Clinical trials: Opiate Substitution Treatment
Substance Related Disorders
Effectiveness of a Training Program for Self-management of the Substance Addiction Consequences - a Study Protocol
The substance dependent population has many health needs in which it is necessary to invest in competent approaches with more evidence.
- Trial name
- ADSProgram (NCT05397925)
- Testing
- ADSProgram - Self management for substance dependence program, Treatment as usual - Regular nursing consultation on a medication-based program
- Where
- 2 sites in Portugal
- Volunteers
- 60 people
- Sponsor
- Nursing School of Lisbon
Drug Overdose, Opioid-Related Disorders
A Tailored, Peer-delivered Intervention to Reduce Recurring Opioid Overdoses
This project will further develop and test the Tailored Telephone Intervention delivered by Peers to Prevent Recurring Opioid Overdoses (TTIP-PRO), a promising, low-cost, intervention to facilitate entry into medication assisted…
- Conditions
- Drug Overdose, Opioid-Related Disorders, Drug Addiction, Drug Abuse
- Trial name
- TTIP-PRO (NCT02922959)
- Testing
- Peer Intervention, naloxone nasal spray kit, Personally-tailored opioid overdose prevention education (information packet)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Cincinnati
Opiate-Replacement Therapy
Automated Prize-based Contingency Management to Increase Counseling Attendance in Opiate-Replacement-Therapy Patients
Background: Treatment outcomes for substance abuse are improved by regular attendance at counseling sessions, and attending at counseling sessions can be futher improved by prize-based incentives.
- Trial name
- NCT01229163
- Testing
- Automated Contingency Management (ACM) software
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Opiate Substitution Treatment
Buprenorphine and Substance Abuse Services for Prescription Opioid Dependence
This is a randomized trial of two group-based models of care for buprenorphine/naloxone (bup/nx) patients in Substance Use (SU) specialty treatment: Standard Medical Management (SMM) and Intensive Outpatient Treatment (IOT).
- Trial name
- NCT02496403
- Testing
- Standard Medical Management (SMM)
- Where
- United States
- Volunteers
- 239 people
- Sponsor
- Kaiser Permanente
Substance Use Disorder
OPAL: "Opiates and PhArmacoLogy"
The aim of this study is to determine the current prevalence of co-addictions, including problem/pathological gambling, in patients receiving Opiate Substitution Treatment (OST), and to then compare patients receiving OST with or…
- Trial name
- OPAL (NCT01847729)
- Where
- 7 sites in France
- Volunteers
- 263 people
- Sponsor
- Nantes University Hospital
Opiate Replacement Therapy
The Effect of Primary Care Opioid Taper Plans on Sustained Opioid Taper
The objective of this study is to examine the effects of opioid taper plans as documented in the electronic medical record for Kaiser Permanente Washington (KPWA) patients.
- Trial name
- NCT03748862
- Testing
- Taper Plan
- Where
- United States
- Volunteers
- 2,500 people
- Sponsor
- Kaiser Permanente
HIV Infections
Safety Study of Once a Day ART and Opiate Substitute.
This study looks at HIV-infected subjects who are on methadone treatment and medicines for HIV.
- Trial name
- 3OD (NCT00324688)
- Testing
- Viread
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Gilead Sciences
Stimulant Use & Co-occuring Opioid Use Disorders
Stimulant Oxytocin Study
This study will investigate the effects of intranasal administration of oxytocin, a social neuropeptide, on reducing stimulant use, enhancing therapeutic engagement, and susceptibility to stress-induced relapse in Veterans with…
- Trial name
- SOS (NCT03016598)
- Testing
- Intranasal oxytocin
- Where
- 3 sites in United States
- Volunteers
- 42 people
- Sponsor
- VA Office of Research and Development
Hepatitis C
The Dublin Zepatier Study
Evaluation of Zepatier in a community-based setting among cirrhotic and non-cirrhotic patients on stable opiate substitution therapy.
- Trial name
- NCT02895958
- Testing
- Zepatier
- Where
- Ireland
- Volunteers
- 3 people
- Sponsor
- Mater Misericordiae University Hospital
Chronic Hepatitis C
An Efficacy and Safety Study of Grazoprevir (MK-5172) + Elbasvir (MK-8742) in the Treatment of Chronic Hepatitis C Virus (HCV) Genotype (GT)1, 4, or 6 Infection in Treatment-Naïve Participants Who Are on Opiate Substitution Therapy (MK-5172-062)
This is a 2-part study. The purpose of Part A is to assess the efficacy and safety of grazoprevir (MK-5172) 100 mg in combination with elbasvir (MK-8742) 50 mg for 12 weeks in the treatment of chronic HCV GT1, GT4, or GT6…
- Trial name
- C-EDGE CO-STAR (NCT02105688)
- Testing
- Grazoprevir 100 mg/Elbasvir 50 mg FDC tablet (MK-5172A)
- Volunteers
- 301 people
- Sponsor
- Merck Sharp & Dohme LLC
Hepatitis C
Identification to Elimination in HCV-Infected Individuals
Approximately 3.5 - 5 million Americans are living with hepatitis C virus (HCV) in the United States. HCV significantly impacts rural Pennsylvania. It is estimated that 160,000 adults in Pennsylvania are living with hepatitis C.
