Clinical trials: Ophthalmic Surgery
Prone Position, Blood Volume
The Effect of High vs. Low Fluid Volume on Ocular Parameters in Prone Spine Surgery
The purpose of this trial is to compare the effect of different fluid volume infusion on ocular parameters in patients undergoing spine surgery in prone position.
- Conditions
- Prone Position, Blood Volume, Intraocular Pressure
- Trial name
- NCT03890510
- Testing
- Ringer's Lactate solution, Spine surgery under general Anesthesia in the prone position
- Where
- China
- Volunteers
- 97 people
- Sponsor
- Huashan Hospital
Open Angle Glaucoma, Ocular Hypertension
Pilocarpine After Combined Cataract/Trabectome Surgery
Combined cataract + trabectome surgery is a surgery designed to help lower the intraocular pressure (pressure in the eye) and hopefully reduce the need for topical drops, progression of glaucoma, and/or further glaucoma…
- Trial name
- PACCT (NCT04005079)
- Testing
- Pilocarpine, Ofloxacin, Prednisolone
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Dry Eye, Dry Eye Disease (DED)
Temporary Tear Duct Filling With Hyaluronic Acid Gel and Assessment of Dry Eye Disease (DED) After Bilateral Cataract Surgery
Dry eye disease can occur or worsen after cataract surgery and may cause ocular discomfort and reduced visual quality. Standard treatment commonly includes artificial tear eye drops, which provide temporary lubrication.
- Conditions
- Dry Eye, Dry Eye Disease (DED), Dry Eye Sensation After Cataract Surgery
- Trial name
- TANAMI (NCT07809022)
- Testing
- LACRIFILL® Canalicular Gel administration
- Where
- Austria
- Volunteers
- 25 people
- Sponsor
- Medical University of Vienna
Glaucoma, Glaucoma, Open-Angle
Dresden Glaucoma and Treatment Study (DGTS)
To assure the quality of follow-up and treatment, data of glaucoma patients are stored and evaluated after anonymisation.
- Conditions
- Glaucoma, Glaucoma, Open-Angle, Glaucoma, Angle-Closure, Glaucoma, Low Tension
- Trial name
- NCT02959242
- Where
- Germany
- Volunteers
- 10,000 people
- Sponsor
- Technische Universität Dresden
Pterygium
Assessment of Low-temperature Plasma Surgery System in Pterygium With Fibrin Glue and Conjunctival Autografts
Pterygium is a wing-shaped fibrovascular tissue that has proliferated onto the cornea. Ultraviolet radiation and hot, dusty, windy, dry, smoky environments are regarded as risk factors for pterygium .
- Trial name
- NCT03204084
- Testing
- Low-temperature Plasma Surgery System
- Volunteers
- 56 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Cataract Surgery
Proficiency of Eye Drop Instillation in Postoperative Cataract Patients in Ghana
Eye drops must be proficiently instilled to prevent infections following cataract surgery. Proficiency is defined as placing a drop on the ocular surface without touching the applicator's tip.
- Trial name
- NCT01181752
- Where
- Ghana
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Refractive Surgery, Refractive Error - Myopia
Evaluate the Safety and Effectiveness of the AccuraSee™ IOPCL for Secondary Implantation in the Capsular Bag to Improve Near and/or Intermediate Vision Following Previous Cataract Surgery
This is a study to evaluate the safety and effectiveness of the AccuraSee™ intraocular pseudophakic capsular lens (IOPCL) to improve near and/or intermediate vision following previous cataract surgery.
- Trial name
- NCT06625749
- Testing
- Accurasee™ IOPCL
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- OnPoint Vision Inc
Open Angle Glaucoma, Ocular Hypertension
The A D A G I O Study
This study aims to investigate the effect of different types of glaucoma surgery on aqueous dynamics parameters (IOP, aqueous flow rate, trabecular outflow facility and uveoscleral outflow) in patients with uncontrolled open…
- Trial name
- NCT06455683
- Testing
- Glaucoma Surgery
- Volunteers
- 150 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Dry Eye Syndromes, Cataract
A Study of Sodium Carboxymethylcellulose for Post Cataract Surgery Dry Eye Symptoms
This study will evaluate the effect of sodium carboxymethylcellulose eye drops in the treatment of dry eye after cataract surgery.
- Trial name
- RLOTUS (NCT02028754)
- Testing
- Sodium Carboxymethylcellulose, Levofloxacin, Prednisolone
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Allergan
Diabetic Retinopathy, Proliferative Vitreoretinopathy
Molecular Taxonomy of Surgically-harvested Ocular Tissues Defined by Single-cell Transcriptomics
The surgically-harvested eye tissue (ie. vitreous-retinal proliferative membrane, outflow pathway, retinas, and pterygium) is a complex tissue responsible for maintaining intraocular homeostasis or mediating ocular pathogenesis.
