Clinical trials: Ophthalmic Surgery
Cataract, Cataract Surgery
Outcomes of High vs Physiological Intraocular Pressure During Cataract Surgery Using ACTIVE SENTRY
Cataract surgery is a widely performed procedure across the world that helps restore vision in many patients suffering from cataracts. Irrigation is an essential component of the surgery.
- Conditions
- Cataract, Cataract Surgery, Cataract Bilateral
- Trial name
- ACTIVESENTRY (NCT06611670)
- Testing
- Cataract surgery with Active Sentry, Traditional cataract surgery
- Where
- Canada
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Eyelid Diseases, Periorbital Disorder
The Role of Local Tranexamic Acid on Periorbital Oculoplastic Surgery
This study investigates the effect of tranexamic acid, a medication that helps reduce bleeding, in patients undergoing surgeries around their eyes.
- Conditions
- Eyelid Diseases, Periorbital Disorder, Hemorrhage, Surgical Blood Loss
- Trial name
- NCT05672407
- Testing
- Tranexamic acid
- Sponsor
- University of Miami
Diabetic Retinopathy
Safety and Efficacy of Intravitreal Ranibizumab as a Preoperative Adjunct Treatment Before Vitrectomy Surgery in Proliferative Diabetic Retinopathy (PDR) Compared to Vitrectomy Alone
This study investigates the hypothesis that ranibizumab injection given into the eye is a safe, efficacious and helping treatment option applied before surgical intervention of the proliferative diabetic retinal eye disorder.
- Trial name
- VITARM (NCT00931125)
- Testing
- ranibizumab and vitrectomy, vitrectomy without preoperative ranibizumab
- Where
- Hungary
- Volunteers
- 70 people
- Sponsor
- Attila Vajas
Corneal Edema, Corneal Defect
Assessing eFficacy and Safety of DEXTENZA 0.4 mg inseRt, Following Corneal Transplant Surgery
Assessing the efficacy and safety of DEXTENZA, sustained release dexamethasone 0.4 mg insert following corneal transplant surgery (PKP, DSEK, DMEK) as compared to topical prednisolone acetate 1%.
- Conditions
- Corneal Edema, Corneal Defect, Corneal Transplant, Penetrating KeratoPlasty
- Trial name
- NCT04521140
- Testing
- Dextenza 0.4Mg Ophthalmic Insert, Prednisolone Acetate 1% Oph Susp
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Nicole Fram M.D.
Cataracts
Comparison of Centurion® Vision System With Balanced Tip and the Infiniti® Vision System With the Mini Flared Kelman (MFK) Tip During Cataract Extraction Surgery of Hard Lenses
The purpose of this study is to demonstrate that the Centurion® Vision System (CVS) used with the 45° Balanced Tip will result in less Cumulative Dissipated Energy (CDE) than the lnfiniti® Vision System (IVS) used with the 45°…
- Trial name
- NCT02502526
- Testing
- Centurion® Vision System, 45° Balanced Tip, Centurion® Vision System, 45° MFK Tip, lnfiniti® Vision System, 45° MFK Tip
- Volunteers
- 231 people
- Sponsor
- Alcon Research
Dry Eye Disease
Study of Application of Pulse Electrical Stimulation Around Eye in Dry Eye Disease Patients Who Are Scheduled for Laser Epithelial Keratomileusis (LASEK) Surgery
This study aims to evaluate the efficacy and safety of applying pulse Electrical Stimulation around eye after laser keratoplasty (LASEK) in patients with dry eye syndrome.
- Trial name
- NCT06120348
- Testing
- Charge-Balanced, Symmetric Nerve Stimulation
- Where
- 6 sites in South Korea
- Volunteers
- 178 people
- Sponsor
- Nu Eyne Co., Ltd.
Cataract
Evaluating Patient Satisfaction After Cataract Surgery With Multifocal Intraocular Lens
Multifocal lens allow most patients to be spectacle-free after cataract surgery. Most studies published up-to-date have focused on visual acuity, but not on patient-reported outcomes.
- Trial name
- NCT03787576
- Testing
- Cataract surgery
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Clínica Rementería
Ophthalmologic Complication, Epiretinal Membrane
Measuring Subjective Quality of Vision and Metamorphopsia Before and After Epiretinal Membrane and Macular Hole Surgery
Assessing metamorphopsia and quality of vision pre and post epiretinal and macular hole surgery
- Conditions
- Ophthalmologic Complication, Epiretinal Membrane, Metamorphopsia, Macular Holes
- Trial name
- MQUEST (NCT05171621)
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Hayley Westwood
Glaucoma, Open-Angle
Silicone Tube for the Surgical Treatment of Glaucoma
The biocompatible silicone tube miniature drainage device is a small, non-valved implant to shunt aqueous humor underneath the conjunctiva to control the intraocular pressure.
- Trial name
- NCT03558126
- Testing
- silicone tube
- Volunteers
- 36 people
- Sponsor
- yin ying zhao
Pituitary Adenoma, Visual Impairment
Clinical Study of Structural and Functional Evaluation of the Visual Pathway
Sellar area tumors such as pituitary adenoma, craniopharyngioma and meningioma, etc, commonly lead to visual impairment symptoms.
