Clinical trials: Opiate Use Disorder
Family Planning Services, Substance-Related Disorders
Increasing Linkage to Family Planning Care for Individuals With Substance Use Disorder
This study will utilize mixed methods to develop and assess the feasibility and acceptability of a health educator intervention designed to connect patients in recovery from substance use disorder to reproductive health education…
- Conditions
- Family Planning Services, Substance-Related Disorders, Opiate Substitution Treatment, Sexual Health
- Trial name
- NCT04162184
- Testing
- Sexual Health Initiative for Navigation and Education (SHINE) Health Educator Intervention
- Where
- United States
- Volunteers
- 199 people, healthy volunteers welcome
- Sponsor
- Denver Health and Hospital Authority
Opioid-Related Disorders, Hepatitis C (HCV)
Kentucky Outreach Service Kiosk (KyOSK): Reducing HIV, HCV, and Overdose Risk
This study will test the effectiveness, implementation outcomes, and cost effectiveness of a locally-tailored, health kiosk to reduce overdose, hepatitis C, and HIV risk behavior and improve linkage to care in rural Appalachia.
- Conditions
- Opioid-Related Disorders, Hepatitis C (HCV), Human Immunodeficiency Virus (HIV), Drug Overdose
- Trial name
- NCT05657106
- Testing
- Health kiosk
- Where
- United States
- Volunteers
- 752 people, healthy volunteers welcome
- Sponsor
- April M Young
Substance Use Disorders, Treatment Adherence and Compliance
Kentucky Access to Recovery Evaluation
Evaluate the long-term effectiveness of implementing vouchers as a linkage strategy in a population requiring recovery support services (RSS) when no other funding sources are available.
- Trial name
- NCT05889702
- Testing
- KATR Linkage Strategy
- Where
- 2 sites in United States
- Volunteers
- 458 people
- Sponsor
- Terry Bunn
Human Immunodeficiency Virus, Acquired Immunodeficiency Syndrome
Intervention of HIV, Drug Use and the Criminal Justice System in Malaysia
The purpose of this study is to evaluate the relative impact a medical drug (methadone) or behavioral counseling program (Holistic Health Recovery Program) or both (methadone and Holistic Health Recovery Program) has on reducing…
- Conditions
- Human Immunodeficiency Virus, Acquired Immunodeficiency Syndrome, Opiate Addiction, Drug Dependence
- Trial name
- Harapan (NCT02396979)
- Testing
- Methadone, Holistic Health Recovery Program
- Volunteers
- 300 people
- Sponsor
- Yale University
Knee Injuries and Disorders, Hip Injuries and Disorders
Impact of Different Educational Approaches on Post-operative Opiate Utilization After Elective Lower Extremity Surgery
The purpose of this study is to evaluate the use of post-operative opioid use after two different educational interventions. The investigators will compare changes in pain, disability and sleep between groups 6 months after…
- Conditions
- Knee Injuries and Disorders, Hip Injuries and Disorders, Opiate Addiction
- Trial name
- OpiateLEO (NCT02997644)
- Testing
- Video Education, Usual Care Group
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Brooke Army Medical Center
Opioids; Harmful Use
Piloting a Naloxone Intervention in Philadelphia
The escalating opioid overdose epidemic is one of the most serious public health problems confronting the U.S. Death due to drug overdose is a significant and rising cause of mortality and morbidity in Philadelphia.
- Trial name
- NCT03305497
- Testing
- Mobile Phone Application
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Drexel University
Thoracic, Pulmonary Disease
Gabapentin for the Reduction of Opiate Use Following Pulmonary Resection (GROUP Trial)
The aim of this study is to determine if the reduction in narcotic requirement following pulmonary resection with gabapentin is clinically significant when compared to the effect seen with placebo.
- Trial name
- NCT05100160
- Testing
- Gabapentin
- Where
- United States
- Sponsor
- M.D. Anderson Cancer Center
Cocaine-Related Disorders, Opioid-Related Disorders
Fluoxetine to Reduce Cocaine Use in Cocaine and Opioid Addicts
Cocaine addiction is a serious health problem with no available medical treatment for preventing relapse. Fluoxetine, a medication that is currently used to treat depression and anxiety disorders, may also be effective at…
- Trial name
- NCT00142779
- Testing
- Fluoxetine
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Opiate Use Disorder
Application Based Addiction Treatment Adherence Trial
The purpose of this study is to test a smart phone based application (the App) that will allow patients to record their attendance at 12-step meetings.
