Clinical trials: Opioid-Related Disorders
Substance Use Disorders
Benzodiazepine Discontinuation in Opioid Agonist Therapy
The proposed study is a clinical trial, designed to pilot test a Distress Tolerance-Benzodiazepine Discontinuation (DT-BD) intervention for patients on opioid agonist therapy who currently use benzodiazepines.
- Trial name
- BZD-OAT (NCT04109118)
- Testing
- Distress Tolerance - Benzodiazepine Discontinuation (DT-BD), BZD discontinuation protocol
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Boston Medical Center
Opioid-use Disorder, Opioid Dependence
Comparing Two Training Methods for Opioid Wizard
The prevalence of opioid use disorder (OUD) and opioid-related deaths has risen dramatically in recent years. Effective treatments, including medications for opioid use disorder (MOUDs; e.g., buprenorphine-naloxone and methadone)…
- Conditions
- Opioid-use Disorder, Opioid Dependence, Attitude of Health Personnel
- Trial name
- NCT04867382
- Testing
- Online training
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- HealthPartners Institute
Opioid Abuse, Opioid Addiction
The Discriminative Effects of Tramadol in Humans
This research is part of a set of studies whose purpose is to test whether tramadol can be used for the treatment of opioid addiction. Tramadol is already available in the United States as a pain medicine marketed as Ultram.
- Conditions
- Opioid Abuse, Opioid Addiction, Stimulant Abuse, Stimulant Addiction
- Trial name
- NCT00499746
- Testing
- tramadol, Hydromorphone, Methylphenidate
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Opioid Dependence
Brain Mechanisms of Pharmacotherapy in Opioid Use Disorder
This study will investigate the mechanisms of cognitive-behavioral response to medications used for relapse prevention in opioid use disorder (opioid addiction, OUD), through investigation of the neural circuits underlying key…
- Trial name
- NCT04454411
- Testing
- Brixadi, Vivitrol
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Opioid-use Disorder, Medication Assisted Treatment
Psychosocial Pain Management to Improve Opioid Use Disorder Treatment Outcomes
The purpose of this research study is to look at the effect of programs aimed at helping people manage chronic pain and medication treatment.
- Conditions
- Opioid-use Disorder, Medication Assisted Treatment, Chronic Pain
- Trial name
- Persist (NCT04433975)
- Testing
- Psychosocial Pain Management (PPMI), Enhanced Usual Care (EUC)
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- University of Michigan
Opioid-use Disorder
Treatment Navigation for Opioid Use Disorder
The investigators will conduct a pilot randomized controlled trial (RCT) study of 100 people with a history of opioid use disorder releasing to WA Department of Corrections (DOC) community corrections supervision in King County.
- Trial name
- NCT03398265
- Testing
- Treatment Navigation (Intervention), Control
- Where
- 5 sites in United States
- Volunteers
- 17 people
- Sponsor
- University of Washington
Neoplasms, Constipation
Methylnaltrexone for Opioid-induced Constipation in Cancer Patients
The purpose of this study is to evaluate the efficacy of methylnaltrexone in relieving opioid-induced constipation in cancer patients at various stages of disease.
- Conditions
- Neoplasms, Constipation, Opioid-Related Disorders
- Trial name
- NCT01004393
- Testing
- Methylnaltrexone bromide
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Vermont
Opioid-use Disorder, Medication Adherence
CoMBAT Opioid Use Disorder: A Combined Medication and Behavioral Activation Treatment for People Living With Opioid Use Disorder
This study seeks primarily to test, in a two-arm randomized controlled trial (RCT), the feasibility, acceptability, and preliminary efficacy of CoMBAT OUD, an intervention that integrates Behavioral Activation (BA) and substance…
- Conditions
- Opioid-use Disorder, Medication Adherence, Health Care Utilization
- Trial name
- CoMBAT_OUD (NCT04240093)
- Testing
- Behavioral Activation (BA) Therapy, Substance Abuse and Health Navigation Counseling, Medications for Opioid Use Disorder
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Brown University
Opioid-use Disorder
Emergency Department Outcomes for Patients With Opioid Use Disorder
Using mixed methods and triangulating multiples sources of data collected over the course of the parent (CTN-0079 - NCT03544112) and the ancillary studies to evaluate the feasibility, acceptability, sustainability and impact of…
- Trial name
- NCT04289363
- Testing
- Clinical program implementation
- Where
- 2 sites in United States
- Volunteers
- 53 people
- Sponsor
- NYU Langone Health
Opioid-use Disorder
A Pilot Feasibility Study of Mindfulness-Oriented Recovery Enhancement With Pregnant Women With Opioid Use Disorder
Thirty pregnant women with substance use disorder will be recruited to participate in eight sessions of MORE.
- Trial name
- NCT04824521
- Testing
- Mindfulness-Oriented Recovery Enhancement
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Montana
Opioid Dependence, Opioid Withdrawal
Medical Management of Sleep Disturbance During Opioid Tapering
This study will evaluate whether a dual orexin-receptor antagonist approved by the FDA for sleep disturbance, suvorexant (SUVO; Belsomra), will increase total sleep time in patients with opioid use disorder (OUD) undergoing…
- Conditions
- Opioid Dependence, Opioid Withdrawal, Sleep Disturbance
- Trial name
- NCT03789214
- Testing
- Low Dose Suvorexant, High Dose Suvorexant
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Johns Hopkins University
Naloxone
Increasing Naloxone Access for Persons Who Use Opioids
Deaths relating to opioid overdose have rapidly increased over the past two decades. Due to the serious public health concern of the opioid epidemic, federal agencies recommend employing various harm reduction interventions.
- Trial name
- NCT04303000
- Testing
- Opioid Overdose Education with Naloxone Distribution, Opioid Overdose Education
- Where
- 4 sites in United States
- Volunteers
- 111 people
- Sponsor
- University of Alabama at Birmingham
Substance Use, Substance Use Disorders
Peer-Delivered Behavioral Activation for Methadone Adherence - Pilot Phase
The purpose of this study is to evaluate the feasibility and effectiveness of a peer-led, brief, behavioral intervention to improve adherence to medication for opioid use disorder (MOUD) among low-income, minoritized individuals…
- Conditions
- Substance Use, Substance Use Disorders, Opioid-use Disorder, Peer Delivered
- Trial name
- HEAL Together (NCT04248933)
- Testing
- Peer-Delivered Behavioral Activation (Peer Activate)
- Where
- 2 sites in United States
- Volunteers
- 37 people
- Sponsor
- University of Maryland, College Park
Substance Withdrawal Syndrome
Signs and Symptoms of Opioid-associated Iatrogenic Withdrawal in Critically Ill Adults
Mechanically ventilated critically ill adults may require prolonged administration of opioids to facilitate ventilator support and maintain comfort.
- Trial name
- SOWA-ICU (NCT03435614)
- Testing
- Opioids
- Where
- Canada
- Volunteers
- 29 people
- Sponsor
- Marc M. Perreault
Opiate Addiction
Treatment Study Using Depot Naltrexone (1/6) Philadelphia Coord/Data Mgmt Site
The aim of this project is to conduct a multi-site effectiveness study to determine whether the addition of a monthly injection of depot naltrexone to treatment as usual (TAU) will significantly improve outcome in parolees and…
- Trial name
- NCT00781898
- Testing
- Depot naltrexone, Treatment as Usual (TAU)
- Where
- United States
- Volunteers
- 308 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Opioid-Related Disorders
Trial of Adherence App for Buprenorphine Treatment (TAAB) Study
The purpose of this study is to pilot test a smartphone application that allows video-based directly observed therapy for participants receiving buprenorphine treatment for opioid use disorder in office-based settings.
- Trial name
- NCT03779997
- Testing
- Video-based DOT Application
- Where
- 2 sites in United States
- Volunteers
- 78 people
- Sponsor
- University of Washington
Opioid-use Disorder
A Strategy to Improve Success of Treatment Discontinuation in Buprenorphine Responders
This study is an open--label randomized outpatient trial to evaluate feasibility and efficacy of rapid buprenorphine (BUP) discontinuation followed by brief course of treatment with long--acting naltrexone (XR--NTX) and to…
- Trial name
- NCT03232346
- Testing
- Vivitrol, Buprenorphine
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Opioid Use Disorder, Stimulant Use Disorder
Suvorexant for Opioid/Stimulant Co-use
This study will evaluate whether Suvorexant 20mg reduces drug use and craving, and improves sleep and stress among persons with co-occurring opioid use disorder and stimulant use disorder.
- Trial name
- NCT05546515
- Testing
- Suvorexant (dual orexin receptor antagonist)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Johns Hopkins University
Opioid Use Disorder
A Mobile Executive Functioning Intervention for Momentary Craving in Opioid Use Disorders
Even when treated with methadone or buprenorphine maintenance, many people with opioid use disorder (OUD) continue to experience craving.
- Trial name
- NCT05086835
- Testing
- Working Memory Task, Visual Search Task
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Mclean Hospital
Opioid-use Disorder
An Open-Label Pilot Study of Sublocade as Treatment for Opiate Use Disorder
The proposed study is a 12-week, open-label pilot study of sublocade (extended-release burprenorphine, BXR) as treatment for opiate use disorder (OUD) testing positive for Highly Potent Synthetic Opioids (HPSO).
- Trial name
- NCT03861338
- Testing
- Sublocade
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- New York State Psychiatric Institute