Clinical trials: Ophthalmic Solutions
Dry Eye
ALY688 Ophthalmic Solution in Subjects With Dry Eye Disease
Study Evaluating the Safety and Efficacy of Two Concentrations (0.4% and 1%) of ALY688 Ophthalmic Solution in Subjects with Dry Eye Disease
- Trial name
- OASIS-1 (NCT04899518)
- Testing
- ALY688 Ophthalmic Solution
- Where
- United States
- Volunteers
- 922 people
- Sponsor
- Allysta Pharmaceutical
Dry Eye Disease
Assessment of the Safety and Efficacy of BRM421 Ophthalmic Solutions in Dry Eye Subjects.
The objective of this study is to compare the safety and efficacy of BRM421 OS to vehicle for the treatment of the signs and symptoms of dry eye disease.
- Trial name
- NCT05695781
- Testing
- BRM421 Ophthalmic Solution, Vehicle
- Where
- United States
- Volunteers
- 740 people
- Sponsor
- BRIM Biotechnology Inc.
Dry Eye
A Study to Assess Efficacy of HL036 in Subjects With Dry Eyes
The objective of this study was to compare the safety and efficacy of 0.10% and 0.25% HL036 Ophthalmic Solutions to placebo for the treatment of the signs and symptoms of dry eye.
- Trial name
- VELOS-1 (NCT03334539)
- Testing
- HL036 ophthalmic solution
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- HanAll BioPharma Co., Ltd.
Refractive Errors, Myopia
Clinical Assessment of a HYDRAGLYDE® Regimen
The purpose of this study is to evaluate worn AIR OPTIX® plus HYDRAGLYDE® (AOHG) lenses cleaned and disinfected with HYDRAGLYDE® containing lens solutions compared to each of the control habitual silicone hydrogel (SiHy) lenses…
- Conditions
- Refractive Errors, Myopia, Hypermetropia
- Trial name
- NCT03026257
- Testing
- Lotrafilcon B contact lenses with added wetting agent, Samfilcon A contact lenses, POLYQUAD/ALDOX-preserved contact lens solution with added wetting agent
- Where
- 8 sites in United States, Canada and 1 more
- Volunteers
- 323 people
- Sponsor
- Alcon, a Novartis Company
Ocular Hypertension, Open-Angle Glaucoma
A Study of the L-PPDS With Adjunctive Xalatan® Eye Drops in Subjects With OH or OAG
The objective of this study is to investigate how the intraocular pressure (IOP)-lowering effect of the L-PPDS is altered by adjunctive Xalatan therapy.
- Trial name
- NCT01037036
- Testing
- Latanoprost Punctal Plug Delivery System, Xalatan
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Mati Therapeutics Inc.
Open Angle Glaucoma, Ocular Hypertension
DE-111 Against Tafluprost Ophthalmic Solution 0.0015% Alone and Concomitant Use of Tafluprost Ophthalmic Solution 0.0015% Plus Timolol Ophthalmic Solution 0.5%
DE-111 ophthalmic solution will be evaluated for superiority in comparison with Tafluprost 0.0015% ophthalmic solution, or for non-inferiority in comparison with Tafluprost 0.0015% and Timolol ophthalmic solution 0.5% used…
- Trial name
- NCT01342081
- Testing
- DE-111 ophthalmic solution, Tafluprost ophthalmic solution 0.0015%, Concomitant use of tafluprost ophthalmic solution 0.0015% plus timolol ophthalmic solution 0.5%
- Where
- Japan
- Volunteers
- 489 people
- Sponsor
- Santen Pharmaceutical Co., Ltd.
Dry Eye Syndromes, Lubricant Allergy
Safety and Tolerability of PRO-087 Versus Xyel Ofteno® and Systane Ultra®, on the Ocular Surface of Healthy Subjects
Phase I clinical study, to evaluate the safety and tolerability of the preservative-free ophthalmic solution PRO-087 versus Xyel Ofteno® and Systane Ultra®, on the ocular surface of ophthalmological and clinically healthy…
- Conditions
- Dry Eye Syndromes, Lubricant Allergy, Tear Disorder
- Trial name
- PRO-087/I (NCT03524157)
- Testing
- PRO-087, Systane Ultra, Xyel Ofteno
- Where
- Mexico
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Laboratorios Sophia S.A de C.V.
Primary Open-angle Glaucoma (POAG), Ocular Hypertension
Study of SHP639 Eye Drops in Adults With High Eye Pressure or Primary Open-angle Glaucoma
Safety and tolerability of three different concentrations (0.1%, 03%, 0.6%) of the investigational SHP639 eye drops will be evaluated in participants with high eye pressure or primary open-angle glaucoma.
- Trial name
- NCT03131167
- Testing
- SHP639 (n=60)
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Shire
Primary Open Angle Glaucoma of Both Eyes
Comparative Study of Dorzotimol Eye Drops, 20 mg/mL + 5 mg/mL Versus Cosopt® Eye Drops, 20 mg/mL + 5 mg/mL
The goal of this study is to compare efficacy and safety of Dorzotimol eye drops, 20 mg/mL + 5 mg/mL manufactured by JADRAN-GALENSKI LABORATORIJ d.d.
- Trial name
- NCT05973318
- Testing
- Dorzotimol eye drops, 20 mg/mL + 5 mg/mL, Cosopt eye drops, 20 mg/mL + 5 mg/mL
- Where
- Russia
- Volunteers
- 110 people
- Sponsor
- Jadran Galenski laboratorij d.d.
