Clinical trials: Opioid-related Disorders
Opioid Use Disorder
Social Functioning in Opioid Use Disorder
Problems with social functioning are core to opioid use disorder (OUD), though specific, modifiable social functioning targets and how they relate to OUD treatment outcomes are poorly understood.
- Trial name
- OUD (NCT07044466)
- Testing
- CBT4CBT-Buprenorphine
- Where
- United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Opioid Users
Abuse Potential Study of PF-00345439
This study will determine the relative abuse potential of intact and chewed PF-00345439 (Oxycodone Extended-Release Capsules) compared to crushed oxycodone HCL immediate release (IR) tablets and placebo administered orally to…
- Trial name
- NCT01986283
- Testing
- Capsule, PF-00345439, oxycodone
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Pain Therapeutics
Substance Use Disorder, Alcohol Use Disorder
Screening, Evaluation and Assessment (SEA) Protocol at the NIDA IRP
Background: People who will participate in research studies need to undergo proper screening, evaluation, and assessment (SEA). SEA helps keep those who participate in studies safe. It also helps ensure accurate study results.
- Trial name
- NCT06552741
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Opioid-Related Disorders, Pain, Acute
A Comparison of Plasma Concentrations of Hydrocodone and Acetaminophen After Administration of Different Amounts of Tablets of a New and a Marketed Tablet Formulation in Healthy Adults
This clinical trial is being conducted to compare concentrations of hydrocodone and acetaminophen in the blood after administration of different amounts of tablets of a new and a marketed tablet formulation in healthy adults.
- Conditions
- Opioid-Related Disorders, Pain, Acute, Pain, Postoperative
- Trial name
- NCT03137030
- Testing
- GRT7014 - Abuse Deterrend Tablet, Norco 5Mg-325Mg Tablet
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Grünenthal GmbH
Narcotic Abuse
Aprepitant Effects on Oxycodone Response
Addressing the issue of opioid dependence and tolerance has public health implications for the treatment of opioid abuse (both heroin as well as pharmaceutical opioids) and for the treatment of pain.
- Trial name
- NCT00999544
- Testing
- Aprepitant 0mg, Aprepitant 40mg, Aprepitant 200mg
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Sharon Walsh
Opioid Overdose
Pharmacodynamic Evaluation of Intramuscular Nalmefene Autoinjector 1.5 mg Compared to Intranasal Narcan 4 mg
The purpose of this study is to determine the pharmacodynamics (change in minute ventilation) of nalmefene when given as an autoinjector intramuscularly (IM; into the thigh) compared to naloxone when given intranasally (IN; into…
- Trial name
- NCT06719986
- Testing
- Nalmefene HCl injection, Naloxone HCl intranasal
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Purdue Pharma LP
Substance Abuse
A Comparison of How Likely it is That Different Tablets of Oxycodone Will be Broken up and Snorted by Adults Who Sometimes Take Drugs for Pleasure
The trial comprises an Enrollment Visit, a Qualification Phase, a Treatment Phase (including 3 treatment periods), a Final Examination, and a Follow-up Phone Call.
- Trial name
- NCT03765346
- Testing
- Oxycodone IR ADF, Oxycodone API powder
- Where
- Canada
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- Grünenthal GmbH
Opioid Use Disorder
Safety, Tolerability and Pharmacokinetics of NYX-783 and Oxycodone DDI Study
This study proposes to examine the safety, tolerability, and pharmacokinetics (PK) of NYX-783 50 mg and 150 mg versus Placebo (PBO) in combination with acute Oxycodone 15 mg and 30 mg in an inpatient randomized, cross-over study…
- Trial name
- NCT05447286
- Testing
- NYX-783, Oxycodone
- Where
- 2 sites in United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Yale University
Cocaine Dependence, Opioid Dependence
FMRI of Stress and Addictive Disorders
The purpose of this study is to explore whether frontal brain activation in response to stress varies as a function of the presence or extent of early trauma and whether or not this effect is greater in women compared to men.
