Clinical trials: Opioid Use Disorders
Opioid Use Disorder, Substance-Related Disorders
Multimodal Fetal and Placental Imaging and Biomarkers of Clinical Outcomes in Opioid Use Disorder
The goal of this observational study is to learn about the long term effects of prenatal opioid exposure. The main objectives are: Long term goal: to improve the safety and efficacy of maternal Opioid Use Disorder (OUD) and…
- Conditions
- Opioid Use Disorder, Substance-Related Disorders, Pregnancy Related, Narcotic-Related Disorders
- Trial name
- NCT06415994
- Testing
- Buprenorphine or Methadone Treatment, Fetal and Placental MRI, Child Developmental Assessment
- Where
- 2 sites in United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Senthil Sadhasivam
Substance Abuse, Decision Making, Shared
Data2Action Oregon Project: Supporting Data-driven Decision-Making for Substance Use Services, Policy, and Overdose Prevention
Oregon's decision makers (e.g., community service providers, public health, justice, advocacy groups, payers) are calling for comprehensive, current, and trusted data to inform how they allocate resources to improve substance use…
- Conditions
- Substance Abuse, Decision Making, Shared, Implementation Science, Decision Making
- Trial name
- D2A Oregon (NCT06852170)
- Testing
- Co-Design Sessions (CDS), Data products
- Where
- United States
- Volunteers
- 341 people, healthy volunteers welcome
- Sponsor
- Chestnut Health Systems
Opioid-use Disorder, Stigma, Social
SMART Trial: Community Stigma Reduction
The goal of this project is to engage community members from two low-income African American communities (N=200) in a survey study that assesses stigma toward those with Opioid Use Disorder (OUD).
- Trial name
- NCT05075330
- Testing
- Opioid Use Disorder Stigma Reduction
- Where
- United States
- Volunteers
- 199 people, healthy volunteers welcome
- Sponsor
- Karen Derefinko, PhD
Improving Treatment for Opioid Use Disorder in Courts
Facilitating MAT Acceptance & Implementation in Problem Solving & Felony Courts
This study compares two methodologies for improving access to medication assisted treatment (MAT) in Ohio courts where MAT is currently restricted or prohibited. All participating courts are asked to view two educational modules.
- Trial name
- NCT03229447
- Testing
- eLearning Modules, Change Team Intervention
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- National Development and Research Institutes, Inc.
Harm Reduction, Opioid-use Disorder
A Usability Assessment of Naloxone Administration by Untrained Community Members
This will be a randomized, open-label, usability assessment of intramuscular, intranasal, and nasal spray administration of naloxone using two different instruction sets by laypersons.
- Conditions
- Harm Reduction, Opioid-use Disorder, Naloxone
- Trial name
- NCT04025671
- Testing
- Nasal Spray Naloxone, Intramuscular Naloxone, Improvised Nasal Atomizer
- Where
- United States
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- State University of New York - Upstate Medical University
Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
Parental Attitudes and Beliefs Regarding Risks Associated With Opioid Use in Children With Cancer
This study investigates parents' attitudes and beliefs on the risks of opioid use in children with cancer. Pain is the common symptom reported by pediatric cancer patients.
- Trial name
- NCT05055011
- Testing
- Electronic Health Record Review, Survey Administration
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Opioid Use Disorder
Cannabis and Opioid Use Disorder
This study plans to enroll participants with opioid use disorder who are not currently seeking treatment to assess the effects of cannabis on opioid withdrawal and other related outcomes.
- Trial name
- NCT05729932
- Testing
- Inhaled vaporized cannabis, Intransal opioid
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Shanna Babalonis, PhD
Opioid Dependence, Opioid Use Disorder (OUD)
VK4-116 Phase I Study With Food-Effect
This first-in-human, randomized, double-blind, placebo-controlled, single ascending dose (SAD), phase I study is designed to assess the safety, tolerability and pharmacokinetics of VK4-116 in healthy volunteers in fasted and fed…
- Trial name
- NCT06808932
- Testing
- VK4-116
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Post-operative Pain, Acute, Opioid Use, Unspecified
Patient Centered Post-Op Pain Management Software Tool Interventional Study Verses Standard of Care
The goal of this clinical trial is to learn if the Pain Coach App will result in less opioids being prescribed to and used by patients undergoing Shoulder/Hip/Knee Arthroplasty surgery while maintaining the same or better pain…
- Conditions
- Post-operative Pain, Acute, Opioid Use, Unspecified, Arthroplasty Complications, Knee Osteoarthritis
- Trial name
- NCT06469177
- Testing
- Pain Coach App
- Where
- Canada
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority
Opioid Craving, Opioid Use Disorder
Developing a Clinical Outcome Assessment for Opioid Craving
The purpose of this study is to collect information about opioid craving so that the investigators can develop an opioid craving assessment to improve treatments for individuals with opioid use disorder.
