Clinical trials: Opiate Substitution Treatment
Drug Overdose, Opioid-Related Disorders
A Tailored, Peer-delivered Intervention to Reduce Recurring Opioid Overdoses
This project will further develop and test the Tailored Telephone Intervention delivered by Peers to Prevent Recurring Opioid Overdoses (TTIP-PRO), a promising, low-cost, intervention to facilitate entry into medication assisted…
- Conditions
- Drug Overdose, Opioid-Related Disorders, Drug Addiction, Drug Abuse
- Trial name
- TTIP-PRO (NCT02922959)
- Testing
- Peer Intervention, naloxone nasal spray kit, Personally-tailored opioid overdose prevention education (information packet)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Cincinnati
Chronic Hepatitis C
An Efficacy and Safety Study of Grazoprevir (MK-5172) + Elbasvir (MK-8742) in the Treatment of Chronic Hepatitis C Virus (HCV) Genotype (GT)1, 4, or 6 Infection in Treatment-Naïve Participants Who Are on Opiate Substitution Therapy (MK-5172-062)
This is a 2-part study. The purpose of Part A is to assess the efficacy and safety of grazoprevir (MK-5172) 100 mg in combination with elbasvir (MK-8742) 50 mg for 12 weeks in the treatment of chronic HCV GT1, GT4, or GT6…
- Trial name
- C-EDGE CO-STAR (NCT02105688)
- Testing
- Grazoprevir 100 mg/Elbasvir 50 mg FDC tablet (MK-5172A)
- Volunteers
- 301 people
- Sponsor
- Merck Sharp & Dohme LLC
Hepatitis C
Scale-up of Treatment of Hepatitis C Infection Among People Who Inject Drugs
This study is a phase IV, open-label, single arm, multicentre study whose aim is to assess whether interferon-free and ribavirin-free Direct Acting Antiviral (DAA) Hepatitis C Virus (HCV) therapy with grazoprevir/elbasvir, will…
- Trial name
- DARLO-C (NCT02940691)
- Testing
- Grazoprevir/elbasvir
- Where
- 5 sites in Australia
- Volunteers
- 32 people
- Sponsor
- Kirby Institute
Opioid Substitution Treatment
ICE-T Pain Regimen for Total Laparoscopic Hysterectomy
The purpose of this randomized controlled trial is to determine whether, "ICE-T," a multimodal postoperative pain regimen composed of around the clock ice packs, toradol, and tylenol, has improved pain control compared to the…
- Trial name
- NCT03987022
- Testing
- Ketorolac, Opioids, Ice Packs
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- MetroHealth Medical Center
HIV Prevention, Opioid-Related Disorders
Effectiveness of Opiate Replacement Therapy Administered Prior to Release From a Correctional Facility - 1
Much of the HIV/AIDS epidemic is driven by transmission from or to persons addicted to opiates. Many of these individuals pass through a correctional setting each year, creating an opportunity for linkage to substance abuse…
- Trial name
- NCT00142935
- Testing
- Pre-release Initiation of MMT, Post Release Initiation of MMT., Standard of Care Plus
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- The Miriam Hospital
Opioid-Related Disorders, NAS
MOms in REcovery (MORE) Study: Defining Optimal Care
Northern New England has among the highest rates of opioid dependence in the U.S. This region also has among the highest rates of opioid-related deaths in the U.S., with a disproportionate high rate among pregnant women with…
- Conditions
- Opioid-Related Disorders, NAS, Substance Use Disorders, Mental Health
- Trial name
- MORE (NCT04251208)
- Testing
- Observational Study
- Where
- 10 sites in United States
- Volunteers
- 2,510 people
- Sponsor
- Trustees of Dartmouth College
Hepatitis C
Reaching mEthadone Users Attending Community pHarmacies With HCV
Hepatitis C Virus (HCV) is a blood-borne virus that damages the liver and is a major public health threat globally. Most individuals infected with HCV are unaware of it and show no symptoms until presenting with incurable, fatal…
- Trial name
- REACH-HCV (NCT03935906)
- Testing
- Reach Pathway, Education-only Pathway
- Where
- 3 sites in Australia, United Kingdom
