Clinical trials: Opioid Users
Drug Abuse
A Study to Assess the Abuse Potential of Hydrocodone Extended-Release Tablet in Recreational Opioid Users
The purpose of this study is to assess the relative abuse potential of the hydrocodone bitartrate extended-release tablet compared to immediate-release hydrocodone bitartrate.
- Trial name
- NCT01596673
- Testing
- 45-mg hydrocodone bitartrate extended-release tablet (crushed or intact)
- Where
- 2 sites in United States, Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Cephalon
Healthy
Abuse Potential of Gabapentin Taken Orally Concomitantly With Oxycodone Hydrochloride in Healthy, Non-Drug-Dependent, Recreational Opioid Users
The purpose of the present study is to assess prospectively the abuse potential of gabapentin when taken with and without oxycodone compared to placebo in healthy non-drug-dependent recreational opioid drug users under fasted…
- Trial name
- NCT07813026
- Testing
- Oxycodone 20mg, gabapentin 600 mg, Gabapentin 1200mg
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Viatris Inc.
Opioid Use Disorder, Severe, in Sustained Remission, Opioid Use Disorder, Severe, in Early Remission
KAP for Depression in Abstinent Opioid Users
The purpose of the study is to examine whether an investigational medication called ketamine along with psychotherapy is an effective treatment for depression in participants with a history of opioid addiction who have not abused…
- Conditions
- Opioid Use Disorder, Severe, in Sustained Remission, Opioid Use Disorder, Severe, in Early Remission, Major Depressive Disorder
- Trial name
- KReDO (NCT05193318)
- Testing
- Ketamine-assisted psychotherapy
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Medical University of South Carolina
Hepatitis C, Heroin Dependence
Bridging Active Heroin Users to Hepatitis C Treatment Using Buprenorphine - 1
The purpose of this study is to see whether street-recruited heroin users can be successfully treated for hepatitis C after stabilizing them on buprenorphine.
- Trial name
- NCT00249574
- Testing
- Buprenorphine/naloxone, pegInterferon
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
HIV Infections, Opioid-Related Disorders
Drug Treatment Combined With Drug and Risk Reduction Counseling to Prevent of HIV Infection and Death Among Injection Drug Users
Drug abuse and HIV/AIDS are serious global health problems. Injection drug use is currently the major mode of transmission of HIV in many countries.
- Trial name
- NCT00270257
- Testing
- Buprenorphine/Naloxone
- Where
- 4 sites in China, Thailand
- Volunteers
- 1,251 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Opioid-Related Disorders
Mobile Intervention for Young Opioid Users
Opioid use disorders (OUD) are the second most common type of drug use disorder in the US, with nearly 2 million Americans with prescription opioid- (PO) and ~570,000 with heroin-related OUD.
- Trial name
- NCT03610672
- Testing
- OD prevention/response training, OD prevention/response training + PI mobile application
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- National Development and Research Institutes, Inc.
Staphylococcus Aureus Bacteremia, Staphylococcus Aureus Endocarditis
Oritavancin for Staphylococcus Aureus Infections in Opioid Users
This will be a pilot single-arm study consisting of 15 participants evaluating the use of oritavancin in the final consolidation phase (last two weeks of treatment) of systemic infections with Staphylococcus aureus (S.
- Trial name
- NCT03761953
- Testing
- Oritavancin Injection
- Where
- United States
- Sponsor
- University of Pennsylvania
Opioid-related Disorders, Buprenorphine
Neurocognitive Effects of Buprenorphine Among HIV+ and HIV-Opioid Users
The purpose of this study is to examine how Buprenorphine, a form of opioid addiction treatment, changes the ability to think and reason among people addicted to opiates, who are either HIV negative or HIV positive.
- Conditions
- Opioid-related Disorders, Buprenorphine, HIV, Cognition
- Trial name
- NCT01108679
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
HIV Infections, Heroin Dependence
Directly Administered Antiretroviral Therapy (DAART) Among HIV-1infected Injecting Drug Users (IDUs) in Chennai, India
Though the HIV epidemic in India is predominantly among heterosexual populations, it is estimated that there are approximately 1.1 million injection drug users (IDUs) in India with HIV prevalence as high as 64% among IDUs in…
- Trial name
- DAART+ (NCT00709007)
- Testing
- Directly Administered Antiretroviral Therapy (DAART), SAT
- Where
- India
- Sponsor
- Johns Hopkins University
Young Adults, Past-3-month Non-medical Use of Prescription Opioids
Theory-based Social Media Intervention for Non-medical Use of Prescription Opioids in Young Adults
Brief Summary The purposes of this study are to develop and implement a peer-led intervention program on Instagram for promoting prescription opioid use management and fostering psychosocial skills among young adults who engage…
- Conditions
- Young Adults, Past-3-month Non-medical Use of Prescription Opioids, Without Substance Use Disorders, Social Media Users
- Trial name
- NCT06469749
- Testing
- Theory-based and peer-led intervention on Instagram
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Moderate to Severe Chronic Pain
A Study Using fMRI Imaging to Evaluate the Effect of NKTR-181 on Brain Activity in Healthy, Non-physically Dependent Recreational Opioid Users.