- Trial name
- NCT03195205
- Testing
- OraQuick HCV Rapid Antibody Test
- Where
- United States
- Volunteers
- 3,051 people, healthy volunteers welcome
- Sponsor
- TruCare Internal Medicine & Infectious Disease
Chronic Pain
Increased Sensitivity to Pain Caused by Opioids in People Who Have Abused Prescription Opioids
Managing pain in patients who abuse prescription opioids presents many challenges, including the development of opioid-induced hyperalgesia (OIH).
- Trial name
- NCT01821430
- Testing
- Pregabalin
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Georgetown University
Chronic Hepatitis C
Therapy With Ledipasvir/Sofosbuvir in Patients With Genotype 1 HCV Infection Receiving Opiate Substitution Therapy
Patients with chronic hepatitis C that are under opiate substitution therapy are likely to have psychiatric comorbidities such as depression; hence an Interferon based therapy is contraindicated.
- Trial name
- NCT02638233
- Testing
- Sofosbuvir 400mg / Ledipasvir 90 mg (FDC)
- Where
- Austria
- Volunteers
- 40 people
- Sponsor
- Wilhelminenspital Vienna
HIV Infections, Heroin Dependence
Directly Administered Antiretroviral Therapy (DAART) Among HIV-1infected Injecting Drug Users (IDUs) in Chennai, India
Though the HIV epidemic in India is predominantly among heterosexual populations, it is estimated that there are approximately 1.1 million injection drug users (IDUs) in India with HIV prevalence as high as 64% among IDUs in…
- Trial name
- DAART+ (NCT00709007)
- Testing
- Directly Administered Antiretroviral Therapy (DAART), SAT
- Where
- India
- Sponsor
- Johns Hopkins University
Substance Withdrawal Syndrome
The Effect of Valproate on Benzodiazepine Withdrawal Severity
The aim of this study is to determine whether valproate is effective in the treatment of benzodiazepine withdrawal symptoms in subjects receiving maintenance treatment for opiate dependence.
- Trial name
- NCT00570219
- Testing
- valproate
- Where
- Finland
- Volunteers
- 30 people
- Sponsor
- University of Helsinki
Hepatitis C, Chronic, Opioid Dependence, on Agonist Therapy
Integrated Treatment of Hepatitis C Virus Infection
INTRO-HCV is a multicentre randomised controlled clinical trial that will compare the efficacy of integrated treatment of chronic hepatitis C virus infection (HCV) within medically assisted rehabilitation (MAR) clinics providing…
- Trial name
- INTRO-HCV (NCT03155906)
- Testing
- Health care delivery
- Where
- 2 sites in Norway
- Volunteers
- 298 people
- Sponsor
- Haukeland University Hospital
Opioid-Related Disorders, Opiate Substitution Treatment
Slow-Release Oral Morphine for the Treatment of Opioid Use Disorder
This is a non-inferiority randomized clinical trial that will compare slow release oral morphine vs methadone as a second line oral treatment for opioid use disorder.
- Conditions
- Opioid-Related Disorders, Opiate Substitution Treatment, Morphine, Methadone
- Trial name
- pRESTO (NCT03948464)
- Testing
- Slow release oral morphine (SROM), Methadone
- Where
- Canada
- Volunteers
- 27 people
- Sponsor
- M. Eugenia Socias
Opioid Dependence
Completion of OST - a Prospective Study
Only limited information on the process of completing long-term opiate substitution treatment (OST) with substances like methadone exist.
- Trial name
- NCT01722435
- Testing
- Opiate Substitution Treatment
- Volunteers
- 78 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Hepatitis C
Epidemiology of Hepatitis C Virus Infection Among Opioid Substituted Patients
The aim of the present study is to estimate the national annual prevalence and incidence of current hepatitis C virus (HCV) infections among opioid dependent individuals in opioid substitution treatment (OST) based on a…
- Trial name
- ECHO (NCT02395198)
- Where
- 32 sites in Germany
- Volunteers
- 2,467 people
- Sponsor
- Prof. Dr. med. Jens Reimer
Opioid-Related Disorders
Assessment of the Satisfaction of Patient Undergoing Opioid Replacement Therapy Toward Their Management in Community Pharmacy
The patient's compliance to his medication therapy, and therefore the success of the treatment, is particularly related to his pharmacy management.
- Trial name
- SATISFY (NCT03961789)
- Testing
- patients undergoing opioid replacement therapy
- Where
- France
- Volunteers
- 98 people
- Sponsor
- University Hospital, Clermont-Ferrand