- Volunteers
- 1,410 people
- Sponsor
- University of Dundee
Hepatitis C, Chronic
A Collaborative Trial in Injectors of Individualized Treatment for Genotype 2/3
This sudy will determine whether shortening treatment for hepatitis C is feasible, safe and effective for patients who are current injection drug users or receiving opiate substitution therapy and who are responding well to…
- Trial name
- ACTIVATE (NCT01364090)
- Testing
- Pegylated interferon alfa 2b, Ribavirin
- Where
- 17 sites in Australia, Belgium and 5 more
- Volunteers
- 93 people
- Sponsor
- Kirby Institute
HIV, Opioid Dependence
Testing a Community-Friendly Risk Reduction Intervention for Injection Drug Users
To conduct a randomized clinical trial (RCT) of a community-friendly behavioral intervention designed to reduce HIV risk behavior among injection drug users (IDUs) in drug treatment by comparing risk-behavior outcomes of four…
- Trial name
- NCT01741350
- Testing
- Community-friendly Health Recovery Program, Time-and-Attention-Matched Control Condition
- Where
- United States
- Volunteers
- 304 people
- Sponsor
- University of Connecticut
Hepatitis C
Hepatitis C-Video vs. Brochure Education Delivery
The purpose of this study is to determine the most effective way to give patients information regarding hepatitis C virus infection.
- Trial name
- NCT04204447
- Testing
- Hepatitis C Educational Brochure, Hepatitis C Educational Video
- Where
- 2 sites in United States
- Volunteers
- 176 people
- Sponsor
- State University of New York at Buffalo
Opiate Addiction, Pregnancy
Pharmacologically-based Strategies for Opioid Substitution Therapy During Pregnancy
This study is a pharmacodynamic study in pregnant women evaluating the relationship between buprenorphine concentration and outcome such as opioid withdrawal symptoms , NAS scores, neurodevelopmental and neuroanatomic outcomes.
- Trial name
- NCT03831113
- Testing
- Magnitude Group, Frequency Group
- Where
- 2 sites in United States
- Volunteers
- 13 people
- Sponsor
- Steve N. Caritis, MD
Stimulant Use & Co-occuring Opioid Use Disorders
Stimulant Oxytocin Study
This study will investigate the effects of intranasal administration of oxytocin, a social neuropeptide, on reducing stimulant use, enhancing therapeutic engagement, and susceptibility to stress-induced relapse in Veterans with…
- Trial name
- SOS (NCT03016598)
- Testing
- Intranasal oxytocin
- Where
- 3 sites in United States
- Volunteers
- 42 people
- Sponsor
- VA Office of Research and Development
Opioid Dependence
Completion of OST - a Prospective Study
Only limited information on the process of completing long-term opiate substitution treatment (OST) with substances like methadone exist.
- Trial name
- NCT01722435
- Testing
- Opiate Substitution Treatment
- Volunteers
- 78 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
HCV, Buprenorphine
Hepatitis C Treatment to Prevent HIV, Initiate Opioid Substitution Therapy, and Reduce Risky Behavior
This is an open label, non-randomized, observational pilot study to evaluate a model of care for treatment of hepatitis C in people with ongoing injection drug use.
- Conditions
- HCV, Buprenorphine, PreP
- Trial name
- ANCHOR (NCT03221309)
- Testing
- Evaluate model of care for HCV-infected adults with on-going opioid misuse
- Where
- 2 sites in United States
- Volunteers
- 198 people
- Sponsor
- University of Maryland, Baltimore
Opiate Substitution Treatment, Opioid-Related Disorders
Use of a GLP-1R Agonist to Treat Opioid Use Disorder
This research is being done to find out if liraglutide (brand name is Saxenda®) can safely and effectively reduce craving for opioids in patients with opioid use disorder, a primary factor contributing to early relapse.
- Trial name
- NCT04199728
- Testing
- Liraglutide Pen Injector
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Milton S. Hershey Medical Center