Clinical trials: Opioid
Contraception
Improving Reproductive Health for Women in Opioid Medication-Assisted Treatment (OMAT)
Recent research suggests that women with substance use disorders may be at a higher risk of unintended pregnancy. There is a paucity of interventions specifically focused on this population.
- Trial name
- NCT02794597
- Testing
- SHINE intervention group
- Where
- United States
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- Denver Health and Hospital Authority
Abdominal Cancer, Abdomen Disease
Comparison of Postoperative Analgesia Methods in Patients Undergoing Major Intraabdominal Surgery
This study aims to examine the effects of M-TAPA applied for postoperative analgesia in patients who had major intraabdominal surgery on the postoperative pain score, the change in the postoperative total opioid requirement and…
- Trial name
- NCT06384677
- Testing
- M-Tapa Block
- Where
- Turkey (Türkiye)
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Marmara University
Inhalation of Nitrous Oxide, Opioid Analgesic Adverse Reaction
Combination of Nitrous Oxide 70% With Fentanyl Intranasal for Procedural Analgosedation in Children
This study analyzes the analgesic efficacy and adverse events of nitrous oxide 70% combined with basic analgetics compared to nitrous oxide 70% with fentanyl intranasal for analgosedation for short and painful procedures in…
- Conditions
- Inhalation of Nitrous Oxide, Opioid Analgesic Adverse Reaction, Pain
- Trial name
- NCT02533908
- Testing
- Fentanyl intranasal, NaCl 0.9% intranasal
- Where
- Switzerland
- Volunteers
- 402 people, healthy volunteers welcome
- Sponsor
- University Children's Hospital, Zurich
Osteoarthritis of Multiple Joints of Ankle or Foot, Healthy
Effects of Opioids and NSAIDs on Sympathetic Nervous System and Vascular Function
Evaluation of the effect of different analgesic treatments (Tramadol, Paracetamol, Diclofenac) on sympathetic nerve activity, blood pressure, heart rate, heart rate, and vascular function in osteoarthritis patients and healthy…
- Trial name
- OPIOVASC (NCT03781544)
- Testing
- Tramadol, Paracetamol, Diclofenac
- Where
- Switzerland
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Pain
Analgesic Use and Effectiveness for Dental Procedures
Opioid analgesics prescribed by dentists may contribute to the larger national issue of the use and abuse of the drug. On occasion dental pain may be sufficiently severe to support the use of opioids.
- Trial name
- NCT02929602
- Where
- United States
- Volunteers
- 2,773 people, healthy volunteers welcome
- Sponsor
- Pearl Network
Decision Making
Craving & Decision-Making
Craving is the strong desire for something, such as for substances in drug addiction and food or other activities in everyday life.
- Trial name
- NCT06440577
- Testing
- Audio-visual stimuli (Neutral-Relaxing), Audio-visual stimuli (Drug), Audio-visual stimuli (Non-Food)
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Opioid-use Disorder, Pain, Postoperative
BRIDGE Percutaneous Nerve Stimulation for Cesarean Delivery Pain Control
This is a randomized, placebo controlled and natural-history controlled trial to investigate the effectiveness of NSS-2 BRIDGE® for postpartum women with AND without opioid use disorder (OUD).
- Trial name
- NCT04365465
- Testing
- NSS-2 Bridge, Inactive NSS-2 Bridge, Active control
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Grace Lim, MD, MS
Cesarean Section Complications, Opioid Use
Personalized Perioperative Analgesia Platform (PPAP) for Cesarean Section
The purpose of this collaborative CTSA (Clinical and Translational Science Award) application is to develop an innovative perioperative precision analgesia platform (PPAP) to improve analgesia and reduce serious immediate and…
- Trial name
- PPAP C-Section (NCT05380531)
- Testing
- Preoperative Genotyping
- Where
- 4 sites in United States
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Senthil Sadhasivam
Economics, Fraud
The Effect of Informative Letters on the Prescription and Receipt of Opioids
Inappropriate prescribing exposes patients to health risks and results in wasteful public expenditures. This study will evaluate an approach to fighting abusive prescription: sending letters to suspected potentially inappropriate…
- Conditions
- Economics, Fraud, Delivery of Health Care, Health Expenditures
- Trial name
- NCT03202745
- Testing
- Patient Consequences Letter, Prescriber Consequences Letter
- Volunteers
- healthy volunteers welcome
- Sponsor
- Abdul Latif Jameel Poverty Action Lab
Alcohol Dependence
ALK33-001: A Study of RDC-0313 Administered to Healthy Adults
The purpose of this study is to determine the pharmacokinetics, safety, and tolerability of RDC-0313 following oral administration.