- Conditions
- Diabetic Retinopathy, Proliferative Vitreoretinopathy, Pterygium, Glaucoma
- Trial name
- Eyesinglecell (NCT04682054)
- Testing
- ocular surgery
- Where
- China
- Volunteers
- 80 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Cataract in Child
FLACS in Pediatric Patients Using FEMTO LDV-Z8
This study is a single center prospective observational case series. The framework of this clinical investigation is post market clinical follow up of pediatric FLACS using the Femto LDV Z8.
- Trial name
- NCT05241756
- Testing
- FLACS using FEMTO LDV-Z8
- Where
- Belgium
- Volunteers
- 12 people
- Sponsor
- Ziemer Ophthalmic Systems AG
Aphakia, Corneal Astigmatism
Evaluation of the Safety and Performance of the HARMONI® Toric Lens
The purpose of this study was to evaluate the safety and effectiveness of the HARMONI® Modular Intraocular Lens System with a toric optic (HMTIOL) in subjects with pre-existing corneal astigmatism in need of cataract surgery.
- Conditions
- Aphakia, Corneal Astigmatism, Cataract
- Trial name
- NCT03050697
- Testing
- HARMONI® Modular Toric Intraocular Lens, Cataract extraction with intraocular lens (IOL) implantation
- Where
- New Zealand
- Volunteers
- 16 people
- Sponsor
- ClarVista Medical
Intraocular Pressure
Ocular-hypertensive Response to Topical Steroids in Children After Bilateral Strabismus Surgery
This study aims to compare the effects of topical (Rimexolone versus Dexamethasone) on the IOP in children under 13 years of age who underwent bilateral strabismus surgery, and to compare the effects of topical (Rimexolone versus…
- Trial name
- NCT02816905
- Testing
- 0.1 % Dexamethasone, 0.1% Fluorometholone, 1% Rimexolone
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Glaucoma
Use of Bevacizumab to Modulate the Outcomes of Trabeculectomy Surgery
Vascular epithelial growth factor (VEGF) plays a critical role in vessel growth and wound healing. Bevacizumab, a non specific VEGF inhibitor, has been successfully used for the treatment of eye diseases associated with…
- Trial name
- NCT01229202
- Testing
- Bevacizumab
- Where
- Canada
- Sponsor
- Nova Scotia Health Authority
Cataract
Comparison of Two Non-diffractive Enhanced Monofocal Intraocular Lenses
Comparison of the clinical performance of two enhanced monofocal IOLs with similar design.
- Trial name
- NCT06345820
- Testing
- Evolux, Tecnis Eyhance
- Where
- Austria
- Volunteers
- 35 people
- Sponsor
- Vienna Institute for Research in Ocular Surgery
Open Angle Glaucoma
Surgical Treatment of Refractory Open Angle Glaucoma
The primary objective of this study is to evaluate the safety, efficacy, and performance of the Suprachoroidal Dissection Instrument in creating a fistula between Schlemm's canal and the suprachoroidal space in refractory, open…
- Trial name
- NCT01212861
- Testing
- Suprachoroidal Dissection Instrument (SDI)
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- iScience Interventional Corporation
Cataracts
Intra-operative Measurements to Predict the Position of the Intraocular Lens Post-operatively
Refractive outcome after cataract surgery mainly depends on the prediction of the intraocular lens that is implanted in the eye during surgery.
- Trial name
- NCT01867541
- Volunteers
- 70 people
- Sponsor
- Prim. Prof. Dr. Oliver Findl, MBA
Endophthalmitis
Safety and Efficacy of Intracameral Zimoxin for Prevention of Endophthalmitis After Cataract Surgery
Intracameral injection of 0.1% moxifloxacin solution after cataract surgery to prevent endophthalmitis
- Trial name
- NCT03244072
- Testing
- Moxifloxacin
- Where
- United States
- Volunteers
- 60,000 people, healthy volunteers welcome
- Sponsor
- Jason Ahee, M.D.
Basedow Disease
Clinical and Surgical Outcomes of Total Thyroidectomy in Basedow's Disease: the Effect of Lugol Solution
Preoperative preparation of patient with Basedow's disease is crucial to avoid severe thyrotoxicosis resulting from leakage of thyroid hormone into the circulation at the time of surgery.
- Trial name
- BALU (NCT05784792)
- Testing
- Lugol -
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- University of Padova
Blepharoptosis
Saline Injection - Assisted Anesthesia in Eyelid Surgery
The investigators hypothesize that injection of saline to the upper eyelids prior to lidocaine/adrenaline injection will reduce pain of the local anesthetic in comparison to injection of lidocaine alone.
- Trial name
- NCT01239498
- Testing
- Injection of Saline + Lidocaine/Adrenaline, Lidocaine/Adrenaline only
- Where
- 2 sites in Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
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