Clinical trials: Opioid-Induced Disorders
Opioid Use Disorder
A Study to Evaluate the Abuse Potential of Oxymorphone Compared to Other Mu Opioid Agonists.
Significant public health concerns have arisen from the intravenous misuse of oxymorphone, a potent mu-opioid pain medication. However, little is known about its abuse potential relative to other mu-opioid analgesics.
- Trial name
- NCT03389750
- Testing
- Intravenous Challenge Drug
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- New York State Psychiatric Institute
Opioid-Related Disorders, Opioid Dependence
An Innovative Intervention for OUD Treatment
The Bridge Device (BD) is a neuromodulator medical device that has been cleared by the FDA for Opioid Use Disorder (OUD) treatment.
- Conditions
- Opioid-Related Disorders, Opioid Dependence, Opioid Addiction, Opioid Withdrawal
- Trial name
- Bridge (NCT04325659)
- Testing
- Bridge Device, Lofexidine
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Opioid-use Disorder, Opioid Dependence
Comparing Two Training Methods for Opioid Wizard
The prevalence of opioid use disorder (OUD) and opioid-related deaths has risen dramatically in recent years. Effective treatments, including medications for opioid use disorder (MOUDs; e.g., buprenorphine-naloxone and methadone)…
- Conditions
- Opioid-use Disorder, Opioid Dependence, Attitude of Health Personnel
- Trial name
- NCT04867382
- Testing
- Online training
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- HealthPartners Institute
Opiate Addiction
Onsite Buprenorphine Treatment at Syringe Exchange Programs
This trial will recruit syringe exchange participants with opioid use disorder in New York City and test whether starting buprenorphine treatment at the syringe exchange program is more effective than referral to a community…
- Trial name
- O-BMT (NCT03150173)
- Testing
- Onsite treatment, Enhanced referral, Buprenorphine
- Where
- 3 sites in United States
- Volunteers
- 97 people
- Sponsor
- Montefiore Medical Center
Opioid Dependence
A Study of VIVITROL in the Prevention of Re-arrest and Re-incarceration
This phase 4 study will evaluate the feasibility of initiating subjects on VIVITROL in prison and continuing VIVITROL upon release into the community.
- Trial name
- NCT01453374
- Testing
- VIVITROL 380mg
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Alkermes, Inc.
Opioid Misuse and Addiction, Pain
Toward Zero Prescribed Opioids for Outpatient General Surgery
Investigators have created an opioid reduction "package" which includes patient education, non-narcotic pain control instructions, and limited (or no) opioid pain prescriptions provided at discharge in an attempt to reduce the…
- Trial name
- NCT05327777
- Testing
- Oxycodone, Zero Opioid Protocol
- Where
- United States
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Opioid-Induced Constipation
Safety of Subcutaneous Methylnaltrexone for Opioid-Induced Constipation in Patients With Advanced Illness
This is an open-label, multicenter extension of study 3200K1-4000-WW that will evaluate the safety of methylnaltrexone. This drug will be administered by subcutaneous injection and will be tested in late stage, advanced illness…
- Trial name
- NCT00672139
- Testing
- Methylnaltrexone bromide
- Where
- 46 sites in United States, Australia and 8 more
- Volunteers
- 156 people
- Sponsor
- Bausch Health Americas, Inc.
Healthy
A Study to Characterize the Abuse Liability of ALO-02 in Healthy, Non-Dependent, Recreational Opioid Abusers
The main purpose of this study is to determine if oxycodone and naltrexone combination capsules (ALO-02) have the potential to be abused.
- Trial name
- NCT01746901
- Testing
- intact ALO-02 60 mg/7.2 mg, crushed ALO-02 60 mg/7.2 mg, crushed oxycodone IR 60 mg
- Where
- Canada
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Pfizer
Substance Use, Substance Abuse
Data-driven Identification for Substance Misuse
The investigators propose to develop an open-source, publicly available machine learning model that health systems could download and apply to their electronic health record data marts to screen for substance misuse in their…
- Conditions
- Substance Use, Substance Abuse, Substance-Related Disorders
- Trial name
- NCT03833804
- Testing
- Processing of clinical notes in the EHR data collected during routine care
- Where
- United States
- Volunteers
- 64,996 people
- Sponsor
- University of Wisconsin, Madison
Maternal Opioid Use Disorder, Opioid Exposed Infant
Maternal Buprenorphine-naloxone Treatment and the Infant
The purpose of this mechanistic study is to evaluate the effects that maternal buprenorphine-naloxone maintenance have on the neurobehavioral development of the fetus and infant.