- Trial name
- NCT00800319
- Testing
- RDC-0313
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Alkermes, Inc.
HIV-1-infection, Hepatitis C, Chronic
Switch to Genvoya Followed by HCV Therapy With Epclusa Followed by Simplification of HIV Therapy With Biktarvy in Patients With HIV-HCV Co-Infected Subjects on Opioid Substitution Therapy
The study hypothesis is to determine the feasibility of switching HIV-HCV co-infected patients receiving methadone or buprenorphine/naloxone as opioid substitution therapy with suppressed HIV RNA viral load on current…
- Conditions
- HIV-1-infection, Hepatitis C, Chronic, Methadone Dependence, Opioid Dependence
- Trial name
- NCT03549312
- Testing
- Genvoya, Epclusa, Biktarvy
- Where
- Canada
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Saskatchewan Health Authority - Regina Area
Orthopedic Surgery
Pain Relief After Forefoot Surgery
The aim to test whether continues local anaesthetic infusion via tibial catheter or wound catheter will improve pain relief following forefoot surgery In this sequential prospective randomised, controlled clinical trial,75…
- Trial name
- NCT01019005
- Testing
- Catheter
- Where
- United Kingdom
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Nottingham University Hospitals NHS Trust
Measure Time to First Rescue Analgesia Following Extubation
Opioid Free Anesthesia in Shoulder Arthroscope
The investigators will assess opioid free anesthesia technique as regards effectiveness \& duration of post operative analgesia in shoulder arthroscpe surgeries
- Trial name
- NCT06834854
- Testing
- fentanyl, Lidocaine (drug)
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Experimental Pain Perception
The Relationships Between the Noradrenergic, Opioid and Pain System
The role of alpha2 receptor agonist on pain perception and modulation will be examined. In addition whether this is mediated through the opioid system will be examined.
- Trial name
- NCT01851486
- Testing
- Clonidine, Naloxone, saline
- Where
- Israel
- Volunteers
- healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Opiate Addiction
Buprenorphine and Methadone for Opioid Dependent Chronic Pain Patients
The purpose of this study is to determine if buprenorphine or methadone is better for the treatment of chronic pain among patients who have become addicted to prescription narcotics.
- Trial name
- NCT00879996
- Testing
- Methadone, Buprenorphine/naloxone
- Where
- 2 sites in United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Opioid-Related Disorders, Substance-Related Disorders
Effects of Nitrous Oxide: A Dose-Response Analysis - 5
The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used…
- Trial name
- NCT00000253
- Testing
- 10% N2O, 20% N2O, 30% N2O
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Hypnosis, Endocannabinoids
The Effect of Hypnosis on Blood Concentrations of Endocannabinoids
Introduction: Many interventions such as hypnosis, mindfulness meditation, conditioned pain modulation and placebos have been shown to effectively reduce pain both in the laboratory and in clinical settings.
- Conditions
- Hypnosis, Endocannabinoids, Analgesia
- Trial name
- NCT03407937
- Testing
- Hypnosis, Meditation, Conditioned pain modulation
- Where
- Canada
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Ketorolac, Joint Fusion
Effect of Postoperative Ketorolac on Bone Healing After Joint Fusion
In the midst of the opioid crisis, the use of non-narcotic pain medication has garnered increased interest, particularly in the field of orthopaedic surgery, where narcotic medications are routinely prescribed postoperatively.
- Trial name
- NCT04872283
- Testing
- great toe (1st metatarsophalangeal joint) fusion, IV Ketorolac, Ketorolac Pill
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Rothman Institute Orthopaedics
Opioid Abuse (Disorder)
Nudges and Incentives to Enhance the Opioid Treatment Workforce
This project seeks to examine a critical barrier to optimizing the health care workforce for the treatment of opioid use disorders.
- Trial name
- NCT03834025
- Testing
- Phase 1 Condition 1, Phase 1 Condition 2, Phase 1 Condition 3
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Opioid Use Disorder
Brain Training for Substance Use Disorders
Participants play games designed to train visual attention towards natural, non-drug-related scenarios. A biofeedback loop between gameplay and an electroencephalogram (EEG) system monitors game performance and guides game…
- Trial name
- NCT06870110
- Testing
- Bias Modification Biofeedback
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Neurotype Inc.
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