Clinical trials: Ophthalmic Solutions
Open Angle Glaucoma
Different Glaucoma Treatments Effect on Intraocular Pressure Fluctuation With Postural Change in Eyes With Open-angle Glaucoma
The purpose of this study is to investigate the effect of trabeculectomy, glaucoma drainage devices, cyclophotocoagulation and ocular hypotensive eye-drops on IOP elevation with postural change from the sitting to supine…
- Trial name
- NCT02868502
- Testing
- Goldmann tonometer, Pneumatonometer, Tonopen XL
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Glaucoma
The Efficacy of Citicoline in Eyedrops (OMK1) in Reducing the Progression of Glaucoma
Double-blind study (OMK1 vs. Placebo) A total of 90 patients, 30 per center, will be the study sample. The study will include patients with Primary Open angle Glaucoma (glaucoma or pseudoexfoliation) with a loss of visual field…
- Trial name
- NCT04020705
- Testing
- Citicoline eye drops (OMK1)
- Volunteers
- 90 people
- Sponsor
- Istituto di Ricerca Neuroftalmologia S.r.l.
Keratoconus
Dextenza Versus Topical Steroid Eye Drops for Postoperative Management Following Corneal Crosslinking
This study aims to compare the use of Dextenza, an FDA-approved intracanilular drug-eluting insert that is designed to deliver a tapered dose of dexamethasone to the ocular surface for 30 days, to the standard of care, or the use…
- Trial name
- NCT06235567
- Testing
- Dextenza 0.4Mg Ophthalmic Insert, topical prednisolone acetate 1% (PredForte) eye drops
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- Maanasa Indaram, MD
Diabetic Macular Edema, Age-related Macular Degeneration
A Study of MTP-131 Topical Ophthalmic Solution in Subjects With Diabetic Macular Edema and Non-Exudative Intermediate Age-related Macular Degeneration
This is a Phase 1/2, open-label, dose-escalation clinical study, enrolling 21 subjects in one of the two treatment groups to determine the effects of topical ocular administration of low dose or high dose MTP-131 given twice a…
- Trial name
- SPIOC-101 (NCT02314299)
- Testing
- MTP-131
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Stealth BioTherapeutics Inc.
Open-Angle Glaucoma, Ocular Hypertension
Efficacy and Safety of Brinzolamide/Brimonidine Fixed Combination BID Compared to Brinzolamide BID Plus Brimonidine BID in Subjects With Open-Angle Glaucoma (OAG) or Ocular Hypertension (OHT)
The purpose of this study is to compare the fixed combination (BID) [Brinzolamide 10 mg/mL / Brimonidine 2 mg/mL eyes drops, suspension] to the unfixed combination (BID) [Brinzolamide 10 mg/mL eye drops, suspension plus…
- Trial name
- NCT02339584
- Testing
- Brinzolamide 10 mg/mL / Brimonidine 2 mg/mL fixed combination eye drops, suspension, Brinzolamide 10 mg/mL eye drops, suspension, Brimonidine 2 mg/mL eye drops, solution
- Volunteers
- 493 people
- Sponsor
- Alcon Research
Dry Eye
The Effect of Systane Ultra Lubricant Eye Drops (FID 112903) on Visual Performance
To evaluate the effect of 2 different lubricant eye drops on visual function of patients with dry eye
- Trial name
- NCT00673764
- Testing
- Systane Ultra Lubricant Eye Drops, Optive Lubricant Eye Drops
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Alcon Research
Presbyopia
Safety and Efficacy Study BRIMOCHOL™ PF and Carbachol PF in Subjects With Emmetropic Phakic or Pseudophakic Presbyopia
Safety and Efficacy Study of BRIMOCHOL™ PF and Carbachol PF in Subjects With Emmetropic Phakic and Pseudophakic Presbyopia
- Trial name
- NCT05270863
- Testing
- BRIMOCHOL™ PF, Carbachol PF, Brimonidine tartrate
- Where
- 15 sites in United States
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- Visus Therapeutics
Corneal Ulcers
A Comparison of Three Fluoroquinolone Topical Eyedrops in the Treatment of Infectious Corneal Ulcers.
This Phase II study will evaluate the safety and efficacy of three fluoroquinolone ophthalmic agents to determine the optimal treatment in patients with infectious corneal ulcers.
- Trial name
- Eye02 (NCT01928693)
- Testing
- Besivance 0.6% Ophthalmic Suspension, Zymaxid 0.5% Ophthalmic Solution, Vigamox 0.5% Ophthalmic Solution
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Cornea Consultants Of Nashville
Dry Eye Disease
A Multi-Center, Double-Masked, Randomized, Vehicle-Controlled, Parallel-Group Clinical Trial Evaluating the Safety of Reproxalap Ophthalmic Solution in Subjects With Dry Eye Disease
A Multi-Center, Double-Masked, Randomized, Vehicle-Controlled, Parallel-Group Clinical Trial Evaluating the Safety of 0.25% Reproxalap Ophthalmic Solution in Subjects with Dry Eye Disease
- Trial name
- NCT04735393
- Testing
- Reproxalap Ophthalmic Solution (0.25%)
- Where
- United States
- Volunteers
- 757 people
- Sponsor
- Aldeyra Therapeutics, Inc.
Fuchs Endothelial Corneal Dystrophy
A Study to Evaluate the Safety and Efficacy of K-321 Eye Drops After Descemetorhexis in Participants With Fuchs Endothelial Corneal Dystrophy (FECD)
A study to assess the safety and efficacy of K-321 in participants with FECD after descemetorhexis.
