Clinical trials: Opioid Free Anesthesia
Caudal Block, Pediatric Urologic Surgeries
Comparison of Caudal Block Combined With General Anesthesia and Penile Block and Intravenous Fentanyl in Pediatric Surgeries
Urogenital surgery is one of the most frequently performed surgical procedures in the pediatric patient population. There is no consensus on which analgesic method is most effective for pain control in these patients.
- Conditions
- Caudal Block, Pediatric Urologic Surgeries, Fentanyl, Pediatric Delirium
- Trial name
- NCT06862271
- Testing
- Group 1 ( Caudal block group ), Group 2 (Penile block and IV Fentanyl group)
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Miray Gözde Özdemir
PONV, Opioid Use
Opioid Free Versus Opioid Balanced Anesthesia
OPIOID FREE VERSUS OPIOID BALANCED ANAESTHESIA IN MIDDLE EAR SURGERY AIM OF THE WORK Primary aim: To compare between opioid and opioid free anaesthesia on post-operative nausea and vomiting in middle ear surgery Secondary aim…
- Trial name
- NCT03809949
- Testing
- Fentanyl Opioid anesthesia, Saline Nonopioid anesthesia
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- University of Alexandria
Opioid Free Anaesthesia
Comparison of Opioid Based and Opioid Free Anaesthesia in Transsphenoidal Surgery
This study has been planned to compare the effect of opioid free anaesthesia using dexmedetomidine and ketamine with opioid based anaesthesia using fentanyl in maintaining the intraoperative hemodynamic stability and recovery…
- Trial name
- NCT03120234
- Testing
- Dexmedetomidine, Ketamine, Fentanyl
- Where
- India
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Gastric Cancer
The Effect of Dexmedetomidine During Opioid Free Anesthesia on Postoperative Recovery After Gastrectomy
"Want to know the effect of dexmedetomidine during opioid free anesthesia on postoperative recovery after gastrectomy. Patients undergoing open gastrectomy are divided into dexmedetomidine group and control(remifentanil) group…
- Trial name
- NCT04529135
- Testing
- Dexmedetomidine, Remifentanil
- Where
- South Korea
- Volunteers
- 68 people
- Sponsor
- Gangnam Severance Hospital
Postoperative Delirium, Gastrointestinal Tumors
Opioid-free Anesthesia and Postoperative Delirium
Postoperative delirium (POD) is a common acute and transient form of brain dysfunction in elderly patients following surgery that can lead to serious adverse clinical outcomes and even death.
- Trial name
- NCT07603596
- Testing
- OFA group, OBA group
- Volunteers
- 174 people
- Sponsor
- Qianfoshan Hospital
Kidney Stone, Retrograde Intrarenal Surgery (RIRS)
Multimodal Opioid-Free Anesthesia in RIRS
The goal of this clinical trial is to evaluate whether a dexmedetomidine-ketamine based opioid-free anesthesia (OFA) protocol can provide effective analgesia compared to conventional fentanyl-based anesthesia in adult patients…
- Conditions
- Kidney Stone, Retrograde Intrarenal Surgery (RIRS), Postoperative Pain
- Trial name
- NCT07636070
- Testing
- Dexmedetomidine-Ketamine Opioid-Free Anesthesia, Fentanyl-Based Anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- murat sahin
Chronic Cholecystitis
Anesthesia With Propofol, Dexmedetomidine and Lidocaine Infusions for Laparoscopic Cholecystectomy
Opioids may attenuate postoperative hyperalgesia and postoperative nausea and vomiting. Our hypothesis is: opioid-free total intravenous anesthesia with propofol, dexmedetomidine and lidocaine infusions for laparoscopic…
- Trial name
- NCT01833819
- Testing
- Dexmedetomidine and lidocaine, Remifentanil
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Bezmialem Vakif University
Opioid Free Anesthesia
Opioid Free Anesthesia in Breast Cancer Surgery
A comparison of incidences of postoperative nausea and vomiting (PONV) , postoperative pain severity and recovery parameters in breast cancer patients receiving opioid or opioid-free general anesthesia.
- Trial name
- NCT04390698
- Testing
- paravertebral block, opioid free anesthesia, opioid general anesthesia
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Peking University People's Hospital
Anesthesia, Postoperative Pain
Opioid-free Anesthesia and Acute Postoperative Pain
Control of intraoperative and postoperative pain with the use of opioids constitutes normal practice. Opioid free anesthesia (OFA) is a relatively recent anesthesiology practice according to which opioids are not administered…
- Conditions
- Anesthesia, Postoperative Pain, Cognitive Impairment, Variable
- Trial name
- NCT04976842
- Testing
- OFA, OBA
- Where
- Greece
- Volunteers
- 200 people
- Sponsor
- Attikon Hospital
Opioid-free Anesthesia, Cardiac Surgery
Evaluation of Non-opioid Balanced General Anesthesia in Cardiac Surgery With Extracorporeal Circulation: a Randomized, Controlled, Multicenter Superiority Trial
Opioid-free anesthesia (OFA) is a general anesthesia based on the use of hypnotics and non-opioid analgesics (lidocaine, ketamine, dexamethasone, esmolol).