- Trial name
- NCT03291847
- Testing
- fetal monitoring, Buprenorphine Naloxone
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Johns Hopkins University
Chronic Pain
Effect of Guanfacine on the Reversal of Opioid-induced Hyperalgesia (OIH)
Combination of guanfacine with opioid medication as a standard treatment for chronic pain.
- Trial name
- NCT02192398
- Testing
- Guanfacine
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Massachusetts General Hospital
Cocaine Dependence
Pharmacotherapy & CM for Opioid and Cocaine Dependence
The purpose of this study is to compare the efficacy of the combined treatment modafinil + Contingency Management (CM) to either treatment condition alone or to yoked-controls on cocaine abstinence.
- Trial name
- NCT00838981
- Testing
- Modafinil, Sugar Pill, Contingency Management
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- Yale University
Covid-19, Substance Use
Leveraging Social Networks to Increase COVID-19 Testing Uptake
This two-year project will adapt and conduct a trial examining the ability of two recruitment strategies, chain-referral and credible messenger, to reach those who use opioids and other substances in order to increase their…
- Conditions
- Covid-19, Substance Use, Opioid Use
- Trial name
- NCT04873401
- Testing
- Chain-referral, Credible Messenger
- Where
- United States
- Volunteers
- 498 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Pain
Opioid and Cannabinoid Pharmacokinetic Interactions
We are conducting a study to assess whether smoking marijuana affects the safety of prescribed opioids in patients treated for chronic pain.
- Trial name
- NCT00308555
- Testing
- Cannabis
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of California, San Francisco
Opioid-Induced Constipation (OIC)
A 12-week Extension of the Phase III Study (D3820C00004) to Assess the Effect and Safety of NKTR-118 in Patients With Non-cancer-related Pain and Opioid-induced Constipation
The purpose of this study is to evaluate the effect and safety of NKTR-118 treatment of opioid-induced constipation in patients with non-cancer-related pain over a 6-month period.
- Trial name
- NCT01395524
- Testing
- NKTR-118
- Where
- 116 sites in United States, Australia and 2 more
- Volunteers
- 302 people
- Sponsor
- AstraZeneca
Opioid Misuse
A Digital Intervention to Prevent the Initiation of Opioid Misuse in Adolescents in School-based Health Centers
The primary hypothesis of this study is that at 3 months, there will be a higher proportion of intervention participants vs. control participants who report greater risk of harm from misuse of prescription opioids AND heroin.
- Trial name
- NCT04941950
- Testing
- PlaySmart, Video Game Control
- Where
- 15 sites in United States
- Volunteers
- 533 people, healthy volunteers welcome
- Sponsor
- Tyra Boomer
Opiate Dependence
Employment-Based Depot Naltrexone Clinical Trial
The purpose of this study is to determine whether employment-based naltrexone treatment proves effective in promoting depot naltrexone adherence and drug abstinence.
- Trial name
- NCT00684788
- Testing
- employment-based reinforcement
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Johns Hopkins University
Hypogonadism, Opioid-Related Disorders
Clomiphene Citrate for the Treatment of Low Testosterone Associated With Chronic Opioid Pain Medication Administration
The purpose of this randomized controlled clinical trial is to evaluate the effects of clomiphene citrate compared to placebo (substance without active medication) in men who are taking pain medication (opioids) for chronic pain…
- Conditions
- Hypogonadism, Opioid-Related Disorders, Male Infertility
- Trial name
- NCT01880086
- Testing
- Clomiphene citrate
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Weill Medical College of Cornell University
Drug Dependence
Improving Treatment Outcomes for Prescription Opioid Dependence
Overall, this proposal seeks to improve treatment strategies for the significant public health problem of prescription opioid dependence by determining whether gabapentin, a non-narcotic pharmaceutical agent with minimal abuse…
- Trial name
- GBN (NCT02543944)
- Testing
- Gabapentin, Buprenorphine, Clonidine
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- University of Arkansas
Opiate Dependence
Counseling for Primary Care Office-based Buprenorphine
The major goal is to determine whether adding cognitive behavioral therapy to physician management will increase the efficacy of buprenorphine/naloxone treatment in an office-based primary care setting.
- Trial name
- NCT00595764
- Testing
- Manual-guided Physician Management (PM), Physician Management (PM) combined with on-site manual-guided Cognitive Behavioral Therapy (CBT)
- Where
- 2 sites in United States
- Volunteers
- 141 people
- Sponsor
- Yale University