Clinical trials: Opioid Consumption, Postoperative
Total Knee Replacement, Post Operative Pain
Effect of Mindfulness on Pain After Total Knee Arthroplasty
This study will be a prospective randomized controlled trial evaluating the effectiveness of using Headspace before and after undergoing total knee replacement surgery.
- Conditions
- Total Knee Replacement, Post Operative Pain, Opioid Use
- Trial name
- NCT06118073
- Testing
- Headspace, Total Knee Replacement
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Rothman Institute Orthopaedics
Post Operative Pain
Too Much of a Good Thing? Impact of Initial Prescription Size in Post-cesarean Section Pain Management
This is a randomized controlled trial involving 170 opioid naive women ages 19-40 undergoing scheduled C-sections at Carilion Roanoke Memorial Hospital.
- Trial name
- NCT05360433
- Testing
- Oxycodone oral capsule
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Carilion Clinic
Tibial Fractures, Fibula Fracture
Effect of Palmitoylethanolamide on Reducing Opioid Consumption for Below Knee Fracture Fixation
Palmitoylethanolamide (PEA), a non-psychoactive cannabis compound derived from peanuts, egg yolks, and soybeans, is an Endogenous FA Amide produced in the body as a biological response and a repair mechanism in chronic…
- Conditions
- Tibial Fractures, Fibula Fracture, Knee Fracture
- Trial name
- NCT05317676
- Testing
- Palmitoylethanolamide
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, Irvine
Acute Post-operative Pain, Chronic Post Operative Pain
Duloxetine Impact on Postoperative Pain Control and Outcomes
1. Evaluate differences between patients taking Duloxetine or placebo following lateral lumbar interbody fusion for postoperative narcotic consumption. 2.
- Conditions
- Acute Post-operative Pain, Chronic Post Operative Pain, Narcotic Use, Opioid Use
- Trial name
- NCT05611749
- Testing
- Duloxetine 60 MG
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Scripps Health
Post Operative Pain, Spine Surgery
Effects of Continuous ESP Catheters on Recovery, Pain and Opioid Consumption After Multilevel Spine Surgery
Single-shot erector spinae plane (ESP) blocks (ESPB) are emerging as an intervention to improve pain and minimize opioid consumption after lumbar spine surgery.
- Trial name
- NCT05494125
- Testing
- Ropivacaine
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
Artroscopic Surgery, Pain Management
Suzetrigine for Analgesiain Arthroscopic Rotator Cuff Repair
The goal of this prospective is to determinate if Suzetrigine decreased de use of opioids in patients that undergo an arthroscopic rotator cuff repair.
- Conditions
- Artroscopic Surgery, Pain Management, Pain After Shoulder Surgery, Opioid Consumption
- Trial name
- SOAR (NCT07866638)
- Testing
- Suzetrigine (Journavx), Standard multimodal analgesia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Pain, Postoperative, Pain, Acute
'The Effect of Adding LFCN Block to PENG
The incidence of femoral neck fracture in Europe is 330/10000 per year. It is increasing every year due to the aging of the population.
- Conditions
- Pain, Postoperative, Pain, Acute, Nerve Block, Opioid Consumption
- Trial name
- NCT06226675
- Testing
- PENG Block, LFCN block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Zonguldak Bulent Ecevit University
Analgesia
Peri-articular Nerve Group Block Versus Fascia Iliaca Block on Postoperative Pain After Hip Arthroscopy
The study aims to evaluate the efficacy of pericapsular nerve group block versus fascia iliaca block in reducing post operative pain within the first 24 hours following hip arthroscopy
- Trial name
- NCT04423419
- Testing
- PENG block, fascia iliaca block, IV analgesia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assiut University
Postoperative Pain
Effects of TAP and QLB-1 Blocks on Opioid Consumption
Laparoscopic cholecystectomy is associated with less pain than open surgery and a shorter recovery time. While the type of pain experienced after laparoscopy differs from that experienced after laparotomy, it is predominantly…
- Trial name
- NCT06663345
- Testing
- Transversus Abdominis Plan Block (TAPB), Lateral Quadratum Lumborum (QLB-1) Block
- Where
- Turkey (Türkiye)
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Postoperative Pain
Efficacy of Erector Spinae Plane Block in Caridac Surgery
Introduction: Opioid-based pharmacological treatment is frequently used in the treatment of pain after coronary artery bypass graft (CABG) surgery.
