Clinical trials: Opiates
Opioid Overdose
Preventing Opioid Overdose Deaths by Empowering Pharmacists to Dispense Naloxone
Objectives: The purpose of this study was to assess the impact of the Empowering Community Pharmacists program on pharmacists' knowledge, perceived barriers, attitudes, confidence, and intentions regarding naloxone services…
- Trial name
- NCT05093309
- Testing
- Educational Webinar, Resources, Reminders
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Auburn University
Opiate Dependence, Osteoporosis
Bone Density and Serum Testosterone in Male Methadone Maintained Patients
This is a pilot study designed to answer the question " Do men who are receiving methadone maintenance therapy have lower spinal bone densities compared with age-matched controls who are not receiving methadone therapy?" The…
- Conditions
- Opiate Dependence, Osteoporosis, Erectile Dysfunction, Hypogonadism
- Trial name
- NCT00170339
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hennepin Healthcare Research Institute
Driving Behavior
Opiates and Benzodiazepines on Driving
The aim of this research is to assess drug effects (Xanax and Norco) on driving performance. Researchers will use the Alertness Memory Profiler (AMP) application to compare results to previous related studies.
- Trial name
- NCT03447353
- Testing
- Xanax 1Mg Tablet, Norco 10Mg-325Mg Tablet
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Timothy L. Brown
Chronic Pain, Opioid Use
Neuroimaging of Opioid Phase (OPAL)
The purpose of this study is to compare activity in the brains of female adults with chronic pain and/or opioid use, and healthy female adults that may help to develop new and targeted treatments for adults with chronic pain and…
- Trial name
- OPAL (NCT05905419)
- Testing
- Opioid Phase
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Duke University
Opioids; Harmful Use
Piloting a Naloxone Intervention in Philadelphia
The escalating opioid overdose epidemic is one of the most serious public health problems confronting the U.S. Death due to drug overdose is a significant and rising cause of mortality and morbidity in Philadelphia.
- Trial name
- NCT03305497
- Testing
- Mobile Phone Application
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Drexel University
Addiction Opiate
Comparison Between Different Psychotherapy Interventions Regarding Their Effect on Substance Craving
the study aim is to compare betwenn the effect of mindfulness based relapse prevention and other evidence based psychotherapy interventions regaring substance craving.
- Trial name
- NCT05256485
- Testing
- cognitive behavioral therapy,mindfulness based relapse prevention,twelve-step therapy
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Sara Harby
Opioid-Related Disorders
Evaluation of Pharmacy Students' Perception of Opioid / Opiate Dependence
The pharmacist in his professional activity may have to manage opioid dependent patients. This professional activity will result in the provision of opioid substitution treatment (OST), single-use syringes, harm reduction kits…
- Trial name
- STUD_TOX (NCT03859778)
- Testing
- survey
- Where
- France
- Volunteers
- 2,034 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Opioid-Related Disorders, Substance-Related Disorders
Prescription Opioid Effects in Abusers Versus Non-Abusers
The purpose of this study is to examine the abuse liability of oxycodone in individuals with, and without, a history of prescription opioid abuse.
- Trial name
- NCT00158184
- Testing
- oxycodone 15 mg, oxycodone 30 mg
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Opiate-Replacement Therapy
Automated Prize-based Contingency Management to Increase Counseling Attendance in Opiate-Replacement-Therapy Patients
Background: Treatment outcomes for substance abuse are improved by regular attendance at counseling sessions, and attending at counseling sessions can be futher improved by prize-based incentives.
- Trial name
- NCT01229163
- Testing
- Automated Contingency Management (ACM) software
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
HIV Infections, Opioid-Related Disorders
Drug Treatment Combined With Drug and Risk Reduction Counseling to Prevent of HIV Infection and Death Among Injection Drug Users
Drug abuse and HIV/AIDS are serious global health problems. Injection drug use is currently the major mode of transmission of HIV in many countries.
