Clinical trials: Ophthalmic Imaging
Progressive Supranuclear Palsy, Corticobasal Degeneration
Tau Imaging in Subjects With Progressive Supranuclear Palsy, Corticobasal Degeneration and Healthy Volunteers
This study will evaluate flortaucipir for brain imaging of tau in subjects with progressive supranuclear palsy (PSP), corticobasal degeneration (CBD) and healthy volunteers.
- Trial name
- NCT02167594
- Testing
- Flortaucipir F18, Brain PET scan
- Where
- 5 sites in United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Avid Radiopharmaceuticals
Dry Eye Syndrome, Epiphora
Optical Coherence Tomography of Ocular Structures in Epiphora and Dry Eye Syndrome.
The primary aim of the study is to investigate whether optical coherence tomography (OCT) may be a useful tool for investigating the in-vivo histology of ocular structures in patients with tear film pathology.
- Conditions
- Dry Eye Syndrome, Epiphora, Sjögren's Syndrome
- Trial name
- OCT (NCT02849093)
- Testing
- Non-invasive OCT imaging
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bedford Hospital NHS Trust
Stroke, Visual Field Defect
Visual Restoration Using Focused Ultrasound Stimulation and Immersive Virtual Reality After Stroke
This research will explore if brain stimulation combined with virtual reality therapy improves visual impairment. The stimulation technique is called low-intensity focused ultrasound stimulation (LIFUS).
- Conditions
- Stroke, Visual Field Defect, Visual Field Defect Following Cerebrovascular Accident, Hemianopia
- Trial name
- LIFU-IVR (NCT06875206)
- Testing
- Low-intensity focused ultrasound, Immersive virtual reality, Inactive Low-intensity focused ultrasound
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Duke University
Optic Disc Drusen
Spectral Domain OCT Imaging in Patients With Optic Nerve Head Drusen (Tuebingen SD-OCT IN OPTIC NERVE HEAD DRUSEN STUDY)
Optic nerve head Drusen are a mostly bilateral change of the optic nerve, eventually causing a slow, but progression loss of the visual fields.
- Trial name
- TODS (NCT02793206)
- Testing
- Imaging
- Where
- Germany
- Volunteers
- 35 people
- Sponsor
- University Hospital Tuebingen
Retinal Vascular Disorder, Macular Degeneration
Ocular Imaging Study Using Advanced OCT
The purpose of this study is to evaluate this AngioScan angiography software on patients with various retinal vascular disorders.
- Trial name
- NCT02827071
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of California, Los Angeles
Dry Eye Syndromes, Corneal Disease
Prospective Study to Validate the Imaging Biomarker for NCP (R33)
The aim of this study is establish the reliability and clinical utility of microneuromas as identified via in vivo confocal microscopy as the diagnostic biomarker for NCP.
- Trial name
- NCT05653921
- Testing
- In vivo confocal microscopy (IVCM)
- Where
- 2 sites in United States
- Volunteers
- 438 people, healthy volunteers welcome
- Sponsor
- Tufts Medical Center
Ocular Pathologies
Compact Auto-Aligning Multi-Modal Eye Imaging to Diagnose Traumatic Eye Injury
The purpose of this study is to test an investigational eye imaging device by taking pictures of participants eyes with a single image capture that takes only seconds.
- Trial name
- NCT07218835
- Testing
- Auto-aligning Ocular imaging instrument
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Duke University
Diabetes, Diabetic Retinopathy
Pivotal Trial of Automated Artificial Intelligence (AI) Based System for Early Diagnosis of Diabetic Retinopathy
In this pivotal trial, we aim to perform a prospective study to find the efficacy of iPredict-DR, an artificial intelligence (AI) based software tool on early diagnosis of Diabetic Retinopathy (DR) in the primary care and…
- Trial name
- NCT07151001
- Testing
- No intervention
- Where
- United States
- Volunteers
- 922 people, healthy volunteers welcome
- Sponsor
- iHealthScreen Inc
Eye Diseases, Eye Infections
The EXPLORE Study - The Use of Binocular OCT Imaging for the Assessment of Ocular Disease
Optical coherence tomography (OCT) is an imaging modality, first described in 1991, that provides cross-sectional images of the eye in a non-invasive manner.
