Clinical trials: Opioid Dependence Fentanyl
Fentanyl Dependence
The Effects of Fentanyl Abuse on Executive Function and Related Brain Activity
There is a widespread abuse of prescription opioids and a dramatic increase in the availability of illicit opioids. These have created the "opioid epidemic" which is one of the most severe public health crisis in US History.
- Trial name
- NCT05469217
- Testing
- fMRI brain imaging
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ariel University
Opioid Dependence Fentanyl
Buprenorphine Induction for Fentanyl Dependent Opioid Users
The overall goal of this pilot study is to characterize illicit fentanyl and combination fentanyl and opioid dependence explicitly, by assessing physiologic barriers to effective buprenorphine induction.
- Trial name
- NCT04794790
- Testing
- Buprenorphine/naloxone
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Opioid Dependence
An Assessment of Fentanyl Dose Requirements in Opioid-maintained Individuals
This study seeks to determine the suitable doses of fentanyl with acceptable adverse effect and safety profile in opioid-dependent patients.
- Trial name
- FEN001 (NCT01358500)
- Testing
- Fentanyl
- Where
- Australia
- Volunteers
- 24 people
- Sponsor
- University of Adelaide
Opioid Use Disorder (OUD)
MethaLoad Dose-Finding Study
Methadone is an effective treatment for opioid use disorder (OUD), but starting it has become harder now that most people with OUD use fentanyl. Methadone is usually started at a low dose and increased slowly over several weeks.
- Trial name
- NCT06877858
- Testing
- Methadone hydrochloride
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Ashish P Thakrar, MD MS
Opioid Use Disorder
Rapid Outpatient Low-dose Initiation of Buprenorphine for OUD With Fentanyl Use
The goal of this clinical trial is to learn if buprenorphine can be started for opioid use disorder with fentanyl use without requiring or precipitating opioid withdrawal.
- Trial name
- ROLDI (NCT06379984)
- Testing
- Buprenorphine
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Pennsylvania