Clinical trials: Opioid Use Disorders
Acute Pain, Chronic Pain
The Use of Venlafaxine in Reducing Pain in Primary Total Knee Replacement
Patients experience pain after their knee replacement surgery - and some may continue to experience persistent pain long after their knee replacement surgery.
- Conditions
- Acute Pain, Chronic Pain, Knee Pain Chronic, Neuropathic Pain
- Trial name
- NCT05023278
- Testing
- Venlafaxine 37.5 MG
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Smoking
E-cigarettes as a Harm Reduction Strategy
E-cigarettes have emerged as an effective strategy for replacing cigarettes among smokers from the general population, but there is a dearth of studies investigating their utility in replacing cigarettes among smokers with opioid…
- Trial name
- NCT06277271
- Testing
- E-cigarette
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Prisma Health-Upstate
Opioid-use Disorder
CBT4CBT-Buprenorphine + Recovery Coach for Office-based Buprenorphine
To conduct an 8-week pilot, randomized trial evaluating the feasibility, acceptability, and efficacy of an integrated intervention involving CBT4CBT-Buprenorphine + Recovery Coach in a population of 60 individuals who meet…
- Trial name
- NCT04824404
- Testing
- CBT4CBT-Buprenorphine + Recovery Coach
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Prisma Health-Upstate
Narcotic Use, Central Sleep Apnea
Diagnosis of Sleep-Related Respiratory Disorders in Patients With Narcotic Medications
The present study is a prospective, single cohort study involving patients on narcotic medications, undergoing overnight sleep studies in the clinical sleep laboratory.
- Trial name
- WP-NARC001 (NCT03670914)
- Testing
- WatchPAT 200
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Non-communicable Diseases (NCD), Addiction to Opioids
Systematic Examination of Health Inequalities: Documentation, Patterns, and Determinants
The existence of social inequalities is a major global issue and a salient challenge for the European Union. During COVID-19 pandemic, health disparities became more evident.
- Conditions
- Non-communicable Diseases (NCD), Addiction to Opioids, Incarceration, Opioid-use Disorders
- Trial name
- CHANCE (NCT07558187)
- Where
- 5 sites in Greece
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
Opioid-use Disorder, Pregnancy Related
Quantitative Sensory Psychophysical Correlates of Pain in Pregnant Women With OUD
This is a prospective observational case-control study comparing quantitative sensory testing data preformed during the third trimester of pregnancy and within 24 hours postpartum in women on medication-assisted treatment for…
- Trial name
- Q-PRONTO (NCT04888962)
- Testing
- OUD
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Opioid-use Disorder
Comparison of Naloxone Pharmacokinetics
Intranasal (IN) naloxone administration is an effective alternative to intravenous (IV) or intramuscular (IM) naloxone by emergency medical services for opioid overdoses and has been used successfully for this purpose as reported…
- Trial name
- NCT03386591
- Testing
- Naloxone, Mucosal atomization device and syringe, Narcan
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Healthy Volunteer Study, Opioid-use Disorder
A Phase 1 Study Investigating the Safety, Tolerability and Pharmacokinetics of KNX100 in Healthy Volunteers
The primary objectives of this study are to evaluate the safety and tolerability of KNX100 administered orally as a single and multiple ascending doses in healthy volunteers.
- Trial name
- KTX101 (NCT04901078)
- Testing
- KNX100
- Where
- Australia
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Kinoxis Therapeutics Pty Ltd
Virtual Reality, Musculoskeletal Pain
Virtual Reality Analgesia In Trauma Rehab
This will be a pilot study utilizing Virtual Reality Analgesia (VRA) as a first line nonpharmacologic analgesic intervention on the Acute Rehabilitation Unit.
- Conditions
- Virtual Reality, Musculoskeletal Pain, Opioid Use, Anxiety
- Trial name
- NCT03894592
- Testing
- Virtual reality
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- New York City Health and Hospitals Corporation
Postoperative Delirium, Postoperative Pain
A Clinical Trial of Intravenous Lidocaine After Spinal Surgery to Prevent Delirium and Reduce Pain
Postoperative delirium is one of the most frequent adverse events following elective non-cardiac surgery and is associated with cognitive impairment at discharge, as well as in-hospital and long-term mortality, however, despite…
- Conditions
- Postoperative Delirium, Postoperative Pain, Spinal Fusion
- Trial name
- LIMPP (NCT05010148)
- Testing
- Lidocaine IV
- Where
- United States
- Volunteers
- 219 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Opioid Use Disorder, Treatment Adherence
Digital Health Intervention to Support Opioid Use Disorder Treatment
In prior studies, the investigative team developed a combined computer- and text message-delivered personalized-feedback intervention (iENDURE) designed to enhance motivation and improve tolerance of distress to support the early…
- Trial name
- iENDURE (NCT03842384)
- Testing
- iENDURE
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Rhode Island Hospital
Pain, Chronic, Opioid Dependence
The Effects of Daily Anti-inflammatory Supplementation on Foundation Pain Index Scores in Chronic Opiate Patients
This is a research study to evaluate the effectiveness of daily supplementation with Root.Health, a plant-based dietary supplement, on reducing levels of 11 abnormal urine biomarkers associated with chronic pain.
