Clinical trials: Opioid Misuse
Morphinan Opioid Overdose
Randomized Trial of Intranasal Versus Intravenous Naloxone in Level of Consciousness in Suspected Opioid Overdose
The purpose of this study is to determine which route of administration is better for treatment of opioid overdosed patients
- Trial name
- NCT01293058
- Testing
- Intranasal naloxone, Intravenous
- Where
- Iran
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Isfahan University of Medical Sciences
Opioid Misuse
A Digital Intervention to Prevent Initiation of Opioid Misuse in Adolescents in School-based Health Centers
This study's specific aims were to: develop a digital intervention as a prevention intervention through focus groups with 40 youth; pilot-test the developed digital intervention with 30 adolescents, using methods from the…
- Trial name
- NCT04109599
- Testing
- PlaySmart, PlaySmart Storyline, Play Smart Mini-Game
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Yale University
Drug Overdose, Opioid-Related Disorders
Buccal Versus Injectable Naloxone: a Phase I Healthy Volunteer Study
Naloxone is the standard treatment in response to cases of suspected opiate overdose. Buccal formulation of naloxone is a novel alternative to the licensed naloxone injection which, by removing the risk of accidental…
- Trial name
- NCT02733822
- Testing
- Naloxone
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- King's College London
Overdose
SOONER Feasibility Study Protocol
Opioid Overdose Education and Naloxone Distribution programs (OEND) involve training and equipping people who are likely to be bystanders to opioid overdose to recognize and respond to opioid-related emergencies by activating…
- Trial name
- SOONER (NCT03821649)
- Testing
- SOONER Training and Naloxone Kit Kit, Community or Hospital-Based Training
- Where
- 4 sites in Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Medication Abuse, Harm Reduction
Clinical Decision Support to Improve System Naloxone Co-prescribing
The objective of this study is to evaluate the impact of a clinical decision support (CDS) alert to facilitate the co-prescribing of naloxone, an opioid overdose reversal agent, with high-risk opioid prescriptions.
- Conditions
- Medication Abuse, Harm Reduction, Opioid Overdose, Opioid Prescribing
- Trial name
- NCT06271668
- Testing
- Naloxone Co-prescribing Clinical Decision Support (CDS)
- Where
- United States
- Volunteers
- 114,272 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Healthy
A Study to Characterize the Abuse Liability of ALO-02 in Healthy, Non-Dependent, Recreational Opioid Abusers
The main purpose of this study is to determine if oxycodone and naltrexone combination capsules (ALO-02) have the potential to be abused.
- Trial name
- NCT01746901
- Testing
- intact ALO-02 60 mg/7.2 mg, crushed ALO-02 60 mg/7.2 mg, crushed oxycodone IR 60 mg
- Where
- Canada
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Pfizer
Middle Schools, School Exclusion
Preventing School Exclusion and Opioid Misuse: Effectiveness of the Inclusive Skill-building Learning Approach (ISLA)
This project will test the effectiveness of the Inclusive Skill-building Learning Approach (ISLA) in reducing the use of exclusionary discipline, improving teacher practice and student outcomes, and decreasing substance misuse…
- Conditions
- Middle Schools, School Exclusion, School Community, Teaching Practices
- Trial name
- ISLA (NCT06292078)
- Testing
- Instructional Skill-Building Learning Approach (ISLA)
- Where
- 3 sites in United States
- Volunteers
- 5,076 people, healthy volunteers welcome
- Sponsor
- University of Oregon
Opioid Overdose, Drug Overdose
The Rhode Island Prescription and Illicit Drug Study
This study will test the efficacy of a novel drug-checking intervention to prevent fatal and non-fatal overdose among people who use drugs (PWUD), who are 18-65 years old at the time of enrollment.
- Trial name
- RAPIDS (NCT04372238)
- Testing
- RAPIDS Intervention, Standard OEND
- Where
- United States
- Volunteers
- 509 people, healthy volunteers welcome
- Sponsor
- Brown University
Chronic Back Pain
Behavioral and Cognitive Predictors of Persistent Pain and Opioid Misuse in Chronic Pain
Chronic lower back pain (CLBP) affects approximately 20% of the global population. The study objective is to determine if impulsivity, inhibitory control, drug choice, and/or cognitive distortions predict opioid misuse and…
- Trial name
- NCT06288282
- Testing
- No Intervention
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
ACL Tear, Opioid Misuse
Exparel vs. ACB With Bupivacaine for ACL Reconstruction
Opioid misuse and addiction among children and adolescents is an increasingly concerning problem. Post-surgical opioid prescriptions for commonly performed surgeries such as anterior cruciate ligament reconstruction (ACLR)…
- Conditions
- ACL Tear, Opioid Misuse, Pain, Anxiety
- Trial name
- NCT06274008
- Testing
- Exparel
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Orange County
Substance Use, Substance-Related Disorders
Clinician Practice Companion to Address Youth Substance Use
Substance use, including the use of opioids, cannabis, and other drugs, is common among adolescents and young adults, and overdose has become a leading cause of death among youth in Canada and the United States.
- Conditions
- Substance Use, Substance-Related Disorders, Adolescent Substance Use, Cannabis Use
- Trial name
- NCT07725289
- Testing
- Practice Companion
- Where
- 5 sites in United States, Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Pain, Acute, Opioid Misuse
The Effect of a Charcoal Deactivation Pouch on Opioid Disposal After Cesarean Delivery
Background: There is scarce literature investigating how patients dispose of unused opioid supplies after their cesarean postoperative pain has faded.
- Conditions
- Pain, Acute, Opioid Misuse, Obstetric Pain, Cesarean Section Complications
- Trial name
- NCT05498025
- Testing
- Deterra activated charcoal pouch
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Geisinger Clinic
Opioid Overdose
UnityPhilly Response App for Overdose Reversal
The goal of this clinical trial is to discover if an overdose prevention app (UnityPhilly) can encourage citizen responders to respond and prevent opioid overdoses using the UnityPhilly app.
- Trial name
- NCT06466005
- Testing
- UnityPhilly app
- Where
- United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Drexel University
Opioid Overdose
Naloxone Nasal Spray Pharmacokinetic Study
This study aims to compare the pharmacokinetics of naloxone when administered as the Mitovie nasal spray (Test Product) and as a solution for injection (Comparator Product) administered intranasally using a mucosal atomization…
- Trial name
- NCT01622504
- Testing
- MVP005, Naloxone hydrochloride solution for injection with mucosal atomization device
- Where
- Jordan
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Mitovie Pharma Ltd
Opioids
WorkWell - Preventing Prescription Opioid Misuse Among Employees Working in High Risk Industries
WorkWell is a mobile-delivered behavioral intervention designed to prevent prescription opioid misuse and overuse among construction workers and healthcare workers.
- Trial name
- WW (NCT07799766)
- Testing
- WorkWell
- Where
- 2 sites in United States
- Volunteers
- 759 people, healthy volunteers welcome
- Sponsor
- Prevention Strategies, LLC
Drug Overdose, Opioid-Related Disorders
Pharmacokinetic Evaluation of Intranasal and Intramuscular Naloxone in Healthy Volunteers
To determine the pharmacokinetics of 4 intranasal doses of naloxone compared to a 0.4 mg dose of naloxone administrated intramuscular and to identify an appropriate intranasal dose that could achieve systemic exposure comparable…
- Trial name
- NCT02572089
- Testing
- Naloxone
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Opioid Overdose
Tailoring Overdose Education for Black Churches
Church-based interventions are culturally acceptable, reduce access barriers, and can be brought to scale in under-resourced communities.
- Trial name
- NCT05645016
- Testing
- COEST
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Opioid Misuse, Chronic Pain
Consensus-based Algorithms to Address Opioid Misuse Behaviors Among Individuals Prescribed Long-term Opioid Therapy
The NIH Helping to End Addiction Long-term (HEAL) initiative has identified a critical next step to addressing the opioid crisis: improving treatments for opioid misuse behaviors (e.g., using more opioids than prescribed, illicit…
- Trial name
- NCT05182606
- Testing
- Pilot study of algorithms implementation package
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Parenting, Parent-Child Relations
Parenting Young Children Study
Opioid use is rising at unprecedented levels and has reached epidemic proportions in some areas of the country, particularly rural areas.
- Conditions
- Parenting, Parent-Child Relations, Opioid Misuse, Opioid Use Disorder
- Trial name
- NCT05180487
- Testing
- Family Check-Up
- Where
- United States
- Volunteers
- 356 people, healthy volunteers welcome
- Sponsor
- University of Oregon
Opioid Overdose
Opioids and Police Safety Study
Overdose deaths are currently the largest cause of accidental death in the US and opioid-related overdose deaths constitute the overwhelming majority of these deaths.
- Trial name
- OPS (NCT05008523)
- Testing
- Opioids and Police Safety Occupational Risk Reduction Training (OPS), Opioids and Police Safety Occupational Risk Reduction Training (COVID)
- Where
- United States
- Volunteers
- 333 people, healthy volunteers welcome
- Sponsor
- New York University