The main purpose of this study is to evaluate the effect of NKTR-181 on brain activity in healthy, non-physically dependent recreational opioid users. This study will last about 88 days for each participant.
- Trial name
- NCT03802227
- Testing
- NKTR-181, Oxycodone IR
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Nektar Therapeutics
Nalbuphine, Opioid Abuse
Oral Abuse Potential Study of Nalbuphine
The purpose of this study is to measure the effects of a drug called nalbuphine (an opioid drug) compared with the effects of hydromorphone (an opioid drug) and placebo (contains no active drug ingredients).
- Trial name
- NCT04018664
- Testing
- Nalbuphine HCl solution
- Where
- Canada
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Trevi Therapeutics
Respiratory Depression
Single Dose Crossover Study to Compare the Respiratory Drive After Administration of Belbuca, Oxycodone and Placebo.
The purpose of this study is to explore and compare VRH after administration of Belbuca, Oxycodone HCl and Placebo in recreational opioid users.
- Trial name
- NCT03996694
- Testing
- Belbuca 300 µg, Belbuca 600 µg, Belbuca 900 µg
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- BioDelivery Sciences International
Opioid-Related Disorders, Substance-Related Disorders
Buprenorphine Dose Escalation Trial for Treatment of Non-Dependent Opiate Users - 2
The purpose of this study is to evaluate the effect, pharmacokinetics and dose proportionality of buprenorphine when administered to non-dependent opiate users.
- Trial name
- NCT00015041
- Testing
- Buprenorphine
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Healthy
To Evaluate the Relative Abuse Potential of Hydrocodone Bitartrate and Acetaminophen
Evaluation of abuse potential in recreational abusers of Hydrocodone Bitartrate and Acetaminophen versus NORCO®.
- Trial name
- NCT03567941
- Testing
- Hydrocodon bitartrate-acetaminophen arm 1, Hydrocodon bitartrate-acetaminophen arm 2, Reference
- Where
- Canada
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Sun Pharma Advanced Research Company Limited
Abuse, Drug
A Study to Assess the Abuse Potential of Intranasal Cebranopadol
The purpose of this study to Assess the Abuse Potential of Intranasal Cebranopadol Compared to Oxycodone and Placebo in Healthy, Nondependent Recreational Opioid Users.
- Trial name
- NCT06453265
- Testing
- Cebranopadol- 600 ug, Cebranopadol- 800ug, Cebranopadol- 1000ug
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Tris Pharma, Inc.
Opioid Overdose
Incidence and Predictors of Opioid Overdose and Death Among Long-Term Users of Opioid Analgesics
Retrospective study to assess incidence and predictors of opioid abuse overdose and death associated with opioid overdose among patients prescribed opioid products in long-term use.
- Trial name
- NCT02662153
- Testing
- Observation only
- Where
- 4 sites in United States
- Volunteers
- 808,455 people
- Sponsor
- Member Companies of the Opioid PMR Consortium
Substance Abuse
A Comparison of How Likely it is That Different Tablets of Oxycodone Will be Broken up and Snorted by Adults Who Sometimes Take Drugs for Pleasure
The trial comprises an Enrollment Visit, a Qualification Phase, a Treatment Phase (including 3 treatment periods), a Final Examination, and a Follow-up Phone Call.
- Trial name
- NCT03765346
- Testing
- Oxycodone IR ADF, Oxycodone API powder
- Where
- Canada
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- Grünenthal GmbH
Safety, Pharmacokinetics
Single Ascending Doses of Kratom in Healthy Nondependent Adults With Opioid Experience
Kratom (Mitragyna speciosa) is a plant often used to self-treat conditions such as pain, coughing, diarrhea, anxiety and depression, opioid use disorder, and opioid withdrawal.
- Conditions
- Safety, Pharmacokinetics, Pharmacodynamics
- Trial name
- NCT06072170
- Testing
- Kratom
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Altasciences Company Inc.
HIV-positive Individuals
MyTPill: A Novel Strategy to Monitor Antiretroviral Adherence Among HIV+ Prescription Opioid Users
This study compares several different antiretroviral adherence measures, including digital pills, in HIV+ individuals who are maintained on opioid analgesics.
- Trial name
- MyTPill (NCT03978793)
- Testing
- MyTPill, a digital pill
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Ohio State University