- Trial name
- NCT00270257
- Testing
- Buprenorphine/Naloxone
- Where
- 4 sites in China, Thailand
- Volunteers
- 1,251 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Post Operative Pain, Regional Anesthesia Morbidity
Does ESP Block Reduce Pain and Opiates Consumption After Surgery
The patients will be randomly assigned to standard therapy or standard therapy+ESP nerve block. After surgery pain level and narcotic consumption will be measured, and vital signs and side effects will bo monitored for up to 72…
- Conditions
- Post Operative Pain, Regional Anesthesia Morbidity, Opioid-Related Disorders, Chronic Pain
- Trial name
- NCT05512897
- Testing
- erector spinea plane block
- Where
- Israel
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Michael Dubilet MD
Accidental Overdose of Opiate
Rapid Self-Testing to Prevent Fentanyl Overdose Among Young People Who Use Drugs
The research team will enroll 100 young adults who use cocaine, heroin, inject drugs, or purchase prescription medications on the illicit market in a pilot study to be known as the Rhode Island Young Adult Prescription and…
- Trial name
- RAPiDS2 (NCT03373825)
- Testing
- Take home rapid drug test
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Brown University
Opiate Abuse, Marijuana Abuse
Detecting Drugs of Abuse Via Exhaled Breath Samples Using Differential Mobility Spectrometry
This Phase II STTR program consists of two major goals within the overarching goal of developing and validating a proprietary device (BID2) for marijuana and opioid detection in breath samples.
- Conditions
- Opiate Abuse, Marijuana Abuse, Diagnostic
- Trial name
- NCT05384470
- Testing
- Marihuana, BID2 Instrument - breathalyzer
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Opioid Use, Alcohol Drinking
The Behavioral Effects of Opioids and Alcohol
This study will examine the effects of doses of alcohol/placebo and doses of opioid/placebo, alone and in combination. The primary outcomes are related to pharmacodynamic measures (subjective ratings of drug liking and other…
- Trial name
- NCT04300751
- Testing
- Alcohol, Opioid Agonist
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Sharon Walsh
Hepatitis C
Hepatitis C Education for Pregnant Women With Opiate Dependence - Phase 2
The goal of this study is to assess patients' attitudes and knowledge of Hepatitis C, analyze the variables that may influence patients' knowledge, and educate patients on Hepatitis C.
- Trial name
- NCT03320889
- Testing
- Educational Intervention
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- TriHealth Inc.
Cocaine Abuse, Opiate Dependence
Pharmacotherapy Dosing Regimen in Cocaine and Opiate Dependent Individuals - 8
The purpose of this study is to examine two medications, modafinil and citalopram, in the treatment of cocaine dependent individuals who are maintained on methadone.
- Trial name
- NCT00218036
- Testing
- Modafinil 200mg, Modafinil 400mg, Citalopram 20mg
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Neuroscience of Dreaming, Healthy
The Impact of the Opiate Antagonist Naltrexone on the Emotional Valence of Dreams
In this study, the investigators pose the question which influence the opioid circuit has on positive valent situations in dreams.
- Trial name
- NCT02792140
- Testing
- Naltrexone
- Where
- Switzerland
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Bern
Substance-Related Disorders
Brain Electrophysiological Study(EEG/ERP) on Opiate Addicts Treating by Bilateral NAc/ALIC Deep Brain Stimulation
Drug addiction is compulsive and spontaneous drug-taking behavior which is characterized by non-medical usage, long and repeated exposure to addictive drugs and gradually increasing drug-taking dosage and frequency,and become a…
- Trial name
- NCT02594306
- Testing
- Emotional pictures stimulation system, Deep brain stimulation, adjacent contact stimulation
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Tang-Du Hospital
Infections, Human Immunodeficiency Virus and Hepatitis
Methadone-Dolutegravir (DTG - GSK1349572) Drug Interaction Study.
Dolutegravir (DTG, GSK1349572) is an integrase inhibitor that is currently in Phase 3 clinical development for the treatment of HIV infection.
- Trial name
- NCT01467518
- Testing
- Dolutegravir, Methadone
- Where
- Canada
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- ViiV Healthcare
Smoking Cessation
A Pilot Text Messaging Intervention to Reduce Smoking in Office-based Buprenorphine and Inpatient Detoxification Patients
The primary purpose of this study is to understand the feasibility of a text messaging intervention developed by the National Cancer Institute, known as Smokefreetxt, to improve smoking cessation among opiate and/or alcohol…
- Trial name
- NCT02665208
- Testing
- Treatment As Usual (TAU), Nicotine Replacement Therapies, Text Message Intervention (TMI)
- Where
- United States
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health