Clinical trials: Opioid Use Disorders
Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
Parental Attitudes and Beliefs Regarding Risks Associated With Opioid Use in Children With Cancer
This study investigates parents' attitudes and beliefs on the risks of opioid use in children with cancer. Pain is the common symptom reported by pediatric cancer patients.
- Trial name
- NCT05055011
- Testing
- Electronic Health Record Review, Survey Administration
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Overdose Risk, Opioid Use Disorder
Kentucky Women's Justice Community Overdose Innovation Network - Phase II
This project continues our work with women in the Kentucky Women's Justice Community Overdose Innovation Network Phase II (WJCOIN-II) with the overall aim of reducing overdose risk during the transition from jail to rural…
- Conditions
- Overdose Risk, Opioid Use Disorder, Stimulant Use Disorders
- Trial name
- WJCOIN-II (NCT07179614)
- Testing
- Overdose Prevention Intervention Package (OPIP)
- Where
- 3 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Michele Staton
Anxiety, Opioid Use
Effects of Hypnosis Therapy on Outcomes in Shoulder Replacement Therapy
The purpose of this study is to collect information to evaluate the role of the psychogenic component of pain induced by anxiety on postoperative outcomes in major orthopaedic surgery and to determine whether hypnosis therapy…
- Trial name
- NCT04889833
- Testing
- hypnosis therapy
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Foundation for Orthopaedic Research and Education
Young Adults, Past-3-month Non-medical Use of Prescription Opioids
Theory-based Social Media Intervention for Non-medical Use of Prescription Opioids in Young Adults
Brief Summary The purposes of this study are to develop and implement a peer-led intervention program on Instagram for promoting prescription opioid use management and fostering psychosocial skills among young adults who engage…
- Conditions
- Young Adults, Past-3-month Non-medical Use of Prescription Opioids, Without Substance Use Disorders, Social Media Users
- Trial name
- NCT06469749
- Testing
- Theory-based and peer-led intervention on Instagram
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Opioid-use Disorder, Opioid Use, Unspecified
Opioid Use Disorder in Pregnancy in Long-Term Maternal/Infant Outcomes
The objective of this study is to better understand the comprehensive integration of both clinical and genetic factors that will help to identify mothers who could be at an increased risk of poor response to opioid substitution…
- Conditions
- Opioid-use Disorder, Opioid Use, Unspecified, Buprenorphine Dependence
- Trial name
- Mother/BabyOUD (NCT03923374)
- Testing
- Subutex / Buprenorphine, Fetal & Neonatal MRI, DNA/Genetic/Pharmacokenetic Blood Draws
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Senthil Sadhasivam
Opioid-use Disorder
Buprenorphine vs Buprenorphine/Naloxone on the Effects of Maternal Symptomatology
This study will assesses the efficacy of buprenorphine/naloxone vs buprenorphine on maternal withdrawal symptoms and drug cravings.
- Trial name
- NCT03740243
- Testing
- Buprenorphine/naloxone, Buprenorphine
- Volunteers
- healthy volunteers welcome
- Sponsor
- Stony Brook University
Pain Management
Search to Advance Limited Use of Opioids Pilot: Optimization of Non-Opioid Therapy With a Steroid
To provide health care professionals, including dentists, with the best possible evidence for clinical decision making when deciding upon analgesics and use of corticosteroid for acute post-surgical pain management; a pilot…
- Trial name
- SAILS-Steroid (NCT06074263)
- Testing
- Dexamethasone 8mg
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Opioid-use Disorder
Study of a Novel Subcutaneous Depot Formulation of Buprenorphine
INDV-6200 is being developed for the treatment of opioid dependency and is expected to provide sustained buprenorphine plasma concentrations.
- Trial name
- NCT03715634
- Testing
- INDV-6200, SL Buprenorphine, Nalorex
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Indivior Inc.
Contraception
Improving Reproductive Health for Women in Opioid Medication-Assisted Treatment (OMAT)
Recent research suggests that women with substance use disorders may be at a higher risk of unintended pregnancy. There is a paucity of interventions specifically focused on this population.
- Trial name
- NCT02794597
- Testing
- SHINE intervention group
- Where
- United States
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- Denver Health and Hospital Authority
Opioid Use, Substance Use Disorders
Evaluation of the Safety and Effects of Psychoactive Substances in People With Past Opioid Use
The purpose of this study is to understand how kratom affects people. In this study, kratom will be compared with another substance and a placebo (an inactive substance).
- Conditions
- Opioid Use, Substance Use Disorders, Opioid Analgesia
- Trial name
- NCT07218549
- Testing
- Oxycodone HCl, Kratom 8g, Kratom 12g
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Christopher D. Verrico
Opiod Use Disorder
EEG Biomarkers for OUD: Diagnostic, Prognostic, and Predictive Applications
The US is suffering from a national opioid epidemic characterized by significant costs, overdoses, and deaths. Conventional Opioid Use Disorder (OUD) treatments (i.e., pharmacological and psychosocial interventions) are…
- Trial name
- NCT07085351
- Where
- 3 sites in United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Community Reinforcement And Family Training, Family Health
We The Village Family Support Study
The United States is in the midst of an opioid crisis. Over-prescription of opioid analgesic pain relievers contributed to a rapid escalation of use and misuse of these substances across the country.