- Trial name
- NCT04680741
- Testing
- Addiction Pilot App behavior tracking
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- The Cleveland Clinic
Rotator Cuff Tear Arthropathy
Effect of Ibuprofen on Postoperative Opiate Medication Use and Shoulder Functional Outcomes
This will be a randomized controlled trial to determine if postoperative ibuprofen after arthroscopic rotator cuff repair impacts postoperative opiate medication use, Visual Analog Scale (VAS) pain scores, shoulder range of…
- Trial name
- NCT02588027
- Testing
- Ibuprofen
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- University of California, San Francisco
Opioid Overdose, Opioid Use Disorder
Safety, Tolerability, and Pharmacokinetics of CSX-1004
This is a Phase 1a, randomized, double-blind, single ascending dose study, designed to assess the safety, tolerability, and PK of a single CSX-1004 injection, administered by IV infusion across a range of doses in healthy adult…
- Trial name
- NCT06005402
- Testing
- CSX-1004
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Cessation Therapeutics, Inc.
Cocaine Addiction, Opiate Addiction
Real Time Assessment of Drug Craving, Use, and Abstinence During Outpatient: A Development and Feasibility Study
Background: The treatment of addiction often hinges on preventing relapse into drug-using behaviors, which occurs at high rates even after prolonged abstinence.
- Trial name
- NCT00292136
- Where
- United States
- Volunteers
- 230 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Opioid Use Disorder, Alcohol Use Disorder
Removing Barriers: Community Partnering for Innovative Solutions to the Opioid Crisis
The opioid epidemic has become one of America's deadliest crises, surpassing car crashes, firearms, and HIV/AIDS as a leading cause of death for Americans under fifty years of age.
- Conditions
- Opioid Use Disorder, Alcohol Use Disorder, Health Risk Behaviors, Criminal Behavior
- Trial name
- RB (NCT05665179)
- Testing
- Removing Barriers to Recovery
- Where
- 2 sites in United States
- Volunteers
- 800 people
- Sponsor
- University of Michigan
Opiate Antagonist Overdose, Opioid-Related Disorders
Naloxone Auto-injector as a Universal Precaution for Patients With Opioid Use Disorder
The purpose of this pilot-study is to to distribute naloxone auto-injector in a "Universal Precaution" manner to patients with opioid substance use disorder.
- Trial name
- NCT02669901
- Testing
- Naloxone Auto-Injector
- Where
- United States
- Volunteers
- 395 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Opiate Withdrawal Syndrome
Treatment of Withdrawal Symptoms and Prevention of Relapse in Patients With Tramadol Abuse
Tramadol abuse is a public health problem in Egypt. There are no approved medications for treatment of withdrawal symptoms or prevention of relapse in patients with tramadol abuse.
- Trial name
- NCT05569031
- Testing
- Venlafaxine, Lofexidine
- Where
- Egypt
- Volunteers
- 52 people
- Sponsor
- Zagazig University
Opiate Abuse, Opiate Overdose
FAVOR Opioid Recovery Coaching Evaluation
The Emergency Department (ED) is an ideal location to identify patients in need of treatment for opioid addiction. A local non-profit community-based addiction recovery program, Faces and Voices of Recovery (FAVOR) utilizes a…
- Conditions
- Opiate Abuse, Opiate Overdose, Opioid-use Disorder
- Trial name
- FORCE (NCT03798470)
- Testing
- Peer Addiction Counseling
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Prisma Health-Upstate
Opioid Use Disorder, Opioid Overdose
Health Insurance Instability and Mortality Among Patients Receiving Bup Tx for OUD
The goal of this multi-site observational cohort study is to link electronic health records (EHR) with novel data sources to examine insurance instability and its association with all-cause and overdose mortality in adult…
- Conditions
- Opioid Use Disorder, Opioid Overdose, Death
- Trial name
- NCT05944133
- Testing
- No intervention, observational retrospective study
- Where
- United States
- Volunteers
- 27,257 people
- Sponsor
- Kaiser Permanente
Opioid Use Disorder (OUD)
MethaLoad Dose-Finding Study
Methadone is an effective treatment for opioid use disorder (OUD), but starting it has become harder now that most people with OUD use fentanyl. Methadone is usually started at a low dose and increased slowly over several weeks.
- Trial name
- NCT06877858
- Testing
- Methadone hydrochloride
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Ashish P Thakrar, MD MS
Smoking, Tobacco Smoking
Pilot Study of Contingency Management for Smoking Cessation
The purpose of this study is to see whether contingency management (CM) can be successfully added as an adjunct treatment to standard stop smoking services in outpatients undergoing treatment for opiate addiction.
- Conditions
- Smoking, Tobacco Smoking, Smoking, Tobacco, Smoking Cessation
- Trial name
- NCT03015597
- Testing
- Contingency Management
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- King's College London
Opioid Use Disorder, Stimulant Use Disorder
Suvorexant for Opioid/Stimulant Co-use
This study will evaluate whether Suvorexant 20mg reduces drug use and craving, and improves sleep and stress among persons with co-occurring opioid use disorder and stimulant use disorder.
- Trial name
- NCT05546515
- Testing
- Suvorexant (dual orexin receptor antagonist)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Johns Hopkins University