Clinical trials: Opioids
Opioid Use Disorder, Opioid Dependence
Measuring Acute Drug Demand in Humans
This research is being done to evaluate whether suvorexant may reduce the use of, subjective liking, and demand for various drugs.
- Trial name
- NCT05829655
- Testing
- Drug A (Blinded Drug), Drug B (Blinded Drug), Drug C (Blinded Drug)
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Multimodal Analgesia, Nonsteroidal Anti-inflammatory Drugs
NSAID vs. Narcotics
This will be a single-center, prospective observational study. The study will compare post-operative pain scores and narcotic consumption between two groups of patients - one cohort will receive ibuprofen (Motrin) and Percocet…
- Trial name
- NCT02915055
- Testing
- Ibuprofen 600 mg, standard oxycodone/acetaminophen
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Post-operative Pain, Acute, Cesarean Section
Management of Postoperative Pain After Cesarean Delivery Using Bridge Auricular Percutaneous Nerve Field Stimulator
Post-cesarean section (CS) pain is commonly treated with acetaminophen, ibuprofen, and opioid medications as needed following delivery.
- Conditions
- Post-operative Pain, Acute, Cesarean Section, Opioid Use Disorder, Opioids; Harmful Use
- Trial name
- NCT06434714
- Testing
- Auricular percutaneous nerve field stimulator
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Inova Health Care Services
Conscious Sedation Failure During Procedure
Remifentanil Effect-site Prediction by Algometry
This study validates the pharmacodynamic analgesic predictions (effect) given by Minto's remifentanil pharmacokinetic and dynamic model in conscious sedation.
- Trial name
- NCT05115578
- Testing
- Remifentanil 1 MG Injection [Ultiva], Midazolam 1 MG/ML Prefilled Syringe, Saline solution
- Where
- Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Chronic Pain
Development/Testing of SUMMIT: a Tool to Help Patients Manage Pain While Tapering Opioids
There are nearly one million veterans being treated with long-term opioid therapy (LTOT) for chronic pain. Numerous short and long-term harms associated with LTOT and mounting evidence suggest they have modest or no benefit.
- Trial name
- NCT04746833
- Testing
- SUMMIT, control
- Where
- 4 sites in United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Pain, Chronic Pain
Negating Opioid and Pain Actively Through Intervention
Chronic pain is one of the most prevalent and debilitating medical conditions and opioid analgesics are a commonly prescribed class of medications in the United States.
- Conditions
- Pain, Chronic Pain, Opioid Use
- Trial name
- NOPAIN (NCT03306147)
- Testing
- Pain education with follow up encounters
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Thyroid Surgeries, Intraoperative Analgesic Use
qCON/qNOX-Guided Anesthesia in Patients Undergoing Thyroidectomy Surgery
The aim of this study is to evaluate the effect of using the non-invasive Conox monitor on intraoperative opioid consumption. Additionally, the study aims to assess the impact of Conox monitoring on recovery time, postoperative…
- Conditions
- Thyroid Surgeries, Intraoperative Analgesic Use, Anesthesia Depth Monitoring
- Trial name
- NCT07445659
- Testing
- Connox EEG Monitoring, standard anesthesia management
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Kayseri City Hospital
Pain, Postoperative, Pain, Acute
Pectoral Nerve Blocks (PECs) for Cardiovascular Implantable Electronic Device Placement
The purpose of this study is to determine whether administration of a pectoral nerve blocks (Pecs I and II) with 0.25% bupivacaine are more effective as compared to placebo to provide analgesia for cardiac implantable electronic…
- Conditions
- Pain, Postoperative, Pain, Acute, Pain, Chest, Pain
- Trial name
- NCT05283980
- Testing
- 0.25% Bupivacaine
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Pain, Acute, Opioid Misuse
The Effect of a Charcoal Deactivation Pouch on Opioid Disposal After Cesarean Delivery
Background: There is scarce literature investigating how patients dispose of unused opioid supplies after their cesarean postoperative pain has faded.
- Conditions
- Pain, Acute, Opioid Misuse, Obstetric Pain, Cesarean Section Complications
- Trial name
- NCT05498025
- Testing
- Deterra activated charcoal pouch
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Geisinger Clinic
Laparoscopic Cholecystectomy
Dexamethasone-Enhanced TAP Block in Lapchole
The transversus abdominis plane (TAP) block is widely used as part of analgesia for abdominal surgeries such as laparoscopic cholecystectomy. While bupivacaine is commonly used for TAP blocks with reported success.