Geographic Atrophy, Age-Related Macular Degeneration
Geographic Atrophy Treatment Evaluation
The purpose of this study was to evaluate the safety and efficacy of AL-8309B Ophthalmic Solution versus Vehicle administered as a topical ocular drop for the treatment for geographic atrophy (GA) secondary to age-related macular…
- Trial name
- GATE (NCT00890097)
- Testing
- AL-8309B Ophthalmic Solution, AL-8309B Vehicle
- Volunteers
- 772 people
- Sponsor
- Alcon Research
Glaucoma
How Similar Are Changes to the Surface of the Eye When Two Different Glaucoma Eye Drops Are Used?
To determine whether one glaucoma eye drop is less likely to cause changes to the surface of the eye (conjunctiva) than another. The two different prostaglandins are Xalatan and Travatan Z.
- Trial name
- NCT00798694
- Testing
- Xalatan, Travatan Z
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Wills Eye
Thyroid Eye Disease
Development of an AI Solution to Evaluate Clinical Activity of TAO Using Periocular Images Taken by Smartphones in Patients With Thyroid Dysfunction
This study was conducted to develop an AI solution to evaluate clinical activity score (CAS) of thyroid associated orbitopathy (TAO) using periocular selfie images taken by smartphones in patients with thyroid dysfunction.
- Trial name
- NCT05731154
- Testing
- taking periorbital selfie images using smartphones
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Seoul National University Bundang Hospital
Healthy Volunteers
Systemic Pharmacokinetic Study of T4032 (Unpreserved Bimatoprost 0.01%) Eye Gel Versus Lumigan® 0.01% Eye Drops in 40 Healthy Volunteers
This study is being performed to compare the systemic pharmacokinetic profiles of T4032 and Lumigan 0.01% given that T4032 has a different formulation (in terms of excipients) from the reference product.
- Trial name
- NCT05729594
- Testing
- Bimatoprost Ophthalmic
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Laboratoires Thea
Ophthalmic Solutions, Glaucoma
Evaluation of a New Method for Instilling Eye Drops
The purpose of this project is to demonstrate that there is a new easier method to instill eye drops in ones own eye that is as effective as applying a drop directly to their open eye.
- Trial name
- NCT02697318
- Testing
- Timolol maleate 0.5% ophthalmic solution
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Waterloo
Ocular Hypertension
An Open-Label Study of an Ophthalmic Solution to Reduce Intraocular Pressure in Patients With Ocular Hypertension
The purpose of this study is to determine the safety and tolerability of topical C-KAD Ophthalmic Solution in reducing intraocular pressure in patients with ocular hypertension.
- Trial name
- NCT00825396
- Testing
- C-KAD Ophthalmic Solution
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Chakshu Research, Inc.
Cataract Surgery
Study of DE-108 Ophthalmic Solution in Patients Who Are Scheduled for Cataract Surgery
The purpose of this study is to evaluate superior efficacy of DE-108 ophthalmic solution to that of Levofloxacin 0.5% ophthalmic solution as well as safety of the former used for perioperative bacteria eradication in patients who…
- Trial name
- NCT02573610
- Testing
- DE-108, Levofloxacin 0.5%
- Where
- 6 sites in South Korea
- Volunteers
- 576 people
- Sponsor
- Santen Pharmaceutical Co., Ltd.
Dry Eye Disease
A Phase 2b Study Evaluating the Safety and Efficacy of AR-15512 Ophthalmic Solution for the Treatment of Dry Eye Disease
This is a Phase 2b, multicenter, vehicle-controlled, double-masked, randomized study. All subjects enrolled will have dry eye disease.
- Trial name
- COMET-1 (NCT04498182)
- Testing
- AR-15512 Ophthalmic Solution, AR-15512 Ophthalmic Solution Vehicle
- Where
- 15 sites in United States
- Volunteers
- 369 people
- Sponsor
- Aerie Pharmaceuticals
Dry Eye Disease
Evaluation of Tear Film Quality and Stability in Subjects With Dry Eye Disease Using OC-01 (Varenicline Solution) Nasal Spray 0.03 mg as Compared to Vehicle Control Nasal Spray
A randomized, controlled, double-masked, investigator-initiated trial to evaluate tear film quality and stability in subjects with dry eye disease using OC-01 (varenicline solution) nasal spray 0.03 mg as compared to vehicle…
- Trial name
- TSUNAMI (NCT05514041)
- Testing
- Varenicline solution
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Stephenson Eye Associates
Dry Eye
A Study to Evaluate the Safety and Efficacy of VSJ-110 Compared to Placebo in the Treatment of Dry Eye
The purpose of this study is to determine the safety and efficacy of VSJ-110 compared to placebo in the treatment of dry eye.
- Trial name
- NCT06296966
- Testing
- VSJ-110
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Vanda Pharmaceuticals
Congenital Hereditary Endothelial Dystrophy of Cornea
CHED - Congenital Hereditary Endothelial Dystrophy: New Paradigm Shift in Therapy Using Topical Eye Drops
CHED- Congenital Endothelial Endothelial Dystrophy is a condition that causes corneal cloudiness. Since, currently only surgery is being done to cure this condition, we are taking up the research of using topical eye drops for…
- Trial name
- NCT04843839
- Testing
- Nepafenac 0.1% Oph Susp, Refresh Tears 0.5% Lubricant Eye Drops
- Where
- India
- Volunteers
- 30 people
- Sponsor
- L.V. Prasad Eye Institute
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