- Conditions
- Eye Diseases, Eye Infections, Eye Inflammation
- Trial name
- NCT03553017
- Testing
- Binocular OCT
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- University College, London
Eye Disease
Characterization of Potential Biomarkers of Eye Disease and Vision
Characterize potential biomarkers of sight-threatening eye diseases based on the information acquired in clinical practice at CEC, AIBILI
- Trial name
- EYE-MARKER (NCT02500862)
- Where
- Portugal
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Association for Innovation and Biomedical Research on Light and Image
Retinitis Pigmentosa, Maculopathy, Age Related
High Resolution Retina Imaging
To increase the clinical experience of using the rtx1 camera in various retinal disorders and to follow the evolution of structural alterations during retinal diseases using adaptive optics imaging with the rtx1 camera
- Conditions
- Retinitis Pigmentosa, Maculopathy, Age Related, Macular Dystrophy, Macular Edema
- Trial name
- IHR (NCT04128150)
- Where
- 3 sites in France
- Volunteers
- 1,000 people
- Sponsor
- Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts
Keratoconus, High Myopia
Anterior Segment and Corneal Parameters in Keratoconus and High Myopic Astigmatism Using Schiempflug Imaging
The purpose of this study was to compare Scheimpflug corneal tomography findings in keratoconus and high myopic astigmatic eyes, as well as to establish the parameters distinguishing keratoconus from high myopic astigmatism.
- Trial name
- NCT06739018
- Testing
- pentacam scheimpflug tomography
- Where
- 2 sites in Egypt
- Volunteers
- 66 people
- Sponsor
- Assiut University
Primary Angle-Closure Glaucoma
Vitreous Zonule in Primary Angle-Closure Glaucoma
This study aims to investigate the role of the vitreous zonule (VZ) in the pathogenesis of primary angle-closure glaucoma (PACG) and to explore the feasibility of three-dimensional ultrasound biomicroscopy (3D-UBM) for imaging…
- Trial name
- NCT07523139
- Where
- China
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- Peking University People's Hospital
Retinoblastoma
PCI Imaging System in Pediatric Ophthalmology
The purpose of this study is to compare the RetCam (Clarity Medical Systems, Pleasanton, CA) to a new prototype pediatric imaging system, COSMOS, produced by Phoenix Clinical Incorporated (PCI) (Pleasanton, CA).
- Trial name
- NCT02617862
- Testing
- Examination under anaesthetic (EUA), RetCam, COSMOS
- Where
- Canada
- Volunteers
- 6 people
- Sponsor
- Brenda Gallie
Retinal Diseases, Diabetic Retinopathy
Evaluation of Diabetic Retinopathy Using Ultra-Widefield Fundus Images Compared With Two-Field Fundus Images
This study aims to compare the accuracy of evaluating diabetic retinopathy using ultra-widefield fundus images versus two-field fundus images.
- Conditions
- Retinal Diseases, Diabetic Retinopathy, Diabetes Complications, Diabetes Mellitus
- Trial name
- NCT05836194
- Where
- China
- Volunteers
- 769 people
- Sponsor
- Ningbo Eye Hospital
Eye Diseases
Imaging of Corneal and Crystalline by Near Infrared Retro-illumination
Retroillumination photography is difficult. The reflections on the cornea and the lens are constant and prevent from obtaining a complete and clear image.
- Trial name
- RETRO-ILLUMI (NCT05717543)
- Testing
- Retro-illuminator
- Where
- France
- Volunteers
- 384 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Diabetic Retinopathy
Prospective Cohort Study on Predicting the Progression of Diabetic Microangiopathy Using Multimodal Eye Imaging
To develop an artificial intelligence (AI) model to predict DR progression based on a prospective cohort database.With use of an innovative AI model and a validated machine learning algorithm, based on multimodal vascular and…
- Trial name
- NCT06727955
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Peking University Third Hospital
Coronary Artery Disease, Acute Cerebrovascular Accident
Incidence of Acute Cerebrovascular Events Using Either Minimized or Standard Cardiopulmonary Bypass Circuit
The prospective, randomized, two centre study investigates acute cerebrovascular events during extracorporal circulation and the early post operative outcome when using either the minimized cardiopulmonary bypass circuit…
- Conditions
- Coronary Artery Disease, Acute Cerebrovascular Accident, Intracranial Embolism, Embolism, Air
- Trial name
- ROCsafeTM (NCT00862160)
- Testing
- ROCsafeTM
- Where
- 2 sites in Germany
- Volunteers
- 64 people
- Sponsor
- Hannover Medical School
Macular Degeneration
Noninvasive Imaging Biomarkers of Treatable Macrovascular Disease in Age-related Macular Degeneration.
The purpose of this prospective study is to investigate whether ophthalmic artery stenosis (narrowing of the ophthalmic artery) contributes to the development and progression of geographic atrophy (GA), an advanced form of dry…
- Trial name
- NCT07798323
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Scott Raymond
Diabete Mellitus, Diabetic Retinopathy
Multi-modal Imaging and Artificial Intelligence Diagnostic System for Multi-level Clinical Application
This study is to build an multi-modal artificial intelligence ophthalmological imaging diagnostic system covering multi-level medical institutions.
- Trial name
- NCT03899623
- Where
- China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University