Clinical trials: Opioid-Free Anesthesia
Opioid-free Anesthesia, Geriatric Population
Opioid-free Anesthesia and Quality of Recovery After General Anesthesia
This study aimed to evaluate the effect of an opioid-free anesthesia protocol on postoperative recovery quality in patients aged 65 years and older undergoing major surgery.
- Trial name
- NCT06846333
- Volunteers
- 60 people
- Sponsor
- Selcuk University
Cleft Lip Palate, Orofacial Cleft
Effect of Opioid-Free vs Opioid-Based Anesthesia on Postoperative Pain and Emergence Agitation in Children Undergoing Cleft Surgery
Orofacial clefts are among the most common congenital malformations, affecting approximately 1 in 700-1500 live births worldwide.
- Conditions
- Cleft Lip Palate, Orofacial Cleft, Agitation, Emergence, Analgesia Assessment
- Trial name
- NCT07557576
- Testing
- Ketamine (1 mg/kg), Dexmedetomidine (1-0,8-0,6-0,4 mcg/kg/h), Fentanyl 5 mcg/kg
- Where
- Croatia
- Volunteers
- 90 people
- Sponsor
- Iva Smiljanić
Gynecologic Disease
Opioid-free Anesthesia in Gynecologic Surgery
Post-operative nausea and vomiting (PONV) is common for the patients undergoing laparoscopic gynecologic surgery. PONV is a major factor for patient dissatisfaction, delayed patient recovery and increased medical expenses.
- Trial name
- NCT04700761
- Testing
- Opioid-free anesthesia, Opioid-using anesthesia
- Where
- South Korea
- Volunteers
- 164 people
- Sponsor
- Seoul National University Bundang Hospital
Opioid-free Anesthesia
COMPARISON OF OPIOID-FREE AND OPIOID-BASED ANESTHESIA TECHNIQUES ON qNOX INDEX IN ABDOMINAL SURGERY UNDER GENERAL ANESTHESIA
This study is a randomized, double-blind controlled clinical trial designed to evaluate the effects of opioid-free anesthesia (OFA) compared with opioid-based anesthesia (OBA) in adult patients undergoing elective abdominal…
- Trial name
- OFA-OBA (NCT07310524)
- Testing
- Non Opioid Analgesics
- Where
- Indonesia
- Volunteers
- 42 people
- Sponsor
- Muhammad Rahman Efendi Nasution
Opioid Free Anaesthesia, Opioid Anaesthesia
Postoperative Opioid-Sparing Effect of a Pecto-Intercostal Fascial Block and Opioid-Free Anesthesia.
The present study aims to assess the difference in postoperative opioid consumption between patients who intraoperatively receive a pecto-intercostal facial block combined with opioid-free anesthesia versus a traditional…
- Trial name
- NCT04854577
- Testing
- Opioid Free Anesthesia, Traditional Anesthetic Regimen
- Volunteers
- 64 people
- Sponsor
- Algemeen Stedelijk Ziekenhuis
Supra-tentorial Tumor
A Comparative Study Between Opioids Free Anesthesia and Opioid Anesthesia in Patients With Supratentorial Tumor Resection
Anesthesia for cranial surgeries is charactarized by periods of unpleasant stimuli interspersed with periods of low stimulation, which may compromise hemodynamic regulation.
- Trial name
- NCT06791811
- Testing
- OFA, OA
- Where
- Egypt
- Volunteers
- 86 people
- Sponsor
- Kasr El Aini Hospital
Analgesics, Opioid
Benefits of Opioid Free Anesthesia on Morphine Consumption in Gastric Bypass
Opioid free anesthesia is a recent anesthesia technique with the aim to avoid peroperative use of morphinics to allow a diminution of secondary morphinics effects in the postoperative period.
- Trial name
- NCT05004519
- Testing
- Dexmedetomidine Injection [Precedex], Remifentanil
- Where
- Belgium
- Volunteers
- 183 people
- Sponsor
- matthieu clanet
Decreased Lung Compliance, Oxygen Requirement
Impact of OFA During LPV on Postoperative Oxygen Saturation
Opioids used intra operative increase the amount of opioids needed post operative to control post operative pain. if opioids are given post operative, we assume that more atelectasis and hypoxia takes place even after lung…
- Trial name
- NCT03660306
- Testing
- opioid anesthesia, opioid free anesthesia
- Where
- Belgium
- Volunteers
- 64 people
- Sponsor
- AZ Sint-Jan AV
Pain, Postoperative, Anesthesia, Local
Wound Infiltration as Part of an Opioid Free Pain Management Pathway Following Cesarean Delivery
This study will investigate the effect of three types of wound infiltration on post Cesarean opioid analgesia consumption when used in conjunction with an opioid free postoperative analgesia pathway.
- Conditions
- Pain, Postoperative, Anesthesia, Local, Opioid Use
- Trial name
- NCT03545516
- Testing
- Bupivacaine, Dexmedetomidine
- Where
- United States
- Volunteers
- 540 people, healthy volunteers welcome
- Sponsor
- Richmond University Medical Center
Postoperative Pain, Percutaneous Nephrolithotomy
The Effectiveness of Quadro İliac Plane Block in Percutaneous Nephrolithotomies
Our aim was to investigate the effect of quadro iliac plane block on postoperative analgesia in patients undergoing percutaneous nephrolithotomy surgery and to determine which areas of the skin this block anesthetizes.
