Clinical trials: Opioid Pain Medication
Pain
Phoenix Thera-Lase for Treating Chronic Pain in Patients Taking Opioid on a PRN Basis
Hypothesis: Use of high level vs low level cold laser treatments will reduce chronic pain and the need for PRN opioid-containing analgesic medications.
- Trial name
- NCT02964000
- Testing
- Low level 1 Watt, Phoenix Thera-Lase System 42, Phoenix Thera-Lase System 74
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Phoenix Thera-lase Systems, LLC
Drug Effect, Rib Fractures
Trial of Injected Liposomal Bupivacaine vs Bupivacaine Infusion After Surgical Stabilization of Rib Fractures
Rib fractures represent a common injury pattern this is highly associated with patient morbidity and mortality, as pain control remains a challenge.
- Conditions
- Drug Effect, Rib Fractures, Rib Trauma, Surgical Procedure, Unspecified
- Trial name
- NCT03305666
- Testing
- Liposomal bupivacaine injection, Bupivacaine indwelling catheter
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Denver Health and Hospital Authority
Opioid Use, Opioid Dependence
Project 1 Aim 2, Adaptations of the Brain in Chronic Pain With Opioid Exposure
This study is designed to track brain functional changes in individuals with i) chronic back pain + opioid use (CBP+O) and individuals with ii) chronic back pain + opioid misuse disorder (CBP+mOUD) following a brief drug delay…
- Conditions
- Opioid Use, Opioid Dependence, Opioid-use Disorder, Narcotic Use
- Trial name
- NCT05463367
- Testing
- Carbidopa-Levodopa 25 Mg-100 Mg Oral Tablet, Naproxen 500 Mg, Opioids
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Northwestern University
Postoperative Pain
Comparison of the Efficacy and Safety of Q8003 Versus Its Individual Components in Bunionectomy Patients
This is a randomized, double-blind, multicenter, fixed dose factorial study of Q8003 12 mg/8 mg and Q8003 6 mg/4 mg versus its individual morphine sulfate and oxycodone hydrochloride components for the management of acute…
- Trial name
- NCT00831051
- Testing
- Q8003, Morphine sulfate, Oxycodone HCl
- Where
- 6 sites in United States
- Volunteers
- 197 people
- Sponsor
- QRxPharma Inc.
Opioid Use, Side Effect of Drug
Pharmacokinetics of Morphine and Oxycodone in Frail Elderly Undergoing Cardiac Surgery
Single centre observational cohort study. 20 older patients undergoing cardiac surgery who receive standard of care pain treatment.
- Conditions
- Opioid Use, Side Effect of Drug, Postoperative Pain
- Trial name
- NCT04696445
- Testing
- Morphine & Oxycodone
- Where
- Netherlands
- Volunteers
- 34 people
- Sponsor
- St. Antonius Hospital
Chronic Pain
A Study to Assess the Safety and Effectiveness of Durogesic (Fentanyl Transdermal Patch) in the Treatment of Children With Chronic Pain Requiring Long-term Narcotic Pain Relief Therapy
The purpose of this study is to assess the effectiveness and safety of Durogesic® (a transdermal patch delivering the narcotic pain-reliever fentanyl) in the treatment of children with chronic pain requiring long-term narcotic…
- Trial name
- NCT00271453
- Testing
- Durogesic® (fentanyl transdermal drug delivery system)
- Volunteers
- 41 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Cesarean Section; Complications, Wound, Infection (Following Delivery), Postoperative Pain
Comparison of Two Routes of Administration of a Multimodal Analgesic Protocol in Postoperative Cesarean Section
Many drugs with various mechanisms of action are used for postcaesarean pain relief. Although the response to pain relief is sometimes believed to be individual, it is very important to establish the most effective with the least…
- Conditions
- Cesarean Section; Complications, Wound, Infection (Following Delivery), Postoperative Pain, Spinal Anaesthesia During the Puerperium
- Trial name
- NCT03626753
- Testing
- Nefopam 20 MG/ML, "Nefopam (Acupan)" 20 MG/ML Injectable Solution, "Acetaminophen, (paracetamol)" 500Mg Tab
- Where
- Tunisia
- Volunteers
- 200 people
- Sponsor
- Centre de Maternité de Monastir
Opiate Dependence, Substance-related Disorders
Prescription Opioid Addiction Treatment Study (POATS)
The purpose of this study is to determine whether treatment outcome for subjects dependent on prescription opioid analgesics can be improved by adding individual drug counseling to the prescription of buprenorphine/naloxone with…
- Conditions
- Opiate Dependence, Substance-related Disorders, Opioid-related Disorders
- Trial name
- NCT00316277
- Testing
- Standard Medical Management (SMM) of Prescription Opiate Abuse, Enhanced Medical Management (EMM) of Prescription Opiate Abuse
- Where
- 12 sites in United States
- Volunteers
- 653 people
- Sponsor
- Mclean Hospital
Hepatectomy
Intravenous Lidocaine for Hepatectomy
Liver resection is increasingly performed for hepatic tumors, mainly primary liver cancers and resectable metastases, but also for some benign lesions.
- Trial name
- ILHEP (NCT07590830)
- Testing
- Standardized General Anesthesia Induction and Maintenance Protocol incorporating Intravenous Lidocaine
- Where
- 9 sites in France
- Volunteers
- 312 people
- Sponsor
- Rennes University Hospital
Pain, Acute Pain
Optimal Management of Pain in Hospitalized Patients - Opioid Tolerant Populations.
Pain is a symptom that drives hospital admissions, and pain management is required by most patients during their hospital stay. Further, the use of medications such as opioids can lead to upward-spiraling doses, especially among…
- Conditions
- Pain, Acute Pain, Postoperative Pain
- Trial name
- NCT02470728
- Testing
- New Clinical Pathway
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Duke University
Foot and Ankle Procedures
Efficacy of Popliteal Nerve Blocks With and Without Dexamethasone on the Duration of Analgesia for Foot & Ankle Surgery
The purpose of this research study to evaluate the effects of dexamethasone as an addition to peripheral nerve block (Put the nerve to sleep with Bupivacaine a numbing medication) on length of pain relief (analgesia)…
- Trial name
- NCT01975285
- Testing
- Dexamethasone, Saline
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Cedars-Sinai Medical Center
Acute Post Operative Pain, Hip Fracture
Pain Relief Comparison: Pericapsular Nerve Group Versus Quadratus Lumborum Block for Positioning in Femur Fracture Surgery
This study aims to compare the analgesic efficacy of Ultrasound Guided Pericapsular Nerve Group Block and Quadratus Lumborum Block for pain relief During patient Positioning for Spinal Anesthesia in proximal femur fracture…
- Conditions
- Acute Post Operative Pain, Hip Fracture, Regional Anaesthesia, Quadratus Lumborum Block
- Trial name
- NCT06917807
- Testing
- Pericapsuler nerve group block, Quadratus lumborum block
- Where
- Egypt
- Volunteers
- 42 people
- Sponsor
- Ain Shams University
Advanced Cancers
Self Reported Deviations From Opioid Analgesic Prescription
Primary Objective: 1. To determine the frequency of self-reported over and under use of opioid analgesics in patients with advanced cancer.
- Trial name
- NCT00907192
- Testing
- Personal Interview, Questionnaire
- Where
- United States
- Volunteers
- 201 people
- Sponsor
- M.D. Anderson Cancer Center
Opioid Use, Pain Postoperative
Comparison of Pain Relief After Arthroscopic Knee Surgery: Adductor Canal Block and Genicular Nerve Block
This prospective randomized study aims to compare the analgesic efficacy of Adductor Canal Block (ACB) and Genicular Nerve Block (GNB) groups to relieve postoperative pain in participants between ages of 18-72 undergoing…
- Conditions
- Opioid Use, Pain Postoperative, Arthroscopic Knee Surgeries
- Trial name
- NCT06909851
- Testing
- Adductor Canal Block (ACB), Genicular Nerve Block (GNB)
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Post Surgical Pain
Recovery Toolkits: Assessment of Pragmatic Behavioral Pain Medicine Delivered In Hospital After Surgery
Behavioral pain medicine is largely absent from perioperative pathways, and on post-surgical recovery units. The goal of this project was to develop and implement "Recovery Toolkits", physical branded bags presented to patients…
- Trial name
- NCT03828669
- Testing
- Recovery Toolkits
- Where
- United States
- Volunteers
- 649 people
- Sponsor
- Stanford University
Pain
Study of Medication Compliance - a Comparison of Patients in Pain Management and Pre-surgical Patients
In this study medication compliance regarding current drug use is investigated using toxicological analyzes in two patient groups: patients from a pain management department and pre-surgical control patients.
- Trial name
- NCT01625065
- Where
- Germany
- Volunteers
- 343 people
- Sponsor
- Ruhr University of Bochum
Non-Medical Opioid Use
Reducing Non-Medical Opioid Use: An Automatically Adaptive mHealth Intervention
In recent years in the U.S., problems associated with opioid prescriptions, including non-medical use and overdose, increased to historically unprecedented levels and represent a public health crisis.
- Trial name
- NCT02990377
- Testing
- RL-supported IVR intervention
- Where
- United States
- Volunteers
- 459 people
- Sponsor
- University of Michigan
Opioid Dependence, Chronic Pain
Standardized Natural Psilocybin-assisted Psychotherapy for Tapering of Opioid Medication
This is an open-label pilot trial to assess the safety and feasibility of a novel 8-week psilocybin-assisted psychotherapy intervention to facilitate successful tapering/discontinuation of opioid pain medication in adult patients…
- Trial name
- NCT05585229
- Testing
- Psilocybin-assisted Psychotherapy
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University of British Columbia
Prostate Cancer
Does Postoperative Gabapentin Reduce Pain, Opioid Consumption and Anxiety and Have a Positive Effect on Health Related Quality of Life After Radical Prostatectomy?
The Acute Pain Service (APS) at Sunnybrook has been using Gabapentin 200 mg three times a day (TID) resulting in anecdotal benefits in terms of analgesia and opioid sparing effects.
- Trial name
- NCT00982800
- Testing
- Gabapentin
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Sunnybrook Health Sciences Centre
Postoperative Pain Management, Cholecystectomy, Laparoscopic
Analgesic Efficacy of Bupivacaine Infiltration, Erector Spinae Plane Block, and Intrathecal Morphine in Laparoscopic Cholecystectomy
This study is designed to compare three different methods of pain control after laparoscopic gallbladder surgery (laparoscopic cholecystectomy).
- Trial name
- ITM-ESP-IPLA (NCT07203794)
- Testing
- Bupivacaine Infiltration, Erector Spinae Plane Block, Intrathecal Morphine
- Where
- Turkey (Türkiye)
- Volunteers
- 132 people
- Sponsor
- Ataturk University