- Trial name
- NCT05312957
- Testing
- erector spinae plane block
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Abant Izzet Baysal University
Multimodal Analgesia, Nonsteroidal Anti-inflammatory Drugs
NSAID vs. Narcotics
This will be a single-center, prospective observational study. The study will compare post-operative pain scores and narcotic consumption between two groups of patients - one cohort will receive ibuprofen (Motrin) and Percocet…
- Trial name
- NCT02915055
- Testing
- Ibuprofen 600 mg, standard oxycodone/acetaminophen
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Postoperative Pain
Analgetic Effect of Preoperative Pregabalin in Patients Undergoing Nephrectomy
Pregabalin 300mg or placebo are administered 1 hour preoperatively in patients undergoing elective nephrectomy. Postoperatively, patients receive a patient controlled analgesia device for self delivering opioids.
- Trial name
- PregabaNeph (NCT00957177)
- Testing
- Pregabalin
- Where
- Austria
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Efficacy of Dextromethorphan, Morphine Consumption
Efficacy of Pre- and Post-Operative Oral Dextromethorphan
We studied the effect of dextromethorphan (DEX), an N-methyl-d-aspartate antagonist, on analgesic consumption and pain scoring after abdominal hysterectomy.
- Conditions
- Efficacy of Dextromethorphan, Morphine Consumption, Pain
- Trial name
- NCT00199303
- Testing
- pre-operatively followed by 30 mg three times per day after surgery
- Where
- Thailand
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Khon Kaen University
Pain, Postoperative
Does IVPCA Increase Opioid Consumption and Side Effects in Fast Track Orthopedic Procedures?
The study aims to compare the use of intravenous patient controlled analgesia (IVPCA) versus the delivery of pain relief (per oral and intravenous (IV) medications as rescues analgesia) on an as needed basis within a well defined…
- Trial name
- NCT02880800
- Testing
- Morphine as IVPCA, Hydromorphone as IVPCA, Morphine
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Mount Sinai Hospital, Canada
Total Knee Arthroplasty
Medrol Dosepak for Outpatient Total Knee Arthroplasty
The purpose of this study is to evaluate the efficacy of an oral methylprednisolone taper on acute postoperative pain, function, opioid consumption, nausea, and complications following outpatient total knee arthroplasty (TKA).
- Trial name
- NCT05097976
- Testing
- Methylprednisolone
- Where
- United States
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Analgesia, Surgical Procedure, Unspecified
TLIP Block Versus Modified TLIP Block for Posterior Decompression and Stabilization Surgery
This study aimed to compare the analgesia effectivity of TLIP and modified TLIP block in Posterior Lumbar Decompression and Stabilization Surgery Perioperatively.
- Trial name
- NCT05104203
- Testing
- Thoracolumbar Interfascial Plane block, Modified Thorcolumbar Interfascial Plane block
- Where
- Indonesia
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Pain, Postoperative
Erector Spinae Plane Block Analgesia for Lumbar Spine Fusion Surgery
The purpose of this study was to investigate the effect of a bilateral ultrasound guided erector spinae plane block on the pain scores and opoid utiliziation in fusion surgery of the lumbar spine.
- Trial name
- NCT04749095
- Testing
- Erector spinae plane block
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Benha University
Opioid Abuse (Disorder), Opioid Analgesia
Reducing Opioid Use After Upper Extremity Surgery: Testing Lower Prescriptions and Pill Quantity
The goal of this clinical trial is to evaluate strategies for optimizing postoperative multimodal pain regimens and reducing opioid dependency in patients undergoing upper extremity surgery.
- Conditions
- Opioid Abuse (Disorder), Opioid Analgesia, Opioid Analgesic Adverse Reaction, Opioid Consumption
- Trial name
- NCT07750639
- Testing
- Naproxen, Acetaminophen, oxycodone
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- AdventHealth