Clinical trials: Opioid-Induced Respiratory Depression, open to volunteers
Post Surgical Respiratory Failure, Respiratory Complication
Clinical Evaluation of an Alarm Activated Detection System to Enable Early Intervention of Emerging Respiratory Decline With the Linshom Medical Continuous Predictive Respiratory Sensor (CPRS)
Investigators will enroll 493 patients who will undergo non-cardiac surgery, receive supplemental oxygen via face mask or nasal cannula, and will be on continuous pulse oximetry monitor in the Post Anesthesia Care Unit (PACU).
- Conditions
- Post Surgical Respiratory Failure, Respiratory Complication, Opioid Induced Respiratory Depression, Respiratory Arrest
- Trial name
- NCT07793981
- Testing
- Linshom Continuous Predictive Respiratory Monitoring
- Where
- 2 sites in United States
- Volunteers
- 394 people
- Sponsor
- Linshom Medical, Inc.
Opioid-Induced Respiratory Depression, Postoperative Complications (Cardiopulmonary)
Pupillometry in Identifying Risk of Postoperative Opioid-induced Respiratory Depression in Children Undergoing Tonsillectomy
This study will evaluate whether quantitative pupillometry measurements can be used to identify children at risk for postoperative opioid-induced respiratory depression (OIRD) following tonsillectomy.
- Conditions
- Opioid-Induced Respiratory Depression, Postoperative Complications (Cardiopulmonary), Respiratory Complications Due to Anesthesia
- Trial name
- NCT07573150
- Testing
- Infrared Pupillometry
- Where
- 2 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- NeurOptics Inc
Respiration Disorders
Respiratory Monitoring System That Detects & Predicts OIRD
This study is being conducted to evaluate the ability of the Respiratory Monitoring System (RMS) to detect and predict opioid induced respiratory depression (OIRD) in post-operative surgical patients managed with opioid…
- Trial name
- RTM-NIH-SBIR-2 (NCT07217197)
- Testing
- Study to evaluate a Respiratory Monitoring System (RMS) with a Tracheal Sound Sensor (TSS) for detecting and predicting opioid induced respiratory Depression (OIRD).
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Thomas Jefferson University
Obesity & Overweight, Respiratory Depression
Oxytocin for Respiratory Compromise and Hypoventilation Induced by Drugs
Drug overdose is a national crisis. The primary cause of death associated with opioids is opioid-induced respiratory depression.
- Conditions
- Obesity & Overweight, Respiratory Depression, Intranasal Drug Administration, Oxytocin
- Trial name
- ORCHID (NCT07902752)
- Testing
- Intranasal Oxytocin 40 i.u.
- Volunteers
- 100 people
- Sponsor
- George Washington University
Opioids, Obstructive Sleep Apnea (OSA)
Impacts of Opioids on Respiratory Drive During Sleep
The investigators are studying the impact that opioids have on breathing during sleep in healthy participants and those diagnosed with obstructive sleep apnea.
- Trial name
- OIRD (NCT06854211)
- Testing
- Morphine p.o.
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Respiratory Complications, Opioid Induced Respiratory Depression
Timing of Opioid Administration and Postoperative Respiratory Depression.
The goal of this study is to determine if a relationship can be detected between the administration of an opioid and quantitative respiratory depression in spontaneously breathing non-intubated patients who have undergone general…
- Conditions
- Respiratory Complications, Opioid Induced Respiratory Depression, Postoperative Respiratory Complications
- Trial name
- NCT07227389
- Testing
- Respiratory volume monitoring
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Wayne State University