- Trial name
- OFACAR (NCT04886453)
- Testing
- Balanced general anesthesia without morphine, Standard general anesthesia balanced with morphine, Data collection
- Where
- France
- Volunteers
- 321 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Long-term-opioid-free Anesthesia
Long-term-opioid-free Anesthesia in Anterior Cervical Surgery
We design this randomized controlled trial to explore the safety and efficacy of the long-term-opioid-free anesthesia in anterior cervical surgery, to reduce the dosage of perioperative long-acting opioids and promoting…
- Trial name
- NCT05548465
- Testing
- Remifentanil Hydrochloride, Sufentanil Citrate
- Where
- China
- Volunteers
- 100 people
- Sponsor
- West China Hospital
Anesthesia
Opioid Free Anesthesia and Continuous Post-operative Pulse Oximetry Monitoring in the Obese Patient
Anaesthesia has three major components, analgesia, muscle relaxation and hypnosis. For a long time, opioids have been covering the analgesia function.
- Trial name
- NCT03124680
- Testing
- Opioid free, opioid group
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- Université Libre de Bruxelles
Obesity, Postoperative Pain
OFA vs OBA in Bariatric Surgery
This study compares two different anesthesia techniques in patients with obesity undergoing bariatric surgery: one that includes opioids (OBA), and one that avoids them completely (OFA).
- Conditions
- Obesity, Postoperative Pain, Bariatric Surgery, Opioid-free Anesthesia
- Trial name
- OFA VS OBA1 (NCT07075302)
- Where
- Spain
- Volunteers
- 70 people
- Sponsor
- Hospital HM Nou Delfos
Postoperative Pain
Opioid-Free vs Opioid-Based Anesthesia for Nasal Surgeries
The goal of this clinical trial is to evaluate and compare the efficacy, onset, duration of action, analgesic effect, and side effects of opioid-free anesthesia using dexmedetomidine and lignocaine versus conventional…
- Trial name
- Dex/Lido/Fent (NCT07350668)
- Testing
- dexmedetomidine and lignocaine infusion, Fentanyl infusion
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Benha University
Morbid Obesity, Opioid Use
Inflammatory Response to Opioid Versus Opioid Free Anesthesia
Anesthetic agents, including opioids can modulate the altered immune function in patients with obesity through mechanisms that involve the expression and release of cytokines.
- Conditions
- Morbid Obesity, Opioid Use, Fentanyl Adverse Reaction, Cytokine Storm
- Trial name
- NCT04854252
- Testing
- Fentanyl
- Where
- Mexico
- Volunteers
- 40 people
- Sponsor
- University of Guadalajara
Anesthesia
Opioid Free Anesthesia: What About Patient Comfort?
66 female patients undergoing breast cancer surgery were randomized in the Jules Bordet Institute, the Belgian oncology institute. One group received an opioid anesthesia, the other group an opioid free one.
- Trial name
- NCT02882035
- Testing
- OFA
- Where
- Belgium
- Volunteers
- 66 people
- Sponsor
- Université Libre de Bruxelles
Opioid Free Anesthesia
Intraoperative Retrolaminar Block as Opioid Free Anesthesia After Posterior Lumber Spine Discectomy
Opioid-free intraoperative protocols have been successfully used in specific surgical populations with equal or superior results to classic general anesthetic approaches.
- Trial name
- NCT05312866
- Testing
- Standard analgesia (paracetamol +fentanyl), Retrolaminar block with bupivacaine + magnesium sulfate + dexamethasone
- Where
- Egypt
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Implicite Memorization
Dreams or Implicite Memorization Under OFA
The Dreams study is an observational study aimed at evaluating the incidence of connected awareness after intubation, intraoperative explicit and implicit memorization, and postoperative well-being in patients receiving general…
- Trial name
- Dreams (NCT06822660)
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre
Maxillofacial Surgery
Opioid Free Anesthesia in Maxillofacial Surgery
Opioid free anesthesia is a promising practice in anesthesia. Studies already carried out have compared OFA to an opioid or "opioid anesthesia" (OA) protocol without the use of antihyperalgesic in the OA protocol.
- Trial name
- NCT05031676
- Testing
- opioid free anesthesia
- Where
- Burkina Faso
- Volunteers
- 66 people
- Sponsor
- Université NAZI BONI
Gynecologic Disease
the Effect of Opioid-free General Anesthesia
This study is performed to investigate the effect of opioid-free general anesthesia on the recovery quality after gynecological laparoscopy.
- Trial name
- NCT04409964
- Testing
- Dexmedetomidine Hydrochloride, Lidocaine Hydrochloride, Remifentanil Hydrochloride
- Where
- 2 sites in South Korea
- Volunteers
- 78 people
- Sponsor
- The Catholic University of Korea