- Conditions
- Pain, Chronic, Opioid Dependence, Opioid Use, Inflammation Chronic
- Trial name
- NCT05896878
- Testing
- Root.Health Dietary Supplement
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Hudson Medical
Opioid-Related Disorders, Hepatitis C (HCV)
Kentucky Outreach Service Kiosk (KyOSK): Reducing HIV, HCV, and Overdose Risk
This study will test the effectiveness, implementation outcomes, and cost effectiveness of a locally-tailored, health kiosk to reduce overdose, hepatitis C, and HIV risk behavior and improve linkage to care in rural Appalachia.
- Conditions
- Opioid-Related Disorders, Hepatitis C (HCV), Human Immunodeficiency Virus (HIV), Drug Overdose
- Trial name
- NCT05657106
- Testing
- Health kiosk
- Where
- United States
- Volunteers
- 752 people, healthy volunteers welcome
- Sponsor
- April M Young
HIV Infections, Opioid Use
Evaluation of Neuroinflammation FNOS PET/CT in HIV (+) and (-) Subjects With OUD and Healthy Controls
The purpose of this research is to measure the extent of inflammation in the brain between different groups of participants using a radioactive tracer called [18F]NOS.
- Trial name
- NCT04401917
- Testing
- [18F]NOS
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Opioid-use Disorder, Pregnancy Related
STEPuP: Prenatal Provider Education and Training to Improve Medication-assisted Treatment Use During Pregnancy
This research will test the effectiveness of a prenatal provider education and training program designed to facilitate provider adoption of evidence-based practices for the treatment of OUD during pregnancy.
- Trial name
- STEPuP (NCT04527926)
- Testing
- STEPuP Intervention, Usual Care
- Where
- United States
- Volunteers
- 1,022 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Cocaine Dependence, Cocaine-Related Disorders
Aripiprazole for Prevention of Relapse to Cocaine Use in Methadone-Maintenance Patients
Background: The effectiveness of methadone maintenance for treatment of heroin addiction has been well established. However, patients maintained on methadone may relapse to cocaine use, even when they are enrolled in a…
- Conditions
- Cocaine Dependence, Cocaine-Related Disorders, Opioid-Related Disorders
- Trial name
- NCT00780702
- Testing
- Airipiprazole
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Post Operative Pain Control, Narcotic Use
Sprix for Postoperative Pain Control Following Gynecologic Surgery
The ongoing opioid epidemic has altered both how physicians prescribe narcotics and patients' perceptions of those prescriptions.
- Conditions
- Post Operative Pain Control, Narcotic Use, Pelvic Organ Prolapse, Urinary Incontinence , Stress
- Trial name
- NCT04444830
- Testing
- Sprix
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Louisville
Opioid Use Disorder, Substance-Related Disorders
Maternal Brain Imaging in Opioid Use Disorder
This research study aims to learn more about opioid use disorder (OUD) during pregnancy and how outcomes for pregnant women and their newborns can be improved.
- Conditions
- Opioid Use Disorder, Substance-Related Disorders, Substance Use, Pregnancy Related
- Trial name
- NCT06008990
- Testing
- Buprenorphine, Maternal Brain MRI, Blood Samples
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Indiana University
Postoperative Pain, Narcotic Use
Postoperative Opt-In Narcotic Treatment Study
pills go unused, generating waste and leaving an opportunity for misuse and abuse. In a recent study, researchers let patients choose what medications to go home with after surgery.
- Conditions
- Postoperative Pain, Narcotic Use, Analgesia, Endocrine Surgery
- Trial name
- POINT (NCT04710069)
- Testing
- POINT
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Opiate Withdrawal Syndrome
A Study of Oral Ibogaine in Opioid Withdrawal
Study DMX-IB 201 is a Phase 1/2a study of ibogaine consisting of an initial single ascending dose escalation stage to determine the maximum tolerated dose (MTD) or treat-to-target dose (TTD) in healthy volunteers, followed by a…
- Trial name
- NCT05029401
- Testing
- DMX-1002
- Where
- 2 sites in United Kingdom
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- atai Therapeutics, Inc.