- Conditions
- Pituitary Adenoma, Visual Impairment, Sellar Tumor, Neuroimaging
- Trial name
- NCT03591315
- Testing
- resting state fMRI, visual tasking state fMRI, diffusion tensor imaging
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Xiangya Hospital of Central South University
Surgery--Complications, Retinoblastoma Bilateral
Sutures in Orbital Implants in Retinoblastoma Patients
The purpose of this study is to evaluate different sutures for orbital implants in retinoblastoma patients.
- Trial name
- NCT04383860
- Testing
- 5-0 suture, 4-0 suture
- Volunteers
- 132 people
- Sponsor
- Sun Yat-sen University
Diabetic Retinopathy, Diabetic Cataract
Pars Plana Vitrectomy Combined With Phacoemulsification Cataract Surgery in Phakic Diabetes Retinopathy Patients
Pars plana vitrectomy (PPV) is one of the most widely used surgical therapies to proliferative diabetic retinopathy in the world.
- Trial name
- NCT04729023
- Testing
- Pars plana vitrectomy combined with cataract surgery., Pars plana vitrectomy with subsequent cataract surgery.
- Where
- China
- Volunteers
- 129 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
VR-based Informed Consent, Cataract and Intraocular Lens Surgery
VR for Cataract Anxiety Lowering Management
Cataract is currently the leading cause of blindness globally, and surgery is the only effective treatment. With the advancement of medical technology, cataract surgery is usually performed under topical anesthesia, which means…
- Trial name
- VR-CALM (NCT07586280)
- Testing
- Virtual reality simulation of intraoperative audiovisual experience
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Epiretinal Membrane, Macular Pucker
Perioperative Topical Nepafenac After Epiretinal Membrane Surgery
This prospective comparative study evaluates whether perioperative topical nepafenac improves early anatomical and functional recovery after pars plana vitrectomy with epiretinal membrane and internal limiting membrane peeling.
- Trial name
- NEPERM (NCT07736690)
- Testing
- Nepafenac 0.1% Ophthalmic Suspension, Pars Plana Vitrectomy With Epiretinal Membrane and Internal Limiting Membrane Peeling
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ankara Yildirim Beyazıt University
Blepharitis, Dry Eye Syndrome
Treatment of Meibomian Gland Dysfunction Prior to Cataract Surgery
The purpose of this pilot feasibility study is to assess whether treating meibomian gland dysfunction (MGD) prior to cataract surgery helps promote meibomian gland function, visual quality and ocular comfort after cataract…
- Trial name
- NCT01808560
- Testing
- LipiFlow Pre-Treatment, LipiFlow Post-treatment
- Where
- 7 sites in United States
- Volunteers
- 34 people
- Sponsor
- TearScience, Inc.
Macular Edema, Cystoid, Vision Disorders
Intraoperative Dexamethasone Implant Improves Outcome of Cataract Surgery With Diabetic Macular Edema
This study is undertaken to determine the effect of intravitreal long acting dexamethasone implant, (Ozurdex®) in improving outcome of cataract surgery in patients with diabetic macular edema.
- Conditions
- Macular Edema, Cystoid, Vision Disorders, Diabetic Macular Edema, Cystoid Macular Edema Following Cataract Surgery
- Trial name
- NCT01546402
- Testing
- Dexamethasone Drug delivery system (Ozurdex), Cataract surgery
- Where
- India
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Marfan Syndrome, Lens Subluxation or Dislocation
Surgical Treatment of Marfan Syndrome With Subluxation Lens
To analyze the postoperative visual effects, and to compare the safety and efficacy of different surgical treatment with of Marfan Syndrome with subluxation lens.
- Trial name
- NCT05578469
- Testing
- surgical treatment of Marfan Syndrome with subluxation lens
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Ectasia
Intrastromal Corneal Ring for Ectasia After Refractive Surgery (Anel)
To evaluate the clinical outcomes of intrastromal corneal ring segment (ICRS) implantation to correct keratoconus on eyes with prior refractive surgery.
- Trial name
- NCT02008253
- Testing
- INTRASTROMAL CORNEAL RING SEGMENT
- Where
- Brazil
- Volunteers
- 29 people
- Sponsor
- Instituto de Olhos de Goiania
Conjunctival Diseases, Pterygium
The Use of Natural Latex Biomembrane in Ocular Surface Reconstruction
The main problem of ocular surface reconstruction is the lack of viable conjunctival tissue. The use of a biocompatible latex biomembrane in ocular surface healing, like post pterygium surgery, could be an alternative therapeutic…
- Trial name
- NCT01250353
- Testing
- pterygium surgery
- Where
- Brazil
- Volunteers
- 127 people
- Sponsor
- University of Sao Paulo
Open Angle Glaucoma (OAG) Surgeries, Deep Sclerectomy
Deep Sclerectomy With Scleral Bed Fenestration Versus Trabeculectomy in Medically Uncontrolled Primary Open Angle Glaucoma Patients
this study tries to find the efficacy of adding certain modifications to deep sclerectomy in primary open angle glaucoma patients who can no be controlled by medical therapy and if it can reach trabeculectomy efficacy or not
- Conditions
- Open Angle Glaucoma (OAG) Surgeries, Deep Sclerectomy, Open Angle Glaucoma (OAG)
- Trial name
- NCT07800637
- Testing
- deep sclerectomy with scleral bed fenestration, Trabeculectomy
- Where
- Egypt
- Volunteers
- 39 people
- Sponsor
- Minia University
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