- Trial name
- NCT05795699
- Testing
- Ripasudil
- Where
- 50 sites in United States, Canada and 4 more
- Volunteers
- 107 people
- Sponsor
- Kowa Research Institute, Inc.
Chronic Myeloproliferative Disorders, Graft Versus Host Disease
Cyclosporine Eye Drops in Preventing Graft-Versus-Host Disease of the Eye in Patients Who Have Undergone Donor Stem Cell Transplant for Hematologic Cancer or Bone Marrow Failure Disorder
RATIONALE: Cyclosporine eye drops may prevent graft-versus-host disease of the eye in patients who have undergone donor stem cell transplant for hematologic cancer or bone marrow failure disorder.
- Conditions
- Chronic Myeloproliferative Disorders, Graft Versus Host Disease, Leukemia, Lymphoma
- Trial name
- NCT00755040
- Testing
- cyclosporine ophthalmic emulsion
- Where
- 5 sites in United States
- Volunteers
- 164 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Glaucoma, Open-Angle, Ocular Hypertension
Safety and Efficacy of Three Formulations of AGN-210669 Ophthalmic Solution Compared With Bimatoprost Ophthalmic Solution
This study will evaluate the safety, efficacy and dose-response of AGN-210669. This study will also compare AGN-210669 with bimatoprost ophthalmic solution (LUMIGAN®).
- Trial name
- NCT01001195
- Testing
- AGN-210669 ophthalmic solution, 0.1%, AGN-210669 ophthalmic solution, 0.075%, AGN-210669 ophthalmic solution, 0.05%
- Where
- United States
- Volunteers
- 165 people
- Sponsor
- Allergan
Glaucoma, Ocular Hypertension
Safety and Efficacy of Triple Combination Therapy With Dorzolamide Hydrochloride / Brimonidine Tartrate / Timolol Ophthalmic Solution in Patients With Glaucoma or Ocular Hypertension
This study will investigate the safety and efficacy of Triple Combination Therapy with dorzolamide hydrochloride/brimonidine tartrate/timolol ophthalmic solution in patients with glaucoma or ocular hypertension who have elevated…
- Trial name
- NCT01284166
- Testing
- dorzolamide hydrochloride 2.0%/brimonidine tartrate 0.2%/timolol 0.5% ophthalmic solution
- Sponsor
- Allergan
Myopia
Study of Atropine Sulfate Eye Drops(0.01%) in Treating Near-work-induced Transient Myopia in Children
This study is a randomized, double-blind, placebo-controlled, parallel-group study to evaluate the safety and efficacy of atropine sulfate eye drops (0.01%) in treating transient myopia induced by near work tasks (NITM) in…
- Trial name
- NCT06697522
- Testing
- Atropine Sulfate
- Where
- China
- Volunteers
- 148 people
- Sponsor
- Ocumension Therapeutics (Suzhou) Co., Ltd
Retinopathy of Prematurity
Mother Milk as a Eye Drop & Premature Retinopathy
The aim of this study is to investigate the effect of using breast milk as eye drops on ROP (Retinopathy of prematurity) disease observed in less then 32 weeks gestational age preterm babies.
- Trial name
- NCT04883931
- Testing
- Normal Saline, Breast milk
- Where
- Turkey (Türkiye)
- Volunteers
- 101 people
- Sponsor
- Baskent University
Corneal Endothelial Cell Loss, Corneal Endothelial Damage Following the Hard Nuclear Cataract Surgery
A Study of CA201A Eye Drops to Prevent Corneal Endothelial Cell Loss in Patients Undergoing Cataract Surgery
This study is designed to assess whether an investigational eye drop called CA201A can help protect the cornea (the outer covering of the eye) and reduce damage to corneal endothelial cells following cataract surgery, without…
- Trial name
- NCT07694375
- Testing
- Ophthalmic solution (matching formulation without ascorbic acid), Ascorbic acid ophthalmic solution 5%
- Where
- 8 sites in Australia
- Volunteers
- 200 people
- Sponsor
- Caravel Oculus Pty Ltd
Ligneous Conjunctivitis
Efficacy/Safety of Human Plasminogen Eye Drop in Ligneous Conjunctivitis Patients
Kedrion Human Plasminogen, a sterile human plasma-derived plasminogen preparation for topical ocular use will be evaluated for the indication of treatment of ligneous conjunctivitis.
- Trial name
- NCT01554956
- Testing
- Human Plasminogen
- Where
- 3 sites in United States, Italy
- Volunteers
- 12 people
- Sponsor
- Kedrion S.p.A.
Keratoconus
Accelerated Corneal Cross-linking With Different Riboflavin Solutions
Following the Bunsen-Roscoe law, accelerated cross-linking protocols with higher irradiation intensities and shorter irradiation times have been introduced.
- Trial name
- NCT03187912
- Testing
- Riboflavin
- Where
- Austria
- Volunteers
- 60 people
- Sponsor
- Medical University of Vienna
Vision Disorders
Study of A New Contact Lens Cleaning and Disinfecting Solution
The objective of this study is to evaluate the safety and efficacy of a new investigational cleaning and disinfecting solution (Test) compared to Clear Care cleaning and disinfecting solution (Control) when used by contact lens…
- Trial name
- NCT01318577
- Testing
- Investigational Cleaning & Disinfecting Solution, Clear Care Solution
- Where
- United States
- Volunteers
- 444 people, healthy volunteers welcome
- Sponsor
- Bausch & Lomb Incorporated
Urea in Blood; High
Antibacterial Activity of Urea Against Ocular Bacteria
Antibacterial properties of urea was tested against 35 isolates from ocular infections.
- Trial name
- NCT04020406
- Testing
- Antibacterial Activity
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Assiut University
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