- Conditions
- Community Reinforcement And Family Training, Family Health, Substance-Related Disorders
- Trial name
- NCT04250077
- Testing
- Community Reinforcement And Family Training (CRAFT), We The Village Peer Community Forum
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- We The Village, Inc.
Harm Reduction, Opioid-use Disorder
A Usability Assessment of Naloxone Administration by Untrained Community Members
This will be a randomized, open-label, usability assessment of intramuscular, intranasal, and nasal spray administration of naloxone using two different instruction sets by laypersons.
- Conditions
- Harm Reduction, Opioid-use Disorder, Naloxone
- Trial name
- NCT04025671
- Testing
- Nasal Spray Naloxone, Intramuscular Naloxone, Improvised Nasal Atomizer
- Where
- United States
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- State University of New York - Upstate Medical University
Alcohol Use Disorder
Imaging CRF X NOP Interactions in Alcohol Use Disorder
This positron emission tomography imaging study uses [C-11]NOP-1A and hydrocortisone to image stress-modulating proteins in heavy drinking alcohol use disorder (AUD) subjects and healthy controls (HC).
- Trial name
- NCT07612631
- Testing
- Baseline [C-11]NOP-1A PET scan, Hydrocortisone, Post-hydrocortisone [C-11]NOP-1A PET scan
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Rajesh Narendran
Opioid Use Disorder, Substance Use Disorders
SMART Brain Health in African-Americans
The investigators hypothesize that opioid use in African-Americans will be associated with hypodopaminergic alleles that alter the threshold for activating feelings of reward and pleasure within the dopaminergic system, and that…
- Conditions
- Opioid Use Disorder, Substance Use Disorders, Dopamine Dysregulation Syndrome, African Americans
- Trial name
- SMART (NCT03861832)
- Testing
- KB220Z
- Where
- 2 sites in United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Howard University
Substance Use, HIV Infections
Kentucky Communities and Researchers Engaging to Halt the Opioid Epidemic (CARE2HOPE)
This study will test the effects of an intervention to reduce substance use and related harms among people leaving rural jails or otherwise involved in the criminal justice system.
- Conditions
- Substance Use, HIV Infections, HCV Infection, Sexually Transmitted Infections (Not HIV or Hepatitis)
- Trial name
- NCT04134767
- Testing
- Health Linkage, Overdose Education
- Where
- United States
- Volunteers
- 234 people, healthy volunteers welcome
- Sponsor
- April M Young
Opioid-use Disorder, Medication Adherence
CoMBAT Opioid Use Disorder: A Combined Medication and Behavioral Activation Treatment for People Living With Opioid Use Disorder
This study seeks primarily to test, in a two-arm randomized controlled trial (RCT), the feasibility, acceptability, and preliminary efficacy of CoMBAT OUD, an intervention that integrates Behavioral Activation (BA) and substance…
- Conditions
- Opioid-use Disorder, Medication Adherence, Health Care Utilization
- Trial name
- CoMBAT_OUD (NCT04240093)
- Testing
- Behavioral Activation (BA) Therapy, Substance Abuse and Health Navigation Counseling, Medications for Opioid Use Disorder
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Brown University
Opioid-use Disorder
Buprenorphine as Adjunct to Outpatient Induction Onto Vivitrol
The study will enroll 30 opioid-dependent participants into an open-label pilot outpatient study of methods to facilitate induction and stabilization onto XR-NTX.
- Trial name
- NCT03113409
- Testing
- Buprenorphine, Naltrexone, Vivitrol
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Family Planning Services, Substance-Related Disorders
Increasing Linkage to Family Planning Care for Individuals With Substance Use Disorder
This study will utilize mixed methods to develop and assess the feasibility and acceptability of a health educator intervention designed to connect patients in recovery from substance use disorder to reproductive health education…
- Conditions
- Family Planning Services, Substance-Related Disorders, Opiate Substitution Treatment, Sexual Health
- Trial name
- NCT04162184
- Testing
- Sexual Health Initiative for Navigation and Education (SHINE) Health Educator Intervention
- Where
- United States
- Volunteers
- 199 people, healthy volunteers welcome
- Sponsor
- Denver Health and Hospital Authority
Healthy, Opioid Use Disorder
Multi-System Analysis of Opioid Receptor Binding
This study will enroll up to 60 adults (including 30 females and 30 males) in three cohorts of up to 20 subjects each. In all three groups, [11C]carfentanil whole-body PET imaging will be used to examine the central nervous…
- Trial name
- NCT05528848
- Testing
- Carfentanil, C-11, Naloxone, Loperamide Hydrochloride
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania