Clinical trials: Opioid Use Disorders
Bariatric Surgery Candidate, Pain, Postoperative
Efficacy of External Oblique Intercostal Block in Laparoscopic Bariatric Surgery
Laparoscopic bariatric procedures nowadays are employed under ERAS protocol as an ambulatory surgery. Pain after laparoscopic procedures arises significantly from port site incisions in the anterior abdominal wall, and shoulder…
- Conditions
- Bariatric Surgery Candidate, Pain, Postoperative, Narcotic Use, Analgesia
- Trial name
- NCT05592522
- Testing
- External oblique intercostal block, Oblique subcostal TAP block, Posterior Rectus sheath block
- Where
- Saudi Arabia
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Al Mashfa Medical Center
Non-communicable Diseases (NCD), Addiction to Opioids
Systematic Examination of Health Inequalities: Documentation, Patterns, and Determinants
The existence of social inequalities is a major global issue and a salient challenge for the European Union. During COVID-19 pandemic, health disparities became more evident.
- Conditions
- Non-communicable Diseases (NCD), Addiction to Opioids, Incarceration, Opioid-use Disorders
- Trial name
- CHANCE (NCT07558187)
- Where
- 5 sites in Greece
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
Opioid Use Disorder, Criminal Justice
Injectable Extended-Release Buprenorphine (XR-B) in a Correctional Setting: Qualitative Interviews
This qualitative study investigates the potential benefits and challenges of using a once-a-month injectable medication, known as extended-release buprenorphine (XR-B), to treat individuals with opioid use disorder (OUD) within a…
- Conditions
- Opioid Use Disorder, Criminal Justice, Treatment Adherence and Compliance
- Trial name
- NCT06354465
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Lifespan
Opioid Use Disorder
Study of the BIOPIN 6 Naltrexone Implant in Healthy Adults
The purpose of this study is to evaluate the safety and blood levels of a medicine, naltrexone, contained within an implant in healthy volunteers age 18 to 65 years.
- Trial name
- NCT06216132
- Testing
- BIOPIN-6 Active Implant with Naltrexone
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Akyso Therapeutics, LLC
Stress, Early Life Stress
How Does the Opioid System Shape Stress and Social Behaviour in Men and Women and What Role Does Childhood Unpredictability Play?
The study aims to investigate sex differences in the effect of mu-opioid receptor (MOR) activation on stress response and social behaviour modulated by early life stress.
- Conditions
- Stress, Early Life Stress, Sex Differences, Opioid
- Trial name
- MOR-SAFE (NCT07778511)
- Testing
- Morphine
- Where
- Switzerland
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Sara L. Kroll
Opioid Dependence
Re-entry XR-NTX for Rural Individuals With Opioid Use Disorder
The overall aim of this R34 proposal is to examine the feasibility, acceptability, and short-term outcomes associated with an innovative service delivery model to increase adherence to extended-release naltrexone (XR-NTX) during…
- Trial name
- NCT03447743
- Testing
- XR-NTX community location
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Michele Staton
Opioid-use Disorder
Obstetric Pain Management for Women With Opioid Use Disorder (QUEST)
This is a mixed methods longitudinal observational study to assess patient and provider perspectives on pain and pain management among pregnant women with opiate use disorder (OUD).
- Trial name
- QUEST (NCT04308655)
- Testing
- Interview, Surveys
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Human Immunodeficiency Virus, Opioid Use Disorder
Combined Injectable Treatment for HIV and OUD
This is study seeks to evaluate perspectives of a combined injectable treatment for HIV and OUD. Specifically, with the development of new long-acting medications such as cabotegravir co-administered with rilpivirine (CAB/RPV)…
- Trial name
- CHOICE (NCT05991622)
- Testing
- Combined LAI Treatment: Cabenuva and Sublocade
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Rhode Island Hospital
Opioid Court Model, Medication to Treat Opioid Use Disorder
Facilitating Opioid Care Connections
In response to the opioid crisis in New York State (NYS), where the propose project will take place, the Unified Court System (UCS) developed a new treatment court model - the opioid court model (OCM) - designed around 10…
- Conditions
- Opioid Court Model, Medication to Treat Opioid Use Disorder, Opioid Use
- Trial name
- NCT04216719
- Testing
- OCM-RISE
- Where
- United States
- Volunteers
- 3,440 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Opioid-use Disorder, Contraception
Averting NAS Among Opioid-Using Young Women Receiving MAT Using Buprenorphine
The primary objective of this study is to test the efficacy of a Motivational Interviewing and Educational Training intervention with immediate linkage to long acting reversible contraception (LARC) (hereafter known as MIET).
- Conditions
- Opioid-use Disorder, Contraception, Neonatal Abstinence Syndrome
- Trial name
- NAS-MIET (NCT04611659)
- Testing
- Motivational Interviewing and Educational Training (MIET)
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Meharry Medical College
Alcohol Use, Cannabis Use
MATAspire: Mental Health Awareness Tailored App for Substance Prevention and Integrated Resilience Education
The MATAspire intervention is a web-app designed to promote substance misuse prevention education and bolster protective coping skills whereby students complete six weekly interactive modules using a smart device or computer.
- Conditions
- Alcohol Use, Cannabis Use, Nicotine Use, Illicit Drug Use
- Trial name
- MATAspire (NCT06553196)
- Testing
- MATAspire Web-app
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- California State University, Northridge
Opioid Use Disorder, Substance-Related Disorders
Multimodal Fetal and Placental Imaging and Biomarkers of Clinical Outcomes in Opioid Use Disorder
The goal of this observational study is to learn about the long term effects of prenatal opioid exposure. The main objectives are: Long term goal: to improve the safety and efficacy of maternal Opioid Use Disorder (OUD) and…
- Conditions
- Opioid Use Disorder, Substance-Related Disorders, Pregnancy Related, Narcotic-Related Disorders
- Trial name
- NCT06415994
- Testing
- Buprenorphine or Methadone Treatment, Fetal and Placental MRI, Child Developmental Assessment
- Where
- 2 sites in United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Senthil Sadhasivam
Decision Making
Craving & Decision-Making
Craving is the strong desire for something, such as for substances in drug addiction and food or other activities in everyday life.
- Trial name
- NCT06440577
- Testing
- Audio-visual stimuli (Neutral-Relaxing), Audio-visual stimuli (Drug), Audio-visual stimuli (Non-Food)
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Chronic Pain, Chronic Pain Syndrome
Outcomes Mandate National Integration With Cannabis as Medicine
This will be a multistate, multicenter clinical study to determine the efficacy and safety of medical cannabis for a wide variety of chronic medical conditions.
- Conditions
- Chronic Pain, Chronic Pain Syndrome, Chronic Pain Due to Injury, Chronic Pain Due to Trauma
- Trial name
- OMNI-Can (NCT03944447)
- Testing
- Cannabis, Medical, RYAH-Medtech Inhaler
- Where
- 17 sites in United States
- Volunteers
- 200,000 people, healthy volunteers welcome
- Sponsor
- OMNI Medical Services, LLC
Opioid Use Disorder
Low-dose Versus a High-dose Sublingual Buprenorphine Induction
This study proposes to compare a low-dose versus a high-dose buprenorphine induction scheme in 40 fentanyl using people with Opioid Use Disorder (OUD).
- Trial name
- NCT05944952
- Testing
- buprenorphine/naloxone
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Friends Research Institute, Inc.
Arthropathy of Knee, Osteo Arthritis Knee
Meditation and Opioid Consumption in Total Joint Replacement Patients Undergo Primary Total Hip and Knee Replacement
The main purpose of this study is to look at whether meditation techniques can help reduce pain and opioid use after surgery.
- Conditions
- Arthropathy of Knee, Osteo Arthritis Knee, Osteonecrosis, Meditation
- Trial name
- NCT05669066
- Testing
- Mindful meditation
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Opioid Use Disorder
Buprenorphine for Individuals in Jail
This study is an open label randomized controlled trial of extended-release buprenorphine (BRIXADI, XR-B) vs. sublingual buprenorphine (SL-B) in a large metropolitan jail.
- Trial name
- NCT06306443
- Testing
- extended-release buprenorphine (XR-B)
- Where
- 2 sites in United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Friends Research Institute, Inc.
Opioid-use Disorder
Increasing MAT Engagement With Financial Incentives
The increased prevalence of opioid use disorder (OUD) and associated overdoses and adverse events has led to a substantial increase in the number of patients being seen at emergency departments (ED).
- Trial name
- NCT04585399
- Testing
- Contingency management
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Rowan University
Virtual Reality, Musculoskeletal Pain
Virtual Reality Analgesia In Trauma Rehab
This will be a pilot study utilizing Virtual Reality Analgesia (VRA) as a first line nonpharmacologic analgesic intervention on the Acute Rehabilitation Unit.
- Conditions
- Virtual Reality, Musculoskeletal Pain, Opioid Use, Anxiety
- Trial name
- NCT03894592
- Testing
- Virtual reality
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- New York City Health and Hospitals Corporation
Smoking
E-cigarettes as a Harm Reduction Strategy
E-cigarettes have emerged as an effective strategy for replacing cigarettes among smokers from the general population, but there is a dearth of studies investigating their utility in replacing cigarettes among smokers with opioid…
- Trial name
- NCT06277271
- Testing
- E-cigarette
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Prisma Health-Upstate