation
- Trial name
- NCT03461978
- Testing
- Ultrahigh resolution Spectral Domain OCT
- Where
- Austria
- Volunteers
- 14 people
- Sponsor
- Medical University of Vienna
Diabetic Retinopathy
Comparing 3 Imaging Systems
The purpose of this study is to evaluate the quality of ocular images captured on 3 different cameras of patients with diabetic retinopathy.
- Trial name
- COCO (NCT05022615)
- Testing
- Topcon Camera, Optos Camera, Clarus Camera
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- University of Wisconsin, Madison