- Trial name
- NCT07203859
- Testing
- Quadro-İliac Plane Block(QİPB)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Cumhuriyet University
Opioid Free Anesthesia, Opioid Based Anesthesia
Intraoperative Infusion of Dexmedetomidine Versus Lidocaine or Magnesium Sulphate for Enhanced Quality of Recovery After Spine Surgery Fixation
Thoracolumbar fixation is a major spine surgery; it is performed to stabilize the spine after trauma, deformity or advanced degenerative disease.
- Conditions
- Opioid Free Anesthesia, Opioid Based Anesthesia, Spine Fixation Surgeries, Opiod-Related Disorders
- Trial name
- NCT07843953
- Testing
- Group ( L): LICOCAINE, GROUP Dexmedetomidine, Group M: Magnesium sulphate
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Retrolaminar Block, Erector Spinae Plane Block
Retrolaminar Block Versus Erector Spinae Plane Block as Opioid-Free Anesthesia for Enhanced Recovery After Posterior Lumbar Discectomy
The aim of this study is to compare retrolaminar block and erector spine plane block as opioid-free anesthesia for enhanced recovery after posterior lumbar discectomy.
- Conditions
- Retrolaminar Block, Erector Spinae Plane Block, Opioid-Free Anesthesia, Enhanced Recovery
- Trial name
- NCT06725680
- Testing
- Retrolaminar block, Erector spinae plane block
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Tanta University
Pain, Postoperative, Pain
Improved Rehabilitation After Spinal Surgery in Adolescents
Impact of the OFA technique on postoperative recovery from adolescent spine surgery and the incidence of chronic postoperative pain.
- Conditions
- Pain, Postoperative, Pain, Scoliosis, Spinal Fusion
- Trial name
- NCT04183049
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Nantes University Hospital
Obesity, Postoperative Pain
OFA vs OBA in Bariatric Surgery
This study compares two different anesthesia techniques in patients with obesity undergoing bariatric surgery: one that includes opioids (OBA), and one that avoids them completely (OFA).
- Conditions
- Obesity, Postoperative Pain, Bariatric Surgery, Opioid-free Anesthesia
- Trial name
- OFA VS OBA1 (NCT07075302)
- Where
- Spain
- Volunteers
- 70 people
- Sponsor
- Hospital HM Nou Delfos
Obese Patients, Bariatric Surgical Pain
Non-opioid Anesthesia Based on Thoracic Paravertebral Block During Laparoscopic Sleeve Gastrectomy
Regional anesthesia is a technique in which a local anesthetic is injected near a nerve or spinal cord to block sensation, motor stimulation, and pain.
- Conditions
- Obese Patients, Bariatric Surgical Pain, Bariatric Surgery (Sleeve Gastrectomy ), Non-Opioid Pain Management
- Trial name
- NCT07084753
- Testing
- Levobupivacaine, Dexamethasone contained in the solution for thoracic paravertebral block, Adrenaline
- Where
- Croatia
- Volunteers
- 36 people
- Sponsor
- IVO JURISIC
Anesthesia
Opioid-Free Anesthesia in Cardiac Surgery
The use of morphine derivatives is widespread for performing general anesthesia. However, opioids have their own side effects: respiratory depression, digestive ileus, cognitive dysfunction, postoperative hyperalgesia…
- Trial name
- OFACS (NCT04940689)
- Testing
- Dexmédétomidine 0.5 g/kg + lidocaine 1.5 mg/kg, Remifentanil
- Where
- 5 sites in France
- Volunteers
- 268 people
- Sponsor
- University Hospital, Rouen
Opioid Use, Unspecified, Bariatric Surgery Candidate
Effect of Opioid Free Anesthetic on Post-Operative Opioid Consumption After Laparoscopic Bariatric Surgery
A comparison of post-operative opioid use in laparoscopic bariatric surgery patients receiving opioid or opioid-free anesthesia.
- Conditions
- Opioid Use, Unspecified, Bariatric Surgery Candidate, Anesthesia
- Trial name
- NCT04081545
- Testing
- Opioid Anesthetics, Non Opioid Analgesics
- Where
- United States
- Volunteers
- 181 people, healthy volunteers welcome
- Sponsor
- Christine Oryhan
Anesthesia, Opioid
The Effect of Opioid Free Anesthesia Using Ultrasound-Guided Bilateral Transversus Abdominus Plane Block and Dexmedetomidine Infusion
This study aimed to determine the effects of Opioid-free anesthesia using dexmedetomidine and bilateral Transversus abdominis plane block on the quality of recovery, incidence of Opioid-free anesthesia, and post-operative pain…
- Conditions
- Anesthesia, Opioid, Gynecological Surgery
- Trial name
- NCT07114237
- Testing
- Opioid Free Anesthesia, Control group (general anesthesia)
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Tanta University
Cognitive Dysfunction, Opioid Free Anesthesia
Postoperative Cognitive Dysfunction in Transsphenoidal Pituitary Surgeries
In this study, the patients undergoing pituitary surgery in our clinic have examined in two groups. In the first group, anesthesia maintenance was provided with remifentanil and propofol infusion.
- Trial name
- NCT06793150
- Testing
- Remifentanil, dexmedetomidin
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Kocaeli University
Breast Cancer, Mastectomy
A Study to Reduce Persistent Post-mastectomy Pain Using Opioid-free Anesthesia
In 230 patients undergoing mastectomy, the investigators will compare opioid-free anesthesia (OFA) versus conventional opioid-based anesthesia in terms of chronic pain.
- Conditions
- Breast Cancer, Mastectomy, Pain, Chronic, Pain, Post Operative
- Trial name
- RELIEF (NCT05146778)
- Testing
- Opioid-free anesthesia, Conventional opioid-based anesthesia
- Where
- South Korea
- Volunteers
- 230 people
- Sponsor
- Gangnam Severance Hospital