Clinical trials: Ophthalmic Surgery
Myopia, Myopic Astigmatism
A Study of Artificial Intelligence Assisted Small Incision Lenticule Extraction (SMILE) for Surgical Design and Influencing Factors
The goal of this observational study is to learn about the difference of refractive outcomes between Artificial Intelligence and experienced surgeon predicting Nomogram assist SMILE surgical design and the influenced factors of…
- Trial name
- NCT06229301
- Testing
- AI-predicted Nomogram
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Tianjin Eye Hospital
Strabismus
Japanese Strabismus Outcomes Assessment and Research Group Study
This retrospective study constructs the largest multicenter registry of strabismus care in Japan. The registry evaluates real-world surgical and conservative treatment outcomes, safety, and natural history for various types of…
- Trial name
- J-SOAR (NCT07763457)
- Testing
- Strabismus Surgery, Conservative Treatment or Observation
- Where
- Japan
- Volunteers
- 10,000 people
- Sponsor
- Kyoto University, Graduate School of Medicine
Myopia, Refractive Ametropia
Comparison of Two Rotational Alignment Methods for Astigmatism Correction in SMILE Surgery
Small incision lenticule extraction (SMILE) is a commonly used corneal refractive procedure for correcting myopia and myopic astigmatism.
- Trial name
- NCT07696468
- Testing
- Device-assisted cyclotorsion control during SMILE, Manual limbal marking-guided cyclotorsion adjustment during SMILE
- Where
- China
- Volunteers
- 52 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Spinal Surgery, Prone Position
A Prospective Observational Study on Factors Affecting Optic Nerve Sheath Diameter and Visual Acuity in Prone Spinal Surgery
The prone position in spinal surgery can alter intracranial pressure and optic nerve sheath diameter (ONSD) and potentially lead to visual complications.
- Trial name
- PRONE-ONSD (NCT07395115)
- Where
- Turkey (Türkiye)
- Volunteers
- 65 people
- Sponsor
- Istanbul University - Cerrahpasa
Cataract
Prophylactic Treatment: Lessdrops™ vs Standard Drops Regimen
To compare the use of a compounded eye drop containing an antibiotic, a non-steroidal and steroidal anti-inflammatory to standard of care that is the use of 3 different topical medications to prevent inflammation and infection…
- Trial name
- NCT03578276
- Testing
- Pred-Gati-Brom, Prednisolone acetate 1% ophthalmic suspension, Gatifloxacin Ophthalmic
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Carolina Eyecare Physicians, LLC
Surgery, Eye Diseases
Self-adherent Wrap Techniques for Orbital Surgery
The purpose of this study is to evaluate the interface pressure measurements of applying self-adherent wraps on eyes after orbital tumour extirpation.
- Trial name
- NCT03415490
- Testing
- Folded technique of self-adherent wrap, Classic technique of self-adherent wrap
- Where
- China
- Volunteers
- 128 people
- Sponsor
- Sun Yat-sen University
Cataract Senile
Performance of Two Intraocular Lenses With Extended Depth of Vision
Comparison of the capsular bag performance of two extended depth of vision (EDOF) intraocular lenses (IOLs), the Rayone EMV and the Alcon Acrysof IQ Vivity, in a mini-monovision setting
- Trial name
- NCT05194150
- Testing
- non-diffractive monofocal IOL, standard EDOF IOL
- Where
- Austria
- Volunteers
- 48 people
- Sponsor
- Vienna Institute for Research in Ocular Surgery
Ischemic Optic Neuropathy
Safety and Efficacy of Using SightSaver Visual Evoked Potential (VEP) for VEP Monitoring in Prone Spine Surgery
Post-operative visual loss (POVL) following non-ocular surgical procedures is an infrequent but severe complication. Little is understood about this complication, but most cases seem to result from loss of blood flow to the optic…
- Trial name
- SightSaver (NCT02643615)
- Testing
- VEP under TIVA, VEP under balanced anesth., Propofol
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Ohio State University
Cataract, Refractive Errors
Panoptix Trifocal Lens in Post Refractive Myopic Laser Vision Correction Surgery
The two main objectives of this study are to demonstrate safety and effectiveness of implanting the PanOptix Trifocal IOL in patients who have had previous myopic Lasik.
- Trial name
- NCT04698278
- Testing
- PanOptix Trifocal Intraocular Lens
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Parkhurst NuVision Clinical Research LLC
Cataract
Loteprednol vs Prednisolone for the Treatment of Intraocular Inflammation Following Cataract Surgery in Children.
The objective of this study is to compare the efficacy and safety for the treatment of postoperative inflammation following ocular surgery for childhood cataract.
