Clinical trials: Opiate Addiction
Opioid Dependence, on Agonist Therapy
Multi-Center, Open-Label, 24-Week Study of OX219 Safety and Efficacy for Maintenance Treatment of Opioid Dependence
The purpose of this study was to assess safety, efficacy, and treatment retention following extended treatment with OX219, a higher-bioavailability buprenorphine/naloxone (BNX) sublingual tablet formulation in opioid-dependent…
- Trial name
- NCT01903005
- Testing
- Higher bioavailability BNX sublingual tablets
- Where
- 28 sites in United States
- Volunteers
- 668 people
- Sponsor
- Orexo AB
Opiate Addiction, Pregnancy
Immediate Postpartum Nexplanon Placement in Opioid Dependent Women
The investigators have designed a single site, Phase IV open label, prospective observational clinical trial to compare the effect of immediate postpartum Nexplanon placement (IPP) versus standard postpartum contraceptive care…
- Conditions
- Opiate Addiction, Pregnancy, Contraceptive Behavior, Sexual Behavior
- Trial name
- NCT02657148
- Testing
- Nexplanon (etonogestrel contraceptive implant), Standard postpartum contraceptive care
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Pittsburgh
Opioid Use Disorders
Clinical Trial of CAM2038, Long-acting Subcutaneous Buprenorphine Injections for Treatment of Patients With Opioid Dependence
Phase III, randomized, double-blind, double-dummy, active-controlled, parallel group multi-center trial, designed to evaluate the non-inferiority of CAM2038 compared to an existing standard of care (SL BPN/NX) in initiation and…
- Trial name
- NCT02651584
- Testing
- CAM2038 SC injection, SL BPN/NX tabs
- Where
- 36 sites in United States
- Volunteers
- 428 people
- Sponsor
- Braeburn Pharmaceuticals
Polymorphism-Genetic, Pain
Genetic Effects on Dopamine Response to an Opiate
Background: Small differences in genes may alter responses to drugs. One gene that has different forms is the mu opioid receptor gene. People with one form of this gene are more sensitive to alcohol.
- Conditions
- Polymorphism-Genetic, Pain, Addiction
- Trial name
- NCT01878006
- Testing
- Morphine
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Opioid-Related Disorders, Pregnancy
Opioid Dependence Treatment Therapies in Pregnancy
The incidence of opioid dependence in pregnancy increased over the last decade from 1.2 to 5.8 per 1,000 hospital births per year.1 While methadone is the current, standard treatment for opioid dependent (OD) pregnant women…
- Trial name
- NCT03098407
- Testing
- Buprenorphine, Methadone
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
HIV Infections, AIDS
The CORE Buprenorphine Project - An HIV Primary Care Program Demonstration
The goal of this study is to develop and evaluate an innovative model of care to better serve patients who are both HIV-infected and opioid-dependent.
- Conditions
- HIV Infections, AIDS, Opiate Dependence, Post-Traumatic Stress Disorders
- Trial name
- BUP (NCT00227357)
- Testing
- On-site - buprenorphine/naloxone (Suboxone), Off-site - methadone or no agonist
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- Ruth M. Rothstein CORE Center
Opiate Dependence
Reengineering Methadone Treatment Study of Patient-centered Methadone Treatment
The purpose of the study is to determine whether a change in the rules and staff roles in methadone treatment programs will result in greater lengths of stay in treatment and lower rates of heroin and cocaine use, crime and…
- Trial name
- NCT01442493
- Testing
- Patient-Centered Methadone Treatment, Methadone Treatment as usual
- Where
- 2 sites in United States
- Volunteers
- 300 people
- Sponsor
- Friends Research Institute, Inc.
Hepatitis C
Hepatitis C Education for Pregnant Women With Opiate Addiction - Phase 1
The goal of this study is to assess the health literacy level of patients enrolled in the HOPE program, identify any gaps in their knowledge of hepatitis C, analyze the variables that may influence patients' knowledge, and…
- Trial name
- NCT03245931
- Testing
- Qualitative Interview
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- TriHealth Inc.
Opiate Addiction, Borderline Personality Disorder
Evaluation of DBT Compared to Drug Counseling for Opiate Addicts
The purpose of this study is to compare a one year treatment program of Dialectical Behavior Therapy (DBT) + suboxone for opiate addicted individuals meeting criteria for borderline personality disorder (BPD) to a one year…
- Trial name
- NCT00117741
- Testing
- Dialectical Behavior Therapy, Drug Counseling
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- University of Washington
Low Back Pain
Buprenorphine and Methadone for Opioid-dependent Chronic Back Pain Patients
Chronic pain patients are treated with prescription opioids and many exhibit opioid addiction. Currently, there are no evidence-based guidelines to better manage patients with chronic pain and coexistent opioid addiction.
- Trial name
- NCT01559454
- Testing
- Methadone, Buprenorphine/naloxone
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- State University of New York at Buffalo
Opioid-Related Disorders, Heroin Dependence
Buprenorphine Maintenance Treatment of Opioid Dependence in Primary Care: A Randomized Clinical Trial
The study will assess the effectiveness of at-home vs. in-office induction for patients entering buprenorphine maintenance at Associates in Internal Medicine (AIM) primary care clinic.
- Trial name
- NCT00684554
- Testing
- Buprenorphine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- New York State Psychiatric Institute
Opioid Use, Opioid Dependence
Efficiency And Quality In Post-Surgical Pain Therapy After Discharge
Following inpatient surgery, more than 80% of patients are prescribed opioids for use after discharge, yet up to 90% of patients report leftover opioids, and only 16% maximize non-opioid therapy.
- Conditions
- Opioid Use, Opioid Dependence, Opioid Misuse, Post-Surgical Complication
- Trial name
- EQUIPPED (NCT05221866)
- Testing
- Empowering Patient to Steer Their Pain Management After Surgery, Provider-facing Prescription Aid
- Where
- United States
- Volunteers
- 711 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Opiate Dependence
Electronic Compliance Monitoring in Opioid Substitution Treatment
The purpose of this study is to improve unsupervised dosing of opioid substitution medications. The aim of the study is to examine whether electronic compliance monitoring provides some advantages to patients'treatment and what…
- Trial name
- EHSO (NCT01182402)
- Testing
- Compliance monitoring with electronic device
- Where
- Finland
- Volunteers
- 37 people
- Sponsor
- Kuopio University Hospital
Pain
Neuropsychoanalytic Treatment of Failed Back Surgery Syndrome-Opioid Dependence
Opioid Dependent Patients who have failed back surgery syndrome are detoxified and treated with a neuropsychoanalytic paradigm.
- Trial name
- NCT01940588
- Testing
- Neuropsychoanalytic therapy
- Volunteers
- 30 people
- Sponsor
- State University of New York - Upstate Medical University
Opiate Dependence
Behavioral Drug and HIV Risk Reduction Counseling With MMT in China
This study will provide critical data regarding the efficacy for reducing drug-and sex-related HIV transmission risk behaviors, as well as improving methadone maintenance treatment (MMT) outcomes and patient functioning of two…
- Trial name
- NCT01389180
- Testing
- Behavioral Drug and HIV Risk Reduction Counseling, Educational Counseling, Treatment as Usual
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Yale University