- Trial name
- NCT07182110
- Testing
- Dexamethasone enhanced TAP Block, Marcaine- 0.25%
- Where
- Lebanon
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Makassed General Hospital
Compassion Fatigue, Burnout
Resilience Training for First Responders in the Opioid Epidemic
First responders (law enforcement, firefighters, and emergency medical system personnel) are subjected to daily pressures from their duties with resultant compassion fatigue, burnout, anger, poor mental and physical health…
- Conditions
- Compassion Fatigue, Burnout, Stress, Mindfulness
- Trial name
- NCT04929613
- Testing
- Mindfulness-Based Resilience Training
- Where
- 4 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- West Virginia University
Respiratory Depression
ENA-001 for Opioid Induced Respiratory Depression
This study is a Phase I clinical trial to assess the safety, tolerability, and pharmacokinetic (PK) and pharmacodynamic (PD) profiles with single intravenous (IV) and intramuscular (IM) doses of ENA-001.
- Trial name
- NCT06967259
- Testing
- ENA-001
- Where
- 2 sites in United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Enalare Therapeutics Inc.
Cocaine Dependence, Opioid Dependence
FMRI of Stress and Addictive Disorders
The purpose of this study is to explore whether frontal brain activation in response to stress varies as a function of the presence or extent of early trauma and whether or not this effect is greater in women compared to men.
- Conditions
- Cocaine Dependence, Opioid Dependence, Alcoholism, Pathological Gamblers
- Trial name
- NCT01558973
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Yale University
Abuse, Drug
A Trial to Evaluate the Abuse Potential of 3 Doses of GRT6005 in Adult Non-dependent Recreational Opioid Users
The primary objective of this study was to evaluate the abuse potential of single doses of cebranopadol (GRT6005) relative to hydromorphone (immediate-release formulation [IR] and placebo in 48 non-dependent recreational opioid…
- Trial name
- NCT03757559
- Testing
- Cebranopadol 100 micrograms, Cebranopadol 400 micrograms, Hydromorphone hydrochloride 4 milligrams
- Where
- Canada
- Volunteers
- 226 people, healthy volunteers welcome
- Sponsor
- Tris Pharma, Inc.
Gambling, Opioid
Treatment of Gambling Disorder With Fast Acting Opiate Antagonist, Naloxone Nasal Spray
Non-controlled pilot study. Two groups: Group A: naloxone nasal spray max 8 mg/per day; Group B: naloxone max 16 mg/per day. Study duration 8 weeks. Brief intervention.
- Conditions
- Gambling, Opioid, Naloxone, Spray
- Trial name
- NALPILO (NCT03223896)
- Testing
- Naloxone hydrochloride 20mg/ml
- Where
- Finland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Finnish Institute for Health and Welfare
Adolescent Idiopathic Scoliosis, Multimodal Analgesia
Propofol + Remifentanil vs. Propofol + Dexmedetomidine in Adolescent Idiopathic Scoliosis Patients Having Spine Surgery
Patients with Adolescent Idiopathic Scoliosis may need surgery to correct their scoliosis. General anesthesia is required for this surgery, and a multimodal analgesic regimen using combinations of opioid and non-opioid…
- Conditions
- Adolescent Idiopathic Scoliosis, Multimodal Analgesia, Opioid Induced Hyperalgesia, Remifentanil
- Trial name
- NCT06096181
- Testing
- Remifentanil TIVA, Dexmedetomidine TIVA, Propofol TIVA
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Fear
Opioids and Social Support Enhanced Extinction Effects
University of California, Los Angeles researchers will recruit healthy participants (age 18-35) to participate in a study examining whether the administration of naltrexone, an opioid antagonist, eliminates the ability of social…
- Trial name
- SSO (NCT04166071)
- Testing
- Naltrexone
- Where
- 2 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Inflammatory Bowel Diseases
Nabilone Use For Acute Pain in Inflammatory Bowel Disease Patients
This is a clinical trial of nabilone for patients with Inflammatory Bowel Disease (IBD) who are undergoing IBD-related surgery (Any abdominal surgery lasting for more than one hour).
- Trial name
- NCT03422861
- Testing
- Nabilone
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Pharyngeal Dysfunction, Esophageal Dysfunction
Opioids and Esophageal Function
The purpose of this study is to evaluate if opioid-induced effects on the pharynx and esophagus is centrally or peripherally mediated.
- Trial name
- NCT01012960
- Testing
- methylnaltrexone
- Where
- 2 sites in Sweden
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Region Örebro County
Opioid-Related Disorders
Abuse Potential of Intranasal VYCAVERT Tablets (Hydrocodone Bitartrate/Acetaminophen) in Recreational Opioid Users
To determine the relative abuse potential of VYCAVERT (hydrocodone bitartrate and acetaminophen) compared to GENERIC H/A (hydrocodone bitartrate and acetaminophen) when crushed and administered intranasally to non dependent…
- Trial name
- NCT01759446
- Testing
- Generic H/A taken first, Vycavert taken first, Generic H/A plus i taken first
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Acura Pharmaceuticals Inc.
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