- Trial name
- NCT01475643
- Testing
- Loteprednol etabonate, Prednisolones acetate
- Where
- United States
- Volunteers
- 107 people
- Sponsor
- Bausch & Lomb Incorporated
Strabismus
Propofol Versus Sevoflurane Anesthesia in Pediatric Strabismus Surgery: Feasibility of BIS Monitoring
This study is conducted to evaluate importance of bispectral index (BIS) monitoring in patients undergoing strabismus surgery when using propofol in comparison to sevoflurane anesthesia regarding their effects on oculocardiac…
- Trial name
- NCT04485117
- Testing
- Bispectral Index Monitor, Laryngeal Mask Airway, Sevoflurane
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sameh Fathy
Blepharoptosis, Ecchymosis; Eyelid
Fibrin Sealant in Eyelid Surgery
This study is looking at the effect of Tisseel in eyelid surgery. Fibrin sealants (Tisseel) cause there to be less bleeding during surgery. Surgeons have used Tisseel for over two decades to reduce bruising.
- Trial name
- NCT05358977
- Testing
- Tisseel
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Glaucoma, Open-Angle
Investigation of the iStent Inject® Devices in Open-Angle Glaucoma
The aim of this study is to evaluate the safety and intraocular pressure (IOP) lowering effect of two iStent inject devices in combination with cataract surgery in patients with mild-to-moderate open-angle glaucoma.
- Trial name
- NCT03624699
- Testing
- Glaukos iStent inject®
- Where
- Switzerland
- Volunteers
- 42 people
- Sponsor
- Dr. Kaweh Mansouri
Hyperopia
Safety and Effectiveness Study of the MEL 80 Excimer Laser Using LASIK in the Treatment of Hyperopia
The purpose of this study is to determine whether the MEL 80 Excimer Laser is effective in the treatment of hyperopia, when used as part of the Laser In Situ Keratomileusis (LASIK) procedure.
- Trial name
- NCT00762281
- Testing
- MEL 80 Hyperopic LASIK Treatment
- Where
- 6 sites in United States
- Volunteers
- 189 people, healthy volunteers welcome
- Sponsor
- Carl Zeiss Meditec, Inc.
Epiretinal Membranes
Prognostic Factors in Epiretinal Membrane Surgery
Retrospective interventional case series study reporting preoperative clinical and anatomical factors associated with visual recovery 1 year after combined cataract and idiopathic epiretinal membrane surgery.
- Trial name
- NCT02406430
- Testing
- a combined cataract and ERM surgery
- Volunteers
- 142 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Open Angle Glaucoma
Inferonasal MIMS® Procedure: Long-Term Follow-Up Extension Study
A long-term (24 and 30 months) follow-up extension, prospective, non-interventional, open label study for data collection from subjects who underwent prior MIMS® inferonasal surgery, in continuation of the previous clinical…
- Trial name
- NCT06577857
- Testing
- Inferonasal Minimally Invasive Micro Sclerostomy
- Where
- Armenia
- Volunteers
- 44 people
- Sponsor
- Sanoculis Ltd
Cataract
Guangdong Uptake of Surgery Trial
The purpose of this study is: 1. To determine whether an educational intervention designed based on studies in the area is effective in increasing acceptance of surgery and presentation to the hospital, when adjusting for a…
- Trial name
- GUSTO (NCT01123928)
- Testing
- Video and counseling for cataract patients
- Where
- China
- Volunteers
- 434 people
- Sponsor
- Sun Yat-sen University
Pterygium, Recurrence
Surgical Result of Pterygium Extended Removal Followed by Fibrin Glue Assisted Amniotic Membrane Transplantation
The treatment of pterygium is still quite controversial. Previous studies using a large incision for pterygium excision and a large graft and has reported a very low recurrence rate with the P.E.R.F.E.C.T. technique.
- Trial name
- NCT02015000
- Testing
- P.E.R.F.A.M.T
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
Lens Luxation, IOL Subluxation
Long-term Results of Two Surgical Methods for Scleral IOL Implantation and Fixation in Eyes Without Capsular Support: Yamane- Versus 4-flanged Technique
This study is a comparison of the surgical techniques and postoperative outcome between the two intrascleral IOL fixation techniques: Yamane technique versus the 4-flanged technique.
- Conditions
- Lens Luxation, IOL Subluxation, IOL Opacification, Aphakia - No Lens Capsule
- Trial name
- YAMPOINT (NCT06102109)
- Testing
- Pars plana vitrectomy, IOL explantation, Scleral IOL fixation Yamane Technique
- Where
- Austria
- Volunteers
- 100 people
- Sponsor
- Medical University of Vienna
Open Angle Glaucoma (OAG)
Safety and Performance Study of the CyPass System Applier Model 241
This is a retrospective chart review of cases in which the CyPass Micro-Stent was implanted using the Model 241 Applier. The objective of this study is to characterize and evaluate the safety of the Model 241 Applier when used…
- Trial name
- RePASS (NCT02228577)
- Where
- Germany
- Volunteers
- 172 people
- Sponsor
- Transcend Medical, Inc.
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