- Conditions
- Opioid Craving, Opioid Use Disorder, Measure Development
- Trial name
- NCT05109429
- Testing
- Neutral Cue-induced Craving, Visual Opioid Cue-induced Craving, Visual and Tactile Opioid Cue-induced Craving
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Anxiety, Opioid Use
Effects of Hypnosis Therapy on Outcomes in Shoulder Replacement Therapy
The purpose of this study is to collect information to evaluate the role of the psychogenic component of pain induced by anxiety on postoperative outcomes in major orthopaedic surgery and to determine whether hypnosis therapy…
- Trial name
- NCT04889833
- Testing
- hypnosis therapy
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Foundation for Orthopaedic Research and Education
Opioid Use Disorder, Treatment Adherence
Digital Health Intervention to Support Opioid Use Disorder Treatment
In prior studies, the investigative team developed a combined computer- and text message-delivered personalized-feedback intervention (iENDURE) designed to enhance motivation and improve tolerance of distress to support the early…
- Trial name
- iENDURE (NCT03842384)
- Testing
- iENDURE
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Rhode Island Hospital
Pain, Cannabis
Enhancing Medication-based Analgesia in Humans
This is a single-group, within-subject, double-blind, double-dummy, placebo and active-controlled study evaluated whether the FDA-approved cannabinoid dronabinol (Marinol) would enhance analgesia, subjective reports, and…
- Conditions
- Pain, Cannabis, Opioid Use, Unspecified
- Trial name
- NCT02901275
- Testing
- Within-subject test of blinded study medications
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Opiate Withdrawal Syndrome
A Study of Oral Ibogaine in Opioid Withdrawal
Study DMX-IB 201 is a Phase 1/2a study of ibogaine consisting of an initial single ascending dose escalation stage to determine the maximum tolerated dose (MTD) or treat-to-target dose (TTD) in healthy volunteers, followed by a…
- Trial name
- NCT05029401
- Testing
- DMX-1002
- Where
- 2 sites in United Kingdom
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- atai Therapeutics, Inc.
Opioid Use Disorder, Substance Use Disorders
SMART Brain Health in African-Americans
The investigators hypothesize that opioid use in African-Americans will be associated with hypodopaminergic alleles that alter the threshold for activating feelings of reward and pleasure within the dopaminergic system, and that…
- Conditions
- Opioid Use Disorder, Substance Use Disorders, Dopamine Dysregulation Syndrome, African Americans
- Trial name
- SMART (NCT03861832)
- Testing
- KB220Z
- Where
- 2 sites in United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Howard University
Chronic Pain, Opioid Use
Chronic Pain, Opioid Use, and Epidermal Nerve Fiber Density
This pilot study is being performed to examine whether epidermal axons are altered in patients taking opioid therapy for chronic non-cancer pain, and if epidermal axonal changes predict heightened pain sensitivity.
- Conditions
- Chronic Pain, Opioid Use, Nerve Disorders
- Trial name
- COED (NCT04801498)
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Mastectomy; Lymphedema, Chronic Pain
Erector Spinae Block Versus Paravertebral Block on Chronic Pain After Mastectomy
The goal of this clinical trial is to learn if the erector spinae block can reduce the incidence of chronic pain compared to the paravertebral block in adult patients undergoing total mastectomy.
- Conditions
- Mastectomy; Lymphedema, Chronic Pain, Regional Anesthesia Morbidity, Opioid Use
- Trial name
- NCT07561411
- Testing
- Paravertebral block, Erector Spinae block
- Where
- Lebanon
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- American University of Beirut Medical Center
Opioid Use Disorder, Opioid Use Disorder, Severe
Buprenorphine Implementation at Syringe Service Programs to Reduce Overdoses
This study is testing whether offering buprenorphine treatment directly at syringe service programs (SSPs) helps more people start and stay in treatment for opioid use disorder (OUD) than referring them to community buprenorphine…
- Conditions
- Opioid Use Disorder, Opioid Use Disorder, Severe, Opioid Use Disorder, Moderate
- Trial name
- BISTRO (NCT07631598)
- Testing
- Standard of Care Referral, Low Threshold Buprenorphine
- Where
- 8 sites in United States
- Volunteers
- 512 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Opioid Use Disorder
Positron Emission Tomography (PET) Trial to Evaluate Target Occupancy of CVL-354 at Kappa and Mu Opioid Receptors in Brain Following Oral Dosing
The primary purpose of this study is to assess the target occupancy at kappa and mu opioid receptors in the brain after single oral doses of CVL-354 in healthy adult participants.
- Trial name
- NCT05547542
- Testing
- CVL-354, [11C]-LY2795050, [11C]-carfentanil
- Where
- 2 sites in United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Cerevel Therapeutics, LLC
Opioid-use Disorder
Opioid Treatment Program (OTP)-Pharmacy Collaboration for Methadone Maintenance Treatment
The overarching goal of this pilot study is to explore the feasibility, acceptability, and patient/provider satisfaction of pharmacy-based administration and dispensing of methadone for opioid use disorder.
- Trial name
- NCT04308694
- Testing
- Pharmacy-based methadone administration and dispensing
- Where
- 3 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Friends Research Institute, Inc.