- Conditions
- Cocaine Dependence, Opioid Dependence, Alcoholism, Pathological Gamblers
- Trial name
- NCT01558973
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Yale University
Heroin Dependence, Opioid-Related Disorders
Counseling Conditions for Buprenorphine in a Primary Care Clinic - 1
The purpose of this study is to compare the Standard Medical Management (SMM) vs. SMM enhanced with additional education about addiction and recovery (Enhanced Medical Management, EMM)
- Conditions
- Heroin Dependence, Opioid-Related Disorders, Substance Abuse, Intravenous
- Trial name
- NCT00023283
- Testing
- Buprenorphine
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Yale University
Opioid Overdose
Preventing Opioid Overdose Mortality in the United States
This study aims to conduct a randomized controlled trial of 105 syringe services programs (SSPs) throughout the United States to understand the effectiveness of a multifaceted, facilitation-based strategy at advancing naloxone…
- Trial name
- NCT03924505
- Testing
- Organize and Mobilize for Implementation Effectiveness, Dissemination
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- RTI International
Alcohol Use Disorder
Investigating the Mu:Kappa Opioid Receptor Imbalance in Alcohol Use Disorder
The primary objective of this multimodal positron emission tomography (PET) study is to use PET brain imaging to measure both MOR (Mu-Opioid receptors) and KOR (kappa-opioid receptors) in participants with alcohol use disorder…
- Trial name
- Mu Kappa (NCT05957159)
- Testing
- Detoxification Program, PKAB, CFN
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Yale University
Opioid-use Disorder, Opioid Use
The Analgesic Efficacy of Continuous Sub-fascial Bupivacaine Infusion and Lidocaine Patches in Post-cesarean Patients With Opiate Use Disorder: A Comparative Efficacy Analysis
Pregnant women with a history of opioid use disorder, chronic opioid use or those who are on medication assisted treatment will be randomly assigned to receive either a sub-fascial continuous infusion of bupivacaine or…
- Conditions
- Opioid-use Disorder, Opioid Use, Opioid Dependence, Opioid Abuse
- Trial name
- NCT04033562
- Testing
- Lidocaine patch, Ambu ACTion pump, 0.125% bupivacaine at 8cc/hr
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- WellSpan Health
Alcohol Addiction
Study of the Opioid Modulation of the Effect of Alcohol on the Dopaminergic Reward System
About 10% of the calculable loss of health and quality of life in industrial countries can be attributed to excessive alcohol consumption.
- Trial name
- NCT03854942
- Testing
- Naltrexone
- Where
- Germany
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- RWTH Aachen University
Opioid Use, Unspecified, Prescription Drug Abuse (Not Dependent)
An Opioid Prescribing Nudge
Analyze baseline concurrent opioid prescribing metrics at the individual prescriber level in the Duke Health System on the identified three main outcome measures.
- Conditions
- Opioid Use, Unspecified, Prescription Drug Abuse (Not Dependent), Prescription Drug Abuse and Dependency, Health Behavior
- Trial name
- OHS (NCT04069403)
- Testing
- Automated Reports on prescription patterns for their patients
- Where
- United States
- Volunteers
- 427 people, healthy volunteers welcome
- Sponsor
- Duke University
Opioid Dependence
XRB vs. SLB in Jail and at Re-entry: Pilot, Proof of Concept
This is a pilot proof-of-concept randomized controlled trial, open-label and unblinded, examining the feasibility and acceptability of Buprenorphine extended-release vs.
- Trial name
- NCT03604159
- Testing
- Buprenorphine Extended Release, Sublingual Buprenorphine (SUBOXONE, Zubsolv, or generic tablets)
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Opioid Prescribing, Prescription Drug Misuse
E-mails to Nudge Safer and Better-Informed Prescribing of Risky Drugs
This study will test e-mails to encourage engagement with the Minnesota prescription monitoring program (PMP/PDMP) and will evaluate the effect of these e-mails on PMP/PDMP use and controlled substance prescribing.
- Trial name
- NCT06443385
- Testing
- PDMP Legal Mandate E-mail, PDMP Clinical Benefit E-mail
- Where
- United States
- Volunteers
- 7,872 people, healthy volunteers welcome
- Sponsor
- Columbia University
Opioid Use, Alcohol Drinking
TACUNA (Traditions and Connections for Urban Native Americans)
This study responds to Request For Application-DA-19-035, HEAL (Helping End Addiction Long Term) initiative: Preventing OUD in Older Adolescents and Young Adults (ages 16-30) by developing and implementing a culturally centered…
- Conditions
- Opioid Use, Alcohol Drinking, Marijuana Use
- Trial name
- TACUNA (NCT04617938)
- Testing
- TACUNA plus Wellness Circle, Opioid Education Workshop
- Where
- 3 sites in United States
- Volunteers
- 541 people, healthy volunteers welcome
- Sponsor
- RAND
Opioid-use Disorder
Obstetric Pain Management for Women With Opioid Use Disorder (QUEST)
This is a mixed methods longitudinal observational study to assess patient and provider perspectives on pain and pain management among pregnant women with opiate use disorder (OUD).
- Trial name
- QUEST (NCT04308655)
- Testing
- Interview, Surveys
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Substance-Related Disorders
Disrupting SRFOH to Improve Substance Use and Mental Health Outcomes for Parents in Rural Regions
The study will evaluate the effectiveness of the Just Care for Families program in preventing Oregon Department of Human Services (ODHS)-involved parents in rural communities from escalating opioid and/or methamphetamine use and…
- Trial name
- NCT06560866
- Testing
- Just Care for Families
- Where
